scholarly journals Editorial on Special Issue “Tuberculosis Drug Discovery and Development 2019”

2020 ◽  
Vol 10 (17) ◽  
pp. 6069
Author(s):  
Claudia Sala ◽  
Laurent Roberto Chiarelli ◽  
Giovanna Riccardi
Keyword(s):  
Infectious Disease ◽  
Mycobacterium Tuberculosis ◽  
Drug Discovery ◽  
Human Health ◽  
Cause Of Death ◽  
Etiological Agent ◽  
Special Issue ◽  
Drug Discovery And Development ◽  
Global Challenge

Mycobacterium tuberculosis, the etiological agent of human tuberculosis (TB), represents a global challenge to human health since it is the main cause of death by an infectious disease worldwide [...]

scholarly journals New therapeutic modalities in drug discovery and development: Insights & opportunities

ADMET & DMPK ◽  
2021 ◽  
Vol 9 (4) ◽  
pp. 227-230
Author(s):  
Manfred Kansy ◽  
Giulia Caron
Keyword(s):  
Drug Discovery ◽  
Special Issue ◽  
Drug Discovery And Development ◽  
Therapeutic Modalities

New Therapeutic Modalities in Drug Discovery and Development: Insights & Opportunities (Editorial for the special issue of ADMET and DMPK)

MiR-495 regulates cellular ROS levels by targeting sod2 to inhibit intracellular survival of Mycobacterium tuberculosis in macrophages

2021 ◽  
Author(s):  
Xuanxiu Ren ◽  
Wenqi Dong ◽  
Jiajia Feng ◽  
Pei Li ◽  
Yucheng Zheng ◽  
...  
Keyword(s):  
Infectious Disease ◽  
Mycobacterium Tuberculosis ◽  
Human Health ◽  
Theoretical Basis ◽  
Drug Targets ◽  
Early Stage ◽  
Intracellular Survival ◽  
Laboratory Research ◽  
Bacillus Calmette Guerin ◽  
Major Infectious Disease

Mycobacterium tuberculosis is a chronic infectious disease pathogen. To date, tuberculosis is a major infectious disease that endangers human health. To better prevent and treat tuberculosis, it is important to study the pathogenesis of M. tb . Based on early-stage laboratory research results, in this study, we verified the upregulation of sod2 in Bacillus Calmette–Guérin ( BCG ) and H37Rv infection. By detecting BCG / H37Rv intracellular survival in sod2 -silenced and sod2 - overexpressing macrophages, sod2 was found to promote the intracellular survival of BCG / H37Rv. Then, miR-495 was determined to be downregulated by BCG / H37Rv . BCG / H37Rv can upregulate sod2 expression by miR-495 to promote the intracellular survival of BCG / H37Rv through a decline in ROS levels. This study provides a theoretical basis for developing new drug targets and treating tuberculosis.

Hybridization approach to drug discovery inhibiting Mycobacterium tuberculosis. An overview.

2020 ◽  
Vol 20 ◽  
Author(s):  
Daniele Zampieri ◽  
Maria G. Mamolo
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Drug Discovery ◽  
Cause Of Death ◽  
Medicinal Chemistry ◽  
Causes Of Death ◽  
Infectious Agent ◽  
Drug Resistant ◽  
New Chemical Entities ◽  
Hybrid Ligands

: Tuberculosis is one of the top 10 causes of death worldwide and the leading cause of death from a single infectious agent mainly due to Mycobacterium tuberculosis (MTB). Recently, clinical prognoses have worsened due to the emergence of multi-drug resistant (MDR) and extensive-drug resistant (XDR) tuberculosis which lead to the need of new, efficient and safely drugs. Among the several strategies, polypharmacology could be considered one of the best solutions, in particular the multi-target directed ligands strategy (MTDLs), based on the synthesis of hybrid ligands acting against two targets of the pathogen. The framework strategy comprises linking, fusing and merging approaches to develop new chemical entities. With these premises, this review aims to provide an overview of recent hybridization approach, in medicinal chemistry, of the most recent and promising multitargeting antimycobacterial candidates.

scholarly journals Editorial for the Special Issue on Micro/Nanofluidic Devices for Single Cell Analysis, Volume II

Micromachines ◽  
2021 ◽  
Vol 12 (8) ◽  
pp. 875
Author(s):  
Tuhin Subhra Santra ◽  
Fan-Gang Tseng
Keyword(s):  
Drug Discovery ◽  
Single Cell ◽  
Single Cell Analysis ◽  
Compositional Heterogeneity ◽  
Cell Analysis ◽  
Special Issue ◽  
Drug Discovery And Development ◽  
Nanofluidic Devices

The functional, genetic, or compositional heterogeneity of healthy and diseased tissues promotes significant challenges to drug discovery and development [...]

scholarly journals Exploitation of Mangrove Endophytic Fungi for Infectious Disease Drug Discovery

Marine Drugs ◽  
2018 ◽  
Vol 16 (10) ◽  
pp. 376 ◽  
Author(s):  
Danielle Demers ◽  
Matthew Knestrick ◽  
Renee Fleeman ◽  
Rahmy Tawfik ◽  
Ala Azhari ◽  
...  
Keyword(s):  
Infectious Disease ◽  
Mycobacterium Tuberculosis ◽  
Drug Discovery ◽  
Small Molecules ◽  
Endophytic Fungi ◽  
Dna Methyltransferase ◽  
Leishmania Donovani ◽  
Screening Program ◽  
Single Target ◽  
New Antibiotics

There is an acute need for new and effective agents to treat infectious diseases. We conducted a screening program to assess the potential of mangrove-derived endophytic fungi as a source of new antibiotics. Fungi cultured in the presence and absence of small molecule epigenetic modulators were screened against Mycobacterium tuberculosis and the ESKAPE panel of bacterial pathogens, as well as two eukaryotic infective agents, Leishmania donovani and Naegleria fowleri. By comparison of bioactivity data among treatments and targets, trends became evident, such as the result that more than 60% of active extracts were revealed to be selective to a single target. Validating the technique of using small molecules to dysregulate secondary metabolite production pathways, nearly half (44%) of those fungi producing active extracts only did so following histone deacetylase inhibitory (HDACi) or DNA methyltransferase inhibitory (DNMTi) treatment.

Drug Discovery and Development Strategies for COVID-19

2020 ◽  
Vol 2 (2) ◽  
pp. 1-5
Author(s):  
Aarajana Shrestha ◽  
Tara Man Kadayat
Keyword(s):  
Drug Discovery ◽  
Drug Development ◽  
Development Strategies ◽  
Special Issue ◽  
Medical Sciences ◽  
Drug Discovery And Development ◽  
Current Drug ◽  
The World ◽  
Global Threat ◽  
Effective Drugs

COVID-19 Special Issue: Coronavirus Disease 2019 (COVID-19) has emerged as a global threat. Scientists and clinicians are endeavoring to find effective drugs and vaccines for this disease. This special issue of the Europasian Journal of Medical Sciences (EJMS) aims to cover the problems, solutions, and challenges of COVID-19 around the world. In this Editorial, EJMS Editors Aarajana Shrestha and Tara Man Kadayat highlight the processes of drug discovery and development and a brief overview of the current drug development strategies against COVID-19.

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