scholarly journals Cranial Implant Design Applying Shape-Based Interpolation Method via Open-Source Software

2021 ◽  
Vol 11 (16) ◽  
pp. 7604
Author(s):  
Johari Yap Abdullah ◽  
Abdul Manaf Abdullah ◽  
Low Peh Hueh ◽  
Adam Husein ◽  
Helmi Hadi ◽  
...  
Keyword(s):  
Open Source ◽  
Open Source Software ◽  
Interpolation Method ◽  
Implant Design ◽  
Patient Specific ◽  
Dice Similarity Coefficient ◽  
Patient Specific Implants ◽  
Significant Difference ◽  
Cranial Implant ◽  
Cranial Implants

Reconstructing a large skull defect is a challenge, as it normally involves the use of sophisticated proprietary image processing and expensive CAD software. As an alternative, open-source software can be used for this purpose. This study aimed to compare the 3D cranial implants reconstructed from computed tomography (CT) images using the open-source MITK software with commercial 3-matic software for ten decompressive craniectomy patients. The shape-based interpolation method was used, in which the technique of segmenting every fifth and tenth slice of CT data was performed. The final design of patient-specific implants from both software was exported to STL format for analysis. The results of the Kruskal–Wallis test for the surface and volume of cranial implants designed using 3-matic and the two MITK techniques showed no significant difference, p > 0.05. The results of the Hausdorff Distance (HD) and Dice Similarity Coefficient (DSC) analyses for cranial implants designed using 3-matic software and the two different MITK techniques showed that the average points distance for 3-matic versus MITK was 0.28 mm (every tenth slice) and 0.15 mm (every fifth slice), and the similarity between 3-matic and MITK on every tenth and fifth slices were 85.1% and 89.7%, respectively. The results also showed that the open-source MITK software is comparable with the commercial software for designing patient-specific implants.

Mechanical meta-material-based polymer skin graft production by rapid prototyping and replica method

2020 ◽  
Vol ahead-of-print (ahead-of-print) ◽  
Author(s):  
Mohamad Attar ◽  
Seher Selen Aydin ◽  
Aliye Arabaci ◽  
Ilven Mutlu
Keyword(s):  
Elastic Modulus ◽  
Rapid Prototyping ◽  
Skin Graft ◽  
Patient Specific ◽  
Skin Grafts ◽  
Content Type ◽  
Patient Specific Implants ◽  
Cranial Implant ◽  
Liquid Silicone ◽  
Cranial Implants

Purpose The purpose of this paper is the production of mechanical meta-material samples by rapid prototyping (RP) and replica technique for patient-specific skin graft or cranial implant applications in tissue engineering. Design/methodology/approach Positive moulds (patterns) were produced by stereolithography-based RP. Impression moulding method was used for the production of silicone products (skin grafts). Alginate was used as a moulding material (negative mould). Room temperature vulcanising silicone was poured into the cavity of alginate mould and then products were produced. TiO2 powder and carbon fibres were used as reinforcement. Meta-material structured polyurethane reinforced silicone composites were also produced. Liquid components (diisocyanate and polyol) were poured into the mould and then polyurethane was produced. Then, polyurethane was immersed in the liquid silicone. Findings It is found that non-destructive ultrasonic test is a fast and reliable method. Meta-material-based composites show dome-shaped tensile/synclastic surface properties which are important for the skin graft and cranial implants. Increasing the amounts of cross-linking agent and TiO2 particles increased the hardness and elastic modulus. Carbon fibre addition enhanced the elastic modulus. Originality/value Although there are studies on the meta-materials, there is limited study on the RP of the meta-materials for patient-specific implants (skin grafts). Auxetic surface shows perfect fit to curved surface of the skull. Although there are studies on the silicone and polyurethane composites, there is limited study on the characterisation of mechanical properties by ultrasonic tests and strain gauge analysis.

BIOMODELLING OF CRANIO-MAXILLOFACIAL IMPLANT APPLYING OPEN SOURCE SOFTWARE

2015 ◽  
Vol 76 (7) ◽  
Author(s):  
Johari Yap Abdullah ◽  
Zainul Ahmad Rajion ◽  
Marzuki Omar
Keyword(s):  
Additive Manufacturing ◽  
Open Source ◽  
Open Source Software ◽  
Computer Modelling ◽  
3D Models ◽  
Physical Models ◽  
Implant Design ◽  
Patient Specific ◽  
Anatomical Structures ◽  
Computer Aided

Advances in craniofacial medical imaging has allowed the 3D reconstruction of anatomical structures for medical applications, including the design of patient specific implants based on computer-aided design and computer-aided manufacturing (CAD/CAM) platforms. This technology has provided new possibilities to visualize complex medical data through generation of 3–dimensional (3D) physical models via additive manufacturing that can be eventually utilised to assist in diagnosis, surgical planning, implant design, and patient management. Although the study on the construction of cranio-maxillofacial implant based on computer modelling and advanced biomaterial are growing rapidly from other parts of the world, however, in Malaysia is scanty, especially with open source application. For this reason, it leads us to embark in a study to produce a potential locally cranio-maxillofacial implant with equivalent standard as compared to the commercially available product applying open source software. As part of four sub-projects of USM Research University Team (RUT) project, the authors had investigated and applied open source software to perform image processing of CT data, to segment the region of interest of anatomical structures, to create virtual 3D models, and finally to convert the virtual 3D models to a format that compatible for additive manufacturing platform. Further research is ongoing to investigate on designing the cranio-maxillofacial implant using open source CAD software using suitable biomaterial.  

scholarly journals Synthetic skull bone defects for automatic patient-specific craniofacial implant design

2021 ◽  
Vol 8 (1) ◽  
Author(s):  
Jianning Li ◽  
Christina Gsaxner ◽  
Antonio Pepe ◽  
Ana Morais ◽  
Victor Alves ◽  
...  
Keyword(s):  
Bone Defects ◽  
Third Party ◽  
Implant Design ◽  
Patient Specific ◽  
Solid Base ◽  
Skull Bone ◽  
Imaging Data ◽  
Cranial Implant ◽  
Cranial Implants ◽  
Craniofacial Implants

AbstractPatient-specific craniofacial implants are used to repair skull bone defects after trauma or surgery. Currently, cranial implants are designed and produced by third-party suppliers, which is usually time-consuming and expensive. Recent advances in additive manufacturing made the in-hospital or in-operation-room fabrication of personalized implants feasible. However, the implants are still manufactured by external companies. To facilitate an optimized workflow, fast and automatic implant manufacturing is highly desirable. Data-driven approaches, such as deep learning, show currently great potential towards automatic implant design. However, a considerable amount of data is needed to train such algorithms, which is, especially in the medical domain, often a bottleneck. Therefore, we present CT-imaging data of the craniofacial complex from 24 patients, in which we injected various artificial cranial defects, resulting in 240 data pairs and 240 corresponding implants. Based on this work, automatic implant design and manufacturing processes can be trained. Additionally, the data of this work build a solid base for researchers to work on automatic cranial implant designs.

scholarly journals Integrated multi-modality image-guided navigation for neurosurgery: open-source software platform using state-of-the-art clinical hardware

2021 ◽  
Author(s):  
Jonathan Shapey ◽  
Thomas Dowrick ◽  
Rémi Delaunay ◽  
Eleanor C. Mackle ◽  
Stephen Thompson ◽  
...  
Keyword(s):  
Skull Base ◽  
Open Source ◽  
Open Source Software ◽  
Skull Base Surgery ◽  
Patient Specific ◽  
Software Platform ◽  
Image Guided ◽  
Phantom Model ◽  
Technical Requirements ◽  
Navigated Ultrasound

Abstract Purpose Image-guided surgery (IGS) is an integral part of modern neuro-oncology surgery. Navigated ultrasound provides the surgeon with reconstructed views of ultrasound data, but no commercial system presently permits its integration with other essential non-imaging-based intraoperative monitoring modalities such as intraoperative neuromonitoring. Such a system would be particularly useful in skull base neurosurgery. Methods We established functional and technical requirements of an integrated multi-modality IGS system tailored for skull base surgery with the ability to incorporate: (1) preoperative MRI data and associated 3D volume reconstructions, (2) real-time intraoperative neurophysiological data and (3) live reconstructed 3D ultrasound. We created an open-source software platform to integrate with readily available commercial hardware. We tested the accuracy of the system’s ultrasound navigation and reconstruction using a polyvinyl alcohol phantom model and simulated the use of the complete navigation system in a clinical operating room using a patient-specific phantom model. Results Experimental validation of the system’s navigated ultrasound component demonstrated accuracy of $$<4.5\,\hbox {mm}$$ < 4.5 mm and a frame rate of 25 frames per second. Clinical simulation confirmed that system assembly was straightforward, could be achieved in a clinically acceptable time of $$<15\,\hbox {min}$$ < 15 min and performed with a clinically acceptable level of accuracy. Conclusion We present an integrated open-source research platform for multi-modality IGS. The present prototype system was tailored for neurosurgery and met all minimum design requirements focused on skull base surgery. Future work aims to optimise the system further by addressing the remaining target requirements.

scholarly journals Internal Quality Evolution of Open-Source Software Systems

2021 ◽  
Vol 11 (12) ◽  
pp. 5690
Author(s):  
Mamdouh Alenezi
Keyword(s):  
Open Source ◽  
Open Source Software ◽  
Software Evolution ◽  
Quality Metrics ◽  
Internal Quality ◽  
Software Systems ◽  
Software Metric ◽  
Significant Difference ◽  
The Relationship

The evolution of software is necessary for the success of software systems. Studying the evolution of software and understanding it is a vocal topic of study in software engineering. One of the primary concepts of software evolution is that the internal quality of a software system declines when it evolves. In this paper, the method of evolution of the internal quality of object-oriented open-source software systems has been examined by applying a software metric approach. More specifically, we analyze how software systems evolve over versions regarding size and the relationship between size and different internal quality metrics. The results and observations of this research include: (i) there is a significant difference between different systems concerning the LOC variable (ii) there is a significant correlation between all pairwise comparisons of internal quality metrics, and (iii) the effect of complexity and inheritance on the LOC was positive and significant, while the effect of Coupling and Cohesion was not significant.

Shape-based interpolation method in measuring intracranial volume for pre- and post-operative decompressive craniectomy using open source software

Neurocirugía ◽  
2019 ◽  
Vol 30 (3) ◽  
pp. 115-123
Author(s):  
Johari Yap Abdullah ◽  
Zainul Ahmad Rajion ◽  
Arvind Gerard Martin ◽  
Azlan Jaafar ◽  
Abdul Rahman Izaini Ghani ◽  
...  
Keyword(s):  
Open Source ◽  
Open Source Software ◽  
Decompressive Craniectomy ◽  
Interpolation Method ◽  
Intracranial Volume

scholarly journals Ceramic 3D-Printed Titanium Cranioplasty

2020 ◽  
Vol 13 (4) ◽  
pp. 329-333
Author(s):  
Maurice Y. Mommaerts ◽  
Paul R. Depauw ◽  
Erik Nout
Keyword(s):  
Calcium Phosphate ◽  
Case Series ◽  
Titanium Implants ◽  
Border Zone ◽  
Implant Design ◽  
Patient Specific ◽  
Time Range ◽  
Free Calcium ◽  
Cranial Implant ◽  
3D Printed

Study Design: Inlay cranioplasties following partial craniectomy in tumor or trauma cases and onlay cranioplasties for reconstructions of residual developmental skull anomalies are frequently performed using CAD-CAM techniques. Objective: In this case series, we present a novel cranial implant design, being a combination of 3D-printed titanium grade 23 and calcium phosphate paste (CeTi). Methods: The titanium patient-specific implant, manufactured using selective laser melting, has a latticed border with interconnected micropores. The cranioplasty is miniscrew fixed and its border zone subsequently partially filled with calcium phosphate paste to promote osteoinduction and osteoconduction. From April 2017 to April 2019, 8 patients have been treated with such a CeTi implant. The inlay cranioplasties were each time revision surgeries of complicated cases. Results: All implants were successful after a limited follow-up time (range 18-42 months). There were no dehiscences and no infections, and no complaints of thermal conduction. Conclusions: The proposed CeTi cranial implant combines the strength of titanium implants with the biological integration potential of ceramic implants and seems particularly resistant to infection, probably due to the biofunctionalized titanium surface and the antimicrobial activity of elevated intracellular free calcium levels.

scholarly journals Vascular flow simulations using SimVascular and OpenFOAM

2021 ◽  
Author(s):  
Swetha Yogeswaran ◽  
Fei Liu
Keyword(s):  
Fluid Dynamics ◽  
Blood Flow ◽  
Open Source ◽  
Open Source Software ◽  
Flow Analysis ◽  
Coarctation Of The Aorta ◽  
Patient Specific ◽  
Specific Information ◽  
Imaging Data ◽  
Set Up

AbstractApplications of computational fluid dynamics (CFD) techniques to aid in the diagnosis and treatment of cardiovascular disease have entered the research domain in recent years, due to their ability to provide valuable patient-specific information without risks associated with highly invasive procedures. SimVascular [1] [2] is an open-source software which allows streamlined processing and CFD blood flow analysis of medical imaging data. OpenFOAM [3] is a proven open-source software which allows for versatile modeling of various fluid dynamics phenomena. In this study, both SimVascular and OpenFOAM simulations are set up with identical computational mesh, similar numerical schemes, boundary conditions, and material properties, to model blood flow in the coronary artery of a 10 year old patient with Coarctation of the Aorta (CoA) who underwent end-to-side anastomosis. Difference in the flow fields such as flow rate, pressure, vorticity, and wall shear stress between SimVascular and OpenFOAM are analyzed. Similar results are obtained in both simulations up to a certain model time, before the results become drastically different. Both the similarities and differences are documented and discussed.

Shape-based interpolation method in measuring intracranial volume for pre- and post-operative decompressive craniectomy using open source software

2019 ◽  
Vol 30 (3) ◽  
pp. 115-123
Author(s):  
Johari Yap Abdullah ◽  
Zainul Ahmad Rajion ◽  
Arvind Gerard Martin ◽  
Azlan Jaafar ◽  
Abdul Rahman Izaini Ghani ◽  
...  
Keyword(s):  
Open Source ◽  
Open Source Software ◽  
Decompressive Craniectomy ◽  
Interpolation Method ◽  
Intracranial Volume
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