scholarly journals Structures and Applications of Thermoresponsive Hydrogels and Nanocomposite-Hydrogels Based on Copolymers with Poly (Ethylene Glycol) and Poly (Lactide-Co-Glycolide) Blocks

2019 ◽  
Vol 6 (4) ◽  
pp. 107 ◽  
Author(s):  
Tomoki Maeda
Keyword(s):  
Block Copolymers ◽  
Ethylene Glycol ◽  
Biomedical Applications ◽  
Poly Lactic Acid ◽  
Poly Ethylene Glycol ◽  
Nanocomposite Hydrogels ◽  
Regeneration Medicine ◽  
Gelation Behavior ◽  
Thermoresponsive Hydrogels ◽  
Poly Ethylene

Thermoresponsive hydrogels showing biocompatibility and degradability have been under intense investigation for biomedical applications, especially hydrogels composed of hydrophilic poly(ethylene glycol) (PEG) and hydrophobic poly(lactic acid-co-glycolic acid) (PLGA) as first-line materials. Even though various aspects such as gelation behavior, degradation behavior, drug-release behavior, and composition effect have been studied for 20 years since the first report of these hydrogels, there are still many outputs on parameters affecting their gelation, structure, and application. In this review, the current trends of research on linear block copolymers composed of PEG and PLGA during the last 5 years (2014–2019) are summarized. In detail, this review stresses newly found parameters affecting thermoresponsive gelation, findings from structural analysis by simulation, small-angle neutron scattering (SANS), etc., progress in biomedical applications including drug delivery systems and regeneration medicine, and nanocomposites composed of block copolymers with PEG and PLGA and nanomaterials (laponite).

Iron Tris(bipyridine)-Centered Poly(ethylene glycol)-Poly(lactic acid) Star Block Copolymers

2008 ◽  
Vol 41 (23) ◽  
pp. 9397-9405 ◽  
Author(s):  
Gina L. Fiore ◽  
Jessica L. Klinkenberg ◽  
Cassandra L. Fraser
Keyword(s):  
Lactic Acid ◽  
Block Copolymers ◽  
Ethylene Glycol ◽  
Poly Lactic Acid ◽  
Poly Ethylene Glycol ◽  
Star Block Copolymers ◽  
Poly Ethylene

scholarly journals Synthesis and Hydrophilic Performance of Poly(Lactic Acid)-Poly(Ethylene Glycol) Block Copolymers

2016 ◽  
Vol 07 (03) ◽  
pp. 299-305 ◽  
Author(s):  
Gang Xu ◽  
Sihao Chen ◽  
Xiao Yan ◽  
Chunyu Yang ◽  
Zhichang Chen
Keyword(s):  
Lactic Acid ◽  
Block Copolymers ◽  
Ethylene Glycol ◽  
Poly Lactic Acid ◽  
Poly Ethylene Glycol ◽  
Poly Ethylene

Block copolymers of L-lactide and poly(ethylene glycol) for biomedical applications

1994 ◽  
Vol 5 (6-7) ◽  
pp. 308-313 ◽  
Author(s):  
P. Cerral ◽  
M. Tricoli ◽  
L. Lelli ◽  
G. D. Guerra ◽  
R. Sbarbati Del Guerra ◽  
...  
Keyword(s):  
Block Copolymers ◽  
Ethylene Glycol ◽  
Biomedical Applications ◽  
Poly Ethylene Glycol ◽  
Poly Ethylene

Non-toxic polyester urethanes based on poly(lactic acid), poly(ethylene glycol) and lysine diisocyanate

2016 ◽  
Vol 32 (3) ◽  
pp. 225-241 ◽  
Author(s):  
Alena Pavelková ◽  
Pavel Kucharczyk ◽  
Zdenka Kuceková ◽  
Jiří Zedník ◽  
Vladimír Sedlařík
Keyword(s):  
Molecular Weight ◽  
Lactic Acid ◽  
Ethylene Glycol ◽  
Biomedical Applications ◽  
Hydrolytic Degradation ◽  
Chain Extension ◽  
Poly Lactic Acid ◽  
Side Reactions ◽  
Poly Ethylene Glycol ◽  
Poly Ethylene

Poly(lactic acid)-based polymers are highly suitable for temporary biomedical applications, such as tissue support or drug delivery systems. Copolymers of different molecular weight based on poly(lactic acid) and poly(ethylene glycol) were prepared by polycondensation, catalysed by hydrochloric acid. A chain-extension reaction with l-lysine ethyl ester diisocyanate was employed afterwards to obtain polyester urethanes with enhanced properties. The GPC results showed that the molecular weights of the products reached about 50,000 g·mol−1 and the hydrolytic progress was rapid in the first 2 weeks; the drop in Mn equalled approximately 70%. Additionally, elemental analysis of the buffer medium proved that hydrolytic degradation was more rapid in the first stage. Tensile-strength testing revealed that ductility increased alongside reduced molecular weight of poly(ethylene glycol), also suggesting that polymer branching occurred due to side reactions of isocyanate. Based on the envisaged biomedical applications for these polymers, cytotoxicity tests were carried out and the cytotoxic effect was only moderate in the case of 100% polymer extract prepared according to ISO standard 10993-12. In their research, the authors focused on preparing metal-free, catalysed synthesis of polyester urethanes, which could prove useful to numerous biomedical applications.

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