scholarly journals Sulfated Hydrogels in Intervertebral Disc and Cartilage Research

Cells ◽  
2021 ◽  
Vol 10 (12) ◽  
pp. 3568
Author(s):  
Emily Lazarus ◽  
Paola Bermudez-Lekerika ◽  
Daniel Farchione ◽  
Taylor Schofield ◽  
Sloan Howard ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Quality Assurance ◽  
Growth Factors ◽  
Intervertebral Disc ◽  
Current Knowledge ◽  
3D Culture ◽  
Sustained Delivery ◽  
Beneficial Effects ◽  
The Past ◽  
And Cartilage

Hydrogels are commonly used for the 3D culture of musculoskeletal cells. Sulfated hydrogels, which have seen a growing interest over the past years, provide a microenvironment that help maintain the phenotype of chondrocytes and chondrocyte-like cells and can be used for sustained delivery of growth factors and other drugs. Sulfated hydrogels are hence valuable tools to improve cartilage and intervertebral disc tissue engineering. To further advance the utilization of these hydrogels, we identify and summarize the current knowledge about different sulfated hydrogels, highlight their beneficial effects in cartilage and disc research, and review the biofabrication processes most suitable to secure best quality assurance through deposition fidelity, repeatability, and attainment of biocompatible morphologies.

scholarly journals 3D-Bioprinting Strategies Based on In Situ Bone-Healing Mechanism for Vascularized Bone Tissue Engineering

Micromachines ◽  
2021 ◽  
Vol 12 (3) ◽  
pp. 287
Author(s):  
Ye Lin Park ◽  
Kiwon Park ◽  
Jae Min Cha
Keyword(s):  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Bone Healing ◽  
Critical Size ◽  
Current Knowledge ◽  
3D Bioprinting ◽  
The Past ◽  
Regeneration Processes

Over the past decades, a number of bone tissue engineering (BTE) approaches have been developed to address substantial challenges in the management of critical size bone defects. Although the majority of BTE strategies developed in the laboratory have been limited due to lack of clinical relevance in translation, primary prerequisites for the construction of vascularized functional bone grafts have gained confidence owing to the accumulated knowledge of the osteogenic, osteoinductive, and osteoconductive properties of mesenchymal stem cells and bone-relevant biomaterials that reflect bone-healing mechanisms. In this review, we summarize the current knowledge of bone-healing mechanisms focusing on the details that should be embodied in the development of vascularized BTE, and discuss promising strategies based on 3D-bioprinting technologies that efficiently coalesce the abovementioned main features in bone-healing systems, which comprehensively interact during the bone regeneration processes.

Tissue Engineering of the Intervertebral Disc With Cultured Nucleus Pulposus Cells Using Atelocollagen Scaffold and Growth Factors

Spine ◽  
2012 ◽  
Vol 37 (6) ◽  
pp. 452-458 ◽  
Author(s):  
Kwang-Il Lee ◽  
Seong-Hwan Moon ◽  
Hyang Kim ◽  
Un-Hye Kwon ◽  
Ho-Joong Kim ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Growth Factors ◽  
Intervertebral Disc ◽  
Nucleus Pulposus ◽  
Nucleus Pulposus Cells

scholarly journals Proteins and Peptides as Important Modifiers of the Polymer Scaffolds for Tissue Engineering Applications—A Review

Polymers ◽  
2020 ◽  
Vol 12 (4) ◽  
pp. 844 ◽  
Author(s):  
Katarzyna Klimek ◽  
Grazyna Ginalska
Keyword(s):  
Tissue Engineering ◽  
Current Knowledge ◽  
Biological Properties ◽  
Synthetic Polymer ◽  
Bioactive Molecules ◽  
Matrix Proteins ◽  
Polymer Scaffolds ◽  
The Past ◽  
Proliferation And Differentiation ◽  
Proteins And Peptides

Polymer scaffolds constitute a very interesting strategy for tissue engineering. Even though they are generally non-toxic, in some cases, they may not provide suitable support for cell adhesion, proliferation, and differentiation, which decelerates tissue regeneration. To improve biological properties, scaffolds are frequently enriched with bioactive molecules, inter alia extracellular matrix proteins, adhesive peptides, growth factors, hormones, and cytokines. Although there are many papers describing synthesis and properties of polymer scaffolds enriched with proteins or peptides, few reviews comprehensively summarize these bioactive molecules. Thus, this review presents the current knowledge about the most important proteins and peptides used for modification of polymer scaffolds for tissue engineering. This paper also describes the influence of addition of proteins and peptides on physicochemical, mechanical, and biological properties of polymer scaffolds. Moreover, this article sums up the major applications of some biodegradable natural and synthetic polymer scaffolds modified with proteins and peptides, which have been developed within the past five years.

Pediatric Craniofacial Surgery: A Review for the Multidisciplinary Team

2011 ◽  
Vol 48 (6) ◽  
pp. 670-683 ◽  
Author(s):  
Peter J. Taub ◽  
Joshua A. Lampert
Keyword(s):  
Tissue Engineering ◽  
Stem Cell ◽  
World War Ii ◽  
Growth Factors ◽  
Molecular Biology ◽  
Relevant Literature ◽  
Craniofacial Surgery ◽  
World War ◽  
The Past ◽  
Future Direction

Pediatric craniofacial surgery is a specialty that grew dramatically in the 20th century and continues to evolve today. Out of the efforts to correct facial deformities encountered during World War II, the techniques of modern craniofacial surgery developed. An analysis of the relevant literature allowed the authors to explore this historical progression. Current advances in technology, tissue engineering, and molecular biology have further refined pediatric craniofacial surgery. The development of distraction osteogenesis and the progressive study of craniosynostosis provide remarkable examples of this momentum. The growing study of genetics, biotechnology, the influence of growth factors, and stem cell research provide additional avenues of innovation for the future. The following article is intended to reveal a greater understanding of pediatric craniofacial surgery by examining the past, present, and possible future direction. It is intended both for the surgeon, as well as for the nonsurgical individual specialists vital to the multidisciplinary craniofacial team.

scholarly journals Tooth Bioengineering and Regenerative Dentistry

2019 ◽  
Vol 98 (11) ◽  
pp. 1173-1182 ◽  
Author(s):  
P.C. Yelick ◽  
P.T. Sharpe
Keyword(s):  
Tissue Engineering ◽  
Current Knowledge ◽  
Basic Research ◽  
Dental Tissue ◽  
Dental Tissues ◽  
The Past ◽  
Tremendous Progress ◽  
Regenerative Dentistry ◽  
Dental Tissue Engineering ◽  
Made In

Over the past 100 y, tremendous progress has been made in the fields of dental tissue engineering and regenerative dental medicine, collectively known as translational dentistry. Translational dentistry has benefited from the more mature field of tissue engineering and regenerative medicine (TERM), established on the belief that biocompatible scaffolds, cells, and growth factors could be used to create functional, living replacement tissues and organs. TERM, created and pioneered by an interdisciplinary group of clinicians, biomedical engineers, and basic research scientists, works to create bioengineered replacement tissues that provide at least enough function for patients to survive until donor organs are available and, at best, fully functional replacement organs. Ultimately, the goal of both TERM and regenerative dentistry is to bring new and more effective therapies to the clinic to treat those in need. Very recently, the National Institutes of Health/National Institute of Dental and Craniofacial Research invested $24 million over a 3-y period to create dental oral and craniofacial translational resource centers to facilitate the development of more effective therapies to treat edentulism and other dental-related diseases over the next decade. This exciting era in regenerative dentistry, particularly for whole-tooth tissue engineering, builds on many key successes over the past 100 y that have contributed toward our current knowledge and understanding of signaling pathways directing natural tooth and dental tissue development—the foundation for current strategies to engineer functional, living replacement dental tissues and whole teeth. Here we use a historical perspective to present key findings and pivotal advances made in the field of translational dentistry over the past 100 y. We will first describe how this process has evolved over the past 100 y and then hypothesize on what to expect over the next century.

scholarly journals The Insulin/IGF System in Mammalian Sexual Development and Reproduction

2019 ◽  
Vol 20 (18) ◽  
pp. 4440 ◽  
Author(s):  
Neirijnck ◽  
Papaioannou ◽  
Nef
Keyword(s):  
Growth Factors ◽  
Sexual Development ◽  
Current Knowledge ◽  
Reproductive Organs ◽  
Future Studies ◽  
The Past ◽  
Igf System ◽  
The Family ◽  
Males And Females ◽  
Insulin Like Growth Factors

Persistent research over the past few decades has clearly established that the insulin-like family of growth factors, which is composed of insulin and insulin-like growth factors 1 (IGF1) and 2 (IGF2), plays essential roles in sexual development and reproduction of both males and females. Within the male and female reproductive organs, ligands of the family act in an autocrine/paracrine manner, in order to guide different aspects of gonadogenesis, sex determination, sex-specific development or reproductive performance. Although our knowledge has greatly improved over the last years, there are still several facets that remain to be deciphered. In this review, we first briefly outline the principles of sexual development and insulin/IGF signaling, and then present our current knowledge, both in rodents and humans, about the involvement of insulin/IGFs in sexual development and reproductive functions. We conclude by highlighting some interesting remarks and delineating certain unanswered questions that need to be addressed in future studies.

scholarly journals Applications of the amniotic membrane in tissue engineering and regeneration: the hundred-year challenge

2022 ◽  
Vol 13 (1) ◽  
Author(s):  
Hoda Elkhenany ◽  
Azza El-Derby ◽  
Mohamed Abd Elkodous ◽  
Radwa A. Salah ◽  
Ahmed Lotfy ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Tissue Engineering ◽  
Stem Cells ◽  
Growth Factors ◽  
Amniotic Membrane ◽  
Clinical Applications ◽  
Past Century ◽  
The Past ◽  
Potent Growth ◽  
Topical Applications

AbstractThe amniotic membrane (Amnio-M) has various applications in regenerative medicine. It acts as a highly biocompatible natural scaffold and as a source of several types of stem cells and potent growth factors. It also serves as an effective nano-reservoir for drug delivery, thanks to its high entrapment properties. Over the past century, the use of the Amnio-M in the clinic has evolved from a simple sheet for topical applications for skin and corneal repair into more advanced forms, such as micronized dehydrated membrane, amniotic cytokine extract, and solubilized powder injections to regenerate muscles, cartilage, and tendons. This review highlights the development of the Amnio-M over the years and the implication of new and emerging nanotechnology to support expanding its use for tissue engineering and clinical applications. Graphical Abstract

scholarly journals Current insights on use of growth factors as therapy for Intervertebral Disc Degeneration

2018 ◽  
Vol 9 (1) ◽  
pp. 43-52 ◽  
Author(s):  
Justin C. Kennon ◽  
Mohamed E. Awad ◽  
Norman Chutkan ◽  
John DeVine ◽  
Sadanand Fulzele
Keyword(s):  
Tissue Engineering ◽  
Low Back Pain ◽  
Back Pain ◽  
Growth Factors ◽  
Growth Factor ◽  
Intervertebral Disc ◽  
Transforming Growth Factor ◽  
Low Back

AbstractChronic low back pain is a critical health problem and a leading cause of disability in aging populations. A major cause of low back pain is considered to be the degeneration of the intervertebral disc (IVD). Recent advances in therapeutics, particularly cell and tissue engineering, offer potential methods for inhibiting or reversing IVD degeneration, which have previously been impossible. The use of growth factors is under serious consideration as a potential therapy to enhance IVD tissue regeneration. We reviewed the role of chosen prototypical growth factors and growth factor combinations that have the capacity to improve IVD restoration. A number of growth factors have demonstrated potential to modulate the anabolic and anticatabolic effects in both in vitro and animal studies of IVD tissue engineering. Members of the transforming growth factor-β superfamily, IGF-1, GDF-5, BMP-2, BMP-7, and platelet-derived growth factor have all been investigated as possible therapeutic options for IVD regeneration. The role of growth factors in IVD tissue engineering appears promising; however, further extensive research is needed at both basic science and clinical levels before its application is appropriate for clinical use.

scholarly journals Research Advances in Tissue Engineering Materials for Sustained Release of Growth Factors

2015 ◽  
Vol 2015 ◽  
pp. 1-7 ◽  
Author(s):  
Hai-yang Zhao ◽  
Jiang Wu ◽  
Jing-jing Zhu ◽  
Ze-cong Xiao ◽  
Chao-chao He ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Growth Factors ◽  
Sustained Release ◽  
Enzymatic Degradation ◽  
Bone Repair ◽  
Sustained Delivery ◽  
System Disease ◽  
Free Growth ◽  
Intense Research

Growth factors are a class of cytokines that stimulate cell growth and are widely used in clinical practice, such as wound healing, revascularization, bone repair, and nervous system disease. However, free growth factors have a short half-life and are instablein vivo. Therefore, the search of excellent carriers to enhance sustained release of growth factorsin vivohas become an area of intense research interest. The development of controlled-release systems that protect the recombinant growth factors from enzymatic degradation and provide sustained delivery at the injury site during healing should enhance the growth factor’s application in tissue regeneration. Thus, this study reviews current research on commonly used carriers for sustained release of growth factors and their sustained release effects for preservation of their bioactivity and their accomplishment in tissue engineering approaches.

scholarly journals Újabb ismeretek a szövetépítés (tissue engineering) lehetőségeiről a kézsebészetben. Irodalmi áttekintés

2018 ◽  
Vol 159 (34) ◽  
pp. 1385-1389
Author(s):  
Vilmos Bíró
Keyword(s):  
Tissue Engineering ◽  
Hand Surgery ◽  
Review Article ◽  
Experimental Results ◽  
Accelerated Expansion ◽  
Vascular Injuries ◽  
Novel Technologies ◽  
The Past ◽  
And Cartilage

Abstract: In the past decades, an exponential acceleration in the development of tissue engineering methods has taken place. This accelerated expansion can be found in hand surgery, too, and tissue replacements can be applied with the aid of various scaffolds. In his review article, the author discusses the present possibilities of tissue engineering in cases of the tendons, ligaments, nerves, bone- and cartilage tissues, and vascular injuries. These pioneering experimental results and promising novel technologies may play an important role in reconstructive hand surgery in the immediate future. Orv Hetil. 2018; 159(34): 1385–1389.

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