No significant prognostic value of normal precursor B-cell regeneration in paediatric acute myeloid leukaemia after induction treatment

2013 ◽  
Vol 161 (6) ◽  
pp. 861-864 ◽  
Author(s):  
Anne E. Bras ◽  
Marry M. van den Heuvel-Eibrink ◽  
Alita J. van der Sluijs-Gelling ◽  
Eva A. Coenen ◽  
Henk Wind ◽  
...  
Keyword(s):  
Acute Myeloid Leukaemia ◽  
B Cell ◽  
Myeloid Leukaemia ◽  
Prognostic Value ◽  
Induction Treatment ◽  
Cell Regeneration ◽  
Acute Myeloid

Efficacy and feasibility of intensive induction therapy in very elderly patients with acute myeloid leukaemia

2006 ◽  
Vol 24 (18_suppl) ◽  
pp. 16528-16528
Author(s):  
G. Biaggi ◽  
A. Santagostino ◽  
D. Manachino ◽  
T. Posca ◽  
G. Forti ◽  
...  
Keyword(s):  
Elderly Patients ◽  
Acute Myeloid Leukaemia ◽  
Myeloid Leukaemia ◽  
Performance Status ◽  
Best Supportive Care ◽  
Induction Treatment ◽  
Very Elderly ◽  
Ecog Performance Status ◽  
Leukaemia Therapy ◽  
Acute Myeloid

16528 Background: Intensive Induction Treatment (IIT) increases chances of longer survival in acute myeloid leukaemia (AML). Our aim was to improve outcome and to evaluate safety and tolerability of IIT in very elderly patients (pts). Otherwise they have a median surviving time of 11 weeks without treatment. Methods: From October 2003 to November 2005 we treated 23 pts, 16 Males (M) and 7 Female (F); median age 75.5 years (range 68–95). According FAB classification they were 1 M0, 10 M1, 5 M2, 6 M4, 1 M5. ECOG performance status (PS) was 0 in 6 pts, 1 in 5 pts, 2 in 7 pts and 3 in 5 pts. All pts underwent IIT with different schedules: only a female 95 years old had less intensive treatment. Immune-chemotherapy was also admitted. Schedules were: 3+7 IDA+ARA-C in 8 pts; MY-FLAI in 7 pts; VP+ARA-C 1 = ≥ 5 in 2 pts; IDA+ARA-C 1 = ≥ 2 in 4 pts; ARA-C + 6TG in 1 pt. Eleven pts underwent second line treatment. Results: Five pts are alive and 18 dead. We obtained 7 complete responses (CR) (32%) and 1 partial response (PR) (RR 36%);. The median CR duration was 7.5 months (range 1–12).Throughout IIT we observed 5 toxic deaths (23%) because of infections and 2 deaths not leukaemia therapy related (heart failure). The median Overall Survival (OS) was 9 months. Conclusions: Despite the toxic deaths due to the treatment, we obtained in 32% of the pts CR longer compared to palliative or best supportive care; also the median OS was longer than we can expected without chemotherapy. Our data support in our opinion the feasibility and the utility of an IIT in very elderly patients with good PS. No significant financial relationships to disclose.

Cytogenetics and their prognostic value in de novo acute myeloid leukaemia: a report on 283 cases

1989 ◽  
Vol 73 (1) ◽  
pp. 61-67 ◽  
Author(s):  
P. Fenaux ◽  
C. Preudhomme ◽  
J. L. Laï ◽  
P. Morel ◽  
R. Beuscart ◽  
...  
Keyword(s):  
Acute Myeloid Leukaemia ◽  
Myeloid Leukaemia ◽  
Prognostic Value ◽  
De Novo ◽  
Acute Myeloid

scholarly journals Absence of leukaemic CD34+cells in acute myeloid leukaemia is of high prognostic value: a longstanding controversy deciphered

2015 ◽  
Vol 171 (2) ◽  
pp. 227-238 ◽  
Author(s):  
Wendelien Zeijlemaker ◽  
Angèle Kelder ◽  
Rolf Wouters ◽  
Peter J.M. Valk ◽  
Birgit I. Witte ◽  
...  
Keyword(s):  
Acute Myeloid Leukaemia ◽  
Myeloid Leukaemia ◽  
Prognostic Value ◽  
Cd34 Cells ◽  
Acute Myeloid

scholarly journals Wnt Signalling in Acute Myeloid Leukaemia

Cells ◽  
2019 ◽  
Vol 8 (11) ◽  
pp. 1403 ◽  
Author(s):  
Alicja M. Gruszka ◽  
Debora Valli ◽  
Myriam Alcalay
Keyword(s):  
Acute Myeloid Leukaemia ◽  
Myeloid Leukaemia ◽  
Prognostic Value ◽  
Clinical Trial Data ◽  
Trial Data ◽  
Wnt Signalling ◽  
Preclinical Studies ◽  
Malignant Diseases ◽  
Haematopoietic System ◽  
Acute Myeloid

Acute myeloid leukaemia (AML) is a group of malignant diseases of the haematopoietic system. AML occurs as the result of mutations in haematopoietic stem/progenitor cells, which upregulate Wnt signalling through a variety of mechanisms. Other mechanisms of Wnt activation in AML have been described such as Wnt antagonist inactivation through promoter methylation. Wnt signalling is necessary for the maintenance of leukaemic stem cells. Several molecules involved in or modulating Wnt signalling have a prognostic value in AML. These include: β-catenin, LEF-1, phosphorylated-GSK3β, PSMD2, PPARD, XPNPEP, sFRP2, RUNX1, AXIN2, PCDH17, CXXC5, LLGL1 and PTK7. Targeting Wnt signalling for tumour eradication is an approach that is being explored in haematological and solid tumours. A number of preclinical studies confirms its feasibility, albeit, so far no reliable clinical trial data are available to prove its utility and efficacy.

Prognostic value of dysmyelopoietic features in de novo acute myeloid leukaemia: a report on 132 patients

2008 ◽  
Vol 12 (1) ◽  
pp. 57-65 ◽  
Author(s):  
M. H. ESTIENNE ◽  
P. FENAUX ◽  
C. PREUDHOMME ◽  
J. L. LAI ◽  
M. ZANDECKI ◽  
...  
Keyword(s):  
Acute Myeloid Leukaemia ◽  
Myeloid Leukaemia ◽  
Prognostic Value ◽  
De Novo ◽  
Acute Myeloid
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