scholarly journals Ecotoxicological Effect of Single and Combined Exposure of Carbamazepine and Cadmium on Female Danio rerio: A Multibiomarker Study

2019 ◽  
Vol 9 (7) ◽  
pp. 1362 ◽  
Author(s):  
Chunhong Shi ◽  
Yide He ◽  
Jiaxin Liu ◽  
Yue Lu ◽  
Yuting Fan ◽  
...  
Keyword(s):  
Endocrine Disruption ◽  
Danio Rerio ◽  
Antioxidant Systems ◽  
Aquatic Environments ◽  
Toxicity Profile ◽  
Combined Exposure ◽  
Single Exposure ◽  
Aquatic Vertebrates ◽  
Ecotoxicological Effect ◽  
Environmental Relevance

In aquatic environments, organisms are exposed to mixtures of pollutants which may change the toxicity profile of each contaminant, compared to its toxicity alone. Carbamazepine (CBZ) and cadmium (Cd) are among the pollutants that co-occur in aquatic environments. To date, most research about their toxicity towards aquatic vertebrates is based on single exposure experiments. The present study aims to evaluate single and combined effects of CBZ and Cd on biomarkers in female Danio rerio (zebrafish) by exposing them to environmentally relevant concentrations of these two pollutants for ten days. Four kinds of biomarkers involved in antioxidant systems, energy metabolism, nervous system, and endocrine disruption, respectively, were studied. Our research results coincided with those of former studies in single exposure experiments. However, the combined exposure of CBZ and Cd exerted different responses from other studies in which these two contaminants were examined alone in zebrafish. The present study evidenced the need to conduct more coexposure studies to enhance the environmental relevance of these experimental results.

scholarly journals Zebrafish (Danio rerio) model as an early stage screening tool to study the biodistribution and toxicity profile of doxorubicin-loaded mixed micelles

2018 ◽  
Vol 357 ◽  
pp. 106-114 ◽  
Author(s):  
María Natalia Calienni ◽  
Maximiliano Cagel ◽  
Jorge Montanari ◽  
Marcela A. Moretton ◽  
Maria Jimena Prieto ◽  
...  
Keyword(s):  
Danio Rerio ◽  
Mixed Micelles ◽  
Screening Tool ◽  
Early Stage ◽  
Toxicity Profile

Chronic exposure of zebrafish (Danio rerio) to flutolanil leads to endocrine disruption and reproductive disorders

2020 ◽  
Vol 184 ◽  
pp. 109310 ◽  
Author(s):  
Miaomiao Teng ◽  
Chen Wang ◽  
Min Song ◽  
Xiangguang Chen ◽  
Jie Zhang ◽  
...  
Keyword(s):  
Endocrine Disruption ◽  
Danio Rerio ◽  
Chronic Exposure ◽  
Reproductive Disorders

Histopathology as a tool for the evaluation of endocrine disruption in zebrafish (Danio rerio)

2003 ◽  
Vol 22 (4) ◽  
pp. 908-913 ◽  
Author(s):  
Leo T. M. van der Ven ◽  
Piet W. Wester ◽  
Jeff G. Vos
Keyword(s):  
Endocrine Disruption ◽  
Danio Rerio

scholarly journals Teratogenic and developmental toxic effects of etridiazole on zebrafish (Danio rerio) embryos

2020 ◽  
Vol 63 (1) ◽  
Author(s):  
Bala Murali Krishna Vasamsetti ◽  
Nam-Seok Kim ◽  
Kyongmi Chon ◽  
Hong-Hyun Park
Keyword(s):  
Danio Rerio ◽  
Dependent Manner ◽  
Concentration Dependent Manner ◽  
Skeletal Malformations ◽  
Somite Formation ◽  
Aquatic Vertebrates ◽  
Pericardial Edema ◽  
Eye Pigmentation ◽  
Median Effective Concentration ◽  
Morphological Deformities

AbstractEtridiazole (EDZ), a thiadiazole-containing toxic chemical, is widely used as a fungicide. Regular usage of EDZ may reach and contaminate water bodies, but its adverse effects on aquatic vertebrates have not been well studied. Therefore, the present study aimed to evaluate the harmful effects of EDZ using zebrafish (ZF) (Danio rerio) embryos. ZF embryos were treated with 3.75, 7.5, 15, 30, and 60 mg/L of EDZ. Subsequently, mortality and developmental toxicities were quantified at 24, 48, 72, and 96 h post fertilization (hpf). The results showed that embryo mortality was concentration- and time-dependent. The median lethal concentration (LC50) of EDZ at 96-h was 25.58 ± 1.49 mg/L. Besides, EDZ induced a series of morphological deformities, including abnormal somite formation, abnormal eye pigmentation, abnormal tail morphology, tail kinks, skeletal malformations (lordosis, kyphosis, and scoliosis), and yolk sac edema in a concentration-dependent manner. Among the deformities, the most significant were reduced heartbeat and increased incidence of pericardial edema. The median effective concentration (EC50) of EDZ at 96-h was 17.93 ± 2.22 mg/L and the 96-h teratogenic index (TI) value was 1.52. Taken together, these results indicate that EDZ is a teratogen, and primarily affects the cardiovascular system of ZF.

scholarly journals Cell damage in Danio rerio erythrocytes subjected to anthropized water

2021 ◽  
Vol 16 (1) ◽  
pp. 1
Author(s):  
Manoel Francisco Mendes Lassen ◽  
Jefferson Frohlich ◽  
Rodrigo Patera Barcelos ◽  
Roberta Daniele Klein ◽  
Fernando Henrique Borba ◽  
...  
Keyword(s):  
Water Quality ◽  
Danio Rerio ◽  
Cell Damage ◽  
Rio Grande ◽  
Aquatic Environments ◽  
Genetic Integrity ◽  
Rio Grande Do Sul ◽  
Nuclear Abnormalities ◽  
Repair Mechanisms ◽  
Northwest Region

Several factors can lead to alterations of water quality in aquatic environments, leading to numerous consequences for the organisms that inhabit it. The water bodies located in the northwest region of Rio Grande do Sul periodically receive pollutants that may have genotoxic, cytotoxic and mutagenic properties, which affect the genetic integrity of organisms living there. This research analyzed the cytological responses of Danio rerio exposed to anthropized fresh water from the Ijuí River by the micronucleus method as well as by observing nuclear abnormalities in their erythrocytes. The data collected demonstrated higher values of erythrocytes with NA than with MN, suggesting that the cells are efficient in the repair mechanisms required when facing genotoxic substances.

scholarly journals Detection of biomarkers to differentiate endocrine disruption from hepatotoxicity in zebrafish (Danio rerio) using proteomics

Chemosphere ◽  
2020 ◽  
Vol 240 ◽  
pp. 124970 ◽  
Author(s):  
Steve U. Ayobahan ◽  
Sebastian Eilebrecht ◽  
Lisa Baumann ◽  
Matthias Teigeler ◽  
Henner Hollert ◽  
...  
Keyword(s):  
Endocrine Disruption ◽  
Danio Rerio ◽  
Detection Of Biomarkers

Sublethal Effects of Propiconazole On The Metabolism of Lambari Deuterodon Iguape (Eigenmann 1907), A Native Species From Brazil

2021 ◽  
Author(s):  
Marcelo Barbosa Henriques ◽  
Karina Fernandes Oliveira Rezende ◽  
Leonardo Castilho-Barros ◽  
Edison Barbieri
Keyword(s):  
Danio Rerio ◽  
Native Species ◽  
Statistical Difference ◽  
Sublethal Effects ◽  
Metabolic Response ◽  
Ammonia Excretion ◽  
Native Fish ◽  
Aquatic Environments ◽  
Metabolic Rates ◽  
Pesticide Contamination

Abstract The objective of this study was to analyze the sublethal effects of propiconazole on Deuterodon iguape a native fish common in Brazil, which has potential for aquaculture and use as a bioindicator. The hypothesis was to test whether D. iguape has a metabolism similar to Danio rerio so that its use in bioassays may be validated. Lethal concentration (LC50) and metabolic rates were studied in fish exposed to propiconazole. There was an increase and decrease in the metabolic rate at 0.01 and 0.1 µg L-1, with a statistical difference from the control ratio for the two species. The same trend towards ammonia excretion was observed, initially increasing to a concentration of 0.01 µg L-1 and then decreasing as the concentration of propiconazole was increased. The averages of specific ammonia excretion in all concentrations were significantly different compared to the control. It was concluded that exposure to propiconazole increased the metabolic rates of D. Iguape and D. rerio, up to 0.05 µg L-1, and decreased the rates when the concentration was doubled (0.1 µg L-1); causing serious problems in fish metabolism. D. iguape proved to be a good and useful bioindicator for ichthyologists or ecologists in studies of moderate pesticide contamination in freshwater aquatic environments, as its metabolic response was similar to D. rerio.

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