scholarly journals High-affinity triplex targeting of double stranded DNA using chemically modified peptide nucleic acid oligomers

2009 ◽  
Vol 37 (13) ◽  
pp. 4498-4507 ◽  
Author(s):  
Mads E. Hansen ◽  
Thomas Bentin ◽  
Peter E. Nielsen
Keyword(s):  
Nucleic Acid ◽  
Peptide Nucleic Acid ◽  
Chemically Modified ◽  
High Affinity ◽  
Double Stranded Dna

scholarly journals Recent Advances in Chemical Modification of Peptide Nucleic Acids

2012 ◽  
Vol 2012 ◽  
pp. 1-8 ◽  
Author(s):  
Eriks Rozners
Keyword(s):  
Nucleic Acid ◽  
Nucleic Acids ◽  
Peptide Nucleic Acid ◽  
Peptide Nucleic Acids ◽  
Chemical Modifications ◽  
Practical Applications ◽  
High Affinity ◽  
Dna And Rna ◽  
Double Stranded Dna ◽  
Ongoing Effort

Peptide nucleic acid (PNA) has become an extremely powerful tool in chemistry and biology. Although PNA recognizes single-stranded nucleic acids with exceptionally high affinity and sequence selectivity, there is considerable ongoing effort to further improve properties of PNA for both fundamental science and practical applications. The present paper discusses selected recent studies that improve on cellular uptake and binding of PNA to double-stranded DNA and RNA. The focus is on chemical modifications of PNA's backbone and heterocyclic nucleobases. The paper selects representative recent studies and does not attempt to provide comprehensive coverage of the broad and vibrant field of PNA modification.

scholarly journals Cooperative strand invasion of double-stranded DNA by peptide nucleic acid

2005 ◽  
Vol 49 (1) ◽  
pp. 167-168 ◽  
Author(s):  
Toru Sugiyama ◽  
Yasutada Imamura ◽  
Wataru Hakamata ◽  
Masaaki Kurihara ◽  
Atsushi Kittaka
Keyword(s):  
Nucleic Acid ◽  
Peptide Nucleic Acid ◽  
Double Stranded Dna ◽  
Strand Invasion

High-Affinity Homologous Peptide Nucleic Acid Probes for Targeting a Quadruplex-Forming Sequence from aMYCPromoter Element†

Biochemistry ◽  
2007 ◽  
Vol 46 (37) ◽  
pp. 10433-10443 ◽  
Author(s):  
Subhadeep Roy ◽  
Farial A. Tanious ◽  
W. David Wilson ◽  
Danith H. Ly ◽  
Bruce A. Armitage
Keyword(s):  
Nucleic Acid ◽  
Peptide Nucleic Acid ◽  
Nucleic Acid Probes ◽  
High Affinity ◽  
Homologous Peptide

scholarly journals Furan-PNA: a mildly inducible irreversible interstrand crosslinking system targeting single and double stranded DNA

2016 ◽  
Vol 52 (42) ◽  
pp. 6930-6933 ◽  
Author(s):  
A. Manicardi ◽  
E. Gyssels ◽  
R. Corradini ◽  
A. Madder
Keyword(s):  
Nucleic Acid ◽  
Peptide Nucleic Acid ◽  
Double Stranded Dna ◽  
Dna Strand ◽  
Interstrand Crosslinking

Furan-modified peptide nucleic acid (PNA) probes are able to crosslink to DNA strand after hybridization with complementary ssDNA or after stand displacement in dsDNA.

Quinoxaline Antibiotics Enhance Peptide Nucleic Acid Binding to Double-Stranded DNA†

Biochemistry ◽  
2000 ◽  
Vol 39 (31) ◽  
pp. 9502-9507 ◽  
Author(s):  
Niels Erik Møllegaard ◽  
Christian Bailly ◽  
Michael J. Waring ◽  
Peter E. Nielsen
Keyword(s):  
Nucleic Acid ◽  
Peptide Nucleic Acid ◽  
Nucleic Acid Binding ◽  
Double Stranded Dna

Recognition of Double-Stranded Dna by Peptide Nucleic Acid

1997 ◽  
Vol 16 (5-6) ◽  
pp. 599-602 ◽  
Author(s):  
Pernilla Wittung ◽  
Peter Nielsen ◽  
Bengt Nordén
Keyword(s):  
Nucleic Acid ◽  
Peptide Nucleic Acid ◽  
Double Stranded Dna
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