Development of dual ligand-targeted polymeric micelles as drug carriers for cancer therapy in vitro and in vivo

2014 ◽  
Vol 2 (15) ◽  
pp. 2114 ◽  
Author(s):  
Jingmou Yu ◽  
Xin Xie ◽  
Xiaoyuan Xu ◽  
Lei Zhang ◽  
Xueyun Zhou ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Polymeric Micelles ◽  
Drug Carriers

Quercetin Loaded Nanoparticles in Targeting Cancer: Recent Development

2019 ◽  
Vol 19 (13) ◽  
pp. 1560-1576 ◽  
Author(s):  
Manjula Vinayak ◽  
Akhilendra K. Maurya
Keyword(s):  
Silver Nanoparticles ◽  
Clinical Application ◽  
Glycolic Acid ◽  
Water Solubility ◽  
Polymeric Micelles ◽  
Metastatic Cancer ◽  
Chitosan Nanoparticles ◽  
Drug Carriers

:The spread of metastatic cancer cell is the main cause of death worldwide. Cellular and molecular basis of the action of phytochemicals in the modulation of metastatic cancer highlights the importance of fruits and vegetables. Quercetin is a natural bioflavonoid present in fruits, vegetables, seeds, berries, and tea. The cancer-preventive activity of quercetin is well documented due to its anti-inflammatory, anti-proliferative and anti-angiogenic activities. However, poor water solubility and delivery, chemical instability, short half-life, and low-bioavailability of quercetin limit its clinical application in cancer chemoprevention. A better understanding of the molecular mechanism of controlled and regulated drug delivery is essential for the development of novel and effective therapies. To overcome the limitations of accessibility by quercetin, it can be delivered as nanoconjugated quercetin. Nanoconjugated quercetin has attracted much attention due to its controlled drug release, long retention in tumor, enhanced anticancer potential, and promising clinical application. The pharmacological effect of quercetin conjugated nanoparticles typically depends on drug carriers used such as liposomes, silver nanoparticles, silica nanoparticles, PLGA (Poly lactic-co-glycolic acid), PLA (poly(D,L-lactic acid)) nanoparticles, polymeric micelles, chitosan nanoparticles, etc.:In this review, we described various delivery systems of nanoconjugated quercetin like liposomes, silver nanoparticles, PLGA (Poly lactic-co-glycolic acid), and polymeric micelles including DOX conjugated micelles, metal conjugated micelles, nucleic acid conjugated micelles, and antibody-conjugated micelles on in vitro and in vivo tumor models; as well as validated their potential as promising onco-therapeutic agents in light of recent updates.

In-vitro and in-vivo evaluation of pH-responsive polymeric micelles in a photodynamic cancer therapy model

2001 ◽  
Vol 53 (2) ◽  
pp. 155-166 ◽  
Author(s):  
J. Taillefer ◽  
N. Brasseur ◽  
J. E. van Lier ◽  
V. Lenaerts ◽  
D. Le Garrec ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Polymeric Micelles ◽  
Ph Responsive ◽  
In Vivo Evaluation ◽  
Photodynamic Cancer Therapy ◽  
Therapy Model

scholarly journals Biodegradable polymeric micelles coencapsulating paclitaxel and honokiol: a strategy for breast cancer therapy in vitro and in vivo

2017 ◽  
Vol Volume 12 ◽  
pp. 1499-1514 ◽  
Author(s):  
Ning Wang ◽  
Zhihan Wang ◽  
Shihong Nie ◽  
Linjiang Song ◽  
Tao He ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Therapy ◽  
Polymeric Micelles ◽  
Breast Cancer Therapy

scholarly journals Hyperbranched Polyglycerol-Induced Porous Silica Nanoparticles as Drug Carriers for Cancer Therapy In Vitro and In Vivo

ChemistryOpen ◽  
2016 ◽  
Vol 6 (1) ◽  
pp. 158-164 ◽  
Author(s):  
Yang Yang ◽  
Anhe Wang ◽  
Qiang Wei ◽  
Cathleen Schlesener ◽  
Rainer Haag ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Silica Nanoparticles ◽  
Porous Silica ◽  
Drug Carriers ◽  
Hyperbranched Polyglycerol

Curcumin Based Drug Delivery Systems for Cancer Therapy

2020 ◽  
Vol 26 (42) ◽  
pp. 5430-5440
Author(s):  
Ankita Tiwari ◽  
Sanjay K. Jain
Keyword(s):  
Cancer Therapy ◽  
Polymeric Micelles ◽  
Tumor Regression ◽  
Curcuma Longa ◽  
Low Cost ◽  
Aqueous Solubility ◽  
Drug Carriers ◽  
Pharmacokinetic Profile ◽  
Tumor Resistance

Cancer accounts for the second major cause of death globally. Conventional cancer therapies lead to systemic toxicity that forbids their long term application. Besides, tumor resistance and recurrence have been observed in the majority of cases. Thus, the development of such therapy, which will pose minimum side effects, is the need of the hour. Curcumin or diferuloylmethane (CUR) is a natural polyphenol bioactive (obtained from Curcuma longa) which possesses anti-cancer and chemo-preventive activity. It acts by modulating various components of signaling cascades that are involved in cancer cell proliferation, invasion, and apoptosis process. It interacts with the adaptive and innate immune systems of our body and causes tumor regression. This may be the reason behind the attainment of in vivo anti-tumor activity at a very low concentration. Its ease of availability, safety profile, low cost, and multifaceted role in cancer prevention and treatment has made it a promising agent for chemoprevention of many cancers. Regardless of the phenomenal properties, its clinical utility is haltered due to its low aqueous solubility, poor bioavailability, rapid metabolism, and low cellular uptake. In the last few years, a variety of novel drug carriers have been fabricated to enhance the bioavailability and pharmacokinetic profile of CUR to attain better targeting of cancer. In this review, the recent developments in the arena of nanoformulations, like liposomes, polymeric NPs, solid lipid NPs (SNPs), polymeric micelles, nanoemulsions, microspheres, nanogels, etc. in anticancer therapy have been discussed along with a brief overview of the molecular targets for CUR in cancer therapy and role of CUR in cancer immunotherapy.

Curcumin-loaded biodegradable polymeric micelles for colon cancer therapy in vitro and in vivo

Nanoscale ◽  
2011 ◽  
Vol 3 (4) ◽  
pp. 1558 ◽  
Author(s):  
MaLing Gou ◽  
Ke Men ◽  
HuaShan Shi ◽  
MingLi Xiang ◽  
Juan Zhang ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Cancer Therapy ◽  
Polymeric Micelles

scholarly journals The Topical Nanodelivery of Vismodegib Enhances Its Skin Penetration and Performance In Vitro While Reducing Its Toxicity In Vivo

Pharmaceutics ◽  
2021 ◽  
Vol 13 (2) ◽  
pp. 186
Author(s):  
Maria Natalia Calienni ◽  
Daniela Maza Vega ◽  
C. Facundo Temprana ◽  
María Cecilia Izquierdo ◽  
David E. Ybarra ◽  
...  
Keyword(s):  
Side Effects ◽  
Water Solubility ◽  
Polymeric Micelles ◽  
Skin Penetration ◽  
Distribution Volume ◽  
And Performance ◽  
Oral Doses ◽  
Advanced Basal Cell Carcinoma

Vismodegib is a first-in-class inhibitor for advanced basal cell carcinoma treatment. Its daily oral doses present a high distribution volume and several side effects. We evaluated its skin penetration loaded in diverse nanosystems as potential strategies to reduce side effects and drug quantities. Ultradeformable liposomes, ethosomes, colloidal liquid crystals, and dendrimers were able to transport Vismodegib to deep skin layers, while polymeric micelles failed at this. As lipidic systems were the most effective, we assessed the in vitro and in vivo toxicity of Vismodegib-loaded ultradeformable liposomes, apoptosis, and cellular uptake. Vismodegib emerges as a versatile drug that can be loaded in several delivery systems for topical application. These findings may be also useful for the consideration of topical delivery of other drugs with a low water solubility.

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