scholarly journals Molecular Mechanisms of Multi-Organ Failure in COVID-19 and Potential of Stem Cell Therapy

Cells ◽  
2021 ◽  
Vol 10 (11) ◽  
pp. 2878
Author(s):  
Aditya Bhalerao ◽  
Snehal Raut ◽  
Behnam Noorani ◽  
Salvatore Mancuso ◽  
Luca Cucullo
Keyword(s):  
Stem Cell ◽  
Cell Therapy ◽  
Organ Failure ◽  
Stem Cell Therapy ◽  
Molecular Mechanisms ◽  
The Body ◽  
Severe Respiratory Distress ◽  
Multi Organ Failure ◽  
Organ Systems ◽  
Extent Of Damage

As the number of confirmed cases and deaths occurring from Coronavirus disease 2019 (COVID-19) surges worldwide, health experts are striving hard to fully comprehend the extent of damage caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Although COVID-19 primarily manifests itself in the form of severe respiratory distress, it is also known to cause systemic damage to almost all major organs and organ systems within the body. In this review, we discuss the molecular mechanisms leading to multi-organ failure seen in COVID-19 patients. We also examine the potential of stem cell therapy in treating COVID-19 multi-organ failure cases.

Molecular mechanisms of stem cell therapy in alcoholic liver disease

2014 ◽  
Vol 46 (5) ◽  
pp. 391-397 ◽  
Author(s):  
Phillip Levine ◽  
Kelly McDaniel ◽  
Heather Francis ◽  
Lindsey Kennedy ◽  
Gianfranco Alpini ◽  
...  
Keyword(s):  
Stem Cell ◽  
Liver Disease ◽  
Cell Therapy ◽  
Stem Cell Therapy ◽  
Alcoholic Liver Disease ◽  
Molecular Mechanisms

scholarly journals ASSESS THE EFFECTIVENESS OF STRUCTURED TEACHING PROGRAMMED REGARDING COLLECTION OF CORD BLOOD FOR STEM CELL THERAPY AT BRAM HOSPITAL OF RAIPUR

2021 ◽  
Vol 9 (09) ◽  
pp. 363-369
Author(s):  
Tripti Goarya ◽  
◽  
Chandrakala Janghel ◽  
Keyword(s):  
Stem Cells ◽  
Stem Cell ◽  
Cell Therapy ◽  
Cord Blood ◽  
Stem Cell Therapy ◽  
The Body ◽  
Blood Collection ◽  
Structured Teaching ◽  
The Mean ◽  
Cord Blood Collection

The stem cells, derived from the cord blood are hematopoietic stem cells. These have immense potential in curing blood related disorders like blood cancers, thalassemia etc. These can be useful in treating tissue related disorders of heart, bone, spinal cord etc. Stem cells are characterized by the ability to renew through mitotic cell division and differentiate into a diverse range of specialized cell types. Stem Cells are the basic building blocks of the body and have the potential to replenish other cells and give rise to number of tissues which constitute different organs. To conduct the study, 60 antenatal mothers are selected the age range of subjects was 21 to 40 years. The need for the study arises after knowing those antenatal mothers were unaware and having inadequate knowledge regarding cord blood collection for stem cell therapy. The above facts created an interest to conduct a structured teaching programme to assess its effectiveness on knowledge and attitude of antenatal mother on cord blood collection for stem cell therapy. The pretest, the mean score of knowledge is 13.2 mean % is 50.7, & attitude is 31.58, mean % 63.16, the post test the mean score of knowledge is 18.1, mean % is 69.65. Attitude 38.05, mean % 76.1.

scholarly journals A REPORT ON STEM CELLS AND THEIR APPLICATIONS

2020 ◽  
pp. 1-2
Author(s):  
Shantha A R
Keyword(s):  
Stem Cells ◽  
Stem Cell ◽  
Cell Therapy ◽  
Stem Cell Therapy ◽  
Building Blocks ◽  
Cell Types ◽  
The Body ◽  
Cell Therapies ◽  
Undifferentiated Cells ◽  
The Cost

Stem cells are the building blocks of life. They have remarkable potential to regenerate and develop into many different cell types in the body during early life and growth. They are also a class of undifferentiated cells that are able to be differentiated into specialized cells types. Stem cells are characterized by certain features such as totipotency, pluripotency, multipotency, oligopotent and unipotency. The history of stem cell research had an embryonic beginning in the mid 1800s with the discovery that few cells could generate other cells. In the 1900s the first stem cells were discovered when it was found that cells generate blood cells. Nowadays, stem cell therapy is under research and till now, a very few stem cell therapies have been regarded as safe and successful. It is also found that stem cell therapy cast a number of side effects too. The cost of the procedure too is expensive and is not easily affordable.

scholarly journals Therapeutic effects of stem cells in different body systems, a novel method that is yet to gain trust: A comprehensive review

2021 ◽  
Author(s):  
Alireza Ebrahimi ◽  
Hanie Ahmadi ◽  
Zahra Pourfraidon Ghasrodashti ◽  
Nader Tanide ◽  
Reza Shahriarirad ◽  
...  
Keyword(s):  
Stem Cells ◽  
Stem Cell ◽  
Cell Therapy ◽  
Stem Cell Therapy ◽  
Musculoskeletal Diseases ◽  
Large Population ◽  
Therapeutic Effects ◽  
Full Potential ◽  
Differentiation Process ◽  
Organ Systems

Stem cell therapy has been used to treat several types of diseases, and it is expected that its therapeutic uses shall increase as novel lines of evidence begin to appear. Furthermore, stem cells have the potential to make new tissues and organs. Thus, some scientists propose that organ transplantation will significantly rely on stem cell technology and organogenesis in the future. Stem cells and its robust potential to differentiate into specific types of cells and regenerate tissues and body organs, have been investigated by numerous clinician scientists and researchers for their therapeutic effects. Degenerative diseases in different organs have been the main target of stem cell therapy. Neurodegenerative diseases such as Alzheimer's, musculoskeletal diseases such as osteoarthritis, congenital cardiovascular diseases, and blood cell diseases such as leukemia are among the health conditions that have benefited from stem cell therapy advancements. One of the most challenging parts of the process of incorporating stem cells into clinical practice is controlling their division and differentiation potentials. Sometimes, their potential for  uncontrolled growth will make these cells tumorigenic. Another caveat in this process is the ability to control the differentiation process. While stem cells can easily differentiate into a wide variety of cells,  a paracrine effect controlled activity, being in an appropriate medium will cause abnormal differentiation leading to treatment failure. In this review, we aim to provide an overview of the therapeutic effects of stem cells in diseases of various organ systems. In order to advance this new treatment to its full potential, researchers should focus on establishing methods to control the differentiation process, while policymakers should take an active role in providing adequate facilities and equipment for these projects. Large population clinical trials are a necessary tool that will help build trust in this method. Moreover, improving social awareness about the advantages and adverse effects of stem cell therapy is required to develop a rational demand in the society, and consequently, healthcare systems should consider established stem cell-based therapeutic methods in their treatment algorithms.  

Amalgamation of Stem Cells with Nanotechnology: A Unique Therapeutic Approach

2019 ◽  
Vol 14 (2) ◽  
pp. 83-92 ◽  
Author(s):  
Amit Alexander ◽  
Shailendra Saraf ◽  
Swarnlata Saraf ◽  
Mukta Agrawal ◽  
Ravish J. Patel ◽  
...  
Keyword(s):  
Stem Cell ◽  
Cell Therapy ◽  
Stem Cell Therapy ◽  
Cellular Differentiation ◽  
Periodontal Diseases ◽  
The Body ◽  
Physiological Conditions ◽  
Cell Proliferation And Differentiation ◽  
Alternative Approach ◽  
Proliferation And Differentiation

In the last few years, the stem cell therapy has gained much popularity among researchers and scientists of biomedical field. It became an effective and alternative approach for the treatment of various physiological conditions (like accidental injuries, burn damage, organ failure, bone marrow transfusion, etc.) and chronic disorders (diabetes, cancer, neurodegenerative disorders, periodontal diseases, etc.). Due to the unique ability of cellular differentiation and regeneration, stem cell therapy serves as the last hope for various incurable conditions and severe damages. The amalgamation of stem cell therapy with nanotechnology brings new prospects to the stem cell research, as it improves the specificity of the treatment and controls the stem cell proliferation and differentiation. In this review article, we have discussed various nanocarrier systems such as carbon nanotubes, quantum dots, nanofibers, nanoparticles, nanodiamonds, nanoparticle scaffold, etc. utilized for the delivery of stem cell inside the body.

scholarly journals Stemness specificity of epithelial cells – application of cell and tissue technology in regenerative medicine

2018 ◽  
Vol 6 (3) ◽  
pp. 114-119 ◽  
Author(s):  
Magdalena Rojewska ◽  
Małgorzata Popis ◽  
Maurycy Jankowski ◽  
Dorota Bukowska ◽  
Paweł Antosik ◽  
...  
Keyword(s):  
Stem Cells ◽  
Stem Cell ◽  
Regenerative Medicine ◽  
Cell Therapy ◽  
Stem Cell Therapy ◽  
The Body ◽  
Current Evidence ◽  
Epithelial Tissue

AbstractStem cells are cells that have the potential to replicate and/or differentiate, becoming any tissue. This process could be theoretically repeated indefinitely and can be used to create or fix damaged parts any organ. There are many in vivo factors that cause stem cells to replicate and differentiate. Many of these interactions and mechanisms are still unknown. In vitro models have been successful in inducing stem cells to differentiate into the desired lineage using controlled methods. Recently, epithelial tissue has been successfully created using scaffolds on which stem cells are grown in vitro and then transplanted into the host. This transition creates significant problems. This is because in vitro -grown stem cells or stem cell-derived tissues are created in an isolated environment where virtually every aspect can be monitored and controlled. In vivo monitoring and controlling is significantly more difficult for a plethora of reasons. Cells in the body are constantly exposed to many signals and molecules which affect them. Many of the mechanisms behind these interactions and reactions are known but many others are not. As the corpus of knowledge grows, stem cells become closer to being applied in a clinical setting. In this paper, we review the current evidence on stem cell therapy in regenerative medicine and some of the challenges this field faces.

The 100 Most Cited Articles on the Applications of Stem Cells in Osteoarthritis: A Bibliometric Analysis

2020 ◽  
Author(s):  
Keda Yang ◽  
Siming Zhou ◽  
Lin Tao
Keyword(s):  
Stem Cells ◽  
Stem Cell ◽  
Cell Therapy ◽  
Bibliometric Analysis ◽  
Stem Cell Therapy ◽  
Molecular Mechanisms ◽  
The United States ◽  
Research Area ◽  
General Information ◽  
Publication Number

Abstract Background: Stem cells have been applied in the treatment of OA, which had attracted wide attention. However, the research area is relatively extensive, and the research level is variable. In this study, we reviewed the mechanisms and clinical applications of stem cells in OA by using bibliometric analysis for the first time. We also revealed the characteristics, superior results and developmental trends in this field.Methods: The Web of Science core collection database was used to search articles related to the application of stem cells in OA. We collected the general information from the top 100 cited articles. We analyzed and evaluated the articles according to publication number, journals, institutions, countries, keywords and extended keywords.Results: The 100 most cited articles were cited from 129 to 1353 times mainly reviews and original articles. These articles were published from 2001 to 2017 and distributed evenly in America, East Asia and European countries. The United States contributed most in published number and international cooperation. The top ten institutions are mainly major universities and Duke University published a maximum of 10 articles. In terms of journals ,57 articles were published in the top ten journals. The keywords were divided into 8 categories from molecular mechanisms to clinical application.Conclusions: In our study, we found that mesenchymal stem cells (MSCs) which could repair articular cartilage and inhibit local inflammation, are the most widely applied in research and treatment of OA. TGF-βwas crucial during the process. Exosomes are regarded as the active ingredients in stem cell therapy for OA. Microtissue engineering will contribute to accurate and effective stem cell therapy. The findings of our study will contribute to the continuous development of research and direct the research of stem cells in OA.

Remaking the body? Scientists' genetic discourses and practices as examples of changing expectations on embryonic stem cell therapy for diabetes

2007 ◽  
Vol 26 (3) ◽  
pp. 251-268 ◽  
Author(s):  
Steven Wainwright ◽  
Clare Williams ◽  
Mike Michael ◽  
Bobbie Farsides ◽  
Alan Cribb
Keyword(s):  
Stem Cell ◽  
Cell Therapy ◽  
Embryonic Stem Cell ◽  
Stem Cell Therapy ◽  
Embryonic Stem ◽  
The Body

scholarly journals Is Stem Cell a Curer or an Obstruction?

2017 ◽  
Vol 1 (1) ◽  
pp. 17
Author(s):  
Siska Damayanti ◽  
Rina Triana ◽  
Angliana Chouw ◽  
Nurrani Mustika Dewi
Keyword(s):  
Stem Cells ◽  
Stem Cell ◽  
Cell Therapy ◽  
Stem Cell Therapy ◽  
Embryonic Stem ◽  
Cell Types ◽  
Tumor Formation ◽  
The Body ◽  
Negative Effects ◽  
Tissue Repair And Regeneration

Introduction: Each cell in human body is assigned with a specialized function to perform.  Before a cell becomes specialized, it is a stem cell. Stem cell research and therapy is progressing dramatically these days. Stem cell therapy holds enormous treatment potential for many diseases which currently have no or limited therapeutic options. Unfortunately, this potential also comes with side-effects. In this review, the positive and negative effects of regulation of stem cells will be explained.Content: Stem cells are undifferentiated cells that have potential to develop into many different cell types in the body during early life and growth. The type of stem cells are embryonic stem cells, induced pluripotent stem cells, somatic stem cells, foetal stem cells and mesenchymal stem cells. Stem cell transplantation is one form of stem cell therapy, it comes with different sources, and those are autologous and allogenic transplantation stem cells. In an autologous transplant, a patient’s own blood-forming stem cells are collected, meanwhile in an allogeneic transplant, a person’s stem cells are replaced with new stem cells obtained from a donor or from donated umbilical cord blood.Summary: Its abilities to maintain undifferentiated phenotype, self-renewing and differentiate itself into specialized cells, give rise to stem cell as a new innovation for the treatment of various diseases. In the clinical setting, stem cells are being explored in various conditions, such as in tissue repair and regeneration and autoimmune diseases therapy. But along with its benefit, stem cell therapy also holds some harm. It is known that the treatment using stem cell for curing and rehabilitation has the risk in tumor formation.

Regulation of Stem Cell-Based Research in India in Comparison with the US, EU and other Asian Countries: Current Issues and Future Perspectives

2020 ◽  
Vol 15 (6) ◽  
pp. 492-508
Author(s):  
Jobin Jose ◽  
Teena George ◽  
Aaron M. Thomas
Keyword(s):  
Stem Cells ◽  
Stem Cell ◽  
Cell Therapy ◽  
Stem Cell Therapy ◽  
Heart Diseases ◽  
The Body ◽  
Regulatory Agencies ◽  
Cell Therapies ◽  
The Us ◽  
Regenerative Medicines

Stem cell therapy is applicable for repair and replacement of damaged cells and tissues. Apart from transplanting cells to the body, the stem cell therapy directs them to grow new and healthy tissues. Stem cells in the area of regenerative medicines hold tremendous promise that may help to regenerate the damaged tissues and heal various diseases like multiple sclerosis, heart diseases, Parkinson’s disease, and so on. To prove the safety, efficacy, and for the requirement of a licence for manufacturing and sale, all the stem cell therapies should pass the required criteria and undergo certain examinations of the regulatory agencies. The regulatory authorities review the manufacturing procedures of products to assure its purity and potency. This review summarizes the comparative critical evaluations of existing regulations and developments on the stem cells research in India, USA, EU and Asian regions and also discusses the challenges that have to be overcome and the important points that should be understood to position India as a source of the perspective nation in stem cells around the world.

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