scholarly journals Wnt Signalling in Acute Myeloid Leukaemia

Cells ◽  
2019 ◽  
Vol 8 (11) ◽  
pp. 1403 ◽  
Author(s):  
Alicja M. Gruszka ◽  
Debora Valli ◽  
Myriam Alcalay
Keyword(s):  
Acute Myeloid Leukaemia ◽  
Myeloid Leukaemia ◽  
Prognostic Value ◽  
Clinical Trial Data ◽  
Trial Data ◽  
Wnt Signalling ◽  
Preclinical Studies ◽  
Malignant Diseases ◽  
Haematopoietic System ◽  
Acute Myeloid

Acute myeloid leukaemia (AML) is a group of malignant diseases of the haematopoietic system. AML occurs as the result of mutations in haematopoietic stem/progenitor cells, which upregulate Wnt signalling through a variety of mechanisms. Other mechanisms of Wnt activation in AML have been described such as Wnt antagonist inactivation through promoter methylation. Wnt signalling is necessary for the maintenance of leukaemic stem cells. Several molecules involved in or modulating Wnt signalling have a prognostic value in AML. These include: β-catenin, LEF-1, phosphorylated-GSK3β, PSMD2, PPARD, XPNPEP, sFRP2, RUNX1, AXIN2, PCDH17, CXXC5, LLGL1 and PTK7. Targeting Wnt signalling for tumour eradication is an approach that is being explored in haematological and solid tumours. A number of preclinical studies confirms its feasibility, albeit, so far no reliable clinical trial data are available to prove its utility and efficacy.

Cytogenetics and their prognostic value in de novo acute myeloid leukaemia: a report on 283 cases

1989 ◽  
Vol 73 (1) ◽  
pp. 61-67 ◽  
Author(s):  
P. Fenaux ◽  
C. Preudhomme ◽  
J. L. Laï ◽  
P. Morel ◽  
R. Beuscart ◽  
...  
Keyword(s):  
Acute Myeloid Leukaemia ◽  
Myeloid Leukaemia ◽  
Prognostic Value ◽  
De Novo ◽  
Acute Myeloid

scholarly journals Absence of leukaemic CD34+cells in acute myeloid leukaemia is of high prognostic value: a longstanding controversy deciphered

2015 ◽  
Vol 171 (2) ◽  
pp. 227-238 ◽  
Author(s):  
Wendelien Zeijlemaker ◽  
Angèle Kelder ◽  
Rolf Wouters ◽  
Peter J.M. Valk ◽  
Birgit I. Witte ◽  
...  
Keyword(s):  
Acute Myeloid Leukaemia ◽  
Myeloid Leukaemia ◽  
Prognostic Value ◽  
Cd34 Cells ◽  
Acute Myeloid

Prognostic value of dysmyelopoietic features in de novo acute myeloid leukaemia: a report on 132 patients

2008 ◽  
Vol 12 (1) ◽  
pp. 57-65 ◽  
Author(s):  
M. H. ESTIENNE ◽  
P. FENAUX ◽  
C. PREUDHOMME ◽  
J. L. LAI ◽  
M. ZANDECKI ◽  
...  
Keyword(s):  
Acute Myeloid Leukaemia ◽  
Myeloid Leukaemia ◽  
Prognostic Value ◽  
De Novo ◽  
Acute Myeloid

Prognostic value of bone marrow MUC4 expression in acute myeloid leukaemia

2020 ◽  
Vol 77 (4) ◽  
pp. 202-207
Author(s):  
AS Abdelhady ◽  
FF Abdel Hamid ◽  
NM Hassan ◽  
DM Ibrahim
Keyword(s):  
Bone Marrow ◽  
Acute Myeloid Leukaemia ◽  
Myeloid Leukaemia ◽  
Prognostic Value ◽  
Muc4 Expression ◽  
Acute Myeloid

A New Mononuclear Cell (MNC) RNase H Activity-Based Parameter (ψ) With Possible Prognostic Value in Assessing Progression in Acute Myeloid Leukaemia

1990 ◽  
Vol 1 (3-4) ◽  
pp. 209-220 ◽  
Author(s):  
Anastasios D. Papaphilis ◽  
Elli F. Kamper ◽  
Stavroula Grammenou ◽  
Christos Kattamiss ◽  
Gerassimos A. Pangalis
Keyword(s):  
Acute Myeloid Leukaemia ◽  
Myeloid Leukaemia ◽  
Mononuclear Cell ◽  
Prognostic Value ◽  
Rnase H ◽  
Acute Myeloid

No significant prognostic value of normal precursor B-cell regeneration in paediatric acute myeloid leukaemia after induction treatment

2013 ◽  
Vol 161 (6) ◽  
pp. 861-864 ◽  
Author(s):  
Anne E. Bras ◽  
Marry M. van den Heuvel-Eibrink ◽  
Alita J. van der Sluijs-Gelling ◽  
Eva A. Coenen ◽  
Henk Wind ◽  
...  
Keyword(s):  
Acute Myeloid Leukaemia ◽  
B Cell ◽  
Myeloid Leukaemia ◽  
Prognostic Value ◽  
Induction Treatment ◽  
Cell Regeneration ◽  
Acute Myeloid

scholarly journals Double trouble: A case of synchronous presentation of acute myeloid leukaemia and multiple myeloma

2020 ◽  
Vol 4 ◽  
Author(s):  
Nomusa Mashigo
Keyword(s):  
Elderly Patient ◽  
Multiple Myeloma ◽  
Acute Myeloid Leukaemia ◽  
Myeloid Leukaemia ◽  
Alkylating Agents ◽  
Simultaneous Occurrence ◽  
Malignant Diseases ◽  
Previous Exposure ◽  
Prior Therapy ◽  
Acute Myeloid

Malignancies following successful chemotherapy for various malignant diseases, including multiple myeloma (MM), are well known and documented. The occurrence of acute myeloid leukaemia (AML) after chemotherapy for MM with alkylating agents is well described; however, simultaneous occurrence of the two entities with no prior therapy is extremely rare. We describe a case of an elderly patient with no previous exposure to chemotherapy, who was diagnosed with both MM and AML concurrently. Very few similar cases have been described in the literature.

The acute myeloid leukaemia market

2019 ◽  
Vol 19 (4) ◽  
pp. 233-234
Author(s):  
Jorrit Schaefer ◽  
Sorcha Cassidy ◽  
Rachel M. Webster
Keyword(s):  
Acute Myeloid Leukaemia ◽  
Myeloid Leukaemia ◽  
Acute Myeloid
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