scholarly journals Is Sleep Associated with the S-Klotho Anti-Aging Protein in Sedentary Middle-Aged Adults? The FIT-AGEING Study

Antioxidants ◽  
2020 ◽  
Vol 9 (8) ◽  
pp. 738
Author(s):  
Sol Mochón-Benguigui ◽  
Almudena Carneiro-Barrera ◽  
Manuel J. Castillo ◽  
Francisco J. Amaro-Gahete
Keyword(s):  
Sleep Quality ◽  
Plasma Levels ◽  
Sleep Onset ◽  
Enzyme Linked Immunosorbent Assay ◽  
Middle Aged ◽  
Subjective Sleep Quality ◽  
Study Objective ◽  
Sleep Quantity ◽  
Subjective Sleep ◽  
Middle Aged Adults

Sleep and Klotho have both been closely related to the ageing process, both playing a substantial role in the endocrine and immune systems and, thereby, in oxidative stress and chronic inflammation. However, there are no studies elucidating the relationship between sleep and Klotho. Therefore, this study investigated the association of sleep quantity and quality with the shed form of the α-Klotho gene (S-Klotho plasma levels) in sedentary middle-aged adults. A total of 74 volunteers (52.7% women; aged 53.7 ± 5.1) were recruited for the present study. Objective sleep quality parameters (total sleep time (TST), wake after sleep onset (WASO), and sleep efficiency (SE)) were determined using a wrist-worn accelerometer over seven consecutive days, and the subjective sleep quality was assessed by the Pittsburgh Sleep Quality Index (PSQI; higher scores indicate worse sleep quality). The S-Klotho plasma levels were measured in the ethylenediaminetetraacetic acid plasma using a solid-phase sandwich enzyme-linked immunosorbent assay. Objective sleep parameters were associated with the S-Klotho plasma levels only after including the age, fat mass percentage, and lean mass index as covariates. A direct relationship was observed between the subjective sleep quality (inverse of PSQI scores) and the S-Klotho plasma levels in sedentary middle-aged adults. Improving sleep quantity and quality could be considered an anti-aging therapeutic approach for the prevention, slowing, and even reversal of the physiological decline and degenerative pathologies that are certainly related to the aging process.

scholarly journals Relationship between Cortisol Changes during the Night and Subjective and Objective Sleep Quality in Healthy Older People

2020 ◽  
Vol 17 (4) ◽  
pp. 1264
Author(s):  
Matias M. Pulopulos ◽  
Vanesa Hidalgo ◽  
Sara Puig-Perez ◽  
Teresa Montoliu ◽  
Alicia Salvador
Keyword(s):  
Sleep Quality ◽  
Older People ◽  
Hpa Axis ◽  
Sleep Onset ◽  
Quality Data ◽  
Sleep Diary ◽  
Subjective Sleep Quality ◽  
Sleep Quantity ◽  
Subjective Sleep ◽  
Subjective Socioeconomic Status

The aim of this study was to investigate whether the nighttime cortisol release was associated with subjective and objective sleep quality and the discrepancy between them. Forty-five healthy older adults (age range from 56 to 75 years) collected salivary samples immediately before sleep and immediately after awakening on two consecutive nights. Actigraphy was used to assess objective sleep quality and quantity. A sleep diary was used to assess subjective sleep quality. Linear mixed models were performed using subjective and objective sleep quality data from 76 nights to investigate between-subject associations. We observed that larger changes in cortisol levels between sleep onset and awakening, reflecting a healthier circadian rhythm of the Hypothalamic-Pituitary-Adrenal (HPA) axis, were associated with better subjective sleep quality, but not with objective sleep quality. Moreover, smaller changes in nighttime cortisol were associated with lower subjective sleep quality relative to objective sleep quality. All these results were observed even after controlling for important confounders such as sleep quantity, age, sex, subjective socioeconomic status, stress perception, depression, physical activity, and adherence to the salivary sampling protocol. This study demonstrates that subjective sleep quality in older people may be explained, to some extent, by the activity of the HPA axis.

The Effect of Uncoupled Sleep and Dysfunctional Sleep Beliefs on Sleep Outcomes in Older Adults following Online Cognitive Behavioral Therapy for Insomnia: A Single-Group Non-randomized Trial (Preprint)

2021 ◽  
Author(s):  
Yvonne Kutzer ◽  
Lisa Whitehead ◽  
Eimear Quigley ◽  
Shih Ching Fu ◽  
Mandy Stanley
Keyword(s):  
Older Adults ◽  
Cognitive Behavioral Therapy ◽  
Sleep Quality ◽  
Mixed Model ◽  
Linear Mixed Model ◽  
Behavioral Therapy ◽  
Sleep Onset ◽  
Poor Sleep ◽  
Subjective Sleep Quality ◽  
Subjective Sleep

BACKGROUND The current Covid-19 pandemic has brought about a marked interest in sleep health, as well as an increased demand for telehealth services, such as online Cognitive Behavioral Therapy for insomnia (CBT-I). Older adults in particular report a high rate of sleep problems. Recent studies have suggested that dysfunctional sleep beliefs could contribute to the high rates of self-reported insomnia in this age group. In addition, older adults have an increased rate of uncoupled sleep, e.g. displaying an insomnia complaint in the absence of objectively measured poor sleep. It is essential to determine the prevalence of coupled and uncoupled sleep in older adults and to examine the efficacy of online CBT-I to improve sleep outcomes. OBJECTIVE This study aims to assess objective and subjective sleep quality and dysfunctional sleep beliefs in a sample of community-dwelling older adults aged 60-80 years with and without uncoupled sleep in Western Australia following digitally delivered CBT-I. METHODS Objective sleep was measured using wrist actigraphy, and subjective sleep quality via sleep diaries and the Pittsburgh Sleep Quality Index (PSQI). Dysfunctional sleep beliefs were assessed by the Dysfunctional Beliefs and Attitudes about Sleep scale (DBAS-16) prior to and following a four-week online CBT-I programme. Linear mixed model and generalised linear mixed model analyses were conducted to examine objective and subjective sleep onset latency, total sleep time, wake after sleep onset and number of awakenings as well as PSQI and DBAS16 scores, respectively. RESULTS 62 participants (55 females; 88.7%) completed the study. CBT-I effectively reduced dysfunctional sleep beliefs and PSQI scores across all sleep classifications, even in good sleepers without a sleep complaint. Objective and self-reported changes in sleep parameters were mainly demonstrated in complaining poor sleepers. Complaining good sleepers reported a decrease in the number of subjective sleep awakenings only. CONCLUSIONS Online CBT-I was effective in improving the sleep outcomes of individuals who had both subjective and objective poor sleep. However, as the online CBT-I reduced dysfunctional sleep beliefs in all sleep groups, further examination of dysfunctional sleep beliefs and whether they mediate the outcomes of digital CBT-I in older adults will need to be conducted. CLINICALTRIAL Australian New Zealand Clinical Trials Registry (ANZCTR), ACTRN 12619001509156; http://www.anzctr.org.au/Trial/Registration/TrialReview.aspx?id=378451 INTERNATIONAL REGISTERED REPORT RR2-32705

scholarly journals Dietary Inflammatory Index and S-Klotho Plasma Levels in Middle-Aged Adults

Nutrients ◽  
2020 ◽  
Vol 12 (2) ◽  
pp. 281 ◽  
Author(s):  
Lucas Jurado-Fasoli ◽  
Manuel J. Castillo ◽  
Francisco J. Amaro-Gahete
Keyword(s):  
Plasma Levels ◽  
Solid Phase ◽  
Positive Association ◽  
Enzyme Linked Immunosorbent Assay ◽  
Dietary Inflammatory Index ◽  
Middle Aged ◽  
Close Link ◽  
Food Frequency ◽  
Inflammatory Index ◽  
Middle Aged Adults

Background: Soluble Klotho (S-Klotho) is an aging suppressor with a close link with inflammation. However, it is still unknown whether the dietary inflammatory potential is associated with S-Klotho plasma level. We aimed to investigate the association of the Dietary Inflammatory Index (DII) with S-Klotho plasma levels in middle-aged sedentary adults. Methods: 73 middle-aged sedentary adults (40–65 years old) participated in the present study. DII was determined from 28 dietary items obtained by 24 h recalls and food frequency questionnaires. The S-Klotho plasma levels were measured using a solid-phase sandwich enzyme-linked immunosorbent assay. Results: a weak positive association was observed between DII and S-Klotho plasma levels (β = 52.223, R2 = 0.057, p = 0.043), which disappeared after controlling for body mass index (p = 0.057). Conclusions: A pro-inflammatory dietary pattern measured with the DII was slightly and positively associated with S-Klotho plasma levels in middle-aged sedentary adults.

scholarly journals Subjective sleep quality and association with depression syndrome, chronic diseases and health-related physical fitness in the middle-aged and elderly

2021 ◽  
Author(s):  
Min-Fang Hsu ◽  
Kang-Yun Lee ◽  
Tsung-Ching Lin ◽  
Wen-Te Liu ◽  
Shu-Chuan Ho
Keyword(s):  
Depressive Symptoms ◽  
Physical Fitness ◽  
Sleep Quality ◽  
Chronic Diseases ◽  
Sleep Latency ◽  
Middle Aged ◽  
Subjective Sleep Quality ◽  
Subjective Sleep ◽  
Self Rated Health ◽  
Health Related

Abstract Background: As a complex phenomenon, sleep quality is difficult to objectively define and measure, and multiple factors related to sleep quality, such as age, lifestyle, physical activity, and physical fitness, feature prominently in older adult populations. The aim of the present study was to evaluate subjective sleep quality using the Pittsburgh Sleep Quality Index (PSQI) and to associate sleep quality with health-related physical fitness factors, depressive symptoms, and the number of chronic diseases in the middle-aged and elderly.Methods: We enrolled a total of 283 middle-aged and elderly participants from a rehabilitation clinic or health examination department. The PSQI was used to evaluate sleep quality. The health-related fitness assessment included anthropometric and physical fitness parameters. Depressive symptoms were measured with the Center for Epidemiologic Studies Depression Scale (CES-D) short form. Data were analyzed with SPSS 18.0, and descriptive statistics and logistic regression analysis were used for the analyses.Results: Overall, 27.9% of participants in this study demonstrated bad sleepers (with a PSQI score of >5), 10.2% of study participants frequently used sleep medication to help them fall asleep, and 6.0% reported having significant depressive symptoms (with a CES-D score of ≥10). There are two major findings: (1) depression symptoms, the number of chronic diseases, self-rated health, and arthritis were significantly associated with a poor sleep quality, and (2) the 2-min step test was associated with longer sleep latency. These results confirmed that the 2-min step was associated with a longer sleep latency among the health-related physical fitness items.Conclusions: Our study found that depressive syndrome, chronic disease numbers, a poor self-rated health status, and arthritis were the main risk factors that influenced subjective sleep quality.

scholarly journals Effect of kidney transplantation on sleep quality in patients admitted in ICU:a cross-section study in China

2019 ◽  
Author(s):  
Lu Long ◽  
Jia Liu ◽  
Jin Yan ◽  
Jian fei Xie ◽  
Huan Liu ◽  
...  
Keyword(s):  
Kidney Transplantation ◽  
Sleep Quality ◽  
Linear Regression Analysis ◽  
Sleep Onset ◽  
Sleep Time ◽  
Middle Level ◽  
Sleep Disruption ◽  
Poor Sleep ◽  
Subjective Sleep Quality ◽  
Subjective Sleep

Abstract Background Although evidences showed that sleep disorder is common in patient with end stage renal disease (ESRD), less is known about their sleep quality after early post-kidney transplantation (kTx) especially in Intensive Care Unite (ICU). Thus, the purpose of this study is to investigate sleep quality of kTx recipients in ICU and explore factors related poor sleep, second, to measure the correlation of subjective sleep quality and sleep architecture assessed by PSG in kTx recipients. Methods This study recruited participants from ESRD patients registered in transplantation waiting list at the third xiangya hospital of central south university in China. Participants required to complete the Pittsburgh sleep quality index(PSQI) and demographic questionnaire as baseline data and received one night of Polysomnography (PSG) in the ICU within 96 hours of surgery, during which time sound and light data were monitored. After that Richards Campbell sleep questionnaires (RCSQ) also need completed. Results 26 participants self-reported sleep quality and sleep efficiency based on RCSQ was at middle level (49.2 ± 25.6mm), and 14/26(53.8%) kTx recipients in ICU were poor sleepers defined by RCSQ <50. PSG showed that most kTx recipients in ICU had shallow sleep with mainly stage 2 sleep time (80.90 ±70.10 min), lower total sleep time (136.50 ±86.41 min), higher awakening frequency after sleep onset (8.87 ±5.92 times) and long awaken time (94.67 ±75.09 min) when a sleep disruption occured. multiple linear regression analysis showed that self-reported noise and pain were the significant factor affecting sleep(P < 0.05).Conclusion Subjective sleep quality based on RCSQ scored better than objective one measured by PSG in kTx recipients, sleep disruption always remained a substantial problem and affected by self-reported noise and pain.

scholarly journals The serotonin transporter gene-linked polymorphic region (5-HTTLPR) and the sleep-promoting effects of tryptophan: A randomized placebo-controlled crossover study

2019 ◽  
Vol 33 (8) ◽  
pp. 948-954
Author(s):  
Jens H van Dalfsen ◽  
C Rob Markus
Keyword(s):  
Sleep Quality ◽  
Allelic Variation ◽  
Sleep Onset ◽  
Treatment Protocol ◽  
Sleep Diary ◽  
Transporter Gene ◽  
Subjective Sleep Quality ◽  
Subjective Sleep ◽  
Allele Group ◽  
S Allele

Background:The low-expressive short (S) allele of a functional polymorphism (5-HTTLPR) within the serotonin (5-hydroxytriptamine; 5-HT) transporter gene (SLC6A4) has been associated with a reduced functioning of the brain 5-HT system relative to the long (L) allele. As a consequence, the S-allele is found to predispose individuals to a higher risk of sleep quality reduction and clinical insomnia.Aims:The present study investigated whether subchronic pre-sleep tryptophan administration could compensate for this predisposition by improving sleep in 5-HTTLPR S-allele carriers.Methods:In a double-blind placebo-controlled crossover design a sample of homozygous 5-HTTLPR S-allele ( n = 47) and L-allele ( n = 51) carriers were assessed for subjective (sleep diary) and objective (actigraphy) sleep during a treatment protocol consisting of 1 week of placebo (1000 mg/day) and 1 week of tryptophan administration (1000 mg/day).Results:The results support the sleep-promoting effects of tryptophan. Tryptophan improved objective sleep efficiency and objective wake after sleep onset irrespective of allelic variation. There was a marginally significant improvement of subjective sleep quality in the 5-HTTLPR S-allele group but not in the L-allele group following tryptophan relative to placebo intake. In contrast, a significantly poorer sleep quality in the S-allele as opposed to the L-allele group in the placebo condition was not observed in the tryptophan condition.Conclusions:Tryptophan augmentation promises to be a valuable treatment strategy for sleep impairments related to genetic deficiencies in 5-HT functioning.

scholarly journals Adults Consuming an Energy-Restricted US Healthy-Style Eating Pattern at Either the Recommended or a Higher Protein Quantity Perceive a Shift from “Poor” to “Good” Sleep

2020 ◽  
Vol 4 (Supplement_2) ◽  
pp. 528-528
Author(s):  
Joshua Hudson ◽  
Jing Zhou ◽  
Wayne Campbell
Keyword(s):  
Sleep Quality ◽  
Dietary Protein ◽  
Sleep Onset ◽  
Sleep Onset Latency ◽  
Quality Indices ◽  
Subjective Sleep Quality ◽  
Eating Pattern ◽  
Subjective Sleep ◽  
Good Sleep ◽  
Over Time

Abstract Objectives Limited evidence from secondary analyses suggests consuming a higher protein diet during weight loss improves subjective indices of sleep in adults who are overweight and obese. We sought to a priori assess the effects consuming a U.S. Healthy–Style Eating Pattern with the recommended versus a higher amount of protein and moderate energy-restriction on sleep quality indices. Methods Using of a randomized, parallel-design, 51 men and women (mean ± SEM; age: 47 ± 1 y; BMI: 32.6 ± 0.5 kg/m2) consumed a controlled U.S. Healthy-Style Eating Pattern containing 750 kcal/d less than their estimated energy requirement for 12 wk. The additional dietary protein (7.5 oz-eq/d) came from animal-based protein sources and displaced primarily whole and reined grains. Objective and subjective sleep quality indices were measured using wrist-worn actigraphy and questionnaires (Pittsburgh Sleep Quality Index and Epworth Sleepiness Scale), respectively, at pre-, mid- (week 6), and post-intervention (week 12). Results Among all participants, body mass decreased (-6.2 ± 0.4 kg). Dietary protein intake did not affect any of the objective or subjective sleep quality outcomes measured. Over time, objective measures of time spend in bed, time spent sleeping, sleep efficiency, sleep onset latency, and time awake after sleep onset did not change. Subjective measures of global sleep score (GSS, −3.8 ±0.4 au) and daytime sleepiness score (−3.8 ± 0.4 au; both P &lt; 0.001) improved over time. The GSS improvement transitioned the group of participants from being categorized with a poor to a good sleep condition (GSS &gt;5 versus ≤5 au of 0–21 au scale; Pre 7.9 ± 0.5 au, Post: 4.0 ± 0.6 au). Conclusions Although objective sleep quality may not improve, adults with poor sleep may perceive becoming good sleepers while consuming a moderately energy-restricted U.S. Healthy-Style Eating Pattern containing either the recommended or a higher amount of protein. Funding Sources The Beef Checkoff and American Egg Board-Egg Nutrition Center.

773 The relationship between personality and sleep: Subjective cognition as a mediator

SLEEP ◽  
2021 ◽  
Vol 44 (Supplement_2) ◽  
pp. A301-A301
Author(s):  
Anthony Schmiedeler ◽  
Maggie Connell ◽  
Ashley Curtis
Keyword(s):  
Older Adults ◽  
Sleep Quality ◽  
Personality Traits ◽  
Middle Aged ◽  
Subjective Sleep Quality ◽  
Subjective Sleep ◽  
Everyday Cognition ◽  
Individual Personality ◽  
Cognitive Failures ◽  
The Relationship

Abstract Introduction Research has found relationships between sleep quality and personality traits. Poor subjective sleep quality has been observed within individuals scoring high in Neuroticism and low in Conscientiousness. Personality traits have also been associated with cognitive functioning and the link being worse cognition and poor sleep quality is established. However, less is known regarding the role of cognitive functioning in the relationship between personality and sleep quality, particularly in aging populations. This study investigated whether subjective cognition acted as a mediator between individual personality traits and subjective sleep quality in middle-aged and older adults. Methods Middle-aged and older adults (N=269; Mage= 64.5, SD=7.8; 123 women/146 men) who were cognitively healthy completed an online survey through Qualtrics measuring demographics, personality (Big Five Inventory-10; BFI-10), self-reported sleep (Pittsburgh Sleep Quality Index; PSQI), and subjective everyday cognition (Cognitive Failures Questionnaire; CFQ). Separate mediation analyses using SPSS PROCESS macro [and testing for indirect effects using 5,000 bootstrapped samples and 95% Confidence Interval (CI) and controlling for conditional associations among all pathways] examined whether subjective everyday cognition (CFQ scores) mediated the relationship between different personality traits (BFI-10 Conscientiousness and Neuroticism scores) and self-reported sleep (PSQI-Total Score), controlling for age and sex. Results Neuroticism and PSQI-Total Score was partially mediated by CFQ. There was a significant association between Neuroticism and total PSQI (total effect=0.588, SE=0.110, p&lt;0.001). There were positive associations between Neuroticism and CFQ (a-path effect=2.765, SE=0.383, p&lt;0.001) and CFQ and PSQI (b-path effect=0.068, SE=0.017, p&lt;0.001). The indirect effect was significant (effect=0.187, SE=0.054, 95% CI=0.088 to 0.301). There was no association between Conscientiousness and PSQI-Total Score (total effect=-0.123, SE=0.133, p=0.358), therefore mediation analysis (testing of CFQ as a mediator) was discontinued. Conclusion In middle-aged and older adults, subjective everyday cognition mediates the relationship between Neuroticism personality trait and self-reported sleep quality. Individuals scoring higher in Neuroticism report worse subjective sleep quality as their subjective cognitive failures increase. Findings underscore the interacting roles of personality and everyday cognition on perceived sleep. Clinicians should consider individual personality profiles (via personality assessments) and subjective everyday cognitive ratings for a better understanding of the factors impacting middle-aged and older adults’ sleep profiles. Support (if any):

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