A review on the use of computational methods to characterize, design, and optimize tissue engineering scaffolds, with a potential in 3D printing fabrication

2018 ◽  
Vol 107 (5) ◽  
pp. 1329-1351 ◽  
Author(s):  
Shuo Zhang ◽  
Sanjairaj Vijayavenkataraman ◽  
Wen Feng Lu ◽  
Jerry Y H Fuh
Keyword(s):  
Tissue Engineering ◽  
3D Printing ◽  
Computational Methods ◽  
Tissue Engineering Scaffolds

scholarly journals Fabrication of scalable tissue engineering scaffolds with dual-pore microarchitecture by combining 3D printing and particle leaching

2016 ◽  
Vol 61 ◽  
pp. 180-189 ◽  
Author(s):  
Soumyaranjan Mohanty ◽  
Kuldeep Sanger ◽  
Arto Heiskanen ◽  
Jon Trifol ◽  
Peter Szabo ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
3D Printing ◽  
Tissue Engineering Scaffolds

Highly filled poly( l ‐lactic acid)/hydroxyapatite composite for 3D printing of personalized bone tissue engineering scaffolds

2020 ◽  
Vol 138 (2) ◽  
pp. 49662
Author(s):  
Gleb Dubinenko ◽  
Aleksey Zinoviev ◽  
Evgeny Bolbasov ◽  
Anna Kozelskaya ◽  
Evgeniy Shesterikov ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Lactic Acid ◽  
3D Printing ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Tissue Engineering Scaffolds ◽  
Hydroxyapatite Composite

Polymer structure-property requirements for stereolithographic 3D printing of soft tissue engineering scaffolds

Biomaterials ◽  
2017 ◽  
Vol 140 ◽  
pp. 170-188 ◽  
Author(s):  
Ryan J. Mondschein ◽  
Akanksha Kanitkar ◽  
Christopher B. Williams ◽  
Scott S. Verbridge ◽  
Timothy E. Long
Keyword(s):  
Tissue Engineering ◽  
Soft Tissue ◽  
3D Printing ◽  
Polymer Structure ◽  
Structure Property ◽  
Tissue Engineering Scaffolds ◽  
Soft Tissue Engineering

scholarly journals Low-Temperature Deposition Manufacturing: A Versatile Material Extrusion-Based 3D Printing Technology for Fabricating Hierarchically Porous Materials

2019 ◽  
Vol 2019 ◽  
pp. 1-14
Author(s):  
Changyong Liu ◽  
Junda Tong ◽  
Jun Ma ◽  
Daming Wang ◽  
Feng Xu ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
3D Printing ◽  
Low Temperature ◽  
Porous Materials ◽  
Porous Electrodes ◽  
Tissue Engineering Scaffolds ◽  
Material Extrusion ◽  
Low Temperature Deposition ◽  
Wide Range ◽  
Temperature Deposition

Low-temperature deposition manufacturing (LTDM) is a technology that combines material extrusion-based 3D printing and thermally induced phase separation (TIPS) into one process. With this feature, both the merits of 3D printing and TIPS can be incorporated including complex geometries with tailorable ordered macroporous features facilitated by 3D printing and microporous/nanoporous features endowed by TIPS. These macroporous/microporous/nanoporous combined structures are important to some important applications such as tissue engineering scaffolds, porous electrodes for electrochemical energy storage, purification, and filtering applications. However, the unique advantages and potential applications of LTDM have not been fully recognized and exploited yet. In this review, we will discuss the origin, principle, advantages, processes, and machine setup of LTDM technology with an emphasis on its unique advantages in fabricating porous materials. Then, current applications of LTDM including porous tissue engineering scaffolds and emerging porous electrodes for electrochemical storage will be described. The versatility of LTDM including its capability of processing a wide range of materials, multimaterial and gradient structures, and core-shell structures will be introduced. Finally, we will conclude with a perspective and outlook on the future development and applications of LTDM technology.

scholarly journals Triblock Copolymers Based on ε-Caprolactone and Trimethylene Carbonate for the 3D Printing of Tissue Engineering Scaffolds

2017 ◽  
Vol 40 (4) ◽  
pp. 176-184 ◽  
Author(s):  
Aysun Güney ◽  
Jos Malda ◽  
Wouter J.A. Dhert ◽  
Dirk W. Grijpma
Keyword(s):  
Tissue Engineering ◽  
Glass Transition ◽  
3D Printing ◽  
Melting Temperature ◽  
Triblock Copolymers ◽  
Ethylene Carbonate ◽  
Porous Structures ◽  
Trimethylene Carbonate ◽  
Tissue Engineering Scaffolds ◽  
Slow Cooling

Background Biodegradable PCL- b-PTMC- b-PCL triblock copolymers based on trimethylene carbonate (TMC) and ε-caprolactone (CL) were prepared and used in the 3D printing of tissue engineering scaffolds. Triblock copolymers of various molecular weights containing equal amounts of TMC and CL were prepared. These block copolymers combine the low glass transition temperature of amorphous PTMC (approximately -20°C) and the semi-crystallinity of PCL (glass transition approximately -60°C and melting temperature approximately 60°C). Methods PCL- b-PTMC- b-PCL triblock copolymers were synthesized by sequential ring opening polymerization (ROP) of TMC and ε-CL. From these materials, films were prepared by solvent casting and porous structures were prepared by extrusion-based 3D printing. Results Films prepared from a polymer with a relatively high molecular weight of 62 kg/mol had a melting temperature of 58°C and showed tough and resilient behavior, with values of the elastic modulus, tensile strength and elongation at break of approximately 120 MPa, 16 MPa and 620%, respectively. Porous structures were prepared by 3D printing. Ethylene carbonate was used as a crystalizable and water-extractable solvent to prepare structures with microporous strands. Solutions, containing 25 wt% of the triblock copolymer, were extruded at 50°C then cooled at different temperatures. Slow cooling at room temperature resulted in pores with widths of 18 ± 6 μm and lengths of 221 ± 77 μm, rapid cooling with dry ice resulted in pores with widths of 13 ± 3 μm and lengths of 58 ± 12 μm. These PCL- b-PTMC- b-PCL triblock copolymers processed into porous structures at relatively low temperatures may find wide application as designed degradable tissue engineering scaffolds. Conclusions In this preliminary study we prepared biodegradable triblock copolymers based on 1,3-trimethylene carbonate and ε-caprolactone and assessed their physical characteristics. Furthermore, we evaluated their potential as melt-processable thermoplastic elastomeric biomaterials in 3D printing of tissue engineering scaffolds.

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