scholarly journals An Overview of the Antioxidant Effects of Ascorbic Acid and Alpha Lipoic Acid (in Liposomal Forms) as Adjuvant in Cancer Treatment

Antioxidants ◽  
2020 ◽  
Vol 9 (5) ◽  
pp. 359 ◽  
Author(s):  
Mohamed Attia ◽  
Ebtessam Ahmed Essa ◽  
Randa Mohammed Zaki ◽  
Amal Ali Elkordy
Keyword(s):  
Oxidative Stress ◽  
Ascorbic Acid ◽  
Lipoic Acid ◽  
Chemotherapeutic Agents ◽  
Cancer Tissue ◽  
Alpha Lipoic Acid ◽  
Hydrophobic Compounds ◽  
Anticancer Effects ◽  
Hydrophilic Nature ◽  
Combined Use

Antioxidants are known to minimize oxidative stress by interacting with free radicals produced as a result of cell aerobic reactions. Oxidative stress has long been linked to many diseases, especially tumours. Therefore, antioxidants play a crucial role in the prevention or management of free radical-related diseases. However, most of these antioxidants have anticancer effects only if taken in large doses. Others show inadequate bioavailability due to their instability in the blood or having a hydrophilic nature that limits their permeation through the cell membrane. Therefore, entrapping antioxidants in liposomes may overcome these drawbacks as liposomes have the capability to accommodate both hydrophilic and hydrophobic compounds with a considerable stability. Additionally, liposomes have the capability to accumulate at the cancer tissue passively, due to their small sizes, with enhanced drug delivery. Additionally, liposomes can be engineered with targeting moieties to increase the delivery of chemotherapeutic agents to specific tumour cells with decreased accumulation in healthy tissues. Therefore, combined use of liposomes and antioxidants, with or without chemotherapeutic agents, is an attractive strategy to combat varies tumours. This mini review focuses on the liposomal delivery of selected antioxidants, namely ascorbic acid (AA) and alpha-lipoic acid (ALA). The contribution of these nanocarriers in enhancing the antioxidant effect of AA and ALA and consequently their anticancer potentials will be demonstrated.

scholarly journals Hepatoprotective Actions of Ascorbic Acid, Alpha Lipoic Acid and Silymarin or Their Combination Against Acetaminophen-Induced Hepatotoxicity in Rats

Medicina ◽  
2019 ◽  
Vol 55 (5) ◽  
pp. 181 ◽  
Author(s):  
Anmar M. Abdulrazzaq ◽  
Mujtaba Badr ◽  
Omar Gammoh ◽  
Asad A. Abu Khalil ◽  
Bayan Y. Ghanim ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Ascorbic Acid ◽  
Liver Function ◽  
Lipoic Acid ◽  
Rat Hepatocytes ◽  
Serum Levels ◽  
Liver Function Tests ◽  
Alpha Lipoic Acid

Background and objectives: Ascorbic acid, alpha lipoic acid (ALA) and silymarin are well-known antioxidants that have hepatoprotective effects. This study aims to investigate the effects of these three compounds combined with attenuating drug-induced oxidative stress and cellular damage, taking acetaminophen (APAP)-induced toxicity in rats as a model both in vivo and in vitro. Materials and Methods: Freshly cultured primary rat hepatocytes were treated with ascorbic acid, ALA, silymarin and their combination, both with and without the addition of APAP to evaluate their in vitro impact on cell proliferation and mitochondrial activity. In vivo study was performed on rats supplemented with the test compounds or their combination for one week followed by two toxic doses of APAP. Results: Selected liver function tests and oxidative stress markers including superoxide dismutase (SOD), malondialdehyde (MDA) and oxidized glutathione (GSSG) were detected. The in vivo results showed that all three pretreatment compounds and their combination prevented elevation of SOD and GSSG serum levels indicating a diminished burden of oxidative stress. Moreover, ascorbic acid, ALA and silymarin in combination reduced serum levels of liver enzymes; however, silymarin markedly maintained levels of all parameters to normal ranges. Silymarin either alone or combined with ascorbic acid and ALA protected cultured rat hepatocytes and increased cellular metabolic activity. The subjected agents were capable of significantly inhibiting the presence of oxidative stress induced by APAP toxicity and the best result for protection was seen with the use of silymarin. Conclusions: The measured liver function tests may suggest an augmented hepatoprotection of the combination preparation than when compared individually.

scholarly journals Effect of Alpha-lipoic Acid on the Metabolism of Arsenic in Arsenic-loaded Isolated Liver Tissues of Rat

2009 ◽  
Vol 12 (Number 1) ◽  
pp. 3-9
Author(s):  
N Tabassum
Keyword(s):  
Oxidative Stress ◽  
Ascorbic Acid ◽  
Lipoic Acid ◽  
Inorganic Arsenic ◽  
Arsenic Toxicity ◽  
Alpha Lipoic Acid ◽  
Arsenic Metabolism ◽  
Isolated Liver ◽  
Lipid Soluble Antioxidant ◽  
Liver Tissues

The patient of chronic arsenic toxicity shows oxidative stress. To overcome the oxidative stress. several antioxidants such as fl-carotene, ascorbic acid, attocopherol, sine and selenium had been suggested. in the present study. universal antioxidant (both water and lipid soluble antioxidant) alpha-lipoic acid was used to examine the effectiveness of this thin( on arsenic metabolism. Alpha-lipoic acid increases the inethylation of inorganic arsenic and releases nionomethylarsenic acid (MMA) and dimethylarstatic acid (DMA) from the haracellular pool. These results suggest that alpha-lipoic acid increases metabolism of arsenic thereby reduces the concentration of arsenic from arsenic-loaded isolated liver tissues of rat.

Alpha-lipoic acid and coenzyme Q10 combination ameliorates experimental diabetic neuropathy by modulating oxidative stress and apoptosis

Life Sciences ◽  
2019 ◽  
Vol 216 ◽  
pp. 101-110 ◽  
Author(s):  
Nasrin Sadeghiyan Galeshkalami ◽  
Mohammad Abdollahi ◽  
Rezvan Najafi ◽  
Maryam Baeeri ◽  
Akram Jamshidzade ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Diabetic Neuropathy ◽  
Lipoic Acid ◽  
Coenzyme Q10 ◽  
Alpha Lipoic Acid ◽  
Experimental Diabetic Neuropathy

Alpha-lipoic acid defends homocysteine-induced endoplasmic reticulum and oxidative stress in HAECs

2016 ◽  
Vol 80 ◽  
pp. 63-72 ◽  
Author(s):  
Huimin Hu ◽  
Changyuan Wang ◽  
Yue Jin ◽  
Qiang Meng ◽  
Qi Liu ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Endoplasmic Reticulum ◽  
Lipoic Acid ◽  
Alpha Lipoic Acid ◽  
And Oxidative Stress

scholarly journals The role of oxidative stress and effect of alpha-lipoic acid in reexpansion pulmonary edema – an experimental study

2010 ◽  
Vol 6 ◽  
pp. 848-853 ◽  
Author(s):  
Seyfettin Gumus ◽  
Orhan Yucel ◽  
Mehmet Gamsizkan ◽  
Ayse Eken ◽  
Omer Deniz ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Experimental Study ◽  
Pulmonary Edema ◽  
Lipoic Acid ◽  
Alpha Lipoic Acid ◽  
Reexpansion Pulmonary Edema

scholarly journals Alpha-Lipoic Acid Protects Rat Kidney Against Oxidative Stress-Mediated DNA Damage and Apoptosis Induced by Lead

2015 ◽  
Vol 6 (1) ◽  
pp. 1-14 ◽  
Author(s):  
Samy Ali Hussein ◽  
Mohamed Ragaa R. Hassanein ◽  
Aziza Amin ◽  
Asmaa H. Mohammad Hussein
Keyword(s):  
Oxidative Stress ◽  
Dna Damage ◽  
Lipoic Acid ◽  
Rat Kidney ◽  
Alpha Lipoic Acid

scholarly journals Oxidative Stress in 5/6 Nephrectomized Rat Model: Effect of Alpha-Lipoic Acid

Renal Failure ◽  
2012 ◽  
Vol 34 (7) ◽  
pp. 907-914 ◽  
Author(s):  
Xiaofang Yu ◽  
Hong Liu ◽  
Jianzhou Zou ◽  
Jiaming Zhu ◽  
Xunhui Xu ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Lipoic Acid ◽  
Rat Model ◽  
Alpha Lipoic Acid

Activity of Alpha-Lipoic Acid in the Protection against Oxidative Stress in Skin

2000 ◽  
pp. 43-51 ◽  
Author(s):  
M. Podda ◽  
T.M. Zollner ◽  
M. Grundmann-Kollmann ◽  
J.J. Thiele ◽  
L. Packer ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Lipoic Acid ◽  
Alpha Lipoic Acid
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