scholarly journals Protective Effect of Chemically Characterized Polyphenol-Rich Fraction from Apteranthes europaea (Guss.) Murb. subsp. maroccana (Hook.f.) Plowes on Carbon Tetrachloride-Induced Liver Injury in Mice

2021 ◽  
Vol 11 (2) ◽  
pp. 554
Author(s):  
Fatima Ez-Zahra Amrati ◽  
Mohammed Bourhia ◽  
Meryem Slighoua ◽  
Smahane Boukhira ◽  
Riaz Ullah ◽  
...  
Keyword(s):  
Carbon Tetrachloride ◽  
Liver Injury ◽  
Protective Effect ◽  
High Performance ◽  
Chemical Characterization ◽  
Array Detector ◽  
Biochemical Alterations ◽  
Traditional Medicines ◽  
Toxic Liver Injury ◽  
Promising Source

Apteranthes europaea (Guss.) Murb. subsp. maroccana (Hook.f.) Plowes (A. europaea) is a medicinal plant widely used in traditional medicines to treat various diseases including hepatic pathogenesis. This study was conducted to evaluate the protective effect of chemically characterized polyphenol-rich fraction from A. europaea on carbon tetrachloride-induced liver injury in mice. The chemical characterization of A. europaea polyphenol-rich fraction was carried out using HPLC-DAD (high-performance liquid chromatography (HPLC) with a diode-array detector (DAD)). Carbon tetrachloride (CCl4) was used to induce liver injuries in mice as described in previous works. A polyphenol-rich fraction from A. europaea was used at a dose of 50 mg/Kg to study its hepatoprotective effect. Next, histopathological and biochemical alterations were investigated. The HPLC analysis revealed the presence of several phenolic compounds: gallic acid, methyl gallate, rutin, ferulic acid, and resorcinol. Regarding the mice treated with a polyphenol-rich fraction from A. europaea up to 50 mg/Kg and carbon tetrachloride, no significant biochemical nor histological alterations occurred in their liver; meanwhile, serious biochemical and histopathological changes were noted for liver recovered from the mice treated with carbon tetrachloride only. In conclusion, A. europaea extract is a promising source of hepatoprotective agents against toxic liver injury.

Protective effect ofAsteracantha longifoliaextract in mouse liver injury induced by carbon tetrachloride and paracetamol

2003 ◽  
Vol 55 (10) ◽  
pp. 1413-1418 ◽  
Author(s):  
R. P. Hewawasam ◽  
K. A. P. W. Jayatilaka ◽  
C. Pathirana ◽  
L. K. B. Mudduwa
Keyword(s):  
Carbon Tetrachloride ◽  
Liver Injury ◽  
Protective Effect ◽  
Mouse Liver

Protective effect of potato peel extract against carbon tetrachloride-induced liver injury in rats

2008 ◽  
Vol 26 (2) ◽  
pp. 241-246 ◽  
Author(s):  
Nandita Singh ◽  
Vasudeva Kamath ◽  
K. Narasimhamurthy ◽  
P.S. Rajini
Keyword(s):  
Carbon Tetrachloride ◽  
Liver Injury ◽  
Protective Effect ◽  
Potato Peel ◽  
Peel Extract

scholarly journals Protective Effect of Eckol against Acute Hepatic Injury Induced by Carbon Tetrachloride in Mice

Marine Drugs ◽  
2018 ◽  
Vol 16 (9) ◽  
pp. 300 ◽  
Author(s):  
Shulan Li ◽  
Juan Liu ◽  
Mengya Zhang ◽  
Yuan Chen ◽  
Tianxing Zhu ◽  
...  
Keyword(s):  
Carbon Tetrachloride ◽  
Liver Injury ◽  
Protective Effect ◽  
Acute Liver Injury ◽  
Treated Group ◽  
Terminal Deoxynucleotidyl Transferase ◽  
Enhanced Expression ◽  
Pre Treatment

Several in vitro studies have shown the potential hepatoprotective properties of eckol, a natural phlorotannin derived from the brown alga. However, the in vivo hepatoprotective potential of eckol has not been determined. In this study, we performed an in vivo study to investigate the protective effect of eckol and its possible mechanisms on the carbon tetrachloride (CCl4)-induced acute liver injury model in mice. Results revealed that eckol pre-treatment at the dose of 0.5 and 1.0 mg/kg/day for 7 days significantly suppressed the CCl4-induced increases of alanine transaminase (ALT) and aspartate aminotransferase (AST) levels in serum and meliorated morphological liver injury. Terminal deoxynucleotidyl transferase-mediated dUTP nick end labelling (TUNEL) analysis showed that the number of positive apoptotic hepatocytes in the eckol-treated group was lower than that in the CCl4 model group. Western blotting analysis also demonstrated the enhanced expression of bcl-2 and suppressed expression of cleaved caspase-3 by eckol. The CCl4-induced oxidative stress in liver was significantly ameliorated by eckol, which was characterized by reduced malondialdehyde (MDA) formations, and enhanced superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) activities and glutathione (GSH) content. Moreover, the CCl4-induced elevations of pro-inflammatory cytokines tumor necrosis factor (TNF)-α, interleukin (IL)-1β and IL-6 were markedly suppressed in the eckol-treated group. However, eckol enhanced the level of IL-10, a potent anti-inflammatory cytokine, and recruited CD11c+ dendritic cells into the liver tissues of CCl4-treated mice. These results indicated that eckol has the protective effect on CCl4-induced acute liver injury via multiple mechanisms including anti-apoptosis, anti-oxidation, anti-inflammation and immune regulation.

scholarly journals Protective effect and mechanism of ginsenoside Rg1 on carbon tetrachloride-induced acute liver injury

2017 ◽  
Vol 16 (3) ◽  
pp. 2814-2822 ◽  
Author(s):  
Benquan Qi ◽  
Suzhi Zhang ◽  
Daohua Guo ◽  
Sanxing Guo ◽  
Xiaodong Jiang ◽  
...  
Keyword(s):  
Carbon Tetrachloride ◽  
Liver Injury ◽  
Protective Effect ◽  
Acute Liver Injury ◽  
Ginsenoside Rg1

Protective effect of probucol on liver injury induced by carbon tetrachloride in rats

2011 ◽  
Vol 5 (4) ◽  
pp. 899-905 ◽  
Author(s):  
Yu-Tao Zhan ◽  
Jing Weng ◽  
Li Li ◽  
Qing Xu ◽  
Xin Song ◽  
...  
Keyword(s):  
Carbon Tetrachloride ◽  
Liver Injury ◽  
Protective Effect

scholarly journals Protective Effect of Rifampicin against Acute Liver Injury Induced by Carbon Tetrachloride in Mice

1995 ◽  
Vol 69 (4) ◽  
pp. 325-334 ◽  
Author(s):  
Renbin Huang ◽  
Hiroyasu Okuno ◽  
Masashi Takasu ◽  
Yasuko Shiozaki ◽  
Kyoichi Inoue
Keyword(s):  
Carbon Tetrachloride ◽  
Liver Injury ◽  
Protective Effect ◽  
Acute Liver Injury
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