scholarly journals Design and Analyses of a Transdermal Drug Delivery Device (TD3) †

Sensors ◽  
2019 ◽  
Vol 19 (23) ◽  
pp. 5090 ◽  
Author(s):  
Jennifer García ◽  
Ismael Ríos ◽  
Faruk Fonthal Rico
Keyword(s):  
Drug Delivery ◽  
Transdermal Drug Delivery ◽  
Computer Aided Design ◽  
Micro Electro Mechanical System ◽  
Discharge Process ◽  
Microneedle Array ◽  
Delivery Device ◽  
Drug Delivery Device ◽  
Computational Fluid Dynamics Cfd ◽  
Aided Design

In this paper, we introduce a novel type of transdermal drug delivery device (TD3) with a micro-electro-mechanical system (MEMS) design using computer-aided design (CAD) techniques as well as computational fluid dynamics (CFD) simulations regarding the fluid interaction inside the device during the actuation process. For the actuation principles of the chamber and microvalve, both thermopneumatic and piezoelectric principles are employed respectively, originating that the design perfectly integrates those principles through two different components, such as a micropump with integrated microvalves and a microneedle array. The TD3 has shown to be capable of delivering a volumetric flow of 2.92 × 10−5 cm3/s with a 6.6 Hz membrane stroke frequency. The device only needs 116 Pa to complete the suction process and 2560 Pa to complete the discharge process. A 38-microneedle array with 450 µm in length fulfills the function of permeating skin, allowing that the fluid reaches the desired destination and avoiding any possible pain during the insertion.

scholarly journals Sustained acoustic medicine; sonophoresis for nonsteroidal anti-inflammatory drug delivery in arthritis

2020 ◽  
Vol 11 (6) ◽  
pp. 363-372
Author(s):  
Jack Masterson ◽  
Brett Kluge ◽  
Aaron Burdette ◽  
George Lewis Sr
Keyword(s):  
Drug Delivery ◽  
Transdermal Drug Delivery ◽  
Standard Of Care ◽  
Delivery Device ◽  
Skin Model ◽  
Penetration Enhancement ◽  
Drug Delivery Device ◽  
Ultrasound Device ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

Background: Arthritis pain is primarily managed by nonsteroidal anti-inflammatory drugs (NSAIDs), such as diclofenac. Topical diclofenac gel is limited in efficacy due to its limited penetration through the skin. This study investigates the use of a multihour, wearable, localized, sonophoresis transdermal drug delivery device for the penetration enhancement of diclofenac through the skin. Materials & methods: A commercially available, sustained acoustic medicine (sam®) ultrasound device providing 4 h, 1.3 W, 132 mW/cm2, 3 MHz ultrasound treatment was evaluated for increasing the drug delivery of diclofenac gel through a human skin model and was compared with standard of care topical control diclofenac gel. Results: Sonophoresis of the diclofenac gel for 4 h increases diclofenac delivery by 3.8× (p < 0.01), and penetration by 32% (p < 0.01). Conclusion: Sustained acoustic medicine can be used as a transdermal drug-delivery device for nonsteroidal anti-inflammatory drugs.

scholarly journals Novel Drug Delivery Device Using Silicone: Controlled Release of Insoluble Drugs or Two Kinds of Water-Soluble Drugs

2003 ◽  
Vol 51 (1) ◽  
pp. 15-19 ◽  
Author(s):  
Masako Kajihara ◽  
Toshihiko Sugie ◽  
Hiroo Maeda ◽  
Akihiko Sano ◽  
Keiji Fujioka ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Controlled Release ◽  
Water Soluble ◽  
Delivery Device ◽  
Drug Delivery Device ◽  
Water Soluble Drugs ◽  
Insoluble Drugs ◽  
Novel Drug

An Integrated Ship Re-Design/Modification Strategy

2019 ◽  
Vol 161 (A1) ◽  
Keyword(s):  
Computer Aided Design ◽  
Modular Design ◽  
Ship Hull ◽  
Cfd Model ◽  
Hull Form ◽  
Design Modification ◽  
Technical Parameters ◽  
Computational Fluid Dynamics Cfd ◽  
Bulbous Bow ◽  
Aided Design

Herein, we present an integrated ship re-design/modification strategy that integrates the ‘Computer-Aided Design (CAD)’ and ‘Computational Fluid Dynamics (CFD)’ to modify the ship hull form for better performance in resistance. We assume a modular design and the ship hull form modification focuses on the forward module (e.g. bulbous bow) and aft module (e.g. stern bulb) only. The ship hull form CAD model is implemented with NAPA*TM and CFD model is implemented with Shipflow**TM. The basic ship hull form parameters are not changed and the modifications in some of the technical parameters because of re-designed bulbous bow and stern bulb are kept at very minimum. The bulbous bow is re-designed by extending an earlier method (Sharma and Sha (2005b)) and stern bulb parameters for re-design are computed from the experience gained from literature survey. The re-designed hull form is modeled in CAD and is integrated and analyzed with Shipflow**TM. The CAD and CFD integrated model is validated and verified with the ITTC approved recommendations and guidelines. The proposed numerical methodology is implemented on the ship hull form modification of a benchmark ship, i.e. KRISO container ship (KCS). The presented results show that the modified ship hull form of KCS - with only bow and stern modifications - using the present strategy, results into resistance and propulsive improvement.

Sign in / Sign up

Export Citation Format

Share Document