scholarly journals Multimodal Device for Real-Time Monitoring of Skin Oxygen Saturation and Microcirculation Function

Biosensors ◽  
2019 ◽  
Vol 9 (3) ◽  
pp. 97 ◽  
Author(s):  
Uldis Rubins ◽  
Zbignevs Marcinkevics ◽  
Janis Cimurs ◽  
Inga Saknite ◽  
Edgars Kviesis-Kipge ◽  
...  

The present study introduces a recently developed compact hybrid device for real-time monitoring of skin oxygen saturation and temperature distribution. The prototype involves a snapshot hyperspectral camera, multi-wavelength illuminator, thermal camera, and built-in computer with custom-developed software. To validate this device in-vivo we performed upper arm vascular occlusion on eight healthy volunteers. Palm skin oxygen saturation maps were analyzed in real-time using k-means segmentation algorithm and two-layer optical diffuse model. The prototype system demonstrated a satisfying performance of skin hyperspectral measurements in the spectral range of 507–625 nm. The results confirmed the reliability of the proposed system for in-vivo assessment of skin hemoglobin saturation with oxygen and microcirculation.

Head & Neck ◽  
2013 ◽  
Vol 36 (8) ◽  
pp. 1207-1215 ◽  
Author(s):  
Mazen A. Juratli ◽  
Mustafa Sarimollaoglu ◽  
Eric R. Siegel ◽  
Dmitry A. Nedosekin ◽  
Ekaterina I. Galanzha ◽  
...  

2021 ◽  
Vol 900 ◽  
pp. 115674
Author(s):  
Muthaiah Annalakshmi ◽  
Sakthivel Kumaravel ◽  
T.S.T. Balamurugan ◽  
Shen-Ming Chen ◽  
Ju-Liang He

2015 ◽  
Vol 51 (32) ◽  
pp. 6948-6951 ◽  
Author(s):  
Yanfeng Zhang ◽  
Qian Yin ◽  
Jonathan Yen ◽  
Joanne Li ◽  
Hanze Ying ◽  
...  

Anin vitroandin vivodrug-reporting system is developed for real-time monitoring of drug release via the analysis of the concurrently released near-infrared fluorescence dye.


2019 ◽  
Author(s):  
Sebastiano Bariselli ◽  
Nanami Miyazaki ◽  
Alexxai Kravitz

AbstractStimulants are one of the most widely prescribed classes of pharmaceuticals, but it is unclear which brain pathways underlie their therapeutic and adverse actions. Here, with real-time monitoring of circuit plasticity, we demonstrate that psychostimulants strengthen orbitofrontal (OFC) to dorsomedial striatum (DMS) pathway synapses, and increase striatal output in awake mice. In vivo high-frequency stimulation of OFC-DMS pathway blocked stimulant-induced potentiation and the expression of locomotor sensitization, thereby directly linking OFC-DMS plasticity to hyperactivity.


2016 ◽  
Vol 214 (6) ◽  
pp. 649-652 ◽  
Author(s):  
Hema V. Pingali ◽  
Angela K. Hilliker

Translation is carefully regulated to control protein levels and allow quick responses to changes in the environment. Certain questions about translation in vivo have been unattainable until now. In this issue, Pichon et al. (2016. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201605024) describe a new technique to allow real-time monitoring of translation on single mRNAs.


IEEE Access ◽  
2020 ◽  
Vol 8 ◽  
pp. 180815-180824
Author(s):  
Ramin Soltanzadeh ◽  
Bruce Hardy ◽  
Robert D. Mcleod ◽  
Marcia R. Friesen

Nanoscale ◽  
2020 ◽  
Vol 12 (18) ◽  
pp. 10216-10225 ◽  
Author(s):  
Hongjun Zhuang ◽  
Benhao Li ◽  
Mengyao Zhao ◽  
Peng Wei ◽  
Wei Yuan ◽  
...  

Cyanine dye-coordinated upconversion nanoparticles were developed for real-time monitoring drug-induced hepatotoxicity in vivo by ratio-fluorescence and photoacoustic imaging of peroxynitrite.


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