scholarly journals WWOX-Related Neurodevelopmental Disorders: Models and Future Perspectives

Cells ◽  
2021 ◽  
Vol 10 (11) ◽  
pp. 3082
Author(s):  
Daniel J. Steinberg ◽  
Rami I. Aqeilan
Keyword(s):  
Neurological Disorders ◽  
Fragile Site ◽  
Review Article ◽  
Model Systems ◽  
Future Perspectives ◽  
Putative Tumor Suppressor ◽  
The Common ◽  
The Many ◽  
Wwox Gene ◽  
Pleiotropic Function

The WW domain-containing oxidoreductase (WWOX) gene was originally discovered as a putative tumor suppressor spanning the common fragile site FRA16D, but as time has progressed the extent of its pleiotropic function has become apparent. At present, WWOX is a major source of interest in the context of neurological disorders, and more specifically developmental and epileptic encephalopathies (DEEs). This review article aims to introduce the many model systems used through the years to study its function and roles in neuropathies. Similarities and fundamental differences between rodent and human models are discussed. Finally, future perspectives and promising research avenues are suggested.

scholarly journals Drugs and War: What Is the Relationship?

2019 ◽  
Vol 22 (1) ◽  
pp. 57-73
Author(s):  
Peter Andreas
Keyword(s):  
Armed Conflict ◽  
Review Article ◽  
One Dimension ◽  
Psychoactive Drugs ◽  
Psychoactive Substances ◽  
Strategic Objectives ◽  
The Common ◽  
Key Dimensions ◽  
The Many ◽  
The Relationship

What is the relationship between psychoactive drugs and war? This review article identifies and traces five key dimensions of this relationship: war while on drugs, war for drugs, war through drugs, war against drugs, and drugs after war. The review provides empirical illustrations across times, places, and drugs to demonstrate the importance of each of these dimensions. Political scientists and other scholars have typically either ignored the drugs–war relationship or focused on only one dimension. The common tendency is to privilege illegal drugs such as cocaine and heroin in the contemporary era over the historical centrality of legal drugs such as tobacco and alcohol in relation to armed conflict. Placing both history and a wider range of drugs (legal and illegal) front and center in the analysis provides a corrective that allows for a fuller and richer understanding of the multiple linkages between psychoactive substances and warfare. It also suggests that as a counterbalance to contemporary accounts stressing the growing threat posed by drug-financed violent nonstate actors, we should recognize the many ways in which the centuries-old nexus between drugs and war has also been about statecraft and the pursuit of the state's strategic objectives.

Ahara as Pathya and Apathya in Amlapitta - A Review.

2017 ◽  
Vol 2 (1) ◽  
Author(s):  
Rakshith . ◽  
Shivakumar . ◽  
Sreeharsha . ◽  
Divyasree .
Keyword(s):  
Physical Health ◽  
Review Article ◽  
The Other ◽  
Social Health ◽  
Present Review ◽  
Common Disease ◽  
The Core ◽  
Common Disorder ◽  
The Common

The core principles in Ayurveda give prime importance to Agni, Prakriti, Ahara (food) and Vihara (lifestyle) in maintaining health. Present era people are scheduled to one or the other works due to which they are following unrightful food and habits which lead the manifestation of one of the common disorder which troubles person a lot - Amlapitta. By excess “Hurry, Worry and Curry” GIT disorders are the most common, not only affecting physical health but also psychological and social health. Amlapitta is one of that and it is a burning problem of the whole World. Amalpitta is composed of word Amla and Pitta. Amlapitta is a very common disease caused by Vidagdha Pitta with features like Amlodgara, Tiktodgara, Hrit, Kantha Daha etc. Pathya recommended in Amlapitta are Yava, Godhuma, Purana Shali, Mudga Yusha, Lajasaktu etc. Apathya recommended in Amlapitta are Navanna, Avidugdha, Masha, Kulattha, Dadhi and etc. So this present review article throws light on Pathya (conducive) and Apathya (non conducive) in Amlapitta.

scholarly journals Therapeutic Role of Tocilizumab in SARS-CoV-2-Induced Cytokine Storm: Rationale and Current Evidence

2021 ◽  
Vol 22 (6) ◽  
pp. 3059
Author(s):  
Corrado Pelaia ◽  
Cecilia Calabrese ◽  
Eugenio Garofalo ◽  
Andrea Bruni ◽  
Alessandro Vatrella ◽  
...  
Keyword(s):  
Review Article ◽  
Lung Damage ◽  
Current Evidence ◽  
Therapeutic Effects ◽  
Cytokine Storm ◽  
Future Perspectives ◽  
Pathogenic Role ◽  
Refractory Rheumatoid Arthritis ◽  
Life Threatening

Among patients suffering from coronavirus disease 2019 (COVID-19) syndrome, one of the worst possible scenarios is represented by the critical lung damage caused by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2)-induced cytokine storm, responsible for a potentially very dangerous hyperinflammatory condition. Within such a context, interleukin-6 (IL-6) plays a key pathogenic role, thus being a suitable therapeutic target. Indeed, the IL-6-receptor antagonist tocilizumab, already approved for treatment of refractory rheumatoid arthritis, is often used to treat patients with severe COVID-19 symptoms and lung involvement. Therefore, the aim of this review article is to focus on the rationale of tocilizumab utilization in the SARS-CoV-2-triggered cytokine storm, as well as to discuss current evidence and future perspectives, especially with regard to ongoing trials referring to the evaluation of tocilizumab’s therapeutic effects in patients with life-threatening SARS-CoV-2 infection.

scholarly journals Recent Developments in Lignin- and Tannin-Based Non-Isocyanate Polyurethane Resins for Wood Adhesives—A Review

2021 ◽  
Vol 11 (9) ◽  
pp. 4242
Author(s):  
Manggar Arum Aristri ◽  
Muhammad Adly Rahandi Lubis ◽  
Sumit Manohar Yadav ◽  
Petar Antov ◽  
Antonios N. Papadopoulos ◽  
...  
Keyword(s):  
Automotive Industry ◽  
Polymeric Materials ◽  
Review Article ◽  
Future Perspectives ◽  
Wood Adhesives ◽  
Adhesion Properties ◽  
Lighting Industry ◽  
Renewable Natural Resources ◽  
Recent Developments ◽  
Strong Adhesion

This review article aims to summarize the potential of using renewable natural resources, such as lignin and tannin, in the preparation of NIPUs for wood adhesives. Polyurethanes (PUs) are extremely versatile polymeric materials, which have been widely used in numerous applications, e.g., packaging, footwear, construction, the automotive industry, the lighting industry, insulation panels, bedding, furniture, metallurgy, sealants, coatings, foams, and wood adhesives. The isocyanate-based PUs exhibit strong adhesion properties, excellent flexibility, and durability, but they lack renewability. Therefore, this study focused on the development of non-isocyanate polyurethane lignin and tannin resins for wood adhesives. PUs are commercially synthesized using polyols and polyisocyanates. Isocyanates are toxic, costly, and not renewable; thus, a search of suitable alternatives in the synthesis of polyurethane resins is needed. The reaction with diamine compounds could result in NIPUs based on lignin and tannin. The research on bio-based components for PU synthesis confirmed that they have good characteristics as an alternative for the petroleum-based adhesives. The advantages of improved strength, low curing temperatures, shorter pressing times, and isocyanate-free properties were demonstrated by lignin- and tannin-based NIPUs. The elimination of isocyanate, associated with environmental and human health hazards, NIPU synthesis, and its properties and applications, including wood adhesives, are reported comprehensively in this paper. The future perspectives of NIPUs’ production and application were also outlined.

scholarly journals Current Knowledge of Endolysosomal and Autophagy Defects in Hereditary Spastic Paraplegia

Cells ◽  
2021 ◽  
Vol 10 (7) ◽  
pp. 1678
Author(s):  
Liriopé Toupenet Marchesi ◽  
Marion Leblanc ◽  
Giovanni Stevanin
Keyword(s):  
Nervous System ◽  
Motor Neurons ◽  
Neurological Disorders ◽  
Hereditary Spastic Paraplegia ◽  
Current Knowledge ◽  
Spastic Paraplegia ◽  
Functional Convergence ◽  
The Common ◽  
Hsp Genes

Hereditary spastic paraplegia (HSP) refers to a group of neurological disorders involving the degeneration of motor neurons. Due to their clinical and genetic heterogeneity, finding common effective therapeutics is difficult. Therefore, a better understanding of the common pathological mechanisms is necessary. The role of several HSP genes/proteins is linked to the endolysosomal and autophagic pathways, suggesting a functional convergence. Furthermore, impairment of these pathways is particularly interesting since it has been linked to other neurodegenerative diseases, which would suggest that the nervous system is particularly sensitive to the disruption of the endolysosomal and autophagic systems. In this review, we will summarize the involvement of HSP proteins in the endolysosomal and autophagic pathways in order to clarify their functioning and decipher some of the pathological mechanisms leading to HSP.

A review of flexible electric heating element and electric heating garments

2020 ◽  
pp. 152808372096827
Author(s):  
Shu Fang ◽  
Rui Wang ◽  
Haisu Ni ◽  
Hao Liu ◽  
Li Liu
Keyword(s):  
Electric Heating ◽  
Review Article ◽  
Electrical Heating ◽  
Cold Environment ◽  
Passive Heating ◽  
Future Perspectives ◽  
Advantages And Disadvantages ◽  
Smart Garments ◽  
Material Preparation ◽  
Electric Heating Element

Electric heating garment can improve the thermal comfort for people living and working in cold environment. Compared with passive heating materials, electrical heating shows dominant advantages on reusability, controlled temperature, safety and so on. This review article systematically introduced the material preparation, electric-thermal properties, advantages and disadvantages of the existing flexible heating elements, and elaborated the research and application progress of smart garments in detail, providing reference for the research of flexible heating elements and smart garments. And the existing challenges and the possible future perspectives were also discussed.

Review article: Reclaiming the rebellion: 1798 in 1998

1999 ◽  
Vol 31 (123) ◽  
pp. 395-410
Author(s):  
Ian McBride
Keyword(s):  
New York ◽  
Rural Communities ◽  
Review Article ◽  
Physical Force ◽  
Celtic Tiger ◽  
Men And Women ◽  
International Dimension ◽  
Good Friday ◽  
The North ◽  
The Many

Few Irish men and women can have escaped the mighty wave of anniversary fever which broke over the island in the spring of 1998. As if atoning for the failed rebellion itself, the bicentenary of 1798 was neither ill-coordinated nor localised, but a genuinely national phenomenon produced by years of planning and organisation. Emissaries were dispatched from Dublin and Belfast to remote rural communities, and the resonant names of Bartlett, Whelan, Keogh and Graham were heard throughout the land; indeed, the commemoration possessed an international dimension which stretched to Boston, New York, Toronto, Liverpool, London and Glasgow. In bicentenary Wexford — complete with ’98 Heritage Trail and ’98 Village — the values of democracy and pluralism were triumphantly proclaimed. When the time came, the north did not hesitate, but participated enthusiastically. Even the French arrived on cue, this time on bicycle. Just as the 1898 centenary, which contributed to the revitalisation of physical-force nationalism, has now become an established subject in its own right, future historians will surely scrutinise this mother of all anniversaries for evidence concerning the national pulse in the era of the Celtic Tiger and the Good Friday Agreement. In the meantime a survey of some of the many essay collections and monographs published during the bicentenary will permit us to hazard a few generalisations about the current direction of what might now be termed ‘Ninety-Eight Studies’.

Heart failure in an elderly population

2001 ◽  
Vol 11 (4) ◽  
pp. 311-321
Author(s):  
DN Carmichael ◽  
Michael Lye
Keyword(s):  
Heart Failure ◽  
Treatment Options ◽  
Clinical Syndrome ◽  
Point Of View ◽  
Diagnostic Challenge ◽  
The Common ◽  
Characteristic Features ◽  
The Many ◽  
Neuroendocrine Activation ◽  
Symptoms And Signs

Heart failure has been defined in many ways and definitions change over time. The multiplicity of definitions reflect the paucity of our understanding of the primary underlying physiology of heart failure and the many diseases for which heart failure is the common end-point. Fundamentally, heart failure represents a failure of the heart to meet the body’s requirement for blood supply for whatever reason. It is thus a clinical syndrome with characteristic features – not a single disease in its own right. The syndrome includes symptoms and signs of organ underperfusion, fluid retention and neuroendocrine activation. The syndrome arises from a range of possible causes of which ischaemic heart disease is the commonest. From the point of view of a clinician, the underlying pathology will determine treatment options and prognosis. The extensive range of possible aetiologies present a diagnostic challenge both to correctly identify the syndrome amongst all other causes of dyspnoea and to identify the aetiology, allowing optimization of treatment.

scholarly journals Translocation t(3;8)(p14.2;q24.1) in renal cell carcinoma affects expression of the common fragile site at 3p14(FRA3B) in lymphocytes

1988 ◽  
Vol 31 (1) ◽  
pp. 69-73 ◽  
Author(s):  
Thomas W. Glover ◽  
Jane F. Coyle-Morris ◽  
Frederick P. Li ◽  
Robert S. Brown ◽  
Carol S. Berger ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Fragile Site ◽  
Common Fragile Site ◽  
The Common
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