scholarly journals A Murine Oral‐Exposure Model for Nano‐ and Micro‐Particulates: Demonstrating Human Relevance with Food‐Grade Titanium Dioxide

Small ◽  
2020 ◽  
Vol 16 (21) ◽  
pp. 2000486 ◽  
Author(s):  
Sebastian Riedle ◽  
John W. Wills ◽  
Michelle Miniter ◽  
Don E. Otter ◽  
Harjinder Singh ◽  
...  
Keyword(s):  
Titanium Dioxide ◽  
Exposure Model ◽  
Oral Exposure ◽  
Food Grade

Food-grade titanium dioxide particles decrease the bioaccessibility of iron released from spinach leaves in simulated human gastrointestinal tract

2021 ◽  
Author(s):  
Chunyang Li ◽  
Chuanxin Ma ◽  
Heping Shang ◽  
Jason C. White ◽  
David Julian McClements ◽  
...  
Keyword(s):  
Titanium Dioxide ◽  
Gastrointestinal Tract ◽  
Amylase Activity ◽  
Human Gastrointestinal Tract ◽  
Food Grade ◽  
Spinach Leaves

E171 reduced Fe bioaccessibility of spinach in a simulated gastrointestinal tract via two mechanisms: the inhibition of α-amylase activity and adsorption of released Fe from spinach.

scholarly journals Effect of TiO2 on Selected Pathogenic and Opportunistic Intestinal Bacteria

2021 ◽  
Author(s):  
Ewa Baranowska-Wójcik ◽  
Dominik Szwajgier ◽  
Klaudia Gustaw
Keyword(s):  
Titanium Dioxide ◽  
Bacterial Strain ◽  
Intestinal Bacteria ◽  
Food Additive ◽  
Bacterial Strains ◽  
Gastrointestinal Microbiota ◽  
Food Grade ◽  
The Eu

AbstractFood-grade titanium dioxide (TiO2) containing a nanoparticle fraction (TiO2 NPs-nanoparticles) is widely used as a food additive (E171 in the EU). In recent years, questions concerning its effect on the gastrointestinal microbiota have been raised. In the present study, we examined interactions between bacteria and TiO2. The study involved six pathogenic/opportunistic bacterial strains and four different-sized TiO2 types: three types of food-grade E171 compounds and TiO2 NPs (21 nm). Each bacterial strain was exposed to four concentrations of TiO2 (60, 150, 300, and 600 mg/L TiO2). The differences in the growth of the analyzed strains, caused by the type and concentration of TiO2, were observed. The growth of a majority of the strains was shown to be inhibited after exposure to 300 and 600 mg/L of the food-grade E171 and TiO2 NPs.

Vasomotor dysfunction in human subcutaneous arteries exposed ex vivo to food-grade titanium dioxide

2018 ◽  
Vol 120 ◽  
pp. 321-327 ◽  
Author(s):  
Ditte Marie Jensen ◽  
Gry Freja Skovsted ◽  
Jens Lykkesfeldt ◽  
Rasmus Dreier ◽  
Jais Oliver Berg ◽  
...  
Keyword(s):  
Titanium Dioxide ◽  
Ex Vivo ◽  
Food Grade ◽  
Vasomotor Dysfunction

Effect of oral exposure to titanium dioxide nanoparticles on lipid metabolism in Sprague-Dawley rats

Nanoscale ◽  
2020 ◽  
Vol 12 (10) ◽  
pp. 5973-5986 ◽  
Author(s):  
Zhangjian Chen ◽  
Shuo Han ◽  
Pai Zheng ◽  
Di Zhou ◽  
Shupei Zhou ◽  
...  
Keyword(s):  
Titanium Dioxide ◽  
Lipid Metabolism ◽  
Titanium Dioxide Nanoparticles ◽  
Oral Exposure ◽  
Sprague Dawley ◽  
Sprague Dawley Rats

The present study investigated the effect of oral exposure to TiO2 NPs on lipid metabolism by serum lipidomics.

Exploration of cytotoxic and genotoxic endpoints following sub-chronic oral exposure to titanium dioxide nanoparticles

2019 ◽  
Vol 35 (9) ◽  
pp. 577-592 ◽  
Author(s):  
Srijita Chakrabarti ◽  
Danswrang Goyary ◽  
Sanjeev Karmakar ◽  
Pronobesh Chattopadhyay
Keyword(s):  
Titanium Dioxide ◽  
Titanium Dioxide Nanoparticles ◽  
Flow Cytometric Analysis ◽  
Raw 264.7 Cells ◽  
Oral Exposure ◽  
Chromosomal Breakage ◽  
Flow Cytometric ◽  
Higher Doses

Health hazards of titanium dioxide nanoparticles (TiO2-NPs) have raised severe concerns because of the paucity of information regarding the toxic effects among the population. In the present research, the in vitro and in vivo cytotoxic potential of TiO2-NPs were evaluated using flow cytometric techniques. Further, in vitro and in vivo genotoxic endpoints were estimated by means of comet, micronucleus (MN), and chromosomal aberration (CA) assays. In vitro analysis was performed at the concentration range of 10–100 µg/mL using murine RAW 264.7 cells. In vivo experiments were conducted on Albino mice (M/F) by exposing them to 200 and 500 mg/kg TiO2-NPs for 90 days. Decreased percentage of cell viability with higher doses of TiO2-NPs was evident in both in vitro and in vivo flow cytometric analysis. Further, an impaired cell cycle (G0/G1, S, and G2/M) was reflected in the present investigation following the exposure to TiO2-NPs. Increased comet scores such as tail length, % DNA in tail, tail moment, and olive moment were also observed with the higher doses of TiO2-NPs in vitro and in vivo comet assays. Finally, the in vivo MN and CA assays revealed the formation of MN and chromosomal breakage following the exposure to TiO2-NPs.

scholarly journals Interaction of food-grade titanium dioxide nanoparticles with pepsin in simulated gastric fluid

LWT ◽  
2020 ◽  
Vol 134 ◽  
pp. 110208 ◽  
Author(s):  
Yujing Sun ◽  
Tianyuan Zhen ◽  
Yang Li ◽  
Yihui Wang ◽  
Mengwei Wang ◽  
...  
Keyword(s):  
Titanium Dioxide ◽  
Titanium Dioxide Nanoparticles ◽  
Gastric Fluid ◽  
Simulated Gastric Fluid ◽  
Food Grade

scholarly journals Possible effects of titanium dioxide particles on human liver, intestinal tissue, spleen and kidney after oral exposure

2020 ◽  
Vol 14 (7) ◽  
pp. 985-1007 ◽  
Author(s):  
Walter Brand ◽  
Ruud J. B. Peters ◽  
Hedwig M. Braakhuis ◽  
Lidka Maślankiewicz ◽  
Agnes G. Oomen
Keyword(s):  
Titanium Dioxide ◽  
Human Liver ◽  
Oral Exposure ◽  
Intestinal Tissue

Emerging investigator series: protein adsorption and transformation on catalytic and food-grade TiO2 nanoparticles in the presence of dissolved organic carbon

2019 ◽  
Vol 6 (6) ◽  
pp. 1688-1703 ◽  
Author(s):  
Junyeol Kim ◽  
Kyle Doudrick
Keyword(s):  
Titanium Dioxide ◽  
Bovine Serum Albumin ◽  
Organic Carbon ◽  
Serum Albumin ◽  
Surface Chemistry ◽  
Protein Adsorption ◽  
Bovine Serum ◽  
Titanium Dioxide Nanoparticles ◽  
Food Grade ◽  
Exposure History

The adsorption and unfolding behavior of bovine serum albumin onto catalytic- and food-grade titanium dioxide nanoparticles is dependent on the surface chemistry of the nanoparticles and their environmental exposure history.

Food-grade titanium dioxide (E171) by solid or liquid matrix administration induces inflammation, germ cells sloughing in seminiferous tubules and blood-testis barrier disruption in mice

2019 ◽  
Vol 39 (11) ◽  
pp. 1586-1605 ◽  
Author(s):  
Juan Carlos Rodríguez-Escamilla ◽  
Estefany I. Medina-Reyes ◽  
Carolina Rodríguez-Ibarra ◽  
Alejandro Déciga-Alcaraz ◽  
José O. Flores-Flores ◽  
...  
Keyword(s):  
Titanium Dioxide ◽  
Germ Cells ◽  
Seminiferous Tubules ◽  
Liquid Matrix ◽  
Food Grade ◽  
Barrier Disruption ◽  
Blood Testis Barrier
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