scholarly journals An Overview of Bio-Inspired Intelligent Imprinted Polymers for Virus Determination

Biosensors ◽  
2021 ◽  
Vol 11 (3) ◽  
pp. 89
Author(s):  
Shabi Abbas Zaidi
Keyword(s):  
Early Diagnosis ◽  
Molecular Imprinting ◽  
Medical Diagnosis ◽  
Chemical Sensing ◽  
Point Of Care ◽  
Virus Elimination ◽  
Imprinted Polymers ◽  
Molecular Imprinting Polymers ◽  
Disease Therapy ◽  
Recognition Ability

The molecular imprinting polymers (MIPs) have shown their potential in various applications including pharmaceuticals, chemical sensing and biosensing, medical diagnosis, and environmental related issues, owing to their artificial selective biomimetic recognition ability. Despite the challenges posed in the imprinting and recognition of biomacromolecules, the use of MIP for the imprinting of large biomolecular oragnism such as viruses is of huge interest because of the necessity of early diagnosis of virus-induced diseases for clinical and point-of-care (POC) purposes. Thus, many fascinating works have been documented in which such synthetic systems undoubtedly explore a variety of potential implementations, from virus elimination, purification, and diagnosis to virus and bacteria-borne disease therapy. This study is focused comprehensively on the fabrication strategies and their usage in many virus-imprinted works that have appeared in the literature. The drawbacks, challenges, and perspectives are also highlighted.

scholarly journals Molecularly Imprinted Polymers for Chemical Sensing: A Tutorial Review

Chemosensors ◽  
2021 ◽  
Vol 9 (6) ◽  
pp. 123
Author(s):  
Nadja Leibl ◽  
Karsten Haupt ◽  
Carlo Gonzato ◽  
Luminita Duma
Keyword(s):  
Molecularly Imprinted Polymers ◽  
Medical Diagnosis ◽  
Chemical Sensing ◽  
Imprinted Polymer ◽  
Molecularly Imprinted ◽  
Imprinted Polymers ◽  
Main Research ◽  
Industrial Monitoring ◽  
Pros And Cons ◽  
Constant Growth

The field of molecularly imprinted polymer (MIP)-based chemosensors has been experiencing constant growth for several decades. Since the beginning, their continuous development has been driven by the need for simple devices with optimum selectivity for the detection of various compounds in fields such as medical diagnosis, environmental and industrial monitoring, food and toxicological analysis, and, more recently, the detection of traces of explosives or their precursors. This review presents an overview of the main research efforts made so far for the development of MIP-based chemosensors, critically discusses the pros and cons, and gives perspectives for further developments in this field.

Molecular imprinting polymers and their composites: a promising material for diverse applications

2017 ◽  
Vol 5 (3) ◽  
pp. 388-402 ◽  
Author(s):  
Shabi Abbas Zaidi
Keyword(s):  
Molecular Imprinting ◽  
Polymeric Materials ◽  
Promising Material ◽  
Molecular Imprinted Polymers ◽  
Imprinted Polymers ◽  
Molecular Imprinting Polymers

Molecular imprinted polymerization is considered one of the most useful preparation strategies to obtain highly selective polymeric materials called molecular imprinted polymers (MIPs).

scholarly journals Application of molecularly imprinted polymers for the separation and detection of aflatoxin

2020 ◽  
pp. 174751982098037
Author(s):  
Jian-Xiong He ◽  
Huan-Yu Pan ◽  
Li Xu ◽  
Ri-Yuan Tang
Keyword(s):  
Molecular Imprinting ◽  
Molecularly Imprinted Polymers ◽  
Solid Phase ◽  
Bulk Polymerization ◽  
Phase Extraction ◽  
Molecularly Imprinted ◽  
Imprinted Polymers ◽  
Molecular Imprinting Polymers ◽  
Surface Enhanced ◽  
Surface Enhanced Raman

Aflatoxins are extremely harmful carcinogens to humans and animals. In recent years, attention has been directed toward the application of molecular imprinting polymers for the separation and detection of aflatoxin. In this review, polymerization methods for the preparation of molecular imprinting polymers for aflatoxin detection, such as lump-bulk polymerization, spherical molecular imprinting polymer synthesis, surface-imprinted polymerization, and electropolymerization, are described. The applications of molecular imprinting polymers in solid-phase extraction, biosensors, and the surface-enhanced Raman detection of aflatoxin are also reviewed in this paper.

scholarly journals Evaluation of Molecularly Imprinted Polymers for Point-of-Care Testing for Cardiovascular Disease

Sensors ◽  
2019 ◽  
Vol 19 (16) ◽  
pp. 3485 ◽  
Author(s):  
Brian Regan ◽  
Fiona Boyle ◽  
Richard O’Kennedy ◽  
David Collins
Keyword(s):  
Cardiovascular Disease ◽  
Molecular Imprinting ◽  
Molecularly Imprinted Polymers ◽  
Point Of Care ◽  
Analytical Performance ◽  
Point Of Care Testing ◽  
Molecularly Imprinted ◽  
Imprinted Polymers ◽  
Recognition Element ◽  
Recognition Elements

Molecular imprinting is a rapidly growing area of interest involving the synthesis of artificial recognition elements that enable the separation of analyte from a sample matrix and its determination. Traditionally, this approach can be successfully applied to small analyte (<1.5 kDa) separation/ extraction, but, more recently it is finding utility in biomimetic sensors. These sensors consist of a recognition element and a transducer similar to their biosensor counterparts, however, the fundamental distinction is that biomimetic sensors employ an artificial recognition element. Molecularly imprinted polymers (MIPs) employed as the recognition elements in biomimetic sensors contain binding sites complementary in shape and functionality to their target analyte. Despite the growing interest in molecularly imprinting techniques, the commercial adoption of this technology is yet to be widely realised for blood sample analysis. This review aims to assess the applicability of this technology for the point-of-care testing (POCT) of cardiovascular disease-related biomarkers. More specifically, molecular imprinting is critically evaluated with respect to the detection of cardiac biomarkers indicative of acute coronary syndrome (ACS), such as the cardiac troponins (cTns). The challenges associated with the synthesis of MIPs for protein detection are outlined, in addition to enhancement techniques that ultimately improve the analytical performance of biomimetic sensors. The mechanism of detection employed to convert the analyte concentration into a measurable signal in biomimetic sensors will be discussed. Furthermore, the analytical performance of these sensors will be compared with biosensors and their potential implementation within clinical settings will be considered. In addition, the most suitable application of these sensors for cardiovascular assessment will be presented.

scholarly journals Contagion Management at the Méditerranée Infection University Hospital Institute

2021 ◽  
Vol 10 (12) ◽  
pp. 2627
Author(s):  
Pierre-Edouard Fournier ◽  
Sophie Edouard ◽  
Nathalie Wurtz ◽  
Justine Raclot ◽  
Marion Bechet ◽  
...  
Keyword(s):  
Infectious Disease ◽  
Early Diagnosis ◽  
Personal Protective Equipment ◽  
Early Stage ◽  
Point Of Care ◽  
University Hospital ◽  
Protective Equipment ◽  
Monitoring Point ◽  
Epidemiological Monitoring ◽  
Wide Range

The Méditerranée Infection University Hospital Institute (IHU) is located in a recent building, which includes experts on a wide range of infectious disease. The IHU strategy is to develop innovative tools, including epidemiological monitoring, point-of-care laboratories, and the ability to mass screen the population. In this study, we review the strategy and guidelines proposed by the IHU and its application to the COVID-19 pandemic and summarise the various challenges it raises. Early diagnosis enables contagious patients to be isolated and treatment to be initiated at an early stage to reduce the microbial load and contagiousness. In the context of the COVID-19 pandemic, we had to deal with a shortage of personal protective equipment and reagents and a massive influx of patients. Between 27 January 2020 and 5 January 2021, 434,925 nasopharyngeal samples were tested for the presence of SARS-CoV-2. Of them, 12,055 patients with COVID-19 were followed up in our out-patient clinic, and 1888 patients were hospitalised in the Institute. By constantly adapting our strategy to the ongoing situation, the IHU has succeeded in expanding and upgrading its equipment and improving circuits and flows to better manage infected patients.

scholarly journals Strategic use of nanotechnology in drug targeting and its consequences on human health: A focused review

2019 ◽  
Vol 11 (1) ◽  
pp. 38-54 ◽  
Author(s):  
Anand Maurya ◽  
Anurag Kumar Singh ◽  
Gaurav Mishra ◽  
Komal Kumari ◽  
Arati Rai ◽  
...  
Keyword(s):  
Human Health ◽  
Surface Area ◽  
Medical Diagnosis ◽  
Drug Targeting ◽  
Pharmaceutical Market ◽  
Large Surface Area ◽  
Mass Ratio ◽  
Disease Therapy ◽  
Significant Interest ◽  
Medical Benefits

Since the development of first lipid-based nanocarrier system, about 15% of the present pharmaceutical market uses nanomedicines to achieve medical benefits. Nanotechnology is an advanced area to meliorate the delivery of compounds for improved medical diagnosis and curing disease. Nanomedicines are gaining significant interest due to the ultra small size and large surface area to mass ratio. In this review, we discuss the potential of nanotechnology in delivering of active moieties for the disease therapy including their toxicity evidences. This communication will help the formulation scientists in understanding and exploring the new aspects of nanotechnology in the field of nanomedicine.

Fluorescence signaling molecularly imprinted polymers for antibiotics prepared via site-directed post-imprinting introduction of plural fluorescent reporters within the recognition cavity

2016 ◽  
Vol 4 (44) ◽  
pp. 7138-7145 ◽  
Author(s):  
Hirobumi Sunayama ◽  
Takeo Ohta ◽  
Atsushi Kuwahara ◽  
Toshifumi Takeuchi
Keyword(s):  
Molecular Imprinting ◽  
Molecularly Imprinted Polymers ◽  
Fluorescent Dyes ◽  
Specific Binding ◽  
Fluorescence Signal ◽  
Molecularly Imprinted ◽  
Imprinted Polymers ◽  
Fluorescent Reporters ◽  
Binding Event ◽  
Fluorescence Signaling

An antibiotic-imprinted cavity with two different fluorescent dyes was prepared by molecular imprinting and subsequent post-imprinting modifications (PIMs), for the readout of a specific binding event as a fluorescence signal.

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