scholarly journals Design, Modeling, and Analysis of Piezoelectric-Actuated Device for Blood Sampling

2021 ◽  
Vol 11 (18) ◽  
pp. 8449
Author(s):  
Rakesh Kumar Haldkar ◽  
Vijay Kumar Gupta ◽  
Tanuja Sheorey ◽  
Ivan A. Parinov
Keyword(s):  
Drug Delivery ◽  
Blood Volume ◽  
Volume Flow Rate ◽  
Flow Characteristics ◽  
Disease Diagnosis ◽  
Micro Electro Mechanical System ◽  
Diagnostic Purpose ◽  
Piezoelectric Bimorph ◽  
Modeling And Analysis ◽  
Pump Chamber

In recent years, micro electro-mechanical system (MEMS)-based biomedical devices have been investigated by various researchers for biomedicine, disease diagnosis, and liquid drug delivery. The micropump based devices are of considerable significance for accurate drug delivery and disease diagnosis. In the present study, design aspects of the piezoelectric actuated micropump used for extraction of blood sample are presented. A pentagonal microneedle, which is an integral part of the micropump, was used to extract the blood volume. The blood was then delivered to the biosensor, located in the pump chamber, for diagnosis. The purpose of such low-powered devices is to get sufficient blood volume for the diagnostic purpose at the biosensor located within the pump chamber, with a minimum time of actuation, which will eventually cause less pain. ANSYS® simulations were performed on four quarter piezoelectric bimorph actuator (FQPB) at 2.5 volts. The modal and harmonic analysis were carried out with various load conditions for FQPB. The extended microneedle lengths inside the pump chamber showed improved flow characteristics. Enhanced volume flow rate of 1.256 µL/s was obtained at 22,000 Hz applied frequency at the biosensor location.

Magnetic Nanoparticles in Brain Disease Diagnosis and Targeting Drug Delivery

2011 ◽  
Vol 7 (1) ◽  
pp. 37-46 ◽  
Author(s):  
Xin Su ◽  
Xin Zhan ◽  
Fang Tang ◽  
Jingyuan Yao ◽  
Ji Wu
Keyword(s):  
Drug Delivery ◽  
Magnetic Nanoparticles ◽  
Disease Diagnosis ◽  
Brain Disease

scholarly journals Polymeric Drug Delivery System Based on Pluronics for Cancer Treatment

Molecules ◽  
2021 ◽  
Vol 26 (12) ◽  
pp. 3610
Author(s):  
Jialin Yu ◽  
Huayu Qiu ◽  
Shouchun Yin ◽  
Hebin Wang ◽  
Yang Li
Keyword(s):  
Drug Delivery ◽  
Self Assembly ◽  
Drug Delivery Systems ◽  
Tumor Therapy ◽  
Chemical Properties ◽  
Drug Carriers ◽  
Disease Diagnosis ◽  
Delivery Systems ◽  
Polymeric Drug Delivery ◽  
Physical And Chemical

Pluronic polymers (pluronics) are a unique class of synthetic triblock copolymers containing hydrophobic polypropylene oxide (PPO) and hydrophilic polyethylene oxide (PEO) arranged in the PEO-PPO-PEO manner. Due to their excellent biocompatibility and amphiphilic properties, pluronics are an ideal and promising biological material, which is widely used in drug delivery, disease diagnosis, and treatment, among other applications. Through self-assembly or in combination with other materials, pluronics can form nano carriers with different morphologies, representing a kind of multifunctional pharmaceutical excipients. In recent years, the utilization of pluronic-based multi-functional drug carriers in tumor treatment has become widespread, and various responsive drug carriers are designed according to the characteristics of the tumor microenvironment, resulting in major progress in tumor therapy. This review introduces the specific role of pluronic-based polymer drug delivery systems in tumor therapy, focusing on their physical and chemical properties as well as the design aspects of pluronic polymers. Finally, using newer literature reports, this review provides insights into the future potential and challenges posed by different pluronic-based polymer drug delivery systems in tumor therapy.

Numerical Simulation on Air Volume Flow Rate Distribution of Stator Ducts for Salient Pole Synchronous Motor

2014 ◽  
Vol 644-650 ◽  
pp. 373-376
Author(s):  
Li Liu ◽  
Yi Ping Lu ◽  
Jia De Han ◽  
Xue Mei Sun
Keyword(s):  
Flow Rate ◽  
Volume Flow Rate ◽  
Domain Boundary ◽  
Air Flow ◽  
Flow Characteristics ◽  
Synchronous Motor ◽  
Volume Flow ◽  
Rate Distribution ◽  
Salient Pole ◽  
Air Volume

Air volume flow rate distribution of stator ducts along axial and circumferential for salient pole synchronous motor is strongly influenced by the air flow field in the air gap and rotor poles, which is completely different from the flow characteristics of non-salient pole motor and it directly relates to the peak temperature of stator bars and core and axial temperature difference which can affect the safety of the operation. A three-dimensional physical model of 1/8 motor was established and corresponding solution domain boundary conditions were given in this article. The air volume flow rate distribution of stator ducts along axial and circumferential was analyzed based on CFD. The study show that at the same position of the axial stator, the cooling air flow into stator ducts along the circumferential direction is uneven, the air volume flow rate distribution is largely influenced by rotor pole pieces, geometry and position of pole support block and rotor rotation direction.

Recent Progress in Stimuli Responsive Intelligent Nano Scale Drug Delivery Systems: A special focus towards pH sensitive systems

2021 ◽  
Vol 22 ◽  
Author(s):  
Vaidevi Sethuraman ◽  
Kumar Janakiraman ◽  
Venkateshwaran Krishnaswami ◽  
Ruckmani Kandasamy
Keyword(s):  
Drug Delivery ◽  
Cancer Treatment ◽  
Drug Delivery Systems ◽  
Disease Diagnosis ◽  
Delivery Systems ◽  
Ph Sensitive ◽  
Special Focus ◽  
Stimuli Responsive ◽  
Ph Variation ◽  
Responsive Systems

Abstract: Stimuli responsive nanocarriers are gaining much attention due to its versatile multifunctional activities including disease diagnosis and treatment. Recently, clinical applications of nano drug delivery systems for cancer treatment make a considerable challenge due to its limited cellular uptake, low bioavailability, poor targetability, stability issues, and unfavourable pharmacokinetics. To overcome these issues researchers are focussing on stimuli responsive systems. Nano carriers elicit its role through endogenous (pH, temperature, enzyme and redox) or exogenous (temperature, light, magnetic field, ultrasound) stimulus. These systems were designed to overcome the shortcomings such as non-specificity and toxicity associated with the conventional drug delivery systems. The pH variation between healthy cells and tumor microenvironment creates a platform towards the generation of pH sensitive nano delivery systems. Herein, we propose to present an overview of various internal and external stimuli responsive behavior based drug delivery systems. Herein the present review will focus specifically on the significance of various pH- responsive nanomaterials such as polymeric nanoparticles, nano micelles, inorganic based pH sensitive drug delivery carriers such as calcium phosphate nanoparticles, and carbon dots in cancer treatment. Moreover, this review elaborates the recent findings on pH based stimuli responsive drug delivery system with special emphasis towards our reported stimuli responsive systems for cancer treatment.

scholarly journals Design and Analyses of a Transdermal Drug Delivery Device (TD3) †

Sensors ◽  
2019 ◽  
Vol 19 (23) ◽  
pp. 5090 ◽  
Author(s):  
Jennifer García ◽  
Ismael Ríos ◽  
Faruk Fonthal Rico
Keyword(s):  
Drug Delivery ◽  
Transdermal Drug Delivery ◽  
Computer Aided Design ◽  
Micro Electro Mechanical System ◽  
Discharge Process ◽  
Microneedle Array ◽  
Delivery Device ◽  
Drug Delivery Device ◽  
Computational Fluid Dynamics Cfd ◽  
Aided Design

In this paper, we introduce a novel type of transdermal drug delivery device (TD3) with a micro-electro-mechanical system (MEMS) design using computer-aided design (CAD) techniques as well as computational fluid dynamics (CFD) simulations regarding the fluid interaction inside the device during the actuation process. For the actuation principles of the chamber and microvalve, both thermopneumatic and piezoelectric principles are employed respectively, originating that the design perfectly integrates those principles through two different components, such as a micropump with integrated microvalves and a microneedle array. The TD3 has shown to be capable of delivering a volumetric flow of 2.92 × 10−5 cm3/s with a 6.6 Hz membrane stroke frequency. The device only needs 116 Pa to complete the suction process and 2560 Pa to complete the discharge process. A 38-microneedle array with 450 µm in length fulfills the function of permeating skin, allowing that the fluid reaches the desired destination and avoiding any possible pain during the insertion.

Numerical Simulation and Optimal Design Investigation on Air Duct of Floor Standing Air-Conditioner

2011 ◽  
Vol 308-310 ◽  
pp. 563-567
Author(s):  
Zhong Min Wan ◽  
Zu Yi Zheng ◽  
Huan Xin Chen ◽  
Jun Liu ◽  
Ting Xiang Jin
Keyword(s):  
Numerical Simulation ◽  
Flow Rate ◽  
Aerodynamic Characteristic ◽  
Volume Flow Rate ◽  
Structural Characteristics ◽  
Flow Characteristics ◽  
Volume Flow ◽  
Numerical Results ◽  
Air Conditioner ◽  
Duct Flow

According to the structural characteristics of floor standing air-conditioner，three dimensional numerical model of air duct system for a certain floor standing air-conditioner is developed to simulate aerodynamic characteristic of the air duct. Flow characteristics and deficiency of air duct for original floor standing air-conditioner are analyzed, and the optimal schemes of air duct are raised and numerical simulation has been carried on to obtain aerodynamic characteristic of the new air duct. The numerical results show that the volume flow rate of air-conditioner with new air duct is increased by 6.1%. The experimental results of air-conditioner with new air duct show the volume flow rate of new air duct is promoted by 5.6% at the same approximate noise level. The numerical results agree well with the previous experiment.

The Flow Dynamics of an Air-Driven Hydraulic Pump

2015 ◽  
Author(s):  
Yan Shi ◽  
Tiecheng Wu ◽  
Andrew R. Plummer ◽  
Maolin Cai
Keyword(s):  
Volume Flow Rate ◽  
Flow Characteristics ◽  
Area Ratio ◽  
Air Pressure ◽  
Hydraulic Systems ◽  
Hydraulic Pump ◽  
Oil Flow ◽  
System Input ◽  
Output Characteristics ◽  
Set Up

Air-driven hydraulic pumps are widely used to pump high-pressure oil for small hydraulic systems, where it is uneconomic to set up a conventional hydraulic power pack. To obtain good performance of a small hydraulic system, input air flow and output oil flow characteristics of the air-driven hydraulic pump should be properly understood. In this paper, based on a mathematical model which has been experimentally verified, the model of an air-driven hydraulic pump is proposed. Using the software MATLAB/Simulink for simulation, the dynamic characteristics of the pumps are obtained. To set a foundation for the optimization of the pump, the influence of key parameters on the output characteristics of the pump was studied. Through analysis, it can be obtained that, firstly, with an increase in the input air pressure, output oil pressure and area ratio, the ratio of output to input volume flow rate decrease approximately linearly. Moreover, when the output oil pressure was fixed, an energy-saving method to enhance the output oil flow is to enlarge the area ratio of the pump. Furthermore, the output oil flow can be increased rapidly through increasing the input air pressure, but that may result in an increase in compressed air consumption. This research is of use in the performance and design optimization of air-driven hydraulic pumps.

scholarly journals Relationship between Axial Width and Flow Characteristics of Pump Chamber in Double Volute Centrifugal Pump

2020 ◽  
Vol 38 (6) ◽  
pp. 1322-1329
Author(s):  
Wei Dong ◽  
Qingnan He ◽  
Wuke Liang ◽  
Qingxi Wei ◽  
Yan Dong ◽  
...  
Keyword(s):  
Radial Velocity ◽  
Centrifugal Pump ◽  
Great Influence ◽  
Tangential Velocity ◽  
Flow Characteristics ◽  
Core Area ◽  
Chamber Pressure ◽  
Axial Distribution ◽  
Pump Chamber ◽  
The Mean

The axial width of pump chamber has a great influence on the flow characteristics of the pump chamber in the centrifugal pump. A single-stage single-suction double volute centrifugal pump with a semi-open impeller was selected as the object. For the 6 different pump chamber axial width, it was concluded that the pump chamber pressure at the different angles (0°, 90°, 180°, 270°) along the radial variation characteristics according to the contrast analysis of the pump cavity pressure field, velocity field distribution. The correlation between the pump chamber pressure and the impeller radius was revealed. The tangential velocity and radial velocity along the axial distribution curves were draw. The results show that when the axial width of pump chamber increases from 23.9 mm to 43.9 mm, the pressure value of the same radial position increases gradually. The radial pressure difference is decreasing. At the same axial width of pump chamber, the pressure mean increases along the radial approximately parabola. The tangential velocity of different angular directions has little difference in axial distribution. The mean of dimensionless tangential velocity in the turbulent core area decreases from 0.32 to 0.19 with the increasing of pump chamber axial width. The radial velocity varies is greatly along the axial direction. There are eddies at the directions of 0ånd 180°, but the mean of radial velocity in the turbulent core area is about 0. This research provides the reference for centrifugal pump hydraulic design, structural design and the accurate calculation of axial force.

scholarly journals Micro/Nanorobot: A Promising Targeted Drug Delivery System

Pharmaceutics ◽  
2020 ◽  
Vol 12 (7) ◽  
pp. 665 ◽  
Author(s):  
Mengyi Hu ◽  
Xuemei Ge ◽  
Xuan Chen ◽  
Wenwei Mao ◽  
Xiuping Qian ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Electric Fields ◽  
Targeted Drug Delivery ◽  
Disease Diagnosis ◽  
Research Field ◽  
Traditional Drug ◽  
Targeted Drug ◽  
Autonomous Movement

Micro/nanorobot, as a research field, has attracted interest in recent years. It has great potential in medical treatment, as it can be applied in targeted drug delivery, surgical operation, disease diagnosis, etc. Differently from traditional drug delivery, which relies on blood circulation to reach the target, the designed micro/nanorobots can move autonomously, which makes it possible to deliver drugs to the hard-to-reach areas. Micro/nanorobots were driven by exogenous power (magnetic fields, light energy, acoustic fields, electric fields, etc.) or endogenous power (chemical reaction energy). Cell-based micro/nanorobots and DNA origami without autonomous movement ability were also introduced in this article. Although micro/nanorobots have excellent prospects, the current research is mainly based on in vitro experiments; in vivo research is still in its infancy. Further biological experiments are required to verify in vivo drug delivery effects of micro/nanorobots. This paper mainly discusses the research status, challenges, and future development of micro/nanorobots.

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