scholarly journals Release of Aloe vera Extracts from Therapeutic Lenses

2020 ◽  
Vol 10 (24) ◽  
pp. 9055
Author(s):  
Alessandra Pulliero ◽  
Aldo Profumo ◽  
Alberto Izzotti ◽  
Sergio Claudio Saccà
Keyword(s):  
Drug Therapy ◽  
Side Effects ◽  
Aloe Vera ◽  
Corneal Surface ◽  
Ocular Surgery ◽  
Adverse Side Effects ◽  
Ocular Irritation ◽  
Anti Inflammatory ◽  
Microbial Agent

Aloe vera extracts have been used for drug therapy due to their antimicrobial, anti-inflammatory, and epithelia-regenerative actions. Considering the possible adverse side effects on the corneal surface of anti-microbial agent administration after ocular surgery, it is of interest to identify the ability of Aloe vera extract release from a therapeutic lens to prevent ocular irritation. The aim of this research was to evaluate the effects of different lens types on the availability and efficacy of releasing Aloe vera extracts in which they are soaked. Two lens types were examined: (1) non-ionic hydrogel lenses and (2) ionic hydrogel lenses. Aloe vera availability was quantified by LC–MS, and activity was quantified by a spectrophotometer (Nanodrop) at different times: (a) 30 min, (b) 60 min, (c) 2 h, (d) 6 h, and (e) 24 h. The lens allowing for the most abundant passage of Aloe vera extracts was the ionic hydrogel lens, followed by the non-ionic hydrogel lens. The obtained results demonstrate that the best lens allowing for the high and stable release of Aloe vera extract to the corneal surface are those composed of ionic hydrogels.

Towards developing new strategies to reduce the adverse side-effects of nonsteroidal anti-inflammatory drugs

2011 ◽  
Vol 16 (1) ◽  
pp. 25-29 ◽  
Author(s):  
Noritaka Kawada ◽  
Toshiki Moriyama ◽  
Harumi Kitamura ◽  
Ryohei Yamamoto ◽  
Yoshiyuki Furumatsu ◽  
...  
Keyword(s):  
Side Effects ◽  
Adverse Side Effects ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
New Strategies

scholarly journals Involvement of Anti-Inflammatory, Antioxidant, and BDNF Up-Regulating Properties in the Antipsychotic-Like Effect of the Essential Oil of Alpinia Zerumbet in Mice: A Comparative Study With Olanzapine

2021 ◽  
Author(s):  
Fernanda Yvelize Ramos de Araújo ◽  
Adriano José Maia Chaves Filho ◽  
Adriana Mary Nunes ◽  
Gersilene Valente de Oliveira ◽  
Patrícia Xavier Lima Gomes ◽  
...  
Keyword(s):  
Weight Gain ◽  
Drug Therapy ◽  
Side Effects ◽  
Essential Oil ◽  
Negative Symptoms ◽  
Repeated Administration ◽  
Social Impairment ◽  
Standard Drug ◽  
Anti Inflammatory ◽  
Alpinia Zerumbet

Abstract The current drug therapy for schizophrenia effectively treats acute psychosis and its recurrence; however, this mental disorder’s cognitive and negative symptoms are still poorly controlled. Antipsychotics present important side effects, such as weight gain and extrapyramidal effects. The essential oil of Alpinia zerumbet (EOAZ) leaves presents potential antipsychotic properties that need further preclinical investigation. Here, we aimed to determine the effects of EAOZ in the prevention and reversal of schizophrenia-like symptoms (positive, negative, and cognitive) induced by ketamine (KET) repeated administration in mice and putative neurobiological mechanisms related to this effect. To this end, we evaluated antioxidant (GSH, nitrite levels), anti-inflammatory [interleukin (IL)-6], and neurotrophic [brain-derived neurotrophic factor (BDNF)] effects of this oil in hippocampal tissue. The atypical antipsychotic olanzapine (OLZ) was used as standard drug therapy. EOAZ, similarly to OLZ, prevented and reversed most KET-induced schizophrenia-like behavioral alterations, i.e., sensorimotor gating deficits and social impairment. EOAZ had a modest effect on the prevention of KET-associated working memory deficit. Compared to OLZ, EOAZ showed a more favorable side effects profile, inducing less cataleptic and weight gain changes. EOAZ efficiently protected the hippocampus against KET-induced oxidative imbalance, IL-6 increments, and BDNF impairment. In conclusion, our data add more mechanistic evidence for the anti-schizophrenia effects of EOAZ, based on its antioxidant, anti-inflammatory, and BDNF up-regulating actions. The absence of significant side effects observed in current antipsychotic drug therapy seems to be an essential benefit of the oil.

Potential complications of nonsteroidal anti-inflammatory drug therapy

1989 ◽  
Vol 79 (12) ◽  
pp. 605-614
Author(s):  
GD Corrigan ◽  
L Pantig-Felix ◽  
IO Kanat
Keyword(s):  
Health Care ◽  
Patient Satisfaction ◽  
Drug Therapy ◽  
Side Effects ◽  
Mechanism Of Action ◽  
Drug Class ◽  
Inflammatory Drug ◽  
The Us ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

Since indomethacin was first marketed, some 40 years ago, the class of nonsteroidal anti-inflammatory drugs has grown larger than any other drug class in history. At present, there are at least 25 such drugs being used in the US and abroad, both clinically and in research. Despite their widespread use, their implications to health care are just beginning to be understood. The authors review updated theories on the mechanism of action, side effects, and drug interactions of nonsteroidal anti-inflammatory drug therapy. Proposed guidelines for monitoring their use are given. A more thorough understanding of the risks-to-benefits ratio is provided in an effort to achieve maximum patient satisfaction and safety.

scholarly journals EFFEKTIFITAS OBAT HERBAL TERHADAP PENYEMBUHAN JERAWAT : A Systematic Review

2021 ◽  
Vol 1 (2) ◽  
pp. 152-162
Author(s):  
Al Ihksan Agus
Keyword(s):  
Side Effects ◽  
Skin Diseases ◽  
Aloe Vera ◽  
Punica Granatum ◽  
Herbal Remedies ◽  
Tea Tree ◽  
Common Skin ◽  
Herbal Plants ◽  
Aloe Ferox ◽  
Anti Inflammatory

Acne is one of the most common skin diseases and usually affects almost everyone. Herbal remedies can be given to treat acne and do not cause side effects. The purpose of writing is to see the effectiveness of herbal remedies for healing acne. Methods: Recent literature reviews were conducted using the electronic databases of Pubmed, Wiley Online and Science Direct. The review method uses keyword terms and phrases of Herbal Medicine, Acne, and Facial Treatment. Results: From the results of 9 studies, it was found that there was anti-acne activity of herbal plants and was relatively safe because there were no severe side effects compared to conventional or synthetic treatments. And there is the effectiveness of herbal remedies for healing acne. Conclusion: Herbal plants have antioxidant, anti-inflammatory, antibacterial and anti-inflammatory effects. Some of the recommended plants based on journal reviews for treating acne include: Nigela Sativa L, Amurense Phellodendron, Tea Tree Oil, Mangosteen Fruit Skin, Aloe Vera, Lavandulla, Paper Murbey, Green Tea, Hops, Aloe Ferox, Punica Granatum (Pomegranate).

scholarly journals Plant-Derived Anti-Inflammatory Compounds: Hopes and Disappointments regarding the Translation of Preclinical Knowledge into Clinical Progress

2014 ◽  
Vol 2014 ◽  
pp. 1-9 ◽  
Author(s):  
Robert Fürst ◽  
Ilse Zündorf
Keyword(s):  
Drug Therapy ◽  
Side Effects ◽  
Chemical Characterization ◽  
Evidence Based ◽  
Inflammatory Processes ◽  
History Of ◽  
Anti Inflammatory ◽  
Pharmacologically Active ◽  
Clinical Potential ◽  
The 19Th Century

Many diseases have been described to be associated with inflammatory processes. The currently available anti-inflammatory drug therapy is often not successful or causes intolerable side effects. Thus, new anti-inflammatory substances are still urgently needed. Plants were the first source of remedies in the history of mankind. Since their chemical characterization in the 19th century, herbal bioactive compounds have fueled drug development. Also, nowadays, new plant-derived agents continuously enrich our drug arsenal (e.g., vincristine, galantamine, and artemisinin). The number of new, pharmacologically active herbal ingredients, in particular that of anti-inflammatory compounds, rises continuously. The major obstacle in this field is the translation of preclinical knowledge into evidence-based clinical progress. Human trials of good quality are often missing or, when available, are frequently not suitable to really prove a therapeutical value. This minireview will summarize the current situation of 6 very prominent plant-derived anti-inflammatory compounds: curcumin, colchicine, resveratrol, capsaicin, epigallocatechin-3-gallate (EGCG), and quercetin. We will highlight their clinical potential and/or pinpoint an overestimation. Moreover, we will sum up the planned trials in order to provide insights into the inflammatory disorders that are hypothesized to be beneficially influenced by the compound.

scholarly journals The use of hyaluronic acid preparations for the treatment of osteoarthritis of the major joints

2021 ◽  
Vol 4 (2) ◽  
pp. 11-16
Author(s):  
O Kalashnikov ◽  
O Sulyma ◽  
T Osadchuk ◽  
V Zayets ◽  
T Nizalov ◽  
...  
Keyword(s):  
Side Effects ◽  
Adverse Side Effects ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
High Level ◽  
Time Of Administration ◽  
Inflammatory Effect ◽  
The Ideal

The authors of the article analyzed the experience of domestic and foreign experts in the effectiveness of the use of HA preparations in the treatment of osteoarthritis of major joints. Background  and  Objective. To analyze the literature sources in order to determine the effectiveness of the use of HA preparations in the treatment of osteoarthritis of major ligaments. Materials and methods. Articles in specialized scientific journals and collections, Internet resource.Results. The analysis of literature sources determined the important role of HA preparations in the supplying and functioning of the articular cartilage. Researchers are inclined to believe that the ideal HA preparation should be as close as possible to the physiological HA of the synovial fluid of the joint. The developed domestic drug Artro-Patch fully corresponds to these parameters. Conclusions. The use of modern injectable HA preparations is advisable at stages 1–3 of OA. Anti-inflammatory effect of HA preparations makes it possible to reduce the dose and time of administration of non-steroidal anti-inflammatory drugs and, as a consequence, reduce the risk of developing many adverse side effects of NSAIDs. The high level of safety of HA preparations, the absence of serious side effects during their long-term use determine their widespread use in the clinical practice of modern orthopedists.

Nonsteroidal Anti-Inflammatory Drug Therapy and Gastric Side Effects

Drugs ◽  
1990 ◽  
Vol 40 (Supplement 5) ◽  
pp. 16-24 ◽  
Author(s):  
P. Dandona ◽  
J.Y. Jeremy
Keyword(s):  
Drug Therapy ◽  
Side Effects ◽  
Inflammatory Drug ◽  
Anti Inflammatory

scholarly journals Hearbal Detox Extract Formulation From Seven Wonderful Natural Herbs: Garlic, Ginger, Honey, Carrots, Aloe Vera, Dates, & Corn

1970 ◽  
Vol 7 (3) ◽  
pp. 22-30
Author(s):  
Mohammed Yerima Saleh ◽  
Saurabh Chaturvedi ◽  
Bello Ibrahim ◽  
Mohammed Shahid Khan ◽  
Harshita Jain ◽  
...  
Keyword(s):  
Side Effects ◽  
Herbal Remedy ◽  
Aloe Vera ◽  
Current Mode ◽  
Tobacco Products ◽  
Suitable Alternative ◽  
Adverse Side Effects ◽  
Beneficial Effects ◽  
Synthetic Drugs ◽  
Natural Remedy

The current mode of treatment of various diseases that cause as result of tobacco products based on synthetic drugs is very expensive, insalubrious and also not obtainable to all patients,  at the same time these drugs alters genetics and metabolic pathways and also shows great adverse side effects to many patients. Hence, a safe and effective alternative natural remedy is needed to prevent the disease development and progression. In this lookout, natural recipes are indeed healthy and good remedy in the treatment/management of diseases that cause as result of tobacco products and these natural herbs are affordable, accessible and effective without any adverse side effects. These seven wonderful natural recipes (Garlic, ginger, honey, carrots, aloe Vera, dates & corn) are considered to be the most significant ancient herbs that have been used as an herbal remedy for over 2500 years all over the world. Although this research is first of its kind, because there was no such research conducted by any researcher who combined these seven wonderful natural recipes as a therapeutics, however there were several similar earlier studies on one or combination of either these recipes which have shown a very remarkable and suitable alternative remedy in various diseases cure without any side effects. This juice extracts from seven wonderful natural recipes are of paramount important with an immense medical properties and health beneficial effects that treats cancer further complications, cleanse the nicotine & tar from lungs that cause as a result of tobacco uses, boost immune system, as well as serve as an antibiotic in the remedy of many ailments.    

General Practitioners' Evaluation of Side-Effects and Efficacy of Oxamethacin as Compared with Indomethacin

1980 ◽  
Vol 8 (2) ◽  
pp. 156-162 ◽  
Author(s):  
J Polderman ◽  
M Colon
Keyword(s):  
Clinical Trial ◽  
Drug Therapy ◽  
Side Effects ◽  
General Practitioners ◽  
Double Blind ◽  
Inflammatory Drug ◽  
Pathological Conditions ◽  
Maximum Duration ◽  
Double Blind Clinical Trial ◽  
Anti Inflammatory

Sixteen general practitioners conducted a multicentre double-blind clinical trial to compare oxamethacin (100 mg t.i.d.) with indomethacin (50 mg t.i.d.) for a maximum duration of 2 weeks. Each drug was administered to 339 patients suffering from various pathological conditions requiring a non steroidal anti-inflammatory drug. When focusing on patients without associated drug therapy, 126/250 patients (50%) presented a good response on inflammation under oxamethacin and 98/236 patients (42%) a good response under indomethacin (p < 10−2); 141/250 patients (56%) presented a good response on pain under oxamethacin and 117/236 (50%) under indomethacin (p<5.10−2). Side effects and complaints were reported by 34/250 patients (14%) under oxamethacin and by 67/236 (28%) under indomethacin (p < 5.10−5). Some patients stopped treatment because of side-effects: 14/250 (6%) under oxamethacin and 32/236 (14%) under indomethacin (p < 2.10−3).

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