scholarly journals Acute Effects of Resistance Exercise and the Use of GH or IGF-1 Hormones on Oxidative Stress and Antioxidant Markers in Bodybuilders

Antioxidants ◽  
2019 ◽  
Vol 8 (12) ◽  
pp. 587
Author(s):  
Heidar Mohammadjafari ◽  
Hamid Arazi ◽  
Nematollah Nemati ◽  
Tahereh Bagherpoor ◽  
Katsuhiko Suzuki
Keyword(s):  
Oxidative Stress ◽  
Resistance Exercise ◽  
Peptide Hormone ◽  
User Group ◽  
Single Session ◽  
Post Exercise ◽  
User Groups ◽  
Heavy Resistance Exercise ◽  
Hormone Use ◽  
Antioxidant Markers

The aim of this study was to examine the influence of peptide hormone use on oxidative stress and antioxidant responses to a single session of resistance exercise in male bodybuilders. Forty-five male bodybuilders were divided into three groups: bodybuilders using growth hormone for at least 1 year (i.e., 3 to 4 times in the year) (GH-user, n = 15), bodybuilders using insulin-like growth factor-1 for at least 1 year (i.e., 3 to 4 times in the year) (IGF-1-user, n = 15), and peptide hormone-free bodybuilders (Non-user, n = 15). The heavy resistance exercise protocol consisted of five sets with 80% of one repetition maximum for six exercises. Blood samples were obtained pre and post heavy resistance exercise (HRE) in order to evaluate changes in oxidative stress (8-hydroxy-2-deoxyguanosine (8-OHdG), malondialdehyde (MDA), and nitric oxide (NO)) and antioxidant biomarkers (glutathione peroxidase (GPx), catalase (CAT) and glutamate (GLU)) level. All the experimental groups showed increases in MDA (p = 0.038), NO (p = 0.028), GPx (p = 0.012), and GLU (p = 0.003) concentrations after resistance exercise. For 8-OHdG, the Non-user and IGF-1-user groups indicated increases at post-exercise (p = 0.001), without any significant changes in the GH-user group (p = 0.87). In addition, the changes in serum GPx and GLU levels were greater for the GH-user group than the Non-user and IGF-1-user groups (p = 0.001). In conclusion, HRE induced significant increases in 8-OHdG (except to GH-user group), MDA, NO, GPx, and GLU levels with greater changes in GPx and GLU for the GH-user group.

scholarly journals Effects of Self-Administered GH or IGF-1 Hormones on Resting Oxidative Stress and Antioxidant Markers in Men with or Without Resistance Exercise

2020 ◽  
Vol 27 (4) ◽  
pp. 14-17
Author(s):  
Heidar Mohammadjafari ◽  
Hamid Arazi ◽  
Nematollah Nemati ◽  
Tahereh Bagherpoor
Keyword(s):  
Oxidative Stress ◽  
Resistance Exercise ◽  
Peptide Hormone ◽  
Self Administration ◽  
Male Athletes ◽  
Stress Markers ◽  
History Of ◽  
Antioxidant Defense Systems ◽  
Antioxidant Markers

Abstract Introduction. Some athletes and non-athletes use peptide hormones to increase lean body mass and fat loss, but those effects on oxidative stress and antioxidant markers are unknown. The aim of this study was to show the physiological profile of oxidative stress and antioxidant markers in athletes and non-athletes following long-term self-administration of GH or IGF-1 Material and Methods. Seventy-five healthy young men with the history of peptide hormone (i.e., GH or IGF-1) use for at least 1 year (i.e., 3 to 4 times a year) or resistance exercise (RE) experience for at least 3 years volunteered to participate in this study and were divided into 5 selected groups including 1) GH use plus RE (GH+RE, n = 15), 2) IGF-1 use plus RE (IGF-1+RE, n = 15), 3) GH use (GH, n = 15), 4) IGF-1 use (IGF-1, n = 15), and 5) RE only (RE, n = 15). Blood sample was obtained one time in order to evaluate the resting concentration of oxidative stress markers including 8-hydroxy-2-deoxyguanosine (8-OHdG), malondialdehyde (MDA), nitric oxide (NO) and antioxidant defense systems (i.e., glutathione peroxidase [GPx], catalase [CAT], and glutamate [GLU]). Results. There were no significant (p > 0.05) differences among the groups in the 8-OHdG, MDA, NO, GPx, CAT, and GLU levels. Conclusions. Self-administration of peptide hormone and RE for at least 1 year is not accompanied by alterations in resting oxidative stress and the antioxidant system in male athletes and non-athletes.

Effects of Heavy Resistance Exercise Volume on Post-Exercise Androgen Receptor Content in Resistance-Trained Men

2004 ◽  
Vol 36 (Supplement) ◽  
pp. S238
Author(s):  
Nicholas A. Ratamess ◽  
William J. Kraemer ◽  
Jeff S. Volek ◽  
Carl M. Maresh ◽  
Jaci L. Van Heest ◽  
...  
Keyword(s):  
Androgen Receptor ◽  
Resistance Exercise ◽  
Post Exercise ◽  
Heavy Resistance Exercise

Effects of Acute, Heavy-Resistance Exercise on Urinary Peptide Hormone Excretion in Humans

2003 ◽  
Vol 41 (10) ◽  
Author(s):  
Elio F. De Palo ◽  
Rosalba Gatti ◽  
Federica Lancerin ◽  
Carlo B. De Palo ◽  
Enrico Cappellin ◽  
...  
Keyword(s):  
Resistance Exercise ◽  
Peptide Hormone ◽  
Heavy Resistance Exercise ◽  
Urinary Peptide ◽  
Hormone Excretion

Effects of Heavy Resistance Exercise Volume on Post-Exercise Androgen Receptor Content in Resistance-Trained Men

2004 ◽  
Vol 36 (Supplement) ◽  
pp. S238
Author(s):  
Nicholas A. Ratamess ◽  
William J. Kraemer ◽  
Jeff S. Volek ◽  
Carl M. Maresh ◽  
Jaci L. Van Heest ◽  
...  
Keyword(s):  
Androgen Receptor ◽  
Resistance Exercise ◽  
Post Exercise ◽  
Heavy Resistance Exercise

Changes in Hormonal Concentrations after Different Heavy-Resistance Exercise Protocols in Women

1993 ◽  
Author(s):  
William J. Kraemer ◽  
Steven J. Fleck ◽  
Joseph E. Dziados ◽  
Everett A. Harman ◽  
Louis J. Marchitelli
Keyword(s):  
Resistance Exercise ◽  
Heavy Resistance Exercise

The Acute Effects of Androstenedione Supplementation in Healthy Young Males

2000 ◽  
Vol 25 (1) ◽  
pp. 68-78 ◽  
Author(s):  
Craig S. Ballantyne ◽  
Stuart M. Phillips ◽  
Jay R. Macdonald ◽  
Mark A. Tarnopolsky ◽  
J. Duncan Macdougall
Keyword(s):  
Luteinizing Hormone ◽  
Resistance Exercise ◽  
Elevated Plasma ◽  
Acute Effects ◽  
Double Blind ◽  
Male Athletes ◽  
Young Males ◽  
Plasma Estradiol ◽  
Key Words Testosterone ◽  
Heavy Resistance Exercise

We examined the effects of androstenedione supplementation on the hormonal profile of 10 males and its interaction with resistance exercise. Baseline testosterone, luteinizing hormone, estradiol, and androstenedione concentrations were established by venous sampling at 3 hr intervals over 24 hr. Subjects ingested 200 mg of androstenedione daily for 2 days, with second and third day blood samples. Two weeks later, they ingested androstenedione or a placebo for 2 days, in a double-blind, cross-over design. On day 2, they performed heavy resistance exercise with blood sampled before, after, and 90 min post. The supplement elevated plasma androstenedione 2-3-fold and luteinizing hormone ∼70% but did not alter testosterone concentration. Exercise elevated testosterone, with no difference between conditions. Exercise in the supplemented condition significantly elevated plasma estradiol by ∼83% for 90 min. Androstenedione supplementation, thus, is unlikely to provide male athletes with any anabolic benefit and, with heavy resistance exercise, elevates estrogen. Key Words: testosterone, luteinizing hormone, estradiol, fluid shifts, resistance exercise

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