scholarly journals Open Porous Composite Monoliths for Biomedical Applications via Photocrosslinking of Low Internal Phase Nano-Emulsion Templates

2021 ◽  
Vol 11 (12) ◽  
pp. 5338
Author(s):  
Maurizio Celentano ◽  
Raffaele Vecchione ◽  
Maddalena De Simone ◽  
Eliana Esposito ◽  
Monica Patrone ◽  
...  
Keyword(s):  
Polymer Matrix ◽  
Biomedical Applications ◽  
Morphological Alterations ◽  
Permeable Media ◽  
Internal Phase ◽  
Complex Shapes ◽  
Oxidase Enzyme ◽  
Nano Emulsion ◽  
Oxidation Of Glucose ◽  
Porous Morphology

Highly cross-linked polyethylene glycol monoliths (HCPEG) with interconnected micro and nanoporosity are produced via photo-crosslinking of low internal phase emulsions (LIPE). Unlike previous works, this approach allows the pre-processing functionalization of both polymer matrix and porosity by loading both phases of the emulsion template with several active fillers, such as enzymes, semiconductive polymers, and metallic nanostructures. Importantly, both polymer matrix and porosity of the resulting composite HCPEG monoliths show neither serious cross-contamination nor morphological alterations. All in all, this material behaves like a network of nano/micro flasks embedded into a permeable media. Mechanical and dielectric properties of these composites HCPEG monoliths can be tuned by varying the content of fillers. Since these composite materials are produced by photo-crosslinking of LIPEs, they can be easily and rapidly processed into complex shapes like microneedles arrays through replica molding without detrimental modifications of the porous morphology. In principle, the proposed strategy allows us to fabricate medical devices. As proof of concept, we embedded glucose oxidase enzyme in the nanoporosity and the resulting composite porous material retained the catalytic activity towards the oxidation of glucose.

Additive Manufacturing for Medical and Biomedical Applications: Advances and Challenges

2014 ◽  
Vol 783-786 ◽  
pp. 1286-1291 ◽  
Author(s):  
Andrey Koptioug ◽  
Lars Erik Rännar ◽  
Mikael Bäckström ◽  
Marie Cronskär
Keyword(s):  
Electron Beam ◽  
Additive Manufacturing ◽  
Electron Beam Melting ◽  
Biomedical Applications ◽  
Rapid Development ◽  
Industrial Applications ◽  
Post Processing ◽  
New Materials ◽  
Industrial Manufacturing ◽  
Complex Shapes

Additive Manufacturing (AM) has solidly established itself not only in rapid prototyping but also in industrial manufacturing. Its success is mainly determined by a possibility of manufacturing components with extremely complex shapes with minimal material waste. Rapid development of AM technologies includes processes using unique new materials, which in some cases is very hard or impossible to process any other way. Along with traditional industrial applications AM methods are becoming quite successful in biomedical applications, in particular in implant and special tools manufacturing. Here the capacity of AM technologies in producing components with complex geometric shapes is often brought to extreme. Certain issues today are preventing the AM methods taking its deserved place in medical and biomedical applications. Present work reports on the advances in further developing of AM technology, as well as in related post-processing, necessary to address the challenges presented by biomedical applications. Particular examples used are from Electron Beam Melting (EBM), one of the methods from the AM family.

Nanomagnetic Poly(vinyl alcohol) Hydrogels

2013 ◽  
Vol 829 ◽  
pp. 539-543 ◽  
Author(s):  
Sima Asa'di ◽  
Masoud Frounchi ◽  
Susan Dadbin
Keyword(s):  
Magnetic Nanoparticles ◽  
Polymer Matrix ◽  
Vinyl Alcohol ◽  
Biomedical Applications ◽  
Nanocomposite Films ◽  
Poly Vinyl Alcohol ◽  
X Ray Diffraction ◽  
Modified Magnetic Nanoparticles ◽  
Gamma Irradiated ◽  
Surface Modified

Surface modified magnetic nanoparticles (M-NPs) were synthetized and stabilized in poly (vinyl-alcohol) solution. The solutions with various magnetic nanoparticles contents were gamma-irradiated and magnetic poly (vinyl-alcohol) (M-PVA) hydrogels were synthesized. The magnetic hydrogels and also the un-irradiated magnetic poly (vinyl alcohol) nanocomposite films were characterized by scanning electron microscopy (SEM), X-ray diffraction (XRD), vibrating sample magnetometer (VSM), Fourier transform infrared spectroscopy (FTIR) and mechanical measurement. The M-NPs were uniformly dispersed in the polymer matrix due to a strong interaction between the surface-modified M-NPs and polymer matrix. Physical properties of the M-PVA hydrogels, including gel fraction and equilibrium water content were measured to evaluate the applicability of these hydrogels for biomedical applications. XRD, FTIR and VSM results indicated that there are important changes in crystalline, chemical and magnetic properties of hydrogels, arising from irradiation.

Preparation of fluorescent poly(methylmethacrylate) nano capsules via internal phase separation

e-Polymers ◽  
2007 ◽  
Vol 7 (1) ◽  
Author(s):  
Hui Lv ◽  
Quan Lin ◽  
Tongjie Yao ◽  
Kai Zhang ◽  
Junhu Zhang ◽  
...  
Keyword(s):  
Phase Separation ◽  
Internal Phase ◽  
Wide Ph Range ◽  
Potential Applications ◽  
Long Time ◽  
The Mean ◽  
Oil Water ◽  
Ph Range ◽  
Nano Emulsion ◽  
Functional Components

AbstractFluorescent nanocapsules containing Eu3+ complex are prepared by the internal phase separation of poly(methylmethacrylate) (PMMA) within the droplets of oil/water nano-emulsion. The nanocapsules give bright red emission excited by UV irradiation and possess stable fluorescence properties. Their fluorescence intensity is primarily influenced by the emulsifier concentration. It is significant that the fluorescence of the nanocapsules is nearly pH-independent and can be kept for a long time in a wide pH range. In contrast, the fluorescence of Eu3+ complex is easily quenched in acidic or alkalic medium. The mean nanocapsule size is tunable with the concentration and the mode of emulsifier addition. As soft templates, oil cores have potential applications for the incorporation of functional components or drugs.

Potential of Electrospun Graphene Oxide-Gelatin Composite Nanofibers for Biomedical Applications

2015 ◽  
Vol 830-831 ◽  
pp. 581-584
Author(s):  
K Jalaja ◽  
R. James Nirmala
Keyword(s):  
Graphene Oxide ◽  
Polymer Matrix ◽  
Biomedical Applications ◽  
Composite Nanofibers ◽  
Water Resistance ◽  
Mechanical Performance ◽  
Cross Linking ◽  
Reinforcing Effect ◽  
Wide Range ◽  
Versatile Technique

Graphene oxide incorporated polymer matrix provides a multifunctional facet due to the reinforcing effect of graphene oxide (GO) with wide range of properties. Nanofibers are fabricated by a versatile technique known as electrospinning. The present study demonstrates the fabrication of gelatin, a protein nanofibers non-covalently functionalized with GO. The effect of GO on gelatin nanofibers in terms of mechanical performance is studied. In order to improve the water resistance of the resulting nanofibers, cross-linking is performed using dextran aldehyde.

scholarly journals Comparative Study of the Mechanical and Water Absorption Behaviour of Basalt Fiber Reinforced Polymer Matrix Composites with Different Epoxies as Matrix for Biomedical Applications

2021 ◽  
Vol 2021 ◽  
pp. 1-9
Author(s):  
R. Raghavendra Rao ◽  
S. Pradeep ◽  
Nasim Hasan ◽  
B. S. Shivashankara ◽  
Mohamed Abdelghany Elkotb ◽  
...  
Keyword(s):  
Water Absorption ◽  
Polymer Matrix ◽  
Biomedical Applications ◽  
Polymer Matrix Composites ◽  
Testing Machine ◽  
Basalt Fiber ◽  
Weight Ratio ◽  
Matrix Composites ◽  
Specific Strength ◽  
The Many

In comparison to conventional materials, polymer matrix composite materials have witnessed a surge in applicability due to their higher specific strength-to-weight ratio, abundant availability, and ease of shaping. Due to technological, economic, environmental, and societal challenges, bio-based fibers began to emerge quickly for use in industrial components. Due to its unique chemistry-related characteristics, basalt fiber holds a prominent position among the many bio-based fibers. So, it could be thought of used as a replacement for some components used in the biomedical equipments. In the present investigation, plain-woven basalt fiber at a constant percentage of 55% is added as reinforcement to three different epoxy resin-hardener combinations such as Lapox L12-Lapox K6, Araldite LY1564-Aradur 22962, and Araldite LY556-Aradur HY951 as matrix, and comparative studies are carried out. Fabrication is carried out by hand lay-up technique. Test specimens are prepared as per the respective ASTM standards by subjecting the laminate to water jet machining. Mechanical characterization such as tensile, flexural, and density tests is conducted for the test specimen using BISS-50 kN Universal Testing Machine (UTM). Water absorption tests are also conducted for 24 and 48 hours duration. From the results obtained, it is concluded that the highest tensile, flexural strengths are obtained for laminate L3 which used LY556 epoxy and HY951 hardener combination as matrix. Also, less rate of water absorption is seen for L3 laminate for both 24 and 48 hrs which makes it suitable for biomedical applications.

Interconnected macroporous 3D scaffolds templated from gelatin nanoparticle-stabilized high internal phase emulsions for biomedical applications

Soft Matter ◽  
2017 ◽  
Vol 13 (21) ◽  
pp. 3871-3878 ◽  
Author(s):  
Huan Tan ◽  
Jingjing Wei ◽  
Guanqing Sun ◽  
Changdao Mu ◽  
Wei Lin ◽  
...  
Keyword(s):  
Biomedical Applications ◽  
3D Scaffolds ◽  
Internal Phase
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