scholarly journals Investigation of the Characteristics of NLS-PNA: Influence of NLS Location on Invasion Efficiency

2020 ◽  
Vol 10 (23) ◽  
pp. 8663
Author(s):  
Yuichiro Aiba ◽  
Gerardo Urbina ◽  
Masanari Shibata ◽  
Osami Shoji
Keyword(s):  
Nucleic Acid ◽  
Peptide Nucleic Acid ◽  
Promising Method ◽  
Nuclear Localisation Signal ◽  
Nuclear Localisation ◽  
Future Design ◽  
Double Stranded Dna ◽  
The Future

Peptide nucleic acid can recognise sequences in double-stranded DNA (dsDNA) through the formation of a double-duplex invasion complex. This double-duplex invasion is a promising method for the recognition of dsDNA in cellula because peptide nucleic acid (PNA) invasion does not require the prior denaturation of dsDNA. To increase its applicability, we developed PNAs modified with a nuclear localisation signal (NLS) peptide. In this study, the characteristics of NLS-modified PNAs were investigated for the future design of novel peptide-modified PNAs.

scholarly journals Cooperative strand invasion of double-stranded DNA by peptide nucleic acid

2005 ◽  
Vol 49 (1) ◽  
pp. 167-168 ◽  
Author(s):  
Toru Sugiyama ◽  
Yasutada Imamura ◽  
Wataru Hakamata ◽  
Masaaki Kurihara ◽  
Atsushi Kittaka
Keyword(s):  
Nucleic Acid ◽  
Peptide Nucleic Acid ◽  
Double Stranded Dna ◽  
Strand Invasion

scholarly journals Furan-PNA: a mildly inducible irreversible interstrand crosslinking system targeting single and double stranded DNA

2016 ◽  
Vol 52 (42) ◽  
pp. 6930-6933 ◽  
Author(s):  
A. Manicardi ◽  
E. Gyssels ◽  
R. Corradini ◽  
A. Madder
Keyword(s):  
Nucleic Acid ◽  
Peptide Nucleic Acid ◽  
Double Stranded Dna ◽  
Dna Strand ◽  
Interstrand Crosslinking

Furan-modified peptide nucleic acid (PNA) probes are able to crosslink to DNA strand after hybridization with complementary ssDNA or after stand displacement in dsDNA.

Quinoxaline Antibiotics Enhance Peptide Nucleic Acid Binding to Double-Stranded DNA†

Biochemistry ◽  
2000 ◽  
Vol 39 (31) ◽  
pp. 9502-9507 ◽  
Author(s):  
Niels Erik Møllegaard ◽  
Christian Bailly ◽  
Michael J. Waring ◽  
Peter E. Nielsen
Keyword(s):  
Nucleic Acid ◽  
Peptide Nucleic Acid ◽  
Nucleic Acid Binding ◽  
Double Stranded Dna

Recognition of Double-Stranded Dna by Peptide Nucleic Acid

1997 ◽  
Vol 16 (5-6) ◽  
pp. 599-602 ◽  
Author(s):  
Pernilla Wittung ◽  
Peter Nielsen ◽  
Bengt Nordén
Keyword(s):  
Nucleic Acid ◽  
Peptide Nucleic Acid ◽  
Double Stranded Dna
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