scholarly journals Effect of Osteoporosis on Well-Integrated Bone Implants

2021 ◽  
Vol 11 (2) ◽  
pp. 723
Author(s):  
Amani M. Basudan ◽  
Marwa Y. Shaheen ◽  
Abdurahman A. Niazy ◽  
Jeroen J.J.P. van den Beucken ◽  
John A. Jansen ◽  
...  
Keyword(s):  
Dental Implants ◽  
Femoral Condyle ◽  
Bone Implants ◽  
Bone Implant ◽  
Ovx Rats ◽  
Bone Response ◽  
Significant Difference ◽  
Female Wistar Rats ◽  
Edentulous Patients

The installation of dental implants has become a common treatment for edentulous patients. However, concern exists about the influence of osteoporosis on the final implant success. This study evaluated whether an ovariectomy (OVX)-induced osteoporotic condition, induced eight weeks postimplantation in a rat femoral condyle, influences the bone response to already-integrated implants. The implants were inserted in the femoral condyle of 16 female Wistar rats. Eight weeks postimplantation, rats were randomly ovariectomized (OVX) or sham-operated (SHAM). Fourteen weeks later, animals were sacrificed, and implants were used for histological and histomorphometric analyses. A significant reduction in the quantity and quality of trabecular bone around dental implants existed in OVX rats in comparison to the SHAM group. For histomorphometric analysis, the bone area (BA%) showed a significant difference between OVX (34.2 ± 4.3) and SHAM (52.6 ± 12.7) groups (p < 0.05). Bone–implant contact (BIC%) revealed significantly lower values for all implants in OVX (42.5 ± 20.4) versus SHAM (59.0 ± 19.0) rats. Therefore, induction of an osteoporotic condition eight weeks postimplantation in a rat model negatively affects the amount of bone present in close vicinity to bone implants.

scholarly journals Influence of the Thermal Treatment to Address a Better Osseointegration of Ti6Al4V Dental Implants: Histological and Histomorphometrical Study in a Rabbit Model

2018 ◽  
Vol 2018 ◽  
pp. 1-7 ◽  
Author(s):  
Antonio Scarano ◽  
Ezio Crocetta ◽  
Alessandro Quaranta ◽  
Felice Lorusso
Keyword(s):  
Thermal Treatment ◽  
Dental Implants ◽  
Bone Healing ◽  
Rabbit Model ◽  
Titanium Implants ◽  
Control Group ◽  
Left Femur ◽  
Bone Response ◽  
First Choice ◽  
Significant Difference

Background. Pure titanium continues to be the first choice for dental implants and represents the gold standard for their biocompatibility and physical and mechanical characteristics, while the titanium alloy (Ti6Al4V) has good mechanical properties. The surface structure of the titanium oxide layer formation on the surface influences and improves the bone response around dental implants. Purpose. The purpose of this study is to evaluate the influence of a thermal treatment of Ti6Al4V implant surfaces and the bone healing response in a rabbit model. Methods. Altogether sixteen implants with same design were inserted into the distal femoral metaphysis. A screw (13 mm long, 4 mm in diameter) was inserted in an implant bed. Each rabbit received two implants, one in the left femur and one in the right femur. The samples were histologically and histomorphometrically evaluated at 8 weeks. Results. A statistically significant difference (p = 0.000034) was present histologically in the percentages of bone-implant contact (BIC) between the test group (BIC = 69.25±4.49%.) and control group (BIC = 56.25 ± 4.8%) by one-way analysis of variance (ANOVA). Significance was set at p ≤ 0.05. Conclusions. The outcome of the present study indicates a novel approach to improving bone healing around titanium implants.

scholarly journals CHARACTERIZATION OF 3D-PRINTING FILAMENT WITH EXTRUDER MELTING TEMPERATURE VARIATION FOR BONE IMPLANT FROM KUPANG SHELL

2022 ◽  
Vol 2 (2) ◽  
pp. 73
Author(s):  
Ananda Maulidha Kusumastuti ◽  
Adik Roni Setiawan ◽  
Asalina Putri Agung Shaliha ◽  
Deden Eko Wiyono ◽  
Achmad Ferdiansyah Pradana Putra
Keyword(s):  
3D Printing ◽  
Mechanical Strength ◽  
Melting Temperature ◽  
Organic Materials ◽  
Bone Implants ◽  
Bone Implant ◽  
Bone Damage ◽  
Mussel Shells

<p><em>The number of bone damage in Indonesia continues to increase. Bone implant is one of the medical treatment methods performed on bone damage. Organic and non-organic materials can be used as bone implants. Non-organic materials are stronger, but not biocompatible, while organic materials are biocompatible, but brittle. The addition of polycaprolactone polymer (PCL) can increase the mechanical strength of 3D printing bone implant filaments. Extruder melting temperature is one of the factors that affect the quality of PCL-HAp filaments for bone implants. Studies related to temperature variations in PCL-HAp materials have not been widely studied. Therefore, it is necessary to characterize 3D printing filaments with variations in the melting temperature of the extruder as bone implants from mussel shells with temperature variables of 65<sup>o</sup>C, 75<sup>o</sup>C, and 85<sup>o</sup>C. From this study, the optimum point was found at the melting extruder temperature of 75<sup>o</sup>C with the results of a diameter of 1.810 and mechanical strength which showed an increase in tensile strength and Young's modulus of PCL-HAp composite in all variables compared to pure PCL. The SEM test showed a rough surface on the filaments that could increase the proliferation and adhesion of good cells for the growth of bone tissue.</em></p>

scholarly journals 7-Tesla MRI Evaluation of the Knee, 25 Years after Cartilage Repair Surgery: The Influence of Intralesional Osteophytes on Biochemical Quality of Cartilage

Cartilage ◽  
2021 ◽  
pp. 194760352110605
Author(s):  
M.P.F. Janssen ◽  
M.J.M. Peters ◽  
E.G.M. Steijvers-Peeters ◽  
P. Szomolanyi ◽  
E.M.C. Jutten ◽  
...  
Keyword(s):  
Articular Cartilage ◽  
Femoral Condyle ◽  
7 Tesla ◽  
Tissue Quality ◽  
Tibial Cartilage ◽  
Osteophyte Formation ◽  
Significant Difference ◽  
Patient Reported ◽  
Biochemical Quality

Objective To evaluate the morphological and biochemical quality of cartilage transplants and surrounding articular cartilage of patients 25 years after perichondrium transplantation (PT) and autologous chondrocyte transplantation (ACT) as measured by ultra-high-field 7-Tesla (7T) magnetic resonance imaging (MRI) and to present these findings next to clinical outcome. Design Seven PT patients and 5 ACT patients who underwent surgery on the femoral condyle between 1986 and 1996 were included. Patient-reported outcome measures (PROMs) were assessed by the clinical questionnaires: Knee injury and Osteoarthritis Outcome Score (KOOS), International Knee Documentation Committee (IKDC), and Visual Analogue Scale (VAS) for knee pain. The morphological (MOCART score) and biochemical quality (glycosaminoglycans [GAGs] content and collagen integrity) of cartilage transplants and surrounding articular cartilage were analyzed by 7T MRI. The results of the PT and ACT patients were compared. Finally, a detailed morphological analysis of the grafts alone was performed. Results No statistically significant difference was found for the PROMs and MOCART scores of PT and ACT patients. Evaluation of the graft alone showed poor repair tissue quality and high prevalence of intralesional osteophyte formation in both the PT and ACT patients. Penetration of the graft surface by the intralesional osteophyte was related to biochemically damaged opposing tibial cartilage; GAG content was significantly lower in patients with an osteophyte penetrating the graft surface. Conclusions Both PT and ACT patients have a high incidence of intralesional osteophyte formation 25 years after surgery. The resulting biochemical damage to the opposing tibial cartilage might be dependent on osteophyte morphology.

scholarly journals Bone Response to Two Dental Implants with Different Sandblasted/Acid-Etched Implant Surfaces: A Histological and Histomorphometrical Study in Rabbits

2017 ◽  
Vol 2017 ◽  
pp. 1-8 ◽  
Author(s):  
Antonio Scarano ◽  
Adriano Piattelli ◽  
Alesandro Quaranta ◽  
Felice Lorusso
Keyword(s):  
Dental Implants ◽  
Model Experiment ◽  
Scientific Evidence ◽  
Bone Implant ◽  
The Past ◽  
Hydrophilic Surfaces ◽  
Bone Response ◽  
Bone Implant Contact ◽  
Implant Dentistry

Background. Scientific evidence in the field of implant dentistry of the past 20 years established that titanium rough surfaces have shown improved osseointegration rates. In a majority of dental implants, the surface microroughness was obtained by grit blasting and/or acid etching. The aim of the study was to evaluate in vivo two different highly hydrophilic surfaces at different experimental times. Methods. Calcium-modified (CA) and SLActive surfaces were evaluated and a total of 18 implants for each type of surface were positioned into the rabbit articular femoral knee-joint in a split model experiment, and they were evaluated histologically and histomorphometrically at 15, 30, and 60 days of healing. Results. Bone-implant contact (BIC) at the two-implant surfaces was significantly different in favor of the CA surface at 15 days (p=0.027), while SLActive displayed not significantly higher values at 30 (p=0.51) and 60 days (p=0.061). Conclusion. Both implant surfaces show an intimate interaction with newly formed bone.

scholarly journals Histomorphometric Evaluation of Peri-Implant Bone Response to Intravenous Administration of Zoledronate (Zometa®) in an Osteoporotic Rat Model

Materials ◽  
2020 ◽  
Vol 13 (22) ◽  
pp. 5248
Author(s):  
Amani M. Basudan ◽  
Marwa Y. Shaheen ◽  
Abdurahman A. Niazy ◽  
Jeroen J. J. P. van den Beucken ◽  
John A. Jansen ◽  
...  
Keyword(s):  
Femoral Condyle ◽  
Titanium Implants ◽  
Histological Evaluation ◽  
Bone Area ◽  
Treatment Regimens ◽  
Implant Placement ◽  
Bone Response ◽  
Female Wistar Rats ◽  
The Right ◽  
Post Implantation

We evaluated the response to peri-implant bone placed in the femoral condyle of osteoporotic rats, following intravenous zoledronate (ZOL) treatment in three settings: pre-implantation (ZOL-Pre), post-implantation (ZOL-Post), and pre- + post-implantation (ZOL-Pre+Post). Twenty-four female Wistar rats were ovariectomized (OVX). After 12 weeks, the rats received titanium implants in the right femoral condyle. ZOL (0.04 mg/kg, weekly) was administered to six rats 4 weeks pre-implantation and was stopped at implant placement. To another six rats, ZOL was given post-implantation and continued for 6 weeks. Additional six rats received ZOL treatment pre- and post-implantation. Control animals received weekly saline intravenous injections. At 6 weeks post-implantation, samples were retrieved for histological evaluation of the percentage of bone area (%BA) and of the percentage of bone-to-implant contact (%BIC). BA% for ZOL-Pre (29.6% ± 9.0%) and ZOL-Post (27.9% ± 5.6%) rats were significantly increased compared to that of the controls (17.3% ± 3.9%, p < 0.05). In contrast, ZOL-Pre+Post rats (20.4% ± 5.0%) showed similar BA% compared to Saline controls (p = 0.731). BIC% revealed a significant increase for ZOL-Post (65.8% ± 16.9%) and ZOL-Pre+Post (68.3% ± 10.0%) rats compared with that of Saline controls (43.3% ± 9.6%, p < 0.05), while ZOL-Pre rats (55.6% ± 19%) showed a BIC% comparable to that of Saline controls (p = 0.408). Our results suggest that receiving intravenous ZOL treatment before or after implant placement enhances peri-implant bone responses in terms of bone area. However, the effect of different ZOL treatment regimens on BIC% was found to be inconclusive.

scholarly journals The effect of osseodensification and different thread designs on the dental implant primary stability

F1000Research ◽  
2018 ◽  
Vol 7 ◽  
pp. 1898 ◽  
Author(s):  
Abdullah Saleh Almutairi ◽  
Maher Abdullatif Walid ◽  
Mohamed Ahmed Alkhodary
Keyword(s):  
Dental Implants ◽  
Primary Stability ◽  
Chi Square ◽  
Machined Surface ◽  
Lateral Direction ◽  
Bone Implant ◽  
Significance Level ◽  
Thread Pitch ◽  
Custom Made ◽  
Significant Difference

Background: It is difficult to achieve good primary stability of dental implants in soft bone, such as that in the posterior maxillae. Osseodensification (OD) burs, working in a non-subtractive fashion, condense the implant osteotomy bone in lateral direction and increase in the bone implant contact. Also, dental implants with deeper threads, and decreased thread pitch can increase initial bone implant anchorage. Methods: This study utilized 48 custom-made machined surface dental implants that were 13 mm long, with a major diameter of 4.5 mm and a minor diameter of 3.5 mm, a thread pitch of 1 mm, a thread depth of 0.5 mm, and a 4 mm long cutting flute at the apex.  The implants were divided into 4 groups, each group was made of 12 implants with a different thread design; V-shaped, trapezoid, buttress, and reverse buttress. The implants were inserted in 4-mm thick cancellous bone slices obtained from the head of Cow femur bone. The ostoetomies were prepared by conventional drilling and by OD drilling. Each inserted implant was then tested for primary stability using the Periotest. The Periotest values (PTVs) for the implant stability were tabulated and analyzed using a chi square test at significance level p< 0.05. Results: The results of this this study revealed no statistically significant difference between the Periotest readings for the implants in each category placed in either the OD or the regular osteotomies. However, it has been found that the implants placed in regular drilling ostoetomies had a significantly better primary stability than the implants placed in OD osteotomies. Conclusions: It was concluded that OD is not necessary in situations where there is bone of good quality and quantity.

scholarly journals Irregular Bone Defect Detection and Device on Dental Implants

2010 ◽  
Vol 4 (2) ◽  
Author(s):  
H.-B. Zhuang ◽  
Min-Chun Pan
Keyword(s):  
Dental Implants ◽  
Bone Defects ◽  
Acoustic Excitation ◽  
Dental Surgery ◽  
Bone Implant ◽  
Detection Techniques ◽  
Overall Evaluation ◽  
Edentulous Patients ◽  
Dental Implant Surgery

Dental implants are generally used in edentulous patients. The key issue of this dental surgery is the effective osseointegration of implants with spongy bone and cortical bone and then they become a part of loading structure. Current osseointegration detection devices only offer overall evaluation without the information of location and orientation of bone defects. This study is to develop detection techniques to measure the quantity as well as to locate the orientation of imperfection around bone-implant interface based on resonance frequency analysis (RFA). A noncontact measurement technique is performed with acoustic excitation through a loud-speaker and displacement response via a capacity-type pick-up. In the first and second series experiments, RFA is applied to estimate the orientation and quantity of irregular bone defects on various in-vitro faulty models. The variation in RF not only locates the orientation and depth of defects but also reflects the change of boundary conditions surrounding the defective models. According to these results, the detection technique to locate irregular osseointegration is established. Furthermore, the detection device to this end is proposed as well. The proposed examining approach and device are promising and able to assist dentists in dental implant surgery.

scholarly journals Infrared Thermographic Assessment of Cooling Effectiveness in Selected Dental Implant Systems

2016 ◽  
Vol 2016 ◽  
pp. 1-8 ◽  
Author(s):  
Karol Kirstein ◽  
Maciej Dobrzyński ◽  
Piotr Kosior ◽  
Aleksander Chrószcz ◽  
Krzysztof Dudek ◽  
...  
Keyword(s):  
Dental Implant ◽  
Room Temperature ◽  
Saline Solution ◽  
Temperature Fluctuations ◽  
Site Preparation ◽  
Cooling Effectiveness ◽  
Bone Implant ◽  
Significant Difference ◽  
Implant Site Preparation

The excessive temperature fluctuations during dental implant site preparation may affect the process of bone-implant osseointegration. In the presented studies, we aimed to assess the quality of cooling during the use of 3 different dental implant systems (BEGO®, NEO BIOTECH®, and BIOMET 3i®). The swine rib was chosen as a study model. The preparation of dental implant site was performed with the use of 3 different speeds of rotation (800, 1,200, and 1,500 rpm) and three types of cooling: with saline solution at room temperature, with saline solution cooled down to 3°C, and without cooling. A statistically significant difference in temperature fluctuations was observed between BEGO and NEO BIOTECH dental systems when cooling with saline solution at 3°C was used (22.3°C versus 21.8°C). In case of all three evaluated dental implant systems, the highest temperature fluctuations occurred when pilot drills were used for implant site preparation. The critical temperature, defined in the available literature, was exceeded only in case of pilot drills (of all 3 systems) used at rotation speed of 1,500 rpm without cooling.

Sequential Bone Response to Immediately Loaded Mini-Implants, in vivo Study

2006 ◽  
Vol 925 ◽  
Author(s):  
Glaucio Serra Guimarães ◽  
Liliane Siqueira de Morais ◽  
Carlos Nelson Elias ◽  
Marc Andre Meyers
Keyword(s):  
Dental Implants ◽  
Titanium Implants ◽  
Test Material ◽  
Removal Torque ◽  
Bone Implant ◽  
Subcutaneous Injections ◽  
Mini Implants ◽  
Bone Response ◽  
The Right

ABSTRACTThe use of osseointegrated titanium implants has been related like an excellent alternative to traditional orthodontic anchorage methodologies, and they are a necessity when dental elements lack quantity or quality, when extraoral devices are impractical, or when noncompliance during treatment is likely. In orthodontics, the implants can be use to anchor different movements. However, conventional dental implants can only be placed in limited areas such as the retromolar or the edentulous areas. Another limitation has been the direction of the force application and conventional dental implants are troublesome for patients because of the severity of the surgery, the discomfort of the initial healing, and the difficulty of oral hygiene. Due to these factors, mini-implants became widely used. They have little limitations related to the local of implantation, the surgical procedure of insertion is relatively simple and the control of direction and quantify of the force is simple to be done. These improvements were obtained due to decrease of the size, but these changes could result on significant changes to the bone-implant interface. Since, the orthodontic treatment has to be done as fast as possible. The purpose of this work is to analyze the bone healing reactions to immediately loaded mini-implant of titanium alloy grade 4 by histological, fluorescent and SEM observation, by histomorphometric analysis and by removal torque test. Material and method: Seventy two mini-implants were inserted in eighteen New Zealand rabbits. Four mini-implants were put in the right tibiae of each rabbit and two of then were loaded immediately with 100 gf. Subcutaneous injections of fluorescent labels were administrated in defined periods. The animals were euthanized after 1, 4 and 12 weeks, performing three time analysis and the tibias were dissected and prepared to microcopy analysis and to removal torque test. Results: The results indicated that all the mini-implants remained stable during experimental time. The SEM findings indicated no differences between load and unload group in one and four weeks period, although, the 12 weeks loaded group demonstrated more mature bone formation than the unload group in the same time. These findings suggest that the force can be applied after insertion of the mini-implant without compromises their stability.

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