scholarly journals The Protective Effect of Hepatocyte Growth-Promoting Factor (pHGF) Against Carbon Tetrachloride-Induced Acute Liver Injury in Rats

2001 ◽  
Vol 68 (2) ◽  
pp. 154-164 ◽  
Author(s):  
Wei Dai ◽  
Shigeru Sato ◽  
Goro Asano
Keyword(s):  
Carbon Tetrachloride ◽  
Liver Injury ◽  
Protective Effect ◽  
Acute Liver Injury ◽  
Growth Promoting ◽  
Hepatocyte Growth

scholarly journals Protective Effect of Eckol against Acute Hepatic Injury Induced by Carbon Tetrachloride in Mice

Marine Drugs ◽  
2018 ◽  
Vol 16 (9) ◽  
pp. 300 ◽  
Author(s):  
Shulan Li ◽  
Juan Liu ◽  
Mengya Zhang ◽  
Yuan Chen ◽  
Tianxing Zhu ◽  
...  
Keyword(s):  
Carbon Tetrachloride ◽  
Liver Injury ◽  
Protective Effect ◽  
Acute Liver Injury ◽  
Treated Group ◽  
Terminal Deoxynucleotidyl Transferase ◽  
Enhanced Expression ◽  
Pre Treatment

Several in vitro studies have shown the potential hepatoprotective properties of eckol, a natural phlorotannin derived from the brown alga. However, the in vivo hepatoprotective potential of eckol has not been determined. In this study, we performed an in vivo study to investigate the protective effect of eckol and its possible mechanisms on the carbon tetrachloride (CCl4)-induced acute liver injury model in mice. Results revealed that eckol pre-treatment at the dose of 0.5 and 1.0 mg/kg/day for 7 days significantly suppressed the CCl4-induced increases of alanine transaminase (ALT) and aspartate aminotransferase (AST) levels in serum and meliorated morphological liver injury. Terminal deoxynucleotidyl transferase-mediated dUTP nick end labelling (TUNEL) analysis showed that the number of positive apoptotic hepatocytes in the eckol-treated group was lower than that in the CCl4 model group. Western blotting analysis also demonstrated the enhanced expression of bcl-2 and suppressed expression of cleaved caspase-3 by eckol. The CCl4-induced oxidative stress in liver was significantly ameliorated by eckol, which was characterized by reduced malondialdehyde (MDA) formations, and enhanced superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) activities and glutathione (GSH) content. Moreover, the CCl4-induced elevations of pro-inflammatory cytokines tumor necrosis factor (TNF)-α, interleukin (IL)-1β and IL-6 were markedly suppressed in the eckol-treated group. However, eckol enhanced the level of IL-10, a potent anti-inflammatory cytokine, and recruited CD11c+ dendritic cells into the liver tissues of CCl4-treated mice. These results indicated that eckol has the protective effect on CCl4-induced acute liver injury via multiple mechanisms including anti-apoptosis, anti-oxidation, anti-inflammation and immune regulation.

scholarly journals Protective effect and mechanism of ginsenoside Rg1 on carbon tetrachloride-induced acute liver injury

2017 ◽  
Vol 16 (3) ◽  
pp. 2814-2822 ◽  
Author(s):  
Benquan Qi ◽  
Suzhi Zhang ◽  
Daohua Guo ◽  
Sanxing Guo ◽  
Xiaodong Jiang ◽  
...  
Keyword(s):  
Carbon Tetrachloride ◽  
Liver Injury ◽  
Protective Effect ◽  
Acute Liver Injury ◽  
Ginsenoside Rg1

scholarly journals Protective Effect of Rifampicin against Acute Liver Injury Induced by Carbon Tetrachloride in Mice

1995 ◽  
Vol 69 (4) ◽  
pp. 325-334 ◽  
Author(s):  
Renbin Huang ◽  
Hiroyasu Okuno ◽  
Masashi Takasu ◽  
Yasuko Shiozaki ◽  
Kyoichi Inoue
Keyword(s):  
Carbon Tetrachloride ◽  
Liver Injury ◽  
Protective Effect ◽  
Acute Liver Injury

Protective effect of antrosterol from Antrodia camphorata submerged whole broth against carbon tetrachloride-induced acute liver injury in mice

2012 ◽  
Vol 132 (2) ◽  
pp. 709-716 ◽  
Author(s):  
Guan-Jhong Huang ◽  
Jeng-Shyan Deng ◽  
Shyh-Shyun Huang ◽  
Yi-Yuan Shao ◽  
Chin-Chu Chen ◽  
...  
Keyword(s):  
Carbon Tetrachloride ◽  
Liver Injury ◽  
Protective Effect ◽  
Acute Liver Injury ◽  
Antrodia Camphorata

Mechanism of the Protective Effects of Sumac Gall Extract and Gallic Acid on the Progression of CCl4-induced Acute Liver Injury in Rats

1998 ◽  
Vol 26 (03n04) ◽  
pp. 333-341 ◽  
Author(s):  
Shigeyuki Kanai ◽  
Hideyuki Okano
Keyword(s):  
Superoxide Dismutase ◽  
Carbon Tetrachloride ◽  
Liver Injury ◽  
Protective Effect ◽  
Gallic Acid ◽  
Cell Membranes ◽  
Acute Liver Injury ◽  
Radical Scavenging ◽  
Protective Effects ◽  
Preventive Effect

To examine the mechanism of the preventive effect of tannins on the progression of carbon tetrachloride (CCl4)-induced acute liver injury in rats, sumac gall (SG) extract and gallic acid (GA) were used as substitutes for crude tannins, because SG is a kind of Chinese traditional medicinal herb containing large amounts of various tannins, and GA is one of the major constituents of SG. The protective effect of oral (p.o.) and intraperitoneal (i.p.) administration of each substance on progression of CCl4-induced hepatitis was investigated in rats. Speculating that the superoxide dismutase (SOD)-like activities (O2 radical-scavenging activities) and/or protective effects of these substances on cell membranes might play a key role in the mechanism opposing the progression of CCl4-induced hepatitis, the O2 radical-scavenging activities in liver cells and serum in rats were monitored. Both substances significantly prevented the progression of acute liver injury with both p.o. and i.p. administration. These findings suggest that the mechanism for this prevention might be due mainly to the protective effect of these substances on cell membranes rather than O2 radical-scavenging activities.

Protective effect of flavonoids from Cyclocarya paliurus leaves against carbon tetrachloride-induced acute liver injury in mice

2018 ◽  
Vol 119 ◽  
pp. 392-399 ◽  
Author(s):  
Jianhua Xie ◽  
Wenjie Wang ◽  
Caijun Dong ◽  
Lixin Huang ◽  
Hui Wang ◽  
...  
Keyword(s):  
Carbon Tetrachloride ◽  
Liver Injury ◽  
Protective Effect ◽  
Acute Liver Injury ◽  
Cyclocarya Paliurus
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