Rutin inhibits UVB radiation-induced expression of COX-2 and iNOS in hairless mouse skin: p38 MAP kinase and JNK as potential targets

2014 ◽  
Vol 559 ◽  
pp. 38-45 ◽  
Author(s):  
Ki-Seok Choi ◽  
Joydeb Kumar Kundu ◽  
Kyung-Soo Chun ◽  
Hye-Kyung Na ◽  
Young-Joon Surh
Keyword(s):  
Map Kinase ◽  
Mouse Skin ◽  
Hairless Mouse ◽  
P38 Map Kinase ◽  
Uvb Radiation ◽  
Induced Expression ◽  
Hairless Mouse Skin ◽  
Radiation Induced ◽  
Cox 2

Ultrastructure of ultraviolet radiation-induced hairless mouse skin carcinogenesis, with special reference to the epidermal-dermal junction

Pathology ◽  
1986 ◽  
Vol 18 (3) ◽  
pp. 337-344 ◽  
Author(s):  
P.J. Canfield ◽  
G.E. Greenoak ◽  
V.E. Reeve ◽  
C.H. Gallagher ◽  
Fu-Nan Xu ◽  
...  
Keyword(s):  
Ultraviolet Radiation ◽  
Special Reference ◽  
Mouse Skin ◽  
Hairless Mouse ◽  
Skin Carcinogenesis ◽  
Hairless Mouse Skin ◽  
Radiation Induced

scholarly journals [6]-Gingerol inhibits COX-2 expression by blocking the activation of p38 MAP kinase and NF-κB in phorbol ester-stimulated mouse skin

Oncogene ◽  
2005 ◽  
Vol 24 (15) ◽  
pp. 2558-2567 ◽  
Author(s):  
Sue Ok Kim ◽  
Joydeb Kumar Kundu ◽  
Young Kee Shin ◽  
Jin-Hong Park ◽  
Myung-Haing Cho ◽  
...  
Keyword(s):  
Map Kinase ◽  
Phorbol Ester ◽  
Mouse Skin ◽  
P38 Map Kinase ◽  
Cox 2

scholarly journals Protective Effects of Sesamin Against UVB-Induced Skin Inflammation and Photodamage In Vitro and In Vivo

Biomolecules ◽  
2019 ◽  
Vol 9 (9) ◽  
pp. 479 ◽  
Author(s):  
Lin ◽  
Wu ◽  
Hou ◽  
Chien ◽  
Chang ◽  
...  
Keyword(s):  
Protein Expression ◽  
Map Kinase ◽  
Human Fibroblasts ◽  
Mouse Skin ◽  
P38 Map Kinase ◽  
Dermal Fibroblasts ◽  
Tissue Inhibitor Of Metalloproteinase ◽  
Protective Effects ◽  
Cox 2

Ultraviolet (UV) exposure has been demonstrated as the most critical factor causing extrinsic skin aging and inflammation. This study explored the protective effects and mechanisms of sesamin against skin photodamage. Sesamin reduced intracellular reactive oxygen species production after UVB irradiation in human dermal fibroblasts. The sesamin treatment attenuated mitogen-activated protein (MAP) kinase phosphorylation and matrix metalloproteinase (MMPs) overexpression induced by UVB exposure, and it significantly enhanced the tissue inhibitor of metalloproteinase-1 protein expression. Sesamin also elevated the total collagen content in human fibroblasts by inhibiting UVB-induced mothers against decapentaplegic homolog 7 (Smad7) protein expression. Sesamin reduced UVB-induced inducible nitric oxide synthase (i-NOS) and cyclooxygenase-2 (COX-2) overexpression and inhibited nuclear factor-kappa B (NF-κB) translocation. Moreover, sesamin may regulate the c-Jun N-terminal kinases (JNK) and p38 MAP kinase pathways, which inhibit COX-2 expression. Sesamin could reduce UVB-induced inflammation, epidermal hyperplasia, collagen degradation, and wrinkle formation in hairless mice. It also reduced MMP-1, interleukin (IL-1), i-NOS, and NF-κB in the mouse skin. These results demonstrate that sesamin had antiphotodamage and anti-inflammatory activities. Sesamin has potential for use as a skin protection agent in antiphotodamage and skin care products.

scholarly journals MORIN PREVENTS ULTRAVIOLET-B RADIATION-INDUCED PHOTOCARCINOGENESIS THROUGH ACTIVATING THROMBOSPONDIN-1 IN THE MOUSE SKIN

2018 ◽  
Vol 11 (3) ◽  
pp. 171
Author(s):  
Anjugam C ◽  
Sridevi M ◽  
Rajendra Prasad N ◽  
Agilan Balupillai
Keyword(s):  
Growth Factor ◽  
Transforming Growth Factor Beta ◽  
Transforming Growth Factor ◽  
Mouse Skin ◽  
Ultraviolet B ◽  
Uvb Radiation ◽  
Thrombospondin 1 ◽  
Radiation Induced ◽  
Cox 2 ◽  
Uvb Exposure

 Objective: In this study, we investigated whether morin, a natural flavonoid, could able to inhibit ultraviolet B (UVB)-induced carcinogenesis in the skin of Swiss albino mice.Methods: The mice were exposed to UVB radiation (180 mJ/cm2) on weekly thrice for 30 weeks, and morin was administered intraperitoneal and topical application 1 h before UVB exposure. UVB radiation induces the overexpression of cyclooxygenase-2 (COX-2), inducible nitric oxide synthase (iNOS), vascular endothelial growth factor (VEGF), transforming growth factor-beta (TGF-β), and Bcl-2 genes.Results: Morin significantly prevented UVB-induced activation of COX-2, iNOS, VEGF, TGF-β, and Bcl-2 expression in mouse skin. Thrombospondin-1 (TSP), a novel endogenous factor, inhibits angiogenesis and inflammation.Conclusion: The present study illustrates that the protective effect of morin against UVB-induced carcinogenesis may be modulated through activation of TSP-1 in UVB-exposed Swiss albino mice.

Oligonol Inhibits UVB-induced COX-2 Expression in HR-1 Hairless Mouse Skin—AP-1 and C/EBP as Potential Upstream Targets

2008 ◽  
Vol 84 (2) ◽  
pp. 399-406 ◽  
Author(s):  
Joydeb Kumar Kundu ◽  
Eun-Jin Chang ◽  
Hajime Fujii ◽  
Buxiang Sun ◽  
Young-Joon Surh
Keyword(s):  
Mouse Skin ◽  
Hairless Mouse ◽  
Hairless Mouse Skin ◽  
Cox 2

scholarly journals Docosahexaenoic Acid Inhibits UVB-Induced Activation of NF-κB and Expression of COX-2 and NOX-4 in HR-1 Hairless Mouse Skin by Blocking MSK1 Signaling

PLoS ONE ◽  
2011 ◽  
Vol 6 (11) ◽  
pp. e28065 ◽  
Author(s):  
Md. Mostafizur Rahman ◽  
Joydeb Kumar Kundu ◽  
Jun-Wan Shin ◽  
Hye-Kyung Na ◽  
Young-Joon Surh
Keyword(s):  
Docosahexaenoic Acid ◽  
Mouse Skin ◽  
Hairless Mouse ◽  
Hairless Mouse Skin ◽  
Cox 2
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