scholarly journals Central vs. Peripheral Action of Thyroid Hormone in Adaptive Thermogenesis: A Burning Topic

Cells ◽  
2021 ◽  
Vol 10 (6) ◽  
pp. 1327
Author(s):  
Yanis Zekri ◽  
Frédéric Flamant ◽  
Karine Gauthier
Keyword(s):  
Body Mass Index ◽  
Paradigm Shift ◽  
Lower Body ◽  
Crucial Importance ◽  
Pharmacological Agents ◽  
Adaptive Thermogenesis ◽  
Metabolic Properties ◽  
Metabolic Activities ◽  
The Brain ◽  
Peripheral Action

Thyroid hormones (TH) contribute to the control of adaptive thermogenesis, which is associated with both higher energy expenditure and lower body mass index. While it was clearly established that TH act directly in the target tissues to fulfill its metabolic activities, some studies have rather suggested that TH act in the hypothalamus to control these processes. This paradigm shift has subjected the topic to intense debates. This review aims to recapitulate how TH control adaptive thermogenesis and to what extent the brain is involved in this process. This is of crucial importance for the design of new pharmacological agents that would take advantage of the TH metabolic properties.

scholarly journals Are Men More Intuitive When It Comes to Eating and Physical Activity?

2011 ◽  
Vol 6 (2) ◽  
pp. 164-171 ◽  
Author(s):  
Julie Gast ◽  
Hala Madanat ◽  
Amy Campbell Nielson
Keyword(s):  
Physical Activity ◽  
Body Mass Index ◽  
Weight Loss ◽  
Intrinsic Motivation ◽  
Weight Management ◽  
Body Mass ◽  
Demographic Variables ◽  
Intuitive Eating ◽  
Lower Body ◽  
Behavioral Regulation

The purpose of this study was to determine where men fall on the motivation continuum based on intuitive eating status and if motivation for physical activity and intuitive eating are correlated. Results indicate that being an intuitive eater was associated with a lower body mass index. In terms of demographic variables, as age increased, intuitive eating status decreased and body mass index increased. Men scored high on the antidieting and self-care subscales of the Intuitive Eating Scale. Men who were classified as intuitive eaters scored higher on the external and introjected regulation of the Behavioral Regulation in Exercise Questionnaire but no significant differences were reported by eating status and the identified and intrinsic motivation subscales. Intuitive eating holds promise as a weight management and weight loss tool for men. Intuitive eating may also influence initial motivation for physical activity for men.

scholarly journals Prevalence and correlates of suicidal ideation with dermatological morbidities

2018 ◽  
Vol 5 (2) ◽  
pp. 550
Author(s):  
Dharmvir Ranjan Bharati ◽  
Seema Kumari ◽  
Kranti Chand Jaykar ◽  
Ajay Kumar ◽  
Sanjay Kumar Choudhary ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Suicidal Ideation ◽  
Body Mass ◽  
Skin Diseases ◽  
Early Adulthood ◽  
Large Family ◽  
Lower Body ◽  
Suicidal Tendency ◽  
Lower Body Mass Index ◽  
Lower Education

Background: The dermatologic consultation might be a precious opportunity to recognize and treat depression associated with suicidal ideation in these patients. This study aimed to find the prevalence of suicidal ideation among patients with dermatologic conditions, and identifying demographic variables of suicidal ideation. Methods: This institution based cross-sectional study was conducted during February to March 2017, at dermatological out-patients department of the teaching hospital Indira Gandhi Institute of Medical Sciences (IGIMS), Patna, India. Results: Of 396 adults with skin disease 272 (68.69%) were male. Prevalence of suicidal tendency was significantly more among young adults and higher in females (38.7%) than males (1.5%). In males, suicidal tendency was in patients suffering from tinea infection while among females, significantly more observed among patients suffering from tinea 38.71%, psoriasis 22.58% and chronic idiopathic urticaria 16.13%. The risk of suicidal tendency in males were significantly higher among 18–20 years, unemployed, belongs to smaller family, having lower body mass index and suffering from depression. While in females, suicidal tendency was significantly higher among early adulthood, not or lower education, unemployed, no personal income and vegetarian, belongs to large family, no family support, having lower body mass index and suffering from depression as well as suffering from some other medical comorbidity in addition to skin diseases. Conclusions: Risk correlates of suicidal ideation with skin diseases were early adulthood, lower education, unemployment with no personal income, vegetarian diet, large family, no family support, lower body mass index and suffering from depression and comorbidities. 

scholarly journals Physical fitness and nutritional anthropometric status of children from disadvantaged communities in the Nelson Mandela Bay region

2020 ◽  
Vol 32 (1) ◽  
pp. 1-8
Author(s):  
Danielle Smith ◽  
Larissa Adams ◽  
Rosa Du Randt ◽  
Jan Degen ◽  
Stefanie Gall ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Body Composition ◽  
Physical Fitness ◽  
Body Mass ◽  
Muscular Strength ◽  
Background Information ◽  
Lower Body ◽  
Cross Sectional ◽  
Disadvantaged Communities ◽  
Nelson Mandela

Background: Information about the relationships between physical fitness, body composition and nutrition has increased in recent years; however, little is known about physical fitness and the coexistence of under-/overnutrition among children living in disadvantaged areas. Objectives: To determine the physical fitness status and its association with body composition, growth and selected socio- demographics in primary schoolchildren from disadvantaged communities in the Nelson Mandela Bay region. Methods: Nine hundred and sixty-five children (49% girls, M=9.5 years) participated in this cross-sectional study. Height and weight were measured to establish body mass index, and height-for-age z-scores. Physical fitness was assessed using tests from the Eurofit Physical Fitness test battery (flexibility, upper/lower body muscular strength and cardiorespiratory fitness). Between- group differences and cross-sectional associations were examined with univariate (Chi2-tests, analyses of variance) and multivariate methods (mixed linear/logistic regression). Results: Most children had normal weight (76.7%), while 4.5% were underweight and 18.7% were overweight/obese. Underweight children and children with stunted growth (11.5%) had lower average upper body strength (p<0.001). Overweight/obese children had lower scores in weight-bearing activities (p<0.001). Children with higher socio-economic status were more likely to be overweight and obese (p<0.001). In the multivariate analyses, sex, age, body mass index, and stunting were associated with children’s physical fitness. Conclusion: Fitness assessments seem to be a relevant measure of the current health status of children in disadvantaged settings. Compared to international norms, the children in this study had relatively low scores for both upper- and lower body muscular strength. Therefore, effective school-based intervention programmes should be developed to improve children’s physical fitness in disadvantaged schools.

scholarly journals Experimental approach to overexpress pituitary adenylate cyclase activating polypeptide (PACAP) specifically in the hypothalamus

2021 ◽  
Author(s):  
◽  
Yamna Rahim
Keyword(s):  
Energy Expenditure ◽  
Experimental Approach ◽  
Health Condition ◽  
Specific Expression ◽  
Steroidogenic Factor 1 ◽  
Adaptive Thermogenesis ◽  
Brown Adipose ◽  
Pituitary Adenylate Cyclase ◽  
The Brain

Obesity is adetrimental health condition that occurs when energy intake, exceeds energy expenditure. Pituitary adenylatecyclase-activating polypeptide (PACAP) regulates energy expenditure, including adaptive thermogenesis, through the hypothalamic-sympatheticnervous system-brown adipose tissue axis. We hypothesize that PACAP expression in the ventromedial nucleus (VMN) is required for adaptive thermogenesis. To assess this, our goal is to develop an animal model that expresses PACAP specifically in the VMN of the hypothalamus. As a first step to achieving this goal, we established a protocol to deliver an adeno-associatedvirus (AAV) expressing the visible protein eGFP under the control of a VMN-specific promoter, steroidogenic factor 1 (SF1) using stereotaxic surgery. A second step was to develop a protocol to detect PACAP mRNA in the brain using in situ hybridization. Our results showed that the stereotaxic protocol was successful and provides significant progress towards achieving PACAP-specific expression in the VMN.

scholarly journals Penetration of the blood-brain barrier: enhancement of drug delivery and imaging by bacterial glycopeptides.

1995 ◽  
Vol 182 (4) ◽  
pp. 1037-1043 ◽  
Author(s):  
B Spellerberg ◽  
S Prasad ◽  
C Cabellos ◽  
M Burroughs ◽  
P Cahill ◽  
...  
Keyword(s):  
Blood Brain Barrier ◽  
Brain Parenchyma ◽  
Brain Barrier ◽  
Dependent Manner ◽  
Pharmacological Agents ◽  
Barrier Permeability ◽  
Blood Brain Barrier Permeability ◽  
Blood Brain ◽  
Brain Barrier Permeability ◽  
The Brain

The blood-brain barrier restricts the passage of many pharmacological agents into the brain parenchyma. Bacterial glycopeptides induce enhanced blood-brain barrier permeability when they are present in the subarachnoid space during meningitis. By presenting such glycopeptides intravenously, blood-brain barrier permeability in rabbits was enhanced in a reversible time- and dose-dependent manner to agents &lt; or = 20 kD in size. Therapeutic application of this bioactivity was evident as enhanced penetration of the antibiotic penicillin and the magnetic resonance imaging contrast agent gadolinium-diethylene-triamine-pentaacetic acid into the brain parenchyma.

Barriers for recruitment of patients with chronic obstructive pulmonary disease to a controlled telemedicine trial

2016 ◽  
Vol 24 (2) ◽  
pp. 216-224 ◽  
Author(s):  
Eva Broendum ◽  
Charlotte Suppli Ulrik ◽  
Thorbjorn Gregersen ◽  
Ejvind Frausing Hansen ◽  
Allan Green ◽  
...  
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Body Mass Index ◽  
Lung Function ◽  
Pulmonary Disease ◽  
Controlled Trial ◽  
Admission Rate ◽  
Chronic Obstructive ◽  
Lower Body ◽  
Obstructive Pulmonary Disease ◽  
Tailored Approach

The aim of this analysis is to investigate reasons why patients with chronic obstructive pulmonary disease decline to participate in a controlled trial of telemedicine. Patients with previous chronic obstructive pulmonary disease exacerbations were invited to participate in a 6-month randomized telemedicine trial. For eligible patients, reasons for refusal were registered. Of 560 eligible patients, 279 (50%) declined to participate in the trial, 257 (92%) reported a reason: 53 (20.6%) technical concerns, 164 (63.8%) personal reasons, 17 (6.6%) preferred outpatient clinic visits, and 23 (8.9%) did not want to participate in clinical research. Compared to consenting patients, subjects declining participation were significantly older, more often female, had higher lung function (%predicted), lower body mass index, higher admission-rate for chronic obstructive pulmonary disease in the previous year, and were more often diagnosed with osteoporosis. Many eligible patients decline participating in a controlled tele-healthcare trial and, furthermore, a tailored approach for recruiting females and elderly patients appears appropriate.

Snacking may improve dietary fiber density and is associated with a lower body mass index in postmenopausal women

Nutrition ◽  
2021 ◽  
Vol 83 ◽  
pp. 111063
Author(s):  
Aleksandra Skoczek-Rubińska ◽  
Agata Muzsik-Kazimierska ◽  
Agata Chmurzynska ◽  
Prof. Jarosław Walkowiak ◽  
Joanna Bajerska
Keyword(s):  
Body Mass Index ◽  
Postmenopausal Women ◽  
Dietary Fiber ◽  
Body Mass ◽  
Lower Body ◽  
Fiber Density ◽  
Lower Body Mass Index
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