Activity of Alpha-Lipoic Acid in the Protection against Oxidative Stress in Skin

2000 ◽  
pp. 43-51 ◽  
Author(s):  
M. Podda ◽  
T.M. Zollner ◽  
M. Grundmann-Kollmann ◽  
J.J. Thiele ◽  
L. Packer ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Lipoic Acid ◽  
Alpha Lipoic Acid

Alpha-lipoic acid and coenzyme Q10 combination ameliorates experimental diabetic neuropathy by modulating oxidative stress and apoptosis

Life Sciences ◽  
2019 ◽  
Vol 216 ◽  
pp. 101-110 ◽  
Author(s):  
Nasrin Sadeghiyan Galeshkalami ◽  
Mohammad Abdollahi ◽  
Rezvan Najafi ◽  
Maryam Baeeri ◽  
Akram Jamshidzade ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Diabetic Neuropathy ◽  
Lipoic Acid ◽  
Coenzyme Q10 ◽  
Alpha Lipoic Acid ◽  
Experimental Diabetic Neuropathy

Alpha-lipoic acid defends homocysteine-induced endoplasmic reticulum and oxidative stress in HAECs

2016 ◽  
Vol 80 ◽  
pp. 63-72 ◽  
Author(s):  
Huimin Hu ◽  
Changyuan Wang ◽  
Yue Jin ◽  
Qiang Meng ◽  
Qi Liu ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Endoplasmic Reticulum ◽  
Lipoic Acid ◽  
Alpha Lipoic Acid ◽  
And Oxidative Stress

scholarly journals The role of oxidative stress and effect of alpha-lipoic acid in reexpansion pulmonary edema – an experimental study

2010 ◽  
Vol 6 ◽  
pp. 848-853 ◽  
Author(s):  
Seyfettin Gumus ◽  
Orhan Yucel ◽  
Mehmet Gamsizkan ◽  
Ayse Eken ◽  
Omer Deniz ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Experimental Study ◽  
Pulmonary Edema ◽  
Lipoic Acid ◽  
Alpha Lipoic Acid ◽  
Reexpansion Pulmonary Edema

scholarly journals Alpha-Lipoic Acid Protects Rat Kidney Against Oxidative Stress-Mediated DNA Damage and Apoptosis Induced by Lead

2015 ◽  
Vol 6 (1) ◽  
pp. 1-14 ◽  
Author(s):  
Samy Ali Hussein ◽  
Mohamed Ragaa R. Hassanein ◽  
Aziza Amin ◽  
Asmaa H. Mohammad Hussein
Keyword(s):  
Oxidative Stress ◽  
Dna Damage ◽  
Lipoic Acid ◽  
Rat Kidney ◽  
Alpha Lipoic Acid

scholarly journals Oxidative Stress in 5/6 Nephrectomized Rat Model: Effect of Alpha-Lipoic Acid

Renal Failure ◽  
2012 ◽  
Vol 34 (7) ◽  
pp. 907-914 ◽  
Author(s):  
Xiaofang Yu ◽  
Hong Liu ◽  
Jianzhou Zou ◽  
Jiaming Zhu ◽  
Xunhui Xu ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Lipoic Acid ◽  
Rat Model ◽  
Alpha Lipoic Acid

Alpha-Lipoic Acid Prevents Atrial Electrical and Structural Remodeling via Inhibition of NADPH Oxidase in a Rabbit Rapid Atrial Pacing Model

2020 ◽  
Author(s):  
Lei Chen ◽  
Wensu Chen ◽  
Yao Zhang ◽  
Zhirong Wang
Keyword(s):  
Oxidative Stress ◽  
Nadph Oxidase ◽  
Western Blot ◽  
Lipoic Acid ◽  
Right Atrial ◽  
Atrial Pacing ◽  
Alpha Lipoic Acid ◽  
Model Group ◽  
Structural Remodeling ◽  
Masson Staining

Abstract Background The pathogenesis of atrial fibrillation(AF) is complex, and the treatment method is still not satisfactory. A rapid atrial pacing (RAP) model was constructed to study the effects of alpha-lipoic acid (ALA) on electrical and structural remodeling, as well as its possible mechanism in rabbits.Methods A total of 30 rabbits were randomly divided into a sham-operated group (SHAM group), a rapid atrial pacing model group (RAP group) and an alpha-lipoic acid+rapid atrial pacing model group (ALA+RAP group). Their right atriums were paced at a speed of 600 beats/min for 12 h in the RAP and ALA+RAP groups, and the atrial effective refractory period (AERP) and AERP frequency adaptability were determined during the pace. In each group, malondialdehyde (MDA), superoxide dismutase (SOD) and reactive oxygen species (ROS) were detected to observe the effects of oxidative stress. The pathological structure of the atrial tissue was observed through HE and Masson staining. Ultrastructural changes in the atrial myocytes were observed by transmission electron microscopy (TEM), and the expression levels of Nox2 and Nox4 were detected by immunohistochemistry, western blot and ELISA.Results Through testing AERP and AERP frequency adaptability, it was found that in the early stage of rapid atrial pacing, AERP gradually shortened, while ALA injection could remarkably delay this process. Correspondingly, AERP frequency adaptability in the RAP group was reduced, and ALA could enhance it. HE staining showed that pathological changes in the ALA+RAP group were milder than those in the RAP group. And it was found that in the ALA+RAP group, the deposition of collagen in the endomysium was remarkably reduced via Masson staining. Ultrastructure injury in the ALA+RAP group showed various degrees of improvement compared with the RAP group. RAP was accompanied by an increase in oxidative stress levels, and ALA could effectively inhibit RAP-induced oxidative stress in vivo via detecting SOD, MDA and ROS. In addition, Western blot showed that the expression of NOX2 and NOX4 was upregulated in RAP group, but ALA intervention could inhibit their expression. Moreover, immunohistochemistry and ELISA also got similar results as Western blot.Conclusion ALA can inhibit atrial electrical remodeling and structural remodeling by reducing ROS production and alleviating oxidative stress injury induced by rapid right atrial pacing, and its mechanism may be related to inhibiting the activity of NADPH oxidase.

Protective Effect of Alpha-lipoic Acid Against Lead Acetate-Induced Oxidative Stress in the Bone Marrow of Rats

2011 ◽  
Vol 7 (2) ◽  
pp. 217-227 ◽  
Author(s):  
Nagaraja Haleagraha ◽  
Tan Jackie ◽  
Srikumar Chakravart ◽  
Anupama Bangra Kulur
Keyword(s):  
Oxidative Stress ◽  
Bone Marrow ◽  
Protective Effect ◽  
Lipoic Acid ◽  
Lead Acetate ◽  
Alpha Lipoic Acid

scholarly journals The Protective Role of Prenatal Alpha Lipoic Acid Supplementation against Pancreatic Oxidative Damage in Offspring of Valproic Acid-Treated Rats: Histological and Molecular Study

Biology ◽  
2020 ◽  
Vol 9 (9) ◽  
pp. 239
Author(s):  
Fatma M. Ghoneim ◽  
Hani Alrefai ◽  
Ayman Z. Elsamanoudy ◽  
Salwa M. Abo El-khair ◽  
Hanaa A. Khalaf
Keyword(s):  
Oxidative Stress ◽  
Oxidative Damage ◽  
Lipoic Acid ◽  
Caspase 3 ◽  
Protective Role ◽  
Alpha Lipoic Acid ◽  
Group Iii ◽  
Rat Offspring ◽  
Group I

Background: Sodium valproate (VPA) is an antiepileptic drug (AED) licensed for epilepsy and used during pregnancy in various indications. Alpha-lipoic acid (ALA) is a natural compound inducing endogenous antioxidant production. Our study aimed to investigate the effect of prenatal administration of VPA on the pancreas of rat offspring and assess the potential protective role of ALA co-administration during pregnancy. Methods: Twenty-eight pregnant female albino rats were divided into four groups: group I (negative control), group II (positive control, ALA treated), group III (VPA-treated), and group IV (VPA-ALA-treated). The pancreases of the rat offspring were removed at the fourth week postpartum and prepared for histological, immune-histochemical, morphometric, molecular, and oxidative stress marker studies. Results: In group III, there were pyknotic nuclei, vacuolated cytoplasm with ballooning of acinar, α, and β cells of the pancreas. Ultrastructural degeneration of cytoplasmic organelles was detected. Additionally, there was a significant increase in oxidative stress, a decrease in insulin-positive cell percentage, and an increase in glucagon positive cells in comparison to control groups. Moreover, VPA increased the gene expression of an apoptotic marker, caspase-3, with a decrease in anti-apoptotic Bcl2 and nuclear factor erythroid 2-related factor 2 (Nrf2) transcriptional factor. Conversely, ALA improved oxidative stress and apoptosis in group VI, and a consequent improvement of the histological and ultrastructure picture was detected. Conclusion: ALA co-administration with VPA significantly improved the oxidative stress condition, histological and morphometric picture of the pancreas, and restored normal expression of related genes, including Nrf2, caspase-3, and Bcl-2. Administration of α-lipoic acid has a protective effect against VPA-induced pancreatic oxidative damage via its cytoprotective antioxidant effect.

Sign in / Sign up

Export Citation Format

Share Document