scholarly journals Visual Quantitation of Copper Ions Based on a Microfluidic Particle Dam Reflecting the Cu(II)-Catalyzed Oxidative Damage of DNA

Biosensors ◽  
2021 ◽  
Vol 11 (12) ◽  
pp. 487
Author(s):  
Chenyu Cui ◽  
Ting-Hsuan Chen

Due to the use of copper water pipes and the discharge of industrial wastewater, contamination of copper ions in drinking water has become a severe hazard globally. To routinely check water safety on a daily basis, easy-to-use platforms for quantitative analysis of trace amounts of copper ions (Cu2+) in drinking water is needed. Here, we report microfluidic particle accumulation integrated with a Cu(II)-catalyzed Fenton reaction for visual and quantitative copper ion detection. Microparticles (MMPs) and polystyrene microparticles (PMPs) are connected via a single strand DNA, MB155. However, when Cu2+ is present, MB155 is cleaved by hydroxyl free radicals (•OH) produced from Cu2+/hydrogen peroxide (H2O2) Fenton reactions, causing an increased amount of free PMPs. To visually count them, the particle solution is loaded onto a microfluidic chip where free MMPs and MMPs–MB155–PMPs can be collected by the magnetic separator, while the free PMPs continue flowing until being accumulated at the particle dam. The results showed a good linear relationship between the trapping length of PMP accumulation and the Cu2+ concentration from 0 to 300 nM. A limit of detection (LOD) of 70.1 nM was achieved, which is approximately 449 times lower than the 2 × 103 μg·L−1 (~31.5 μM) required by the World Health Organization (WHO). Moreover, the results showed high selectivity and good tolerance to pH and hardness, indicating compatibility for detection in tap water, suggesting a potential platform for the routine monitoring of copper contamination in drinking water.

2012 ◽  
Vol 10 (2) ◽  
pp. 295-310 ◽  
Author(s):  
Vívian Gemiliano Pinto ◽  
Léo Heller ◽  
Rafael Kopschitz Xavier Bastos

In this paper we present a comparative assessment of drinking-water standards from almost all South American countries, using the USA and the Canadian standards and the World Health Organization (WHO) Guidelines as references. Similarities and discrepancies between standards/guidelines were identified through descriptive analyses and, in the case of chemical standards, clustering techniques. In general, one or another of the four consecutive editions of the WHO Guidelines were shown to be quite influential in setting drinking-water standards in the region, but not so much the USA and the Canadian standards. Considerable discrepancies between South American drinking-water standards were found, mainly with respect to chemical substances. Questions are raised about their scientific basis and/or the practicalities for their enforcement. In conclusion, the paper highlights that many drinking-water regulations in South America need updating, taking on the approach of health-based targets in setting these standards, as well as that of a broader risk-based preventive management in the entire supply system to assure water safety.


2014 ◽  
Vol 13 (2) ◽  
pp. 319-339 ◽  
Author(s):  
Gaurav Saxena ◽  
Ram Naresh Bharagava ◽  
Gaurav Kaithwas ◽  
Abhay Raj

Water is critical for life, but many people do not have access to clean and safe drinking water and die because of waterborne diseases. The analysis of drinking water for the presence of indicator microorganisms is key to determining microbiological quality and public health safety. However, drinking water-related illness outbreaks are still occurring worldwide. Moreover, different indicator microorganisms are being used in different countries as a tool for the microbiological examination of drinking water. Therefore, it becomes very important to understand the potentials and limitations of indicator microorganisms before implementing the guidelines and regulations designed by various regulatory agencies. This review provides updated information on traditional and alternative indicator microorganisms with merits and demerits in view of their role in managing the waterborne health risks as well as conventional and molecular methods proposed for monitoring of indicator and pathogenic microorganisms in the water environment. Further, the World Health Organization (WHO) water safety plan is emphasized in order to develop the better approaches designed to meet the requirements of safe drinking water supply for all mankind, which is one of the major challenges of the 21st century.


2012 ◽  
Vol 2 (2) ◽  
pp. 103-111 ◽  
Author(s):  
Richard J. Gelting ◽  
Kristin Delea ◽  
Elizabeth Medlin

A Water Safety Plan (WSP) is a preventive, risk management approach to ensure drinking water safety. The World Health Organization (WHO) guidelines place WSPs within a larger 'framework for safe drinking-water' that links WSPs to health, creating an implicit expectation that implementation of WSPs will safeguard health in areas with acceptable drinking water quality. However, many intervening factors can come between implementation of an individual WSP and ultimate health outcomes. Evaluating the impacts of a WSP, therefore, requires a much broader analysis than simply looking at health improvements. Until recently, little guidance for the monitoring and evaluation of WSPs existed. Drawing examples from existing WSPs in various regions, this paper outlines a conceptual framework for conducting an overall evaluation of the various outcomes and impacts of a WSP. This framework can provide a common basis for implementers to objectively monitor and evaluate the range of outcomes and impacts from WSPs, as well as a common understanding of the time frames within which those results may occur. As implementers understand the various outcomes and impacts of WSPs beyond health, a strong evidence base for the effectiveness of WSPs will develop, further enabling the scaling up of WSP implementation and provision of better quality water.


Author(s):  
Sreenath Bolisetty ◽  
Akram Rahimi ◽  
Raffaele Mezzenga

Tap water quality in Peru fails to meet the world health organization (WHO) drinking water standards; consequently, the local population in Peru has been exposed over the last years to...


2020 ◽  
pp. 12-17
Author(s):  
Muhammad M Abubakar ◽  
Ibrahim Khalil Abubakar

Some sources of drinking water in Kari Estate in Bauchi Metropolis were analyzed for physicochemical contents and coliform contamination. A total of five samples were collected from different sources as follows: 2 sachets water, 2 wells, and tap water. The physicochemical analysis included the determinations of temperature, pH, electrical conductivity, total dissolved solids, turbidity, colour, suspended solids, odour, taste, total hardness, iron, nitrate, nitirite, manganese, ammonia, fluoride and cyanide. The two wells had total coliforms of 6 and 10 and faecal coliforms of 4 and 5 respectively. Tap water had total and faecal coliforms of 7 and 3 respectively. E. coli were identified in the samples from wells while Bacillus sp. were found in the tap water. Although the physicochemical contents of the samples were normal range, coliform counts of the wells and tap water were above those set by the Nigerian Industrial Standards (NIS) and the World Health Organization (WHO) standards. Presence coliforms above the standards indicates contamination and that the water may be unsafe for drinking. The presence of E. coli suggests that improvement in monitoring and water hygiene practices should be employed to improve the drinking water quality.


2010 ◽  
Vol 61 (5) ◽  
pp. 1307-1315 ◽  
Author(s):  
H.-J. Mälzer ◽  
N. Staben ◽  
A. Hein ◽  
W. Merkel

According to the recommendations of the World Health Organization (WHO) for Water Safety Plans (WSP), a Technical Risk Management was developed, which considers standard demands in drinking water treatment in Germany. It was already implemented at several drinking water treatment plants of different size and treatment processes in Germany. Hazards affecting water quality, continuity, and the reliability of supply from catchment to treatment and distribution could be identified by a systematic approach, and suitable control measures were defined. Experiences are presented by detailed examples covering methods, practical consequences, and further outcomes. The method and the benefits for the water suppliers are discussed and an outlook on the future role of WSPs in German water supply is given.


Nanomaterials ◽  
2020 ◽  
Vol 10 (9) ◽  
pp. 1664
Author(s):  
Mingming Cheng ◽  
Chenyan Li ◽  
Weijun Li ◽  
Yingkai Liu

CuO flower-like material (FM) was prepared via the facile hydrothermal method, and Ag nanoparticles were deposited on the CuO FM to obtain Ag@CuO composite. Rhodamine 6G (R6G) was used as the probe molecule on Ag@CuO FM substrate to study surface enhanced Raman scattering (SERS). It is discovered that it exhibited an excellent SERS performance with limit of detection of 3.58 × 10−16 M and enhancement factor (EF) of 3.99 × 1010. More importantly, we used it as a SERS substrate to detect cadmium ions and found that its limit of detection (LOD) reaches up to 2.6 × 10−8 M, which is lower than the highest allowable Cd2+ concentration in drinking water set by the World Health Organization (WHO) and Environmental Protection Agency (EPA). Therefore, the proposed composite can be applicable to the detection of Cd2+ in drinking water and in soil.


2016 ◽  
Vol 78 (2) ◽  
Author(s):  
Fazrul Razman Sulaiman ◽  
Nur Fadhilah Mohd Rafi ◽  
Shytie Nur Shafiqah Kamarudin ◽  
Sharifah Norkhadijah Syed Ismail

This study investigates the physical and chemical properties of bottled water and tap water at a university campus in Pahang, Malaysia. A total of seven bottled water brands, consisting of natural mineral (NM) and packaged drinking (PD) types, were first randomly selected. Three source locations of tap water were also examined. All water samples were analysed for their physicochemical characteristics, including pH, electrical conductivity (EC), temperature (using a YSI multi-parameter), turbidity (using a turbidity meter) and selected trace metals, along with copper (Cu) and zinc (Zn) using graphite furnace atomic absorption spectroscopy (GFAAS). Results were then examined against World Health Organization (WHO) and Malaysian Ministry of Health (MMOH) guidelines for drinking water. Health risks associated with trace metal were estimated using the risk assessment model. Turbidity values for tap water (2.85-4.94 NTU) were slightly higher than bottled water (0.77-1.03 NTU). A low turbidity value (0.77-0.93 NTU) suggests the presence of effective water treatment processes for NM bottled water. A low concentration of EC (0.003-0.010 mS/cm) indicates demineralization of PD bottled water. Overall quality of the bottled water and tap water was in compliance with guidelines recommended by WHO and MMOH, posing a minimum health risk and remaining safe for consumption.


Author(s):  
Dora Cardona Rivas ◽  
Militza Yulain Cardona Guzmán ◽  
Olga Lucía Ocampo López

Objective: To characterize the burden of intestinal infectious diseases attributable to drinking-water quality in 27 municipalities in the central region of Colombia. Materials and methods: A time-trend ecological study. The drinking-water quality of the National Institute of Health and the Institute of Hydrology, Meteorology and Environmental Studies was identified. The disease burden was calculated based on the mortality registered in the National Department of Statistics and the records of morbidity attended by the Social Protection Integrated Information System. The etiological agents reported in morbidity records and the observation of environmental conditions in the municipalities of the study were included. The disease burden was determined according to the methodology recommended by the World Health Organization (WHO).


2021 ◽  
Vol 11 (8) ◽  
Author(s):  
Molla Rahman Shaibur ◽  
Mohammed Sadid Hossain ◽  
Shirina Khatun ◽  
F. K. Sayema Tanzia

AbstractThis study aimed to determine the quality of drinking water supplied in different types of food stalls in Jashore Municipality, Bangladesh. A total of 35 water samples were collected from different tea stalls, street side fast food stalls, normal restaurants and well-furnished restaurants. The water quality was evaluated by determining the distinct physical, chemical and biological parameters. The results revealed that the water used in the food stalls and restaurants for drinking purpose was in desired quality in terms of turbidity, electrical conductivity, pH, total dissolved solids, nitrate (NO3−), sulfate (SO42−), phosphate (PO43−), chloride (Cl−), sodium (Na) and potassium (K) concentrations. The values were within the permissible limit proposed by the Bangladesh Bureau of Statistics and the World Health Organization. Concentrations of calcium (Ca) and magnesium (Mg) found in several samples were higher than the World Health Organization standard. Iron (Fe) concentrations were higher than the permissible limit of the World Health Organization. Only 46% exceeded the permissible limit of Bangladesh Bureau Statistics. The threatening result was that the samples were contaminated by fecal coliform, indicating that the people of Jashore Municipality may have a greater chance of being affected by pathogenic bacteria. The drinking water provided in the street side fast food stalls was biologically contaminated. The findings demonstrate that the drinking water used in food stalls and restaurants of Jashore Municipality did not meet up the potable drinking water quality standards and therefore was detrimental to public health.


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