scholarly journals Effects of Macro-/Micro-Channels on Vascularization and Immune Response of Tissue Engineering Scaffolds

Cells ◽  
2021 ◽  
Vol 10 (6) ◽  
pp. 1514
Author(s):  
Nolan Wen ◽  
Enze Qian ◽  
Yunqing Kang
Keyword(s):  
Tissue Engineering ◽  
Immune Response ◽  
3D Printing ◽  
Porous Scaffolds ◽  
Low Oxygen ◽  
Control Groups ◽  
Tissue Engineering Scaffolds ◽  
Cell Recruitment ◽  
Micro Channels ◽  
Rats And Mice

Although the use of porous scaffolds in tissue engineering has been relatively successful, there are still many limitations that need to be addressed, such as low vascularization, low oxygen and nutrient levels, and immune-induced inflammation. As a result, the current porous scaffolds are insufficient when treating large defects. This paper analyzed scientific research pertaining to the effects of macro-/micro-channels on the cell recruitment, vascularization, and immune response of tissue engineering scaffolds. Most of the studies contained either cell culturing experimentation or experimentation on small animals such as rats and mice. The sacrificial template method, template casting method, and 3D printing method were the most common methods in the fabrication of channeled scaffolds. Some studies combine the sacrificial and 3D printing methods to design and create their scaffold with channels. The overall results from these studies showed that the incorporation of channels within scaffolds greatly increased vascularization, reduced immune response, and was much more beneficial for cell and growth factor recruitment compared with control groups that contained no channels. More research on the effect of micro-/macro-channels on vascularization or immune response in animal models is necessary in the future in order to achieve clinical translation.

scholarly journals Additive Manufacturing of Biopolymers for Tissue Engineering and Regenerative Medicine: An Overview, Potential Applications, Advancements, and Trends

2021 ◽  
Vol 2021 ◽  
pp. 1-20 ◽  
Author(s):  
Dhinakaran Veeman ◽  
M. Swapna Sai ◽  
P. Sureshkumar ◽  
T. Jagadeesha ◽  
L. Natrayan ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Additive Manufacturing ◽  
3D Printing ◽  
Regenerative Medicine ◽  
Tissue Regeneration ◽  
Three Dimensional ◽  
Porous Scaffolds ◽  
Wide Range ◽  
Potential Applications ◽  
Pharmaceutical Industries

As a technique of producing fabric engineering scaffolds, three-dimensional (3D) printing has tremendous possibilities. 3D printing applications are restricted to a wide range of biomaterials in the field of regenerative medicine and tissue engineering. Due to their biocompatibility, bioactiveness, and biodegradability, biopolymers such as collagen, alginate, silk fibroin, chitosan, alginate, cellulose, and starch are used in a variety of fields, including the food, biomedical, regeneration, agriculture, packaging, and pharmaceutical industries. The benefits of producing 3D-printed scaffolds are many, including the capacity to produce complicated geometries, porosity, and multicell coculture and to take growth factors into account. In particular, the additional production of biopolymers offers new options to produce 3D structures and materials with specialised patterns and properties. In the realm of tissue engineering and regenerative medicine (TERM), important progress has been accomplished; now, several state-of-the-art techniques are used to produce porous scaffolds for organ or tissue regeneration to be suited for tissue technology. Natural biopolymeric materials are often better suited for designing and manufacturing healing equipment than temporary implants and tissue regeneration materials owing to its appropriate properties and biocompatibility. The review focuses on the additive manufacturing of biopolymers with significant changes, advancements, trends, and developments in regenerative medicine and tissue engineering with potential applications.

scholarly journals Fabrication of scalable tissue engineering scaffolds with dual-pore microarchitecture by combining 3D printing and particle leaching

2016 ◽  
Vol 61 ◽  
pp. 180-189 ◽  
Author(s):  
Soumyaranjan Mohanty ◽  
Kuldeep Sanger ◽  
Arto Heiskanen ◽  
Jon Trifol ◽  
Peter Szabo ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
3D Printing ◽  
Tissue Engineering Scaffolds

Highly filled poly( l ‐lactic acid)/hydroxyapatite composite for 3D printing of personalized bone tissue engineering scaffolds

2020 ◽  
Vol 138 (2) ◽  
pp. 49662
Author(s):  
Gleb Dubinenko ◽  
Aleksey Zinoviev ◽  
Evgeny Bolbasov ◽  
Anna Kozelskaya ◽  
Evgeniy Shesterikov ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Lactic Acid ◽  
3D Printing ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Tissue Engineering Scaffolds ◽  
Hydroxyapatite Composite

Testing Shape Memory of Porous Polymer Tissue Engineering Scaffolds in Compression

2011 ◽  
Author(s):  
Hugh Lippincott ◽  
Daniel F. Schmidt
Keyword(s):  
Tissue Engineering ◽  
Shape Memory ◽  
Test Methods ◽  
The Body ◽  
Porous Polymer ◽  
Small Samples ◽  
Porous Scaffolds ◽  
Tissue Engineering Scaffolds ◽  
Compression Cycle ◽  
Memory Applications

Shape recovery from memory by porous scaffolds for tissue engineering offers easier insertion and self-retention following placement by minimally invasive surgery. Shape memory testing of porous polymer xerogels focuses on the compression cycle and the special aspects of the cycle and equipment used. This contrasts with normal tensile shape memory (SM) testing. In this work a dynamic mechanical analyzer (DMA) was used on small samples to quickly yield measurement of the SM restoration at various stress levels to emulate the forces exerted on the body by a tissue engineering (TE) scaffold returning to its permanent shape. The DMA testing of a hexamethyl diisocyanate trimer crosslinked castor oil (CO) / polycaprolactone (PCL) blend yielded repeated SM with no creep. The porous CO/PCL showed repeated compressive SM at 50% strain with a SM stress-free recovery ratio of 100%. The peak SM recovery work of 6.4 KJ/m3 was measured at 0.5 MPa stress and 6% to 12% strain. In addition to the potential utility of these materials in a tissue engineering setting, the test methods described here are relevant to a broad range of shape memory applications, from medical devices to morphing airframes to self-deploying structures.

Polymer structure-property requirements for stereolithographic 3D printing of soft tissue engineering scaffolds

Biomaterials ◽  
2017 ◽  
Vol 140 ◽  
pp. 170-188 ◽  
Author(s):  
Ryan J. Mondschein ◽  
Akanksha Kanitkar ◽  
Christopher B. Williams ◽  
Scott S. Verbridge ◽  
Timothy E. Long
Keyword(s):  
Tissue Engineering ◽  
Soft Tissue ◽  
3D Printing ◽  
Polymer Structure ◽  
Structure Property ◽  
Tissue Engineering Scaffolds ◽  
Soft Tissue Engineering

scholarly journals Polymeric Scaffolds in Tissue Engineering Application: A Review

2011 ◽  
Vol 2011 ◽  
pp. 1-19 ◽  
Author(s):  
Brahatheeswaran Dhandayuthapani ◽  
Yasuhiko Yoshida ◽  
Toru Maekawa ◽  
D. Sakthi Kumar
Keyword(s):  
Tissue Engineering ◽  
Extracellular Matrix ◽  
Engineering Application ◽  
Biologically Active ◽  
Porous Scaffolds ◽  
Tissue Engineering Application ◽  
Tissue Engineering Scaffolds ◽  
Matrix Deposition ◽  
Bioactive Agents ◽  
Regenerate Tissue

Current strategies of regenerative medicine are focused on the restoration of pathologically altered tissue architectures by transplantation of cells in combination with supportive scaffolds and biomolecules. In recent years, considerable interest has been given to biologically active scaffolds which are based on similar analogs of the extracellular matrix that have induced synthesis of tissues and organs. To restore function or regenerate tissue, a scaffold is necessary that will act as a temporary matrix for cell proliferation and extracellular matrix deposition, with subsequent ingrowth until the tissues are totally restored or regenerated. Scaffolds have been used for tissue engineering such as bone, cartilage, ligament, skin, vascular tissues, neural tissues, and skeletal muscle and as vehicle for the controlled delivery of drugs, proteins, and DNA. Various technologies come together to construct porous scaffolds to regenerate the tissues/organs and also for controlled and targeted release of bioactive agents in tissue engineering applications. In this paper, an overview of the different types of scaffolds with their material properties is discussed. The fabrication technologies for tissue engineering scaffolds, including the basic and conventional techniques to the more recent ones, are tabulated.

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