scholarly journals Rosmarinus officinalis Essential Oil Improves Scopolamine-Induced Neurobehavioral Changes via Restoration of Cholinergic Function and Brain Antioxidant Status in Zebrafish (Danio rerio)

Antioxidants ◽  
2020 ◽  
Vol 9 (1) ◽  
pp. 62 ◽  
Author(s):  
Luminita Capatina ◽  
Razvan Stefan Boiangiu ◽  
Gabriela Dumitru ◽  
Edoardo Marco Napoli ◽  
Giuseppe Ruberto ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Essential Oil ◽  
Danio Rerio ◽  
Ache Activity ◽  
Underlying Mechanism ◽  
Rosmarinus Officinalis ◽  
Zebrafish Model ◽  
Brain Oxidative Stress ◽  
Brain Ache Activity ◽  
Rosmarinus Officinalis L

Rosmarinus officinalis L. is a traditional herb with various therapeutic applications such as antibacterial, antioxidant, anti-inflammatory, antidepressant, and anticholinesterase activities, and can be used for the prevention or treatment of dementia. In the present study, we tested whether Rosmarinus officinalis L. could counteract scopolamine-induced anxiety, dementia, and brain oxidative stress in the zebrafish model and tried to find the underlying mechanism. Rosmarinus officinalis L. essential oil (REO: 25, 150, and 300 µL/L) was administered by immersion to zebrafish (Danio rerio) once daily for eight days while scopolamine (100 µM) treatment was delivered 30 min before behavioral tests. The antidepressant and cognitive-enhancing actions of the essential oil in the scopolamine zebrafish model was measured in the novel tank diving test (NTT) and Y-maze test. The chemical composition was identified by Gas chromatograph–Mass spectrometry (GC-MS) analysis. The brain oxidative status and acetylcholinesterase (AChE) activity was also determined. REO reversed scopolamine-induced anxiety, memory impairment, and brain oxidative stress. In addition, a reduced brain AChE activity following the administration of REO in scopolamine-treated fish was observed. In conclusion, REO exerted antidepressant-like effect and cognitive-enhancing action and was able to abolish AChE alteration and brain oxidative stress induced by scopolamine.

scholarly journals Origanum vulgare ssp. hirtum (Lamiaceae) Essential Oil Prevents Behavioral and Oxidative Stress Changes in the Scopolamine Zebrafish Model

Molecules ◽  
2021 ◽  
Vol 26 (23) ◽  
pp. 7085
Author(s):  
Luminita Capatina ◽  
Edoardo Marco Napoli ◽  
Giuseppe Ruberto ◽  
Lucian Hritcu
Keyword(s):  
Oxidative Stress ◽  
Cognitive Impairment ◽  
Essential Oil ◽  
Biological Activities ◽  
Gas Chromatography Mass Spectrometry ◽  
Protective Effects ◽  
Origanum Vulgare ◽  
Zebrafish Model ◽  
Stress Changes ◽  
Brain Oxidative Stress

Origanum vulgare ssp. hirtum has been used as medicinal herbs promoting antioxidant, anti-inflammatory, antimicrobial, and neuroprotective activities. We investigated the protective effects and the mechanism of O. vulgare ssp. hirtum essential oil (OEO) on cognitive impairment and brain oxidative stress in a scopolamine (Sco)-induced zebrafish (Danio rerio) model of cognitive impairment. Our results show that exposure to Sco (100 µM) leads to anxiety, spatial memory, and response to novelty dysfunctions, whereas the administration of OEO (25, 150, and 300 µL/L, once daily for 13 days) reduced anxiety-like behavior and improved cognitive ability, which was confirmed by behavioral tests, such as the novel tank-diving test (NTT), Y-maze test, and novel object recognition test (NOR) in zebrafish. Additionally, Sco-induced brain oxidative stress and increasing of acetylcholinesterase (AChE) activity were attenuated by the administration of OEO. The gas chromatography–mass spectrometry (GC-MS) analyses were used to elucidate the OEO composition, comprising thymol (38.82%), p-cymene (20.28%), and γ-terpinene (19.58%) as the main identified components. These findings suggest the ability of OEO to revert the Sco-induced cognitive deficits by restoring the cholinergic system activity and brain antioxidant status. Thus, OEO could be used as perspective sources of bioactive compounds, displaying valuable biological activities, with potential pharmaceutical applications.

scholarly journals EFFECT OF ECLIPTA ALBA ON SCOPOLAMINE INDUCED AMNESIA IN MICE

2018 ◽  
Vol 8 (5-s) ◽  
pp. 162-168
Author(s):  
Harmel Singh Chahal ◽  
Shailendra Sharma
Keyword(s):  
Oxidative Stress ◽  
Learning And Memory ◽  
Morris Water Maze ◽  
Water Maze ◽  
Memory Impairment ◽  
Ache Activity ◽  
Memory Deficits ◽  
Eclipta Alba ◽  
Brain Oxidative Stress ◽  
Brain Ache Activity

The present study deals with the evaluation of potential effects of Eclipta alba (EA) in memory impairment of mice. Memory impairment was induced by scopolamine (3 mg/kg, i.p) in animals. To assess learning and memory in mice Morris water maze test was employed. The acetylcholinestrase enzyme (AChE) activity in brain was measured to evaluate the central cholinergic activity. The levels of thiobarbituric acid-reactive species (TBARS) and reduced glutathione (GSH)in brain were estimated to assess the degree of oxidative stress. Scopolamine treatment produces significant impairment of learning and memory in mice, as reflected by a significant decrease in MWM performance. Scopolamine also produced a significant enhancement of brain AChE activity and brain oxidative stress (increase in TBARS and decrease in GSH) levels. EA (300 and 600 mg/kg,oral) significantly prevented scopolamine-induced learning and memory deficits along with decrease of scopolamine-induced rise in brain AChE activity and brain oxidative stress levels. It may be concluded that Eclipta alba has significant protective action against scopolamine induced memory deficits in mice that can be attributed to its anti AChE and anti oxidant actions. Keywords:  Alzheimer disease, Oxidative stress, Morris water Maze, Scopolamine

Effect of Rosmarinus officinalis L. essential oil combined with different packaging conditions to extend the shelf life of refrigerated beef meat

2017 ◽  
Vol 221 ◽  
pp. 1069-1076 ◽  
Author(s):  
Veronica Sirocchi ◽  
Frank Devlieghere ◽  
Nanou Peelman ◽  
Gianni Sagratini ◽  
Filippo Maggi ◽  
...  
Keyword(s):  
Essential Oil ◽  
Shelf Life ◽  
Rosmarinus Officinalis ◽  
Beef Meat ◽  
Rosmarinus Officinalis L

Tetraclinis articulata essential oil mitigates cognitive deficits and brain oxidative stress in an Alzheimer's disease amyloidosis model

Phytomedicine ◽  
2019 ◽  
Vol 56 ◽  
pp. 57-63 ◽  
Author(s):  
Fatima Zahra Sadiki ◽  
Mostafa El Idrissi ◽  
Oana Cioanca ◽  
Adriana Trifan ◽  
Monica Hancianu ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Essential Oil ◽  
Cognitive Deficits ◽  
Tetraclinis Articulata ◽  
Brain Oxidative Stress
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