scholarly journals The Role of Collagen-Based Biomaterials in Chronic Wound Healing and Sports Medicine Applications

2021 ◽  
Vol 8 (1) ◽  
pp. 8
Author(s):  
David A. Yeung ◽  
Natalie H. Kelly
Keyword(s):  
Tissue Engineering ◽  
Sports Medicine ◽  
Chronic Wound ◽  
Wound Management ◽  
Contributing Factors ◽  
Collagen Scaffolds ◽  
Matrix Component ◽  
The Matrix ◽  
Specific Tissue

Advancements in tissue engineering have taken aim at treating tissue types that have difficulty healing naturally. In order to achieve improved healing conditions, the balance of exogenous matrix, cells, and different factors must be carefully controlled. This review seeks to explore the aspects of tissue engineering in specific tissue types treated in sports medicine and advanced wound management from the perspective of the matrix component. While the predominant material to be discussed is collagen I, it would be remiss not to mention its relation to the other contributing factors to tissue engineered healing. The main categories of materials summarized here are (1) reconstituted collagen scaffolds, (2) decellularized matrix tissue, and (3) non-decellularized tissue. These three groups are ordered by their increase in additional components beyond simply collagen.

The Role of Stem Cells and Tissue Engineering in Orthopaedic Sports Medicine: Current Evidence and Future Directions

2015 ◽  
Vol 31 (5) ◽  
pp. 1017-1021 ◽  
Author(s):  
MaCalus V. Hogan ◽  
Garth N. Walker ◽  
Liang Richard Cui ◽  
Freddie H. Fu ◽  
Johnny Huard
Keyword(s):  
Tissue Engineering ◽  
Stem Cells ◽  
Sports Medicine ◽  
Current Evidence ◽  
Future Directions

scholarly journals The role of intestinal microflora in the development of cholelithiasis (literature review)

2020 ◽  
Vol 10 (1) ◽  
pp. 31-37 ◽  
Author(s):  
N. A. Hohlacheva ◽  
N. N. Glazyrina ◽  
A. P. Lukashevich ◽  
Ja. M. Vahrushev ◽  
T. S. Kosareva
Keyword(s):  
Bile Acids ◽  
Bacterial Growth ◽  
Enterohepatic Circulation ◽  
Stone Formation ◽  
Chemical Properties ◽  
Contributing Factors ◽  
Multi Stage ◽  
The Matrix ◽  
The Many

Cholelithiasis is one of the most common diseases of the digestive system, which affects all segments of the population. Currently, cholelithiasis is considered as a long, multi-stage process in which the period of stone formation is preceded by changes in metabolism and physical and chemical properties of bile. However, among the many contributing factors, insufficient attention is paid to the role of the infectious factor in the development of cholelithiasis. The analysis of the literature data showed that today there are various mechanisms for promoting ob development of cholelithiasis by excess enteral bacterial grouth. First, with excessive bacterial growth, duodeno-biliary reflux leads to infection of the biliary tract and the development of inflammation in the gallbladder. Substances that occur during the inflammatory process (proteins, mucus, exfoliated epithelium) are the matrix on which the gallstone is formed. Secondly, the role of dysbiosis in violation of enterohepatic circulation of bile acids is essential. The change in the ratio of conjugated and deconjugated bile acids contributes to the formation of lithogenic bile. Third, excessive bacterial growth leads to endotoxemia, which has a damaging effect on the metabolism of bile acids in the liver. Finally, in a certain dependence on the microbiota is the digestive and suction functions of the small intestine, but the participation of this channel in cholelithiasis requires further research.

scholarly journals An ancestral role of pericentrin in centriole formation through SAS-6 recruitment

2018 ◽  
Author(s):  
Daisuke Ito ◽  
Sihem Zitouni ◽  
Swadhin Chandra Jana ◽  
Paulo Duarte ◽  
Jaroslaw Surkont ◽  
...  
Keyword(s):  
Expression System ◽  
Spindle Pole Body ◽  
Spindle Pole ◽  
Heterologous Expression System ◽  
Matrix Assembly ◽  
Matrix Component ◽  
Pole Body ◽  
The Matrix ◽  
Interaction Surface

The centrosome is composed of two centrioles surrounded by a microtubule-nucleating pericentriolar matrix (PCM). Centrioles regulate matrix assembly. Here we ask whether the matrix also regulates centriole assembly. To define the interaction between the matrix and individual centriole components, we take advantage of a heterologous expression system using fission yeast. Importantly, its centrosome, the spindle pole body (SPB), has matrix but no centrioles. Surprisingly, we observed that the SPB can recruit several animal centriole components. Pcp1/pericentrin, a conserved matrix component that is often upregulated in cancer, recruits a critical centriole constituent, SAS-6. We further show that this novel interaction is conserved and important for centriole biogenesis and elongation in animals. We speculate that the Pcp1/pericentrin-SAS-6 interaction surface was conserved for one billion years of evolution after centriole loss in yeasts, due to its conserved binding to calmodulin. This study reveals an ancestral relationship between pericentrin and the centriole, where both regulate each other assembly, ensuring mutual localisation.

Role of Biomechanics in Functional Tissue Engineering

2004 ◽  
Vol 844 ◽  
Author(s):  
Kai-Nan An
Keyword(s):  
Tissue Engineering ◽  
Strategic Information ◽  
Functional Tissue Engineering ◽  
Functional Tissue ◽  
Before And After ◽  
The Matrix ◽  
Design And Manufacture ◽  
Stimulation Of

ABSTRACTFunctional tissue engineering establishes functional criteria for design and manufacture of the scaffold matrix for repair and replacement. It also provides useful and strategic information in mechanical stimulation of the cells seeded in the matrix before and after surgical placement to enhance the success of tissue engineering. Biomechanics plays an important role in accomplishing these requirements by assessing the in vivo environment and the material properties.

Extracellular matrix: the gatekeeper of tumor angiogenesis

2019 ◽  
Vol 47 (5) ◽  
pp. 1543-1555 ◽  
Author(s):  
Maurizio Mongiat ◽  
Simone Buraschi ◽  
Eva Andreuzzi ◽  
Thomas Neill ◽  
Renato V. Iozzo
Keyword(s):  
Extracellular Matrix ◽  
Tumor Angiogenesis ◽  
Signaling Cascades ◽  
Cancer Growth ◽  
Cell Behavior ◽  
Metastatic Progression ◽  
Surface Receptors ◽  
The Matrix ◽  
Multiple Signaling

Abstract The extracellular matrix is a network of secreted macromolecules that provides a harmonious meshwork for the growth and homeostatic development of organisms. It conveys multiple signaling cascades affecting specific surface receptors that impact cell behavior. During cancer growth, this bioactive meshwork is remodeled and enriched in newly formed blood vessels, which provide nutrients and oxygen to the growing tumor cells. Remodeling of the tumor microenvironment leads to the formation of bioactive fragments that may have a distinct function from their parent molecules, and the balance among these factors directly influence cell viability and metastatic progression. Indeed, the matrix acts as a gatekeeper by regulating the access of cancer cells to nutrients. Here, we will critically evaluate the role of selected matrix constituents in regulating tumor angiogenesis and provide up-to-date information concerning their primary mechanisms of action.

Role of Growth Factors and Endothelial Cells in Therapeutic Angiogenesis and Tissue Engineering

2006 ◽  
Vol 1 (3) ◽  
pp. 333-343 ◽  
Author(s):  
Masashi Nomi ◽  
Hideaki Miyake ◽  
Yoshifumi Sugita ◽  
Masato Fujisawa ◽  
Shay Soker
Keyword(s):  
Tissue Engineering ◽  
Endothelial Cells ◽  
Growth Factors ◽  
Therapeutic Angiogenesis

Older people’s news dependency and social connectedness

2021 ◽  
pp. 1329878X2110064
Author(s):  
Caroline Fisher ◽  
Sora Park ◽  
Jee Young Lee ◽  
Kate Holland ◽  
Emma John
Keyword(s):  
Older People ◽  
Social Isolation ◽  
News Media ◽  
Digital Literacy ◽  
Social Connectedness ◽  
Aged Care ◽  
Capital City ◽  
Contributing Factors ◽  
Older Citizens

Social isolation has become a growing issue, particularly among older citizens. The ‘digital divide’ has been identified as one of the contributing factors leaving many older citizens behind. While increasing digital literacy among seniors has been identified as one of the remedies, less attention has been paid to the role of news media on the wellbeing and connectedness of older people. Through the lens of the uses and gratifications theory, this article reports on the findings of a survey of 562 news consumers aged 50 years and above who live in Canberra, the capital city of Australia. The analysis highlights the important role of news in reducing feelings of social isolation, particularly for those who spend more time alone and older people with cognitive impairment. Older participants who had difficulty concentrating and learning new tasks were also more dependent on news. We suggest this is due to the habitual, predictable and concise nature of news. These findings contribute to our understanding of the role of news in the wellbeing of older people and point to the need for policymakers and those in the aged care sector to ensure access to news for older citizens to improve the quality of life.

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