scholarly journals Lysophosphatidic Acid Signaling in Cancer

Cancers ◽  
2020 ◽  
Vol 12 (12) ◽  
pp. 3791
Author(s):  
David N. Brindley
Keyword(s):  
Tumor Growth ◽  
Lysophosphatidic Acid ◽  
Special Issue ◽  
The Impact ◽  
Lysophosphatidic Acid Signaling

This Special Issue aims to highlight the impact of discoveries made over the last 25 years on the role of autotaxin (ATX) and lysophosphatidic acid (lysophosphatidate, LPA) signaling in tumor growth, metastasis and the treatment of cancers by chemotherapy, radiotherapy and immunotherapy [...]

scholarly journals Fluvial Geomorphology and River Management

Water ◽  
2021 ◽  
Vol 13 (11) ◽  
pp. 1608
Author(s):  
Salvatore Ivo Giano
Keyword(s):  
Human Activities ◽  
River Restoration ◽  
Fluvial Geomorphology ◽  
Landscape Evolution ◽  
River Management ◽  
Special Issue ◽  
Fluvial Systems ◽  
The Impact

This Special Issue deals with the role of fluvial geomorphology in landscape evolution and the impact of human activities on fluvial systems, which require river restoration and management [...]

scholarly journals Editorial introduction: Gender and political financing

2021 ◽  
pp. 019251212110409
Author(s):  
Rainbow Murray ◽  
Ragnhild Muriaas ◽  
Vibeke Wang
Keyword(s):  
Political Parties ◽  
Case Studies ◽  
Political Institutions ◽  
Institutional Reform ◽  
Special Issue ◽  
Women Candidates ◽  
Female Candidates ◽  
The Cost ◽  
The Impact

Contesting elections is extremely expensive. The need for money excludes many prospective candidates, resulting in the over-representation of wealth within politics. The cost of contesting elections has been underestimated as a cause of women’s under-representation. Covering seven case studies in six papers, this special issue makes theoretical and empirical contributions to understanding how political financing is gendered. We look at the impact on candidates, arguing that the personal costs of running for office can be prohibitive, and that fundraising is harder for female challengers. We also explore the role of political parties, looking at when and how parties might introduce mitigating measures to support female candidates with the costs of running. We demonstrate how political institutions shape the cost of running for office, illustrate how this is gendered and consider the potential consequences of institutional reform. We also note how societal gender norms can have financial repercussions for women candidates.

New ICTs for Knowledge Management in Organizations

2016 ◽  
Vol 20 (3) ◽  
pp. 417-422 ◽  
Author(s):  
Pedro Soto-Acosta ◽  
Juan-Gabriel Cegarra-Navarro
Keyword(s):  
Knowledge Management ◽  
Information And Communication Technologies ◽  
Intellectual Capital ◽  
Collective Intelligence ◽  
Organizational Level ◽  
Special Issue ◽  
Content Type ◽  
Academic Knowledge ◽  
The Impact

Purpose The purpose of this special issue is to point out the possibilities of new information and communication technologies (ICTs) for knowledge management (KM) in organizations, offering different perspectives on and approaches for the role of new ICTs for KM, as well as measuring the impact and diffusion of new ICTs for KM within organizations. Design/methodology/approach The selection of the papers included in this special issue is largely based on the work of the conference “7th European Conference on Intellectual Capital - ECIC” (April 2015, Cartagena, Spain), where the special issue editors organized a track on “New ICTs for Knowledge Management in Organizations”. The conference gathered leading scholars in the fields of intellectual capital and KM, dealing with the acquisition, creation and sharing of collective intelligence and how to utilize increased academic knowledge and networking in promoting economic and organizational innovations and changes. Findings The collection of papers covered in this special issue identifies challenging problems on the role of new ICTs for KM and their role in the design and implementation of innovative products, services or processes in organizations. Research limitations/implications The special issue tries to offer some new relevant advances for the academic and practice communities in the growing body of research analyzing new ICTs for KM. However, the theoretical and empirical advances showed represent only a partial view, which corresponds to the impact of new ICTs for KM at the organizational level of analysis. Practical implications The nature of new ICTs, such as social networking tools, wikis, internal blogging and the way they are used, suggest that nowadays they may differ from traditional organizational systems in two critical ways: the voluntary (typically not mandatory) use and their lack of activity or process orientation. Originality/value The special issue explores the phenomena by integrating different perspectives and approaches, including qualitative and quantitative empirical. This integration overcomes some limitations about the understanding of the issues under investigation.

scholarly journals A hybrid three-scale model of tumor growth

2017 ◽  
Vol 28 (01) ◽  
pp. 61-93 ◽  
Author(s):  
H. L. Rocha ◽  
R. C. Almeida ◽  
E. A. B. F. Lima ◽  
A. C. M. Resende ◽  
J. T. Oden ◽  
...  
Keyword(s):  
Tumor Microenvironment ◽  
Differential Equations ◽  
Tumor Growth ◽  
Nonlinear Differential Equations ◽  
Reaction Diffusion Equations ◽  
Scale Model ◽  
Wide Range ◽  
Induced Stresses ◽  
The Impact

Cancer results from a complex interplay of different biological, chemical, and physical phenomena that span a wide range of time and length scales. Computational modeling may help to unfold the role of multiple evolving factors that exist and interact in the tumor microenvironment. Understanding these complex multiscale interactions is a crucial step toward predicting cancer growth and in developing effective therapies. We integrate different modeling approaches in a multiscale, avascular, hybrid tumor growth model encompassing tissue, cell, and sub-cell scales. At the tissue level, we consider the dispersion of nutrients and growth factors in the tumor microenvironment, which are modeled through reaction–diffusion equations. At the cell level, we use an agent-based model (ABM) to describe normal and tumor cell dynamics, with normal cells kept in homeostasis and cancer cells differentiated into quiescent, proliferative, migratory, apoptotic, hypoxic, and necrotic states. Cell movement is driven by the balance of a variety of forces according to Newton’s second law, including those related to growth-induced stresses. Phenotypic transitions are defined by specific rule of behaviors that depend on microenvironment stimuli. We integrate in each cell/agent a branch of the epidermal growth factor receptor (EGFR) pathway. This pathway is modeled by a system of coupled nonlinear differential equations involving the mass laws of 20 molecules. The rates of change in the concentration of some key molecules trigger proliferation or migration advantage response. The bridge between cell and tissue scales is built through the reaction and source terms of the partial differential equations. Our hybrid model is built in a modular way, enabling the investigation of the role of different mechanisms at multiple scales on tumor progression. This strategy allows representing both the collective behavior due to cell assembly as well as microscopic intracellular phenomena described by signal transduction pathways. Here, we investigate the impact of some mechanisms associated with sustained proliferation on cancer progression. Speci- fically, we focus on the intracellular proliferation/migration-advantage-response driven by the EGFR pathway and on proliferation inhibition due to accumulation of growth-induced stresses. Simulations demonstrate that the model can adequately describe some complex mechanisms of tumor dynamics, including growth arrest in avascular tumors. Both the sub-cell model and growth-induced stresses give rise to heterogeneity in the tumor expansion and a rich variety of tumor behaviors.

scholarly journals The role of career shocks in contemporary career development: key challenges and ways forward

2021 ◽  
Vol 26 (4) ◽  
pp. 453-466
Author(s):  
Jos Akkermans ◽  
Ricardo Rodrigues ◽  
Stefan T. Mol ◽  
Scott E. Seibert ◽  
Svetlana N. Khapova
Keyword(s):  
Career Development ◽  
Lessons Learned ◽  
Future Research ◽  
Special Issue ◽  
Content Type ◽  
Future Research Agenda ◽  
Current State ◽  
Conceptual Clarity ◽  
The Impact

PurposeThis article aims to introduce the special issue entitled “the role of career shocks in contemporary career development,” synthesize key contributions and formulate a future research agenda.Design/methodology/approachThe authors provide an introduction of the current state-of-the-art in career shocks research, offer an overview of the key lessons learned from the special issue and present several important avenues for future research.FindingsThe authors discuss how the special issue articles contribute to a better understanding of career shocks' role in contemporary career development, focusing on (1) conceptual clarity of the notion of career shocks, (2) career outcomes of career shocks, (3) mechanisms that can explain the impact of career shocks and (4) interdisciplinary connectivity.Originality/valueThis article offers a synthesis of the critical contributions made within this special issue, thereby formulating key ways to bring the field of career shocks research forward. It also provides new avenues for research.

Professionalization in Asia – whence and whither

2019 ◽  
Vol 32 (8) ◽  
pp. 2253-2281 ◽  
Author(s):  
Wai Fong Chua ◽  
Maria Cadiz Dyball ◽  
Helen Yee
Keyword(s):  
Research Articles ◽  
Future Research ◽  
State Agencies ◽  
Special Issue ◽  
Accounting Firms ◽  
Content Type ◽  
Asian State ◽  
The Impact ◽  
Published Research

Purpose The purpose of this paper is twofold: first, to assess the impact of the 1999 Special Issue on Professionalization in Asia in the Accounting, Auditing and Accountability Journal (AAAJ); and second, more generally to review research on this topic post-1999. Design/methodology/approach The paper starts with a discussion of the research articles of the Special Issue. It then identifies research that has cited papers in the Special Issue and which focusses on professionalization in Asia to identify relevant subsequent research. In addition, a literature search is conducted to locate post-1999 work that has not cited papers from the Special Issue but has investigated the same topic area. Analyzing both sets of work enables an integrated review of the field and aids the identification of future research opportunities. The study covers published research articles and books on professionalization projects in Asia from 1999 to 2018. In this paper, reference to Asia focusses on East Asia (including countries such as China and Japan), South Asia (including countries such as Bangladesh, India and Sri Lanka), and South East Asia (including countries such as Brunei, Cambodia, Indonesia, Malaysia, the Philippines and Vietnam). Given the elapsed time of near 20 years, there has been sufficient time for research to be published. Therefore, the review focusses on published output only and does not discuss unpublished theses, conference proceedings nor working papers. Findings First, the Special Issue of AAAJ in 1999 generally adopted a critical lens and studied professionalization as projects of market closure and collective mobility. The corporatist framework of Puxty et al. (1987) provided a useful framing to analyze the influence of states, markets and communities on professionalization. Second, the Special Issue has helped to spur interest in understanding professionalization in the region. Post-1999, there are studies of countries not covered in the Special Issue. Third, the themes identified in the Special Issue continue to be relevant and are examined in post-1999 work: the active role of the state, the legacies of colonization, the activities of transnational accounting bodies; and to a lesser degree, the influence of transnational accounting firms. Finally, future research could usefully focus on: the distinctive and more expansive role of Asian state agencies; the conduct of deeper comparative research; the role of accounting firms in the region; and the impact of transnational agencies such as the International Federation of Accountants and the World Bank. Research limitations/implications There are three limitations. First, the review of literature omits unpublished research such as PhD theses and working papers. Second, it focusses only on research published in English. As a result, some work may be excluded. Third, it assesses the contribution of a single issue (i.e. the 1999 AAAJ Special Issue) and does not discuss work that preceded 1999. Originality/value This paper is aimed at assessing the impact of the 1999 Special Issue but also presents a wide-ranging analytical review of published research on accounting professionalization in Asia since 1999. The paper identifies several areas for future research and proposes a modified model of state-market-community-profession relations. In particular, the paper emphasizes the large and distinctive roles of Asian state agencies and the activities of transnational actors (both those within the profession as well as those that are external).

Anxiety, insecurity, and border crossing

2014 ◽  
Vol 24 (2) ◽  
pp. 141-151 ◽  
Author(s):  
Mie Hiramoto ◽  
Joseph Sung-Yul Park
Keyword(s):  
Social Transformation ◽  
Language Contact ◽  
Language Ideologies ◽  
Sense Of Self ◽  
Border Crossing ◽  
Asia Pacific ◽  
Special Issue ◽  
Key Issues ◽  
The Impact

The modern conception of the self is grounded in stability and identity. Under this perspective, anxiety and insecurity of the border are only characteristic of peripheral communities. However, anxiety and insecurity are much more fundamental to linguistic life; heterogeneity of linguistic practice and our constant movement across communities, positions, categories, and identities mean that uncertainty and indeterminacy are just as salient in the way we use language. This special issue builds upon this insight to explore the subjectivities of border crossing in contexts of language contact under globalization. By bringing together studies that explore cases of language and cultural contact across the Asia-Pacific region from the perspective of anxiety and insecurity, it aims to highlight the importance of considering subjectivity in our analysis of language in globalization, and considers the new insights we may gain through an emphasis on the subjective dimensions of contact situations. Together, the contributions to the special issue identify three key issues for further research on the sociolinguistics of globalization: (1) the role of language ideologies in mediating experiences of transnationalism, (2) consequences of globally circulated semiotic resources on local articulations of subjectivities, and (3) the impact of neoliberal projects of social transformation upon our sense of self.

scholarly journals Patrimônio Aplicado e Estudos de Patrimônio Crítico: engajando a sociedade para sustentabilidade e Patrimônios Futuros - Applied Heritage and Critical Heritage Studies engaging society to sustainability and Heritage Futures

2020 ◽  
Vol 17 (34) ◽  
pp. 44-57
Author(s):  
Tiago Silva Alves Muniz
Keyword(s):  
Cultural Heritage ◽  
Special Issue ◽  
Contemporary Archaeology ◽  
Educational Methods ◽  
Heritage Studies ◽  
Critical Heritage ◽  
America Latina ◽  
Global Futures ◽  
The Impact

O presente dossiê tem como objetivo engajando profissionais e a sociedade para sustentabilidade e Patrimônios Futuros. Atividades que refletem sobre museus, patrimônio sensível, educação patrimonial, turismo, arqueologia contemporânea e métodos fazem parte desta edição Cadernos do LEPAARQ, Revista do Laboratório de Ensino e Pesquisa em Antropologia e Arqueologia da Universidade Federal de Pelotas (LEPAARQ-UFPEL). O objetivo aqui é apresentar como museus e atividades internacionais lidam com patrimônio aplicado em diversos contextos e como suas propostas de ações pedagógicas/museológicas podem ser orientadas para o futuro. Para além do impacto da covid-19 no patrimônio cultural (Saladino Muniz, 2020), o dossiê visa dialogar com perspectivas da arqueologia no contemporâneo (Gonzalez-Ruibal, 2006; Hamilakis, 2018; McAtackney McGuire, 2020) abordando engajamento para futuro global considerando o papel do patrimônio cultural (Harrison et al 2020, Holtorf Högberg, 2020), visões desde a América Latina (Muniz Almansa-Sánchez, 2020), interpretações dos patrimônios (Rampim et al 2020) e métodos educacionais (Petersson Holtorf, 2016) no contexto do patrimônio aplicado e por uma saúde planetária (Horton et. Al. 2014). The present special issue aims to engage professionals and society for sustainability and heritage futures. Activities that reflect on museums, sensitive heritage, heritage education, tourism, contemporary archaeology and methods are part of this edition of Cadernos do LEPAARQ - Journal of the Laboratory of Teaching and Research in Anthropology and Archaeology of the Federal University of Pelotas (LEPAARQ-UFPEL). The objective here is to present how museums and international activities deal with applied heritage in different contexts and how their proposals for pedagogical / museological actions can be oriented towards the future. In addition to the impact of covid-19 on cultural heritage (Saladino Muniz, 2020), the special issue aims to dialogue with perspectives on contemporary archaeology (Gonzalez-Ruibal, 2006; Hamilakis, 2018; McAtackney McGuire, 2020), addressing engagement for global futures considering the role of cultural heritage (Harrison et al 2020, Holtorf Högberg, 2020), visions from Latin America (Muniz Almansa-Sánchez, 2020), interpretations of heritage (Rampim et al 2020), contexts of segregation and educational methods (Petersson Holtorf, 2016) in the context of applied heritage and for planetary health (Horton et. Al. 2014).

A Multitude of Actors in Early Modern Diplomacy

2019 ◽  
Vol 23 (5) ◽  
pp. 407-422
Author(s):  
Birgit Tremml-Werner ◽  
Dorothée Goetze
Keyword(s):  
Early Modern ◽  
Foreign Relations ◽  
Diplomatic History ◽  
Special Issue ◽  
Geographic Scope ◽  
The Past ◽  
Social Belonging ◽  
The Impact ◽  
Oriented Research

Abstract This special issue has been motivated by the drive to contextualize the role of individuals of various backgrounds in early modern foreign relations. All contributions cover a broad geographic scope and stress the impact of non-European practices and stages for the study of early modern foreign relations. Four thematic articles follow diverse diplomatic actors, ranging from non-elite envoys to chartered companies, Catholic friars and ministers on ships, to foreign courts, and behind their desks. They provide insights into these individual actors’ functions and achievements and raise questions about social belonging and knowledge channels. The introduction below portrays the development of an actor-oriented research angle in the field of New Diplomatic History over the past decades and addresses blurring concepts and over-generalizations. It attempts to redefine the heterogeneous group of early modern diplomatic actors as products of their involvement in political and material struggles, both at home and abroad.

scholarly journals Distinct functions of AKT isoforms in breast cancer: a comprehensive review

2019 ◽  
Vol 17 (1) ◽  
Author(s):  
Nico Hinz ◽  
Manfred Jücker
Keyword(s):  
Breast Cancer ◽  
Overall Survival ◽  
Tumor Growth ◽  
Therapy Response ◽  
Akt Signaling ◽  
Migration And Invasion ◽  
Akt Isoforms ◽  
Specific Effects ◽  
The Impact

Abstract Background AKT, also known as protein kinase B, is a key element of the PI3K/AKT signaling pathway. Moreover, AKT regulates the hallmarks of cancer, e.g. tumor growth, survival and invasiveness of tumor cells. After AKT was discovered in the early 1990s, further studies revealed that there are three different AKT isoforms, namely AKT1, AKT2 and AKT3. Despite their high similarity of 80%, the distinct AKT isoforms exert non-redundant, partly even opposing effects under physiological and pathological conditions. Breast cancer as the most common cancer entity in women, frequently shows alterations of the PI3K/AKT signaling. Main content A plethora of studies addressed the impact of AKT isoforms on tumor growth, metastasis and angiogenesis of breast cancer as well as on therapy response and overall survival in patients. Therefore, this review aimed to give a comprehensive overview about the isoform-specific effects of AKT in breast cancer and to summarize known downstream and upstream mechanisms. Taking account of conflicting findings among the studies, the majority of the studies reported a tumor initiating role of AKT1, whereas AKT2 is mainly responsible for tumor progression and metastasis. In detail, AKT1 increases cell proliferation through cell cycle proteins like p21, p27 and cyclin D1 and impairs apoptosis e.g. via p53. On the downside AKT1 decreases migration of breast cancer cells, for instance by regulating TSC2, palladin and EMT-proteins. However, AKT2 promotes migration and invasion most notably through regulation of β-integrins, EMT-proteins and F-actin. Whilst AKT3 is associated with a negative ER-status, findings about the role of AKT3 in regulation of the key properties of breast cancer are sparse. Accordingly, AKT1 is mutated and AKT2 is amplified in some cases of breast cancer and AKT isoforms are associated with overall survival and therapy response in an isoform-specific manner. Conclusions Although there are several discussed hypotheses how isoform specificity is achieved, the mechanisms behind the isoform-specific effects remain mostly unrevealed. As a consequence, further effort is necessary to achieve deeper insights into an isoform-specific AKT signaling in breast cancer and the mechanism behind it.

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