Identification of a CTL-directed epitope encoded by an intron of the putative tumor suppressor gene Testin of the common fragile site 7G region: a peptide vaccine candidate for HLA-B52+ and HLA-62+ cancer patients

2003 ◽  
Vol 33 (11) ◽  
pp. 2964-2973 ◽  
Author(s):  
Shinya Ohkouchi ◽  
Naoki Kawamoto ◽  
Makoto Koga ◽  
Fumi Sakanashi ◽  
Shigeki Shichijo ◽  
...  
Keyword(s):  
Tumor Suppressor ◽  
Cancer Patients ◽  
Vaccine Candidate ◽  
Fragile Site ◽  
Peptide Vaccine ◽  
Suppressor Gene ◽  
Common Fragile Site ◽  
Putative Tumor Suppressor Gene ◽  
Putative Tumor Suppressor ◽  
The Common

scholarly journals Molecular Functions of WWOX Potentially Involved in Cancer Development

Cells ◽  
2021 ◽  
Vol 10 (5) ◽  
pp. 1051
Author(s):  
Karim Taouis ◽  
Keltouma Driouch ◽  
Rosette Lidereau ◽  
François Lallemand
Keyword(s):  
Tumor Suppressor ◽  
Gene Mapping ◽  
Tumor Suppressor Gene ◽  
Chromosomal Region ◽  
Fragile Site ◽  
Suppressor Gene ◽  
Cancer Development ◽  
Suppressive Activity ◽  
Putative Tumor Suppressor Gene ◽  
Putative Tumor Suppressor

The WW domain-containing oxidoreductase gene (WWOX) was cloned 21 years ago as a putative tumor suppressor gene mapping to chromosomal fragile site FRA16D. The localization of WWOX in a chromosomal region frequently altered in human cancers has initiated multiple current studies to establish its role in this disease. All of this work suggests that WWOX, due to its ability to interact with a large number of partners, exerts its tumor suppressive activity through a wide variety of molecular actions that are mostly cell specific.

Chromosome Band 1p36 Contains a Putative Tumor Suppressor Gene Important in the Evolution of Chronic Myelocytic Leukemia

Blood ◽  
1998 ◽  
Vol 92 (9) ◽  
pp. 3405-3409 ◽  
Author(s):  
Naoki Mori ◽  
Roberta Morosetti ◽  
Susanne Spira ◽  
Stephen Lee ◽  
Dina Ben-Yehuda ◽  
...  
Keyword(s):  
Tumor Suppressor ◽  
Tumor Suppressor Gene ◽  
Chronic Phase ◽  
Suppressor Gene ◽  
Chromosome 1 ◽  
Common Region ◽  
Putative Tumor Suppressor Gene ◽  
Myelocytic Leukemia ◽  
Putative Tumor Suppressor ◽  
The Common

Chronic myelocytic leukemia (CML) is a common neoplasm of hematopoietic pluripotent stem cells. Although the evolution from chronic phase to blast crisis (BC) in CML patients is an inevitable clinical feature, little is understood about the mechanisms responsible for the transformation. We have previously performed allelotype analysis in CML BC and have detected frequent loss of heterozygosity (LOH) on the short arm of chromosome 1. To know the common region of LOH where a putative tumor suppressor gene may reside, deletional mapping was performed using 33 microsatellite markers spanning chromosome 1 in 30 patients with CML BC (21 myeloid and 9 lymphoid). DNA was extracted from slides of bone marrow smears or from bone marrow mononuclear cells. In each patient, DNA from chronic phase was analyzed alongside DNA from either their BC or accelerated phase. Allelic loss on 1p was observed in 14 of the 30 individuals (47%): 10 of the 21 myeloid and 4 of the 9 lymphoid BC cases. Serial cytogenetic information was available in 10 cases with LOH on 1p; interestingly, deletions in this region were not detected. Two samples showed LOH at all informative loci on 1p, whereas the other 12 samples showed LOH on at least one but not all loci on 1p. The common region of LOH resided proximal to D1S508 and distal to D1S507 (1p36). Our results suggest that a tumor suppressor gene that frequently plays an important role in the evolution to BC resides on 1p36 in CML. © 1998 by The American Society of Hematology.

Chromosome Band 1p36 Contains a Putative Tumor Suppressor Gene Important in the Evolution of Chronic Myelocytic Leukemia

Blood ◽  
1998 ◽  
Vol 92 (9) ◽  
pp. 3405-3409 ◽  
Author(s):  
Naoki Mori ◽  
Roberta Morosetti ◽  
Susanne Spira ◽  
Stephen Lee ◽  
Dina Ben-Yehuda ◽  
...  
Keyword(s):  
Tumor Suppressor ◽  
Tumor Suppressor Gene ◽  
Chronic Phase ◽  
Suppressor Gene ◽  
Chromosome 1 ◽  
Common Region ◽  
Putative Tumor Suppressor Gene ◽  
Myelocytic Leukemia ◽  
Putative Tumor Suppressor ◽  
The Common

Abstract Chronic myelocytic leukemia (CML) is a common neoplasm of hematopoietic pluripotent stem cells. Although the evolution from chronic phase to blast crisis (BC) in CML patients is an inevitable clinical feature, little is understood about the mechanisms responsible for the transformation. We have previously performed allelotype analysis in CML BC and have detected frequent loss of heterozygosity (LOH) on the short arm of chromosome 1. To know the common region of LOH where a putative tumor suppressor gene may reside, deletional mapping was performed using 33 microsatellite markers spanning chromosome 1 in 30 patients with CML BC (21 myeloid and 9 lymphoid). DNA was extracted from slides of bone marrow smears or from bone marrow mononuclear cells. In each patient, DNA from chronic phase was analyzed alongside DNA from either their BC or accelerated phase. Allelic loss on 1p was observed in 14 of the 30 individuals (47%): 10 of the 21 myeloid and 4 of the 9 lymphoid BC cases. Serial cytogenetic information was available in 10 cases with LOH on 1p; interestingly, deletions in this region were not detected. Two samples showed LOH at all informative loci on 1p, whereas the other 12 samples showed LOH on at least one but not all loci on 1p. The common region of LOH resided proximal to D1S508 and distal to D1S507 (1p36). Our results suggest that a tumor suppressor gene that frequently plays an important role in the evolution to BC resides on 1p36 in CML. © 1998 by The American Society of Hematology.

Developmental defects in gorlin syndrome related to a putative tumor suppressor gene on chromosome 9

Cell ◽  
1992 ◽  
Vol 69 (1) ◽  
pp. 111-117 ◽  
Author(s):  
Mae R. Gailani ◽  
Sherri J. Bale ◽  
David J. Leffell ◽  
John J. DiGiovanna ◽  
Gary L. Peck ◽  
...  
Keyword(s):  
Tumor Suppressor ◽  
Tumor Suppressor Gene ◽  
Suppressor Gene ◽  
Chromosome 9 ◽  
Gorlin Syndrome ◽  
Developmental Defects ◽  
Putative Tumor Suppressor Gene ◽  
Putative Tumor Suppressor
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