Role of Neuroglobin in the Neuroprotective Actions of Estradiol and Estrogenic Compounds

George E. Barreto; Andrew J. McGovern; Luis M. Garcia-Segura

doi:10.3390/cells10081907

Role of Neuroglobin in the Neuroprotective Actions of Estradiol and Estrogenic Compounds

Cells ◽

10.3390/cells10081907 ◽

2021 ◽

Vol 10 (8) ◽

pp. 1907

Author(s):

George E. Barreto ◽

Andrew J. McGovern ◽

Luis M. Garcia-Segura

Keyword(s):

Sex Differences ◽

Signaling Pathways ◽

Glial Cell ◽

Potential Application ◽

Neurological Diseases ◽

Brain Pathology ◽

Synthetic Steroids ◽

Neuroprotective Actions ◽

Estrogenic Regulation

Estradiol exerts neuroprotective actions that are mediated by the regulation of a variety of signaling pathways and homeostatic molecules. Among these is neuroglobin, which is upregulated by estradiol and translocated to the mitochondria to sustain neuronal and glial cell adaptation to injury. In this paper, we will discuss the role of neuroglobin in the neuroprotective mechanisms elicited by estradiol acting on neurons, astrocytes and microglia. We will also consider the role of neuroglobin in the neuroprotective actions of clinically relevant synthetic steroids, such as tibolone. Finally, the possible contribution of the estrogenic regulation of neuroglobin to the generation of sex differences in brain pathology and the potential application of neuroglobin as therapy against neurological diseases will be examined.

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Progress in research on the role of Omi/HtrA2 in neurological diseases

Reviews in the Neurosciences ◽

10.1515/revneuro-2018-0004 ◽

2019 ◽

Vol 30 (3) ◽

pp. 279-287 ◽

Cited By ~ 2

Author(s):

Xiao Juan Su ◽

Lingyi Huang ◽

Yi Qu ◽

Dezhi Mu

Keyword(s):

Cell Death ◽

Signaling Pathways ◽

Serine Protease ◽

Brain Damage ◽

Therapeutic Target ◽

Neurological Diseases ◽

Mitochondrial Matrix ◽

Ischemic Brain ◽

External Signals

Abstract Omi/HtrA2 is a serine protease present in the mitochondrial space. When stimulated by external signals, HtrA2 is released into the mitochondrial matrix where it regulates cell death through its interaction with apoptotic and autophagic signaling pathways. Omi/HtrA2 is closely related to the pathogenesis of neurological diseases, such as neurodegeneration and hypoxic ischemic brain damage. Here, we summarize the biological characteristics of Omi/HtrA2 and its role in neurological diseases, which will provide new hints in developing Omi/HtrA2 as a therapeutic target for neurological diseases.

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Sex Differences in the Role of Parental Legitimacy as a Predictor of Bullying Experiences

PsycEXTRA Dataset ◽

10.1037/e621642012-028 ◽

2012 ◽

Author(s):

Stacy A. Jeleniewski ◽

Ellen S. Cohn

Keyword(s):

Sex Differences ◽

Bullying Experiences

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Author response for "The role of Long Non‐Coding RNAs ( lncRNAs ) and downstream signaling pathways in Leukemia progression"

10.1002/hon.2776/v2/response1 ◽

2020 ◽

Author(s):

Yadong Liu ◽

Penghao Sun ◽

Yuhao Zhao ◽

Bin Liu

Keyword(s):

Signaling Pathways ◽

Author Response ◽

Downstream Signaling ◽

Non Coding Rnas

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Neurological consultations and diagnoses in a large, dedicated COVID-19 university hospital

Arquivos de Neuro-Psiquiatria ◽

10.1590/0004-282x20200089 ◽

2020 ◽

Vol 78 (8) ◽

pp. 494-500 ◽

Cited By ~ 4

Author(s):

Adalberto STUDART-NETO ◽

Bruno Fukelmann GUEDES ◽

Raphael de Luca e TUMA ◽

Antonio Edvan CAMELO FILHO ◽

Gabriel Taricani KUBOTA ◽

...

Keyword(s):

Neurological Diseases ◽

Neuromuscular Disorders ◽

Neurological Symptoms ◽

University Hospital ◽

Special Treatment ◽

Nasal Swabs ◽

Neurological Exam ◽

Neurological Conditions ◽

De Medicina

ABSTRACT Background: More than one-third of COVID-19 patients present neurological symptoms ranging from anosmia to stroke and encephalopathy. Furthermore, pre-existing neurological conditions may require special treatment and may be associated with worse outcomes. Notwithstanding, the role of neurologists in COVID-19 is probably underrecognized. Objective: The aim of this study was to report the reasons for requesting neurological consultations by internists and intensivists in a COVID-19-dedicated hospital. Methods: This retrospective study was carried out at Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, Brazil, a 900-bed COVID-19 dedicated center (including 300 intensive care unit beds). COVID-19 diagnosis was confirmed by SARS-CoV-2-RT-PCR in nasal swabs. All inpatient neurology consultations between March 23rd and May 23rd, 2020 were analyzed. Neurologists performed the neurological exam, assessed all available data to diagnose the neurological condition, and requested additional tests deemed necessary. Difficult diagnoses were established in consensus meetings. After diagnosis, neurologists were involved in the treatment. Results: Neurological consultations were requested for 89 out of 1,208 (7.4%) inpatient COVID admissions during that period. Main neurological diagnoses included: encephalopathy (44.4%), stroke (16.7%), previous neurological diseases (9.0%), seizures (9.0%), neuromuscular disorders (5.6%), other acute brain lesions (3.4%), and other mild nonspecific symptoms (11.2%). Conclusions: Most neurological consultations in a COVID-19-dedicated hospital were requested for severe conditions that could have an impact on the outcome. First-line doctors should be able to recognize neurological symptoms; neurologists are important members of the medical team in COVID-19 hospital care.

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