scholarly journals Profiling Non-Coding RNA Changes Associated with 16 Different Engineered Nanomaterials in a Mouse Airway Exposure Model

Cells ◽  
2021 ◽  
Vol 10 (5) ◽  
pp. 1085
Author(s):  
Joseph Ndika ◽  
Piia Karisola ◽  
Pia Kinaret ◽  
Marit Ilves ◽  
Harri Alenius
Keyword(s):  
Titanium Dioxide ◽  
Particle Surface ◽  
Mitotic Cell ◽  
Engineered Nanomaterials ◽  
Exposure Model ◽  
Molecular Events ◽  
Non Coding Rna ◽  
Oropharyngeal Aspiration ◽  
Multi Walled Carbon Nanotubes ◽  
Type Particle

Perturbations in cellular molecular events and their associated biological processes provide opportunities for hazard assessment based on toxicogenomic profiling. Long non-coding RNAs (lncRNAs) are transcribed from DNA but are typically not translated into full-length proteins. Via epigenetic regulation, they play important roles in organismal response to environmental stress. The effects of nanoparticles on this important part of the epigenome are understudied. In this study, we investigated changes in lncRNA associated with hazardous inhalatory exposure of mice to 16 engineered nanomaterials (ENM)–4 ENM (copper oxide, multi-walled carbon nanotubes, spherical titanium dioxide, and rod-like titanium dioxide particles) with 4 different surface chemistries (pristine, COOH, NH2, and PEG). Mice were exposed to 10 µg of ENM by oropharyngeal aspiration for 4 consecutive days, followed by cytological analyses and transcriptomic characterization of whole lung tissues. The number of significantly altered non-coding RNA transcripts, suggestive of their degrees of toxicity, was different for each ENM type. Particle surface chemistry and shape also had varying effects on lncRNA expression. NH2 and PEG caused the strongest and weakest responses, respectively. Via correlational analyses to mRNA expression from the same samples, we could deduce that significantly altered lncRNAs are potential regulators of genes involved in mitotic cell division and DNA damage response. This study sheds more light on epigenetic mechanisms of ENM toxicity and also emphasizes the importance of the lncRNA superfamily as toxicogenomic markers of adverse ENM exposure.

scholarly journals Comparison between multi-walled carbon nanotubes and titanium dioxide nanoparticles as additives on performance of turbine meter oil nano lubricant

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Hadi Pourpasha ◽  
Saeed Zeinali Heris ◽  
Yaghob Mohammadfam
Keyword(s):  
Carbon Nanotubes ◽  
Titanium Dioxide ◽  
Friction Coefficient ◽  
Pressure Drop ◽  
Mass Fraction ◽  
Viscosity Index ◽  
Wear Depth ◽  
Nano Lubricant ◽  
Multi Walled Carbon Nanotubes ◽  
Walled Carbon Nanotubes

AbstractThis research aims of compare the impact of the mass fraction of multi-walled carbon nanotubes (MWCNTs) and titanium dioxide (TiO2) nano additive on the tribological and thermophysical attributes of turbine meter oil. These attributes include the average friction coefficient, pressure drop, wear, flash point, pour point, relative viscosity, kinematics viscosity, and viscosity index. The pressure drops and the average friction coefficient inside the copper tube were simulated and compared with experimental results. In this study, for the synthesis of nano lubricants from turbine meter oil as a pure fluid and from MWCNTs and TiO2 as nano additives in the mass fraction of 0.05, 0.1, 0.2, 0.3, and 0.4 wt.% and from oleic acid and Triton x100 as surfactants were utilized. The results illustrated that the wear depth of copper pins in the presence of nano lubricant with 0.4 wt.% of MWCNTs and 0.1 wt.% TiO2 was improved by 88.26% and 71.43%, respectively. Increasing 0.3 wt.% of TiO2 and MWCNTs into the oil caused to improvement in viscosity index. The simulation data and experimental data for the pressure drop were closer together and indicated a minor error that the maximum error is less than 10%.

Enhancement on Stability of Nanosized Titanium Dioxide in Silicone Suspension Using Diblock Copolymer: Influence of Dispersant Structure

2013 ◽  
Vol 747 ◽  
pp. 599-602
Author(s):  
Surachet Toommee ◽  
Nisanart Traiphol
Keyword(s):  
Titanium Dioxide ◽  
Surface Area ◽  
Diblock Copolymer ◽  
High Efficiency ◽  
Particle Surface ◽  
Ethyl Acrylate ◽  
Polymer Structure ◽  
Particle Agglomeration ◽  
Nanosized Titanium Dioxide ◽  
Enhanced Adsorption

This research investigates using of poly (dimethylsiloxane-b-hydroxy ethyl acrylate) (PDMS-b-PHEA) diblock copolymer to stabilized TiO2nanoparticles in silicone fluid. The polar PHEA segment is expected to anchor on TiO2surface while the non-polar PDMS segment extends into silicone medium. To study effects of polymer structure on its stabilizing efficiency, PDMS-b-PHEA of structures 5-b-0.3, 5-b-1.1 and 8-b-1.0 are used. Results show that suspensions of particle with surface area ~40 and ~200 m2/g can be stabilized for longer than 1 and 7 hrs, respectively. The copolymer with relatively long PHEA and PDMS segments is highly effective as a dispersant. This is due to enhanced adsorption on particle surface and steric stabilization. However, in the system of 40 m2/g-TiO2, excess amounts could lead to polymer entanglement and particle agglomeration. The copolymer dispersant exhibits high efficiency for the 200 m2/g-TiO2suspension as well. In the latter system, higher concentration is required to effectively cover particle surface.

scholarly journals The lncRNA LOC102549805 (U1) modulates neurotoxicity of HIV-1 Tat protein

2020 ◽  
Vol 11 (10) ◽  
Author(s):  
Bahareh Torkzaban ◽  
Kalimuthusamy Natarajaseenivasan ◽  
Taha Mohseni Ahooyi ◽  
Masoud Shekarabi ◽  
Shohreh Amini ◽  
...  
Keyword(s):  
People Living With Hiv ◽  
Tat Protein ◽  
Atp Production ◽  
Neuronal Homeostasis ◽  
Molecular Events ◽  
Non Coding Rna ◽  
Apoptosis Pathways ◽  
Infected Cells ◽  
Living With Hiv ◽  
Hiv 1

Abstract HIV-1 Tat is a potent neurotoxic protein that is released by HIV-1 infected cells in the brain and perturbs neuronal homeostasis, causing a broad range of neurological disorders in people living with HIV-1. Furthermore, the effects of Tat have been addressed in numerous studies to investigate the molecular events associated with neuronal cells survival and death. Here, we discovered that exposure of rat primary neurons to Tat resulted in the up-regulation of an uncharacterized long non-coding RNA (lncRNA), LOC102549805 (lncRNA-U1). Our observations showed that increased expression of lncRNA-U1 in neurons disrupts bioenergetic pathways by dysregulating homeostasis of Ca2+, mitigating mitochondrial oxygen reduction, and decreasing ATP production, all of which point mitochondrial impairment in neurons via the Tat-mediated lncRNA-U1 induction. These changes were associated with imbalances in autophagy and apoptosis pathways. Additionally, this study showed the ability of Tat to modulate expression of the neuropeptide B/W receptor 1 (NPBWR1) gene via up-regulation of lncRNA-U1. Collectively, our results identified Tat-mediated lncRNA-U1 upregulation resulting in disruption of neuronal homeostasis.

Respiratory tract toxicity of titanium dioxide nanoparticles and multi‐walled carbon nanotubes on mice after intranasal exposure

2016 ◽  
Vol 11 (4) ◽  
pp. 183-187 ◽  
Author(s):  
Patinya Sukwong ◽  
Koravit Somkid ◽  
Supunsa Kongseng ◽  
Dakrong Pissuwan ◽  
Krongtong Yoovathaworn
Keyword(s):  
Carbon Nanotubes ◽  
Titanium Dioxide ◽  
Respiratory Tract ◽  
Titanium Dioxide Nanoparticles ◽  
Multi Walled Carbon Nanotubes ◽  
Walled Carbon Nanotubes

scholarly journals A Murine Oral‐Exposure Model for Nano‐ and Micro‐Particulates: Demonstrating Human Relevance with Food‐Grade Titanium Dioxide

Small ◽  
2020 ◽  
Vol 16 (21) ◽  
pp. 2000486 ◽  
Author(s):  
Sebastian Riedle ◽  
John W. Wills ◽  
Michelle Miniter ◽  
Don E. Otter ◽  
Harjinder Singh ◽  
...  
Keyword(s):  
Titanium Dioxide ◽  
Exposure Model ◽  
Oral Exposure ◽  
Food Grade

scholarly journals Effect of Novel Quercetin Titanium Dioxide-Decorated Multi-Walled Carbon Nanotubes Nanocomposite on Bacillus subtilis Biofilm Development

Materials ◽  
2018 ◽  
Vol 11 (1) ◽  
pp. 157 ◽  
Author(s):  
Diana Raie ◽  
Eisha Mhatre ◽  
Doaa El-Desouki ◽  
Ahmed Labena ◽  
Gamal El-Ghannam ◽  
...  
Keyword(s):  
Carbon Nanotubes ◽  
Titanium Dioxide ◽  
Bacillus Subtilis ◽  
Multi Walled Carbon Nanotubes ◽  
Biofilm Development ◽  
Walled Carbon Nanotubes
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