scholarly journals Application of Molecularly Imprinted Polymers (MIP) and Flowing Atmospheric-Pressure Afterglow Mass Spectrometry (FAPA-MS) to Analysis of Nonsteroidal Anti-Inflammatory Drugs (NSAIDs)

2020 ◽  
Vol 10 (12) ◽  
pp. 4217 ◽  
Author(s):  
Maria Guć ◽  
Grzegorz Schroeder
Keyword(s):  
Mass Spectrometry ◽  
Atmospheric Pressure ◽  
Solid Phase ◽  
Rapid Development ◽  
Ion Source ◽  
New Method ◽  
Molecularly Imprinted ◽  
Flowing Atmospheric Pressure Afterglow ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

In recent years, the rapid development of the pharmaceutical industry and the extensive and illicit use of painkillers have led to increased levels of nonsteroidal anti-inflammatory drugs (NSAIDs) in the environment. In view of the significant impact of NSAIDs on living organisms, including humans, their presence in the environment needs to be continuously monitored at trace levels. For this purpose, a combination of molecularly imprinted solid-phase extraction (MISPE) and HPLC-MS analysis is commonly used. MISPE has been utilized in direct, fast, and ecological analysis of drugs using a flowing atmospheric-pressure afterglow ion source for mass spectrometry (FAPA-MS). The new method was applied herein in the determination of naproxen, diclofenac, and ibuprofen. The linear dependence of the intensity of analytical signals on the amount of drugs is in the range of 0.2 μg to 1 g and the method detection limit (MDL) for all drugs is 0.2 μg in environmental samples. The new method also decreased the number of analytical stages, the time and cost of analysis, and the organic solvent consumption, besides being environmentally friendly.

scholarly journals Application of Molecularly Imprinted Polymers (MIP) and Magnetic Molecularly Imprinted Polymers (mag-MIP) to Selective Analysis of Quercetin in Flowing Atmospheric-Pressure Afterglow Mass Spectrometry (FAPA-MS) and in Electrospray Ionization Mass Spectrometry (ESI-MS)

Molecules ◽  
2019 ◽  
Vol 24 (13) ◽  
pp. 2364 ◽  
Author(s):  
Maria Guć ◽  
Grzegorz Schroeder
Keyword(s):  
Mass Spectrometry ◽  
Molecularly Imprinted Polymer ◽  
Molecularly Imprinted Polymers ◽  
Atmospheric Pressure ◽  
Imprinted Polymer ◽  
Molecularly Imprinted ◽  
Imprinted Polymers ◽  
Esi Ms ◽  
Positive Ions ◽  
Flowing Atmospheric Pressure Afterglow

Molecularly imprinted polymer (MIP) and magnetic molecularly imprinted polymer (mag-MIP) for solid extraction and pre-concentration of quercetin have been successfully prepared by thermal polymerization method using quercetin (Q) as a template, acrylamide (AA) as a functional monomer, and ethylene glycol dimethacrylate (EGDMA) as a cross-linking agent. The MIP and mag-MIP were successfully applied in analysis of quercetin by mass spectrometry (MS) methods. To perform ambient plasma ionization experiments, a setup consisting of the heated crucible, a flowing atmospheric-pressure afterglow (FAPA) plasma ion source, and amaZon SL ion trap (Bruker, Bremen, Germany) was used. The heated crucible with programmable temperature allowed desorption of the analytes from MIPs structure which resulted in their direct introduction into the ion stream. The results of Q-MIP/Q-mag-MIP and FAPA-MS measurements were compared with those of the analysis of quercetin by the ESI-MS method without extractions and pre-concentration of analytes on polymers. Limits of detection (LOD) for quercetin solutions in both positive and negative ESI-MS were established at 10−8 M and 10−7 M, respectively. The linearity (R2 = 0.9999) of the proposed analytical procedure for quercetin determination in positive ions was provided in the range between 10−4 M and 10−7 M. Moreover, the same parameters were established for FAPA-MS in positive ions, reaching LOD at 0.005 mg/gMIP and the linearity of the method in the range of 0.015–0.075 mg/gMIP with the correlation coefficient value R2 = 0.9850.

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