A polymorphism, L162V, in the peroxisome proliferator-activated receptor α (PPAR α) gene is associated with lower body mass index in patients with non-insulin-dependent diabetes mellitus

2001 ◽  
Vol 79 (4) ◽  
pp. 198-204 ◽  
Author(s):  
D. Evans ◽  
J. Aberle ◽  
D. Wendt ◽  
A. Wolf ◽  
U. Beisiegel ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Body Mass Index ◽  
Body Mass ◽  
Insulin Dependent Diabetes Mellitus ◽  
Insulin Dependent Diabetes ◽  
Dependent Diabetes Mellitus ◽  
Peroxisome Proliferator ◽  
Lower Body ◽  
Peroxisome Proliferator Activated Receptor ◽  
Insulin Dependent

scholarly journals Leptin Synthesis Is Resistant to Acute Effects of Insulin in Insulin-Dependent Diabetes Mellitus Patients*

1997 ◽  
Vol 82 (2) ◽  
pp. 381-382 ◽  
Author(s):  
Juha A. Tuominen ◽  
Pertti Ebeling ◽  
Ulf-Håkan Stenman ◽  
Mark L. Heiman ◽  
Thomas W. Stephens ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Body Mass Index ◽  
Body Mass ◽  
Body Fat ◽  
Insulin Dependent Diabetes Mellitus ◽  
Insulin Dependent Diabetes ◽  
Dependent Diabetes Mellitus ◽  
Ob Gene ◽  
Insulin Dependent ◽  
Plasma Leptin

Abstract Insulin stimulates ob gene expression and increases serum leptin concentrations in mice and in noninsulin-dependent diabetes mellitus patients. Obese women have higher ob gene messenger ribonucleic acid levels than obese men, suggesting that sex hormones are involved in the regulation of leptin synthesis. We studied the relationship among leptin, insulin, and testosterone in 15 men with insulin-dependent diabetes mellitus (IDDM; age, 29 ± 2 yr; body mass index, 22.7 ± 0.5 kg/m2; body fat, 9.5 ± 1.0%; insulin dose, 44 ± 4 U/day; hemoglobin A1c, 8.1 ± 0.3%; diabetes duration, 12.7 ± 2.0 yr) and 15 healthy control subjects (age, 27 ± 1 yr; body mass index, 22.6 ± 0.4 kg/m2; body fat, 9.6 ± 0.5%) in the fasting state. In addition, the effect of a 4-h euglycemic hyperinsulinemia (∼600 pmol/L) on the plasma leptin concentration was determined. The fasting leptin concentration was negatively correlated to plasma testosterone (r = −0.55; P < 0.05) in IDDM patients. The fasting plasma leptin level rose 25% in healthy subjects (from 1.0 ± 0.2 to 1.3 ± 0.3 ng/mL; P < 0.05). The leptin levels were higher in IDDM subjects (P < 0.01) and remained unchanged (2.7 ± 0.2 vs. 2.7 ± 0.2 ng/mL) during hyperinsulinemia. We reached the following conclusions. 1) In nonobese IDDM patients, leptin synthesis is resistant to the acute effect of insulin. 2) Serum testosterone may contribute to the regulation of leptin synthesis in IDDM patients.

Cardiorespiratory Function as Assessed by Exercise Testing in Patients with Non-Insulin-Dependent Diabetes Mellitus

1996 ◽  
Vol 24 (2) ◽  
pp. 209-213 ◽  
Author(s):  
J Katoh ◽  
Y Hara ◽  
M Kmvsu ◽  
J Miyaji ◽  
K Nabutaki
Keyword(s):  
Diabetes Mellitus ◽  
Body Mass Index ◽  
Body Weight ◽  
Oxygen Uptake ◽  
Body Mass ◽  
Exercise Testing ◽  
Insulin Dependent Diabetes Mellitus ◽  
Dependent Diabetes Mellitus ◽  
Cardiorespiratory Function ◽  
Insulin Dependent

Exercise testing was used to examine 19 cardiorespiratory diabetes mellitus patients, aged 32 – 68 years (body mass index, 27.8 ± 4.8 kg/m2), and 16 healthy volunteers, aged 23 – 57 years (body mass index, 22.7 ± 2.5 kg/m2). A graded cycling exercise test was done, monitoring gas exchange, ventilation and heart rate. Values were significantly higher in the non-insulin-dependent diabetes mellitus (NIDDM) patients than in the controls for fasting blood glucose ( P < 0.01), glycosylated haemoglobin ( P < 0.01), body weight ( P < 0.05) and body mass index ( P < 0.05). The exercise testing produced values that were significantly lower in the patients with NIDDM than in the controls for percentage oxygen uptake ( P < 0.05), maximum load ( P < 0.05), maximum metabolic equivalent ( P < 0.01) and maximum oxygen uptake per unit body weight ( P < 0.01). Ventilatory capacity and forced expiratory volume at 1 sec did not differ significantly in the two groups. These results suggest that general fitness is diminished due to reduced cardiorespiratory function in patients with NIDDM.

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