scholarly journals Flavonoids with Glutathione Antioxidant Synergy: Influence of Free Radicals Inflow

Antioxidants ◽  
2020 ◽  
Vol 9 (8) ◽  
pp. 695 ◽  
Author(s):  
Igor Ilyasov ◽  
Vladimir Beloborodov ◽  
Daniil Antonov ◽  
Anna Dubrovskaya ◽  
Roman Terekhov ◽  
...  
Keyword(s):  
Free Radicals ◽  
Free Radical ◽  
Antioxidant Capacity ◽  
Sulfonic Acid ◽  
Lag Time ◽  
The Other ◽  
Molar Ratio ◽  
Different Types ◽  
Great Excess ◽  
The One

This report explores the antioxidant interaction of combinations of flavonoid–glutathione with different ratios. Two different 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid radical (ABTS•+)-based approaches were applied for the elucidation of the antioxidant capacity of the combinations. Despite using the same radical, the two approaches employ different free radical inflow systems: An instant, great excess of radicals in the end-point decolorization assay, and a steady inflow of radicals in the lag-time assay. As expected, the flavonoid–glutathione pairs showed contrasting results in these two approaches. All the examined combinations showed additive or light subadditive antioxidant capacity effects in the decolorization assay. This effect showed slight dilution dependence and did not change when the initial ABTS•+ concentration was two times as high or low. However, in the lag-time assay, different types of interaction were detected, from subadditivity to considerable synergy. Taxifolin–glutathione combinations demonstrated the greatest synergy, at up to 112%; quercetin and rutin, in combination with glutathione, revealed moderate synergy in the 30–70% range; while morin–glutathione appeared to be additive or subadditive. In general, this study demonstrated that, on the one hand, the effect of flavonoid–glutathione combinations depends both on the flavonoid structure and molar ratio; on the other hand, the manifestation of the synergy of the combination strongly depends on the mode of inflow of the free radicals.

The effect of cation concentration on the nitrogen splitting constant of nitroxide free radicals

1990 ◽  
Vol 55 (10) ◽  
pp. 2377-2380
Author(s):  
Hamza A. Hussain
Keyword(s):  
Hydrogen Peroxide ◽  
Hydrogen Bonding ◽  
Free Radicals ◽  
Esr Spectroscopy ◽  
The Other ◽  
Tetraethylammonium Bromide ◽  
Splitting Constant ◽  
The One ◽  
Positively Charged ◽  
Two Equilibria

Nitroxide free radicals prepared from diethylamine, piperidine and pyrrolidine by oxidation with hydrogen peroxide were studied by ESR spectroscopy. The changes in the 14N splitting constant (aN) caused by the addition of KBr or tetraethylammonium bromide were measured in dependence on the concentration of the ions. For diethylamine nitroxide and piperidine nitroxide, the results are discussed in terms of two equilibria: the one, involving the anion, is associated with a gain or loss of hydrogen bonds to the nitroxide oxygen atom, the other is associated with the formation of solvent shared units involving the cation, which results in changes in the hydrogen bonding strenght. The large increase in the aN value in the case of pyrrolidine nitroxide is explained in terms of an interaction from one side of the positively charged N atom; the increase in aN in the case of diethylamine and piperidine nitroxides is explained in terms of interactions with both sides of the positively charged N atom.

Plausibility and Aesthetic Interpretation

1977 ◽  
Vol 7 (2) ◽  
pp. 327-340 ◽  
Author(s):  
Denis Dutton
Keyword(s):  
Scientific Inquiry ◽  
The Other ◽  
Inquiry Science ◽  
Works Of Art ◽  
Different Types ◽  
Logical Structures ◽  
The One

If a catalogue were made of terms commonly used to affirm the adequacy of critical interpretations of works of art, one word certain to be included would be “plausible.” Yet this term is one which has received precious little attention in the literature of aesthetics. This is odd, inasmuch as I find the notion of plausibility central to an understanding of the nature of criticism. “Plausible” is a perplexing term because it can have radically different meanings depending on the circumstances of its employment. ln the following discussion, I will make some observations about the logic of this concept in connection with its uses in two rather different contexts: the context of scientific inquiry on the one hand, and that of aesthetic interpretation on the other. In distinguishing separate senses of “plausible,” I shall provide reason to resist the temptation to imagine that because logical aspects of two different types of inquiry—science and criticism—happen to be designated by the same term, they may to that extent be considered to have similar logical structures.

Posthuman oder Übermensch. War Nietzsche ein Transhumanist?

2013 ◽  
Vol 42 (1) ◽  
Author(s):  
Michael Skowron
Keyword(s):  
Genetic Manipulation ◽  
Linguistic Analysis ◽  
The Other ◽  
The Internet ◽  
Jürgen Habermas ◽  
Eternal Recurrence ◽  
Different Types ◽  
The Future ◽  
The One ◽  
Michael Sandel

AbstractRecent discussions (especially in the Internet) about the question whether Nietzsche was a Transhumanist or at least a forerunner of the Transhumanist movement have drawn new attention to Nietzsche’s concept of the Overhuman and the relation to the Posthuman. The article is taking a critical stance by turning suggested analogies between education and genetic manipulation of humans into an argument against the latter, by relating self-education to self-overcoming and eternal recurrence of the same (which is excluded by Transhumanists), and by reminding of Nietzsche’s distinction between ‘Overhuman’ and ‘last human’ as two different ways to the future. Linguistic analysis of the epitheta used in speaking of the different ‘types’ in question as well as structural analogies between critical considerations in Michael Sandel and Jürgen Habermas on the one hand, Nietzsche on the other are also evidence that Nietzsche would not have endorsed the technological path to perfection of the human but would emphasize his own way of self-overcoming instead.

Multichannel Modality in Displaying Information

2013 ◽  
Vol 4 (1) ◽  
pp. 60-79 ◽  
Author(s):  
Elisa Benetti ◽  
Gianluca Mazzini
Keyword(s):  
Computer Science ◽  
Public Administration ◽  
The Other ◽  
Public Institution ◽  
Automated System ◽  
Government Services ◽  
Physical Location ◽  
The Past ◽  
Different Types ◽  
The One

Computer science and telecommunications are increasingly important in society and this leads also public administrations to take advantage of ICT, in order to communicate with citizens in a more rapid and simpler way than the complex and paper-based bureaucracy of the past. While on the one hand the use of these technologies responds to the duty of any public institution to involve the largest number of addressees, on the other hand, society must also consider the limitations of these technologies. Firstly not everybody is so familiar in their use. Moreover, the digital administration thus becomes virtual, accessible only through technological devices and not present in a physical location, and is therefore essential to ensure full coverage of the territory, which is currently not always possible. The main novelty of this paper is the implementation of an automated system capable of adapting different types of government services to multiple communication media. The joint exploitation of multiple technologies allows to use the strengths of one of them when are found the limits of another, making this multichannel modality the solution to the requirement of ICT in public administration.

Contributions to the chemistry of the urine; on the variations in the alkaline and earthy phosphates in the healthy state, and on the alkalescence of the urine from fixed alkali

1851 ◽  
Vol 5 ◽  
pp. 561-562
Keyword(s):  
Calcium Sulphate ◽  
The Other ◽  
Test Paper ◽  
Healthy State ◽  
Great Excess ◽  
Acid Reaction ◽  
The Subject ◽  
Alkaline Phosphate ◽  
The One ◽  
Amorphous Precipitate

The author, having observed that in some states of disease there occurs in the urine a great excess of the earthy phosphates, was in­ duced to investigate the subject; and as a preliminary inquiry, to ascertain the variations in the amount of these phosphates at differ­ent times in the same person in a state of health, and to trace the causes which determine an excess or a deficiency of these salts in the urine; noting, at the same time, the variations in the quantity of the alkaline phosphates contained in it, with a view of discovering whether these variations are influenced by the same, or by different causes. The principal results to which his experiments have con­ducted him are the following. The quantity of the earthy phos­phates in the urine voided soon after taking food is considerably greater than in that voided at other times ; and this happens whether the meal consists of animal food or of bread only. After long fast­ing, the proportion of earthy phosphates is considerably diminished. On the other hand, the alkaline phosphates are present in greatest quantity when the food consists of bread alone : when meat alone is taken, the deficiency in those salts is still more marked than the excess in the former case. Exercise occasions no change in the quantity of the earthy phosphates, but causes an increase of nearly one-third in the amount of alkaline phosphates ; but its influence is, on the whole, less than that of diet. The earthy phosphates are in­ creased in quantity by chloride of calcium, sulphate of magnesia, and calcined magnesia taken into the stomach. The author next examines the conditions in which the urine is alkalescent, and which he considers to be of two kinds ; the one, long known as ammoniacal , and arising from the presence of carbonate of ammonia; and the other, which has not hitherto been distinctly re­cognised, arising from fixed alkali, and appearing most frequently in urine secreted during a period of from two to four hours after breakfast, in persons suffering only from defective digestion. Under these circumstances, it may be, when voided, either turbid from amorphous sediment, or clear and alkaline when tested, or free from deposit and slightly acid. If in either of these last cases it be heated, an amorphous precipitate falls down, which is soluble in dilute hy­drochloric acid, or in a solution of biphosphate of soda. Healthy urine may at any time be made to yield a precipitate of earthy phos­phates by heat, even though it be acid, by having a portion of this acid neutralised by any alkali, or by phosphate of soda, the fluid becoming more acid when boiled. A solution of earthy phosphates in biphosphate of soda also gives a precipitate on boiling, if some of its acid reaction is removed by any alkali. The fluid when boiled becomes more acid to test-paper, indicating the formation of a more basic earthy phosphate. A result precisely similar is obtained when common phosphate of soda, phosphate of lime, and a little biphos­phate of soda exist together in solution ; and by varying the quan­tities of each of these substances, the various phenomena which the urine occasionally presents may be imitated. The time at which the alkalescence of the urine from fixed alkali generally occurs, indi­cates the existence of some alkaline phosphate, or of some carbonated alkali in the food.

Glutathione Peroxidase-Like Activity of Simple Selenium Compounds. Peroxides and the Heterocyclic N-Oxide Resazurin Acting as O-Atom Donors

1995 ◽  
Vol 50 (3-4) ◽  
pp. 209-219 ◽  
Author(s):  
Walter A. Prtitz
Keyword(s):  
Free Radicals ◽  
Free Radical ◽  
Glutathione Peroxidase ◽  
Crystal Violet ◽  
The Other ◽  
Atom Transfer ◽  
Selenium Compounds ◽  
Radical Intermediates ◽  
Leuco Crystal Violet ◽  
Acid Pathway

Selenite and selenocystamine [(CyaSe)2] efficiently activate the decomposition of H2O2 y GSH and by other thiols, as demonstrated using a leuco crystal violet POD-based H2O2 assay which is applicable (unlike other assays) also in presence of thiols. The GPx-like activities were estimated to be 3.6 and 2.7 μmol H2O2/min per μmol SeO32- and (CyaSe)2, respectively. Both selenium compounds also activate reduction of the heterocyclic N-oxide resazurin (RN→O) to resorufin (RN) by GSH; H2O2 competes with reduction of this dye. GSSeH and CyaSeH, formed by interaction of GSH with SeO32- and (CyaSe)2, respectively, are likely to be the active reductants. CyaSeH, generated γ-radiolytically from (CyaSe)2, exhibits an absorption peak at 243 nm and is removed by H2O2 with a rate constant of 9.7x102 ᴍ-1 s-1, and slightly slower by hydroperoxides. We have no evidence for one-electron interactions between GSSeH or CyaSeH and H2O2, with formation of free radical intermediates, as previously proposed in the case of selenium-activated reduction of cytochrome c by GSH (Levander et al., Biochemistry 23, 4591-4595 (1973)). Our results can be explained by O-atom transfer from the substrate to the active selenol group. RSeH + H2O2 (RN→O)→RSeOH + H2O (RN), and recycling of RSeOH to RSeH (+ H2O) by GSH, analogous to the selenenic acid pathway of GPx. The substrate specificity appears to be different, however, in that GPx is unable to catalyse RN→O reduction, and GSSeH hardly catalyses the decomposition of cumene- or t-butyl-hydroperoxide; CyaSeH, on the other hand, is active also with the hydroperoxides. RN→O is reduced to RN also by certain oxidizing free radicals, e.g. by the thiyl CyaS·; O -atom transfer may in this case lead to the generation of reactive oxyl radicals.

ECOLOGICAL STUDY OF THE PEAT BOGS OF EASTERN NORTH AMERICA: III. NOTES ON THE BEHAVIOR OF CHAMAEDAPHNE CALYCULATA

1956 ◽  
Vol 34 (1) ◽  
pp. 197-207 ◽  
Author(s):  
Kornelius Lems
Keyword(s):  
Ecological Study ◽  
The Other ◽  
Soil Conditions ◽  
Peat Bogs ◽  
Eastern North America ◽  
Physiological Basis ◽  
Chamaedaphne Calyculata ◽  
Different Types ◽  
The One ◽  
The Relationship

This paper presents data and observations concerning Chamaedaphne calyculata (L.) Moench. (Ericaceae). The branching pattern, the longevity of different types of leaves, and features of flowering are shown to be correlated. The relationship between this complex of features and the habitat is studied, and a few speculations are advanced to explain the physiological basis for the behavior of Chamaedaphne. This study is essentially autecological, and it is hoped that it may constitute a link between the study of soil conditions and the response of plant hormones on the one hand, and phytosociological work in peat bogs on the other hand.

scholarly journals Bayesian over-dispersed Poisson model and the Bornhuetter & Ferguson claims reserving method

2012 ◽  
Vol 6 (2) ◽  
pp. 258-283 ◽  
Author(s):  
Peter D. England ◽  
Richard J. Verrall ◽  
Mario V. Wüthrich
Keyword(s):  
Poisson Model ◽  
The Other ◽  
Prior Distributions ◽  
Prediction Uncertainty ◽  
General Insurance ◽  
Other Hand ◽  
Different Types ◽  
Chain Ladder ◽  
The One ◽  
Classical Chain

AbstractWe consider the Bayesian over-dispersed Poisson (ODP) model for claims reserving in general insurance. We choose two different types of prior distributions for the parameters and then study the different Bayesian predictors. This study leads, on the one hand, to the classical chain ladder predictor and, on the other hand, to Bornhuetter & Ferguson predictors. We highlight (either analytically or numerically) how these predictors are obtained and how their prediction uncertainty can be determined.

scholarly journals Probabilistic kingdom: problem of objectivity in contemporary science

2020 ◽  
Vol 9 (2) ◽  
pp. 317-327
Author(s):  
Paweł Pruski
Keyword(s):  
Modern Science ◽  
The Other ◽  
Objective Probability ◽  
Degrees Of Belief ◽  
Scientific Debate ◽  
Other Hand ◽  
Contemporary Science ◽  
Objective Interpretation ◽  
Different Types ◽  
The One

In modern science, the theory of probability is one of the basic tools. Scientists using probability often refer to its objective interpretation. They emphasize that their probabilistic hypotheses concern objective facts, not degrees of belief. Accordingly, the following questions arise: What is the meaning of this type of probabilistic hypothesis? Is the assumption of objectivity necessary? The paper addresses these questions by analyzing objective probability in the context of the scientific debate on determinism. Two types of arguments will be presented. On the one hand, there is the assertion that objective probability can exist only in an indeterministic world. Then, on the other hand — I analyze the assertions of those who believe in the co‑existence of objective probability and determinism. As a result I show that the acceptance of deterministic and indeterministic fields as possible areas where objective probability can occur is extremely problematic. Depending on the chosen area we encounter different types of problems. Therefore, I show that a significant number of these problems are associated with the acceptance of incorrect metaphysical assumptions. And finally, I postulate that the objectivity of probability (and assumptions pertaining to it) can be reduced (without any losses) to the epistemic variant.

scholarly journals Colonialidad como emparentamiento y limpieza de sangre: un breve estudio sobre los aportes de Santiago Castro-Gómez.

Sincronía ◽  
2021 ◽  
Vol XXV (80) ◽  
pp. 160-175
Author(s):  
Celeste Florencia Ramirez ◽  
Keyword(s):  
Michel Foucault ◽  
The Other ◽  
The Political ◽  
Modus Operandi ◽  
Other Hand ◽  
Limpieza De Sangre ◽  
Different Types ◽  
The One ◽  
Personal Interests ◽  
The Way

In the present work, in the light of the reading of the philosopher Santiago Castro-Gómez, we will try to elucidate his theory about the coloniality of power and the way in which such a device codified the bodies according to the discourse of blood cleansing. So, first, we will briefly develop two different types of theories about power: on the one hand, the theory of the coloniality of power, presented by the Peruvian sociologist Aníbal Quijano; on the other hand, the analytics of power, developed by Michel Foucault. Both theories, which seem incommensurable, are put into dialogue by our philosopher. In the second part of our work, we will prepare to present the practices and modus operandi corresponding to the coloniality of power to manifest its uniqueness in comparison to other types of powers. Likewise, we will show how a certain sector of the population, in an attempt to consolidate their family and personal interests, used these practices to limit corporality. Third, and by way of conclusion, we will make a brief sketch about the link between the coloniality of power and the political practices of current Colombia.

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