scholarly journals Carbon Nanohorns as Effective Nanotherapeutics in Cancer Therapy

2020 ◽  
Vol 7 (1) ◽  
pp. 3
Author(s):  
Manuela Curcio ◽  
Giuseppe Cirillo ◽  
Federica Saletta ◽  
Filip Michniewicz ◽  
Fiore Pasquale Nicoletta ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Carbon Nanostructures ◽  
Carbon Nanomaterials ◽  
Functional Materials ◽  
Drug Carriers ◽  
Cancer Treatments ◽  
Comprehensive Overview ◽  
Carbon Nanohorns ◽  
Conical Horn

Different carbon nanostructures have been explored as functional materials for the development of effective nanomaterials in cancer treatment applications. This review mainly aims to discuss the features, either strength or weakness, of carbon nanohorn (CNH), carbon conical horn-shaped nanostructures of sp2 carbon atoms. The interest for these materials arises from their ability to couple the clinically relevant properties of carbon nanomaterials as drug carriers with the negligible toxicity described in vivo. Here, we offer a comprehensive overview of the recent advances in the use of CNH in cancer treatments, underlining the benefits of each functionalization route and approach, as well as the biological performances of either loaded and unloaded materials, while discussing the importance of delivery devices.

Gold nanospheres and nanorods for anti-cancer therapy: comparative studies of fabrication, surface-decoration, and anti-cancer treatments

Nanoscale ◽  
2020 ◽  
Vol 12 (28) ◽  
pp. 14996-15020
Author(s):  
Wei Mao ◽  
Young Ju Son ◽  
Hyuk Sang Yoo
Keyword(s):  
Gold Nanoparticles ◽  
Cancer Therapy ◽  
Cancer Therapeutics ◽  
Drug Carriers ◽  
Gold Nanospheres ◽  
Cancer Treatments ◽  
Anti Cancer ◽  
Diagnostic Agents ◽  
Irradiation Therapy ◽  
Surface Decoration

Various gold nanoparticles have been explored as cancer therapeutics because they can be widely engineered for use as efficient drug carriers and diagnostic agents, and in photo-irradiation therapy.

scholarly journals Hyperbranched Polyglycerol-Induced Porous Silica Nanoparticles as Drug Carriers for Cancer Therapy In Vitro and In Vivo

ChemistryOpen ◽  
2016 ◽  
Vol 6 (1) ◽  
pp. 158-164 ◽  
Author(s):  
Yang Yang ◽  
Anhe Wang ◽  
Qiang Wei ◽  
Cathleen Schlesener ◽  
Rainer Haag ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Silica Nanoparticles ◽  
Porous Silica ◽  
Drug Carriers ◽  
Hyperbranched Polyglycerol

scholarly journals SO2 gas adsorption on carbon nanomaterials: a comparative study

2018 ◽  
Vol 9 ◽  
pp. 1782-1792 ◽  
Author(s):  
Deepu J Babu ◽  
Divya Puthusseri ◽  
Frank G Kühl ◽  
Sherif Okeil ◽  
Michael Bruns ◽  
...  
Keyword(s):  
Carbon Nanotubes ◽  
Activated Carbon ◽  
Carbon Nanomaterials ◽  
Gas Adsorption ◽  
Adsorption Behavior ◽  
Carbon Adsorbents ◽  
Multiwalled Carbon ◽  
Comprehensive Overview ◽  
Carbon Nanohorns ◽  
Adsorption Characteristics

Owing to their high stability against corrosive gases, carbon-based adsorbents are preferentially used for the adsorptive removal of SO2. In the present study, SO2 adsorption on different carbon nanomaterials namely carbon nanohorns (CNHs), multiwalled carbon nanotubes (MWNTs), single-walled carbon nanotubes (SWNTs) and vertically aligned carbon nanotubes (VACNTs) are investigated and compared against the adsorption characteristics of activated carbon and graphene oxide (GO). A comprehensive overview of the adsorption behavior of this family of carbon adsorbents is given for the first time. The relative influence of surface area and functional groups on the SO2 adsorption characteristics is discussed. The isosteric heat of adsorption values are calculated to quantify the nature of the interaction between the SO2 molecule and the adsorbent. Most importantly, while chemisorption is found to dominate the adsorption behavior in activated carbon, SO2 adsorption on carbon nanomaterials occurs by a physisorption mechanism.

scholarly journals Interactions of Carbon Nanotubes and Carbon Nanohorns with a Model Membrane Layer and Lung Surfactant In Vitro

2019 ◽  
Vol 2019 ◽  
pp. 1-10 ◽  
Author(s):  
Dorota Kondej ◽  
Tomasz R. Sosnowski
Keyword(s):  
Carbon Nanomaterials ◽  
Lung Surfactant ◽  
Surface Elasticity ◽  
Experimental Studies ◽  
Dynamic Surface ◽  
Carbon Nanohorns ◽  
Experimental Systems ◽  
Lipid Layers

A broader use of carbon nanomaterials increases the risk of their inhalation as aerosol dispersed in the air. Inhaled nanometer-sized particles are known to penetrate to the pulmonary region where they interact with the lung surfactant as the first barrier they meet and eventually penetrate to the surface of the cellular layer. This study presents the results of experimental studies of physicochemical interactions between several types of carbon nanomaterials (nanotubes and nanohorns of various size and surface properties) and lipid layers in two qualitatively different experimental systems: Langmuir trough and pulsated drop tensiometer, both providing complementary possibilities to study interfacial properties of the lipid-rich layer. Quantified alterations in mechanical properties if lipid films (equilibrium compressibility, dynamic surface elasticity, and viscosity) indicate that nanocarbons with different wettability may induce concentration-dependent frustration of the lung surfactant and biological membranes in vivo. The observed effects are discussed not only in relation to health effects from nanoparticle inhalation but also to potential medical applications of engineered carbon nanomaterials.

Synthesis and Use of Reactive Molecular Precursors for the Preparation of Carbon Nanomaterials

2017 ◽  
Vol 2 (2) ◽  
Author(s):  
Bjoern Schulte ◽  
Stephen Schrettl ◽  
Holger Frauenrath
Keyword(s):  
Carbon Nanostructures ◽  
Carbon Nanomaterials ◽  
Coupling Reactions ◽  
Carbonaceous Matter ◽  
Comprehensive Overview ◽  
Chemical Functionalization ◽  
Molecular Precursors ◽  
Synthetic Routes ◽  
Forms Of Carbon ◽  
New Generation

AbstractThe use of reactive molecular carbon precursors is required if the preparation of carbon nanostructures and nanomaterials is to be achieved under conditions that are sufficiently benign to control their nanoscopic morphology and tailor their chemical functionalization. Recently, oligoyne precursors have been explored for this purpose, as they are sufficiently stable to be available in tangible quantities but readily rearrange in reactions that yield other forms of carbon. In this chapter, we briefly discuss available synthetic routes toward higher oligoynes that mostly rely on transition metal-mediated coupling reactions. Thereafter, a comprehensive overview of the use of oligoyne derivatives as precursors for carbon nanostructures and nanomaterials is given. While the non-templated conversion of simple oligoynes into carbonaceous matter exemplifies their potential as metastable carbon precursors, the more recent attempts to use functionalized oligoynes in host–guest complexes, self-assembled aggregates, thin films, colloids or other types of supramolecular structures have paved the way toward a new generation of carbon nanomaterials with predictable nanoscopic morphology and chemical functionalization.

Curcumin Based Drug Delivery Systems for Cancer Therapy

2020 ◽  
Vol 26 (42) ◽  
pp. 5430-5440
Author(s):  
Ankita Tiwari ◽  
Sanjay K. Jain
Keyword(s):  
Cancer Therapy ◽  
Polymeric Micelles ◽  
Tumor Regression ◽  
Curcuma Longa ◽  
Low Cost ◽  
Aqueous Solubility ◽  
Drug Carriers ◽  
Pharmacokinetic Profile ◽  
Tumor Resistance

Cancer accounts for the second major cause of death globally. Conventional cancer therapies lead to systemic toxicity that forbids their long term application. Besides, tumor resistance and recurrence have been observed in the majority of cases. Thus, the development of such therapy, which will pose minimum side effects, is the need of the hour. Curcumin or diferuloylmethane (CUR) is a natural polyphenol bioactive (obtained from Curcuma longa) which possesses anti-cancer and chemo-preventive activity. It acts by modulating various components of signaling cascades that are involved in cancer cell proliferation, invasion, and apoptosis process. It interacts with the adaptive and innate immune systems of our body and causes tumor regression. This may be the reason behind the attainment of in vivo anti-tumor activity at a very low concentration. Its ease of availability, safety profile, low cost, and multifaceted role in cancer prevention and treatment has made it a promising agent for chemoprevention of many cancers. Regardless of the phenomenal properties, its clinical utility is haltered due to its low aqueous solubility, poor bioavailability, rapid metabolism, and low cellular uptake. In the last few years, a variety of novel drug carriers have been fabricated to enhance the bioavailability and pharmacokinetic profile of CUR to attain better targeting of cancer. In this review, the recent developments in the arena of nanoformulations, like liposomes, polymeric NPs, solid lipid NPs (SNPs), polymeric micelles, nanoemulsions, microspheres, nanogels, etc. in anticancer therapy have been discussed along with a brief overview of the molecular targets for CUR in cancer therapy and role of CUR in cancer immunotherapy.

Development of dual ligand-targeted polymeric micelles as drug carriers for cancer therapy in vitro and in vivo

2014 ◽  
Vol 2 (15) ◽  
pp. 2114 ◽  
Author(s):  
Jingmou Yu ◽  
Xin Xie ◽  
Xiaoyuan Xu ◽  
Lei Zhang ◽  
Xueyun Zhou ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Polymeric Micelles ◽  
Drug Carriers
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