scholarly journals Exercise and Redox Status Responses Following Alpha-Lipoic Acid Supplementation in G6PD Deficient Individuals

Antioxidants ◽  
2018 ◽  
Vol 7 (11) ◽  
pp. 162 ◽  
Author(s):  
Kalliopi Georgakouli ◽  
Ioannis Fatouros ◽  
Apostolos Fragkos ◽  
Theofanis Tzatzakis ◽  
Chariklia Deli ◽  
...  
Keyword(s):  
Uric Acid ◽  
Lipoic Acid ◽  
G6pd Deficiency ◽  
Acute Exercise ◽  
Thiobarbituric Acid ◽  
Redox Balance ◽  
Redox Status ◽  
Protein Carbonyls ◽  
Alpha Lipoic Acid ◽  
Double Blind

G6PD deficiency renders cells more susceptible to oxidative insults, while antioxidant dietary supplementation could restore redox balance and ameliorate exercise-induced oxidative stress. To examine the effects of alpha-lipoic acid (ALA) supplementation on redox status indices in G6PD deficient individuals, eight male adults with G6PD deficiency (D) participated in this randomized double-blind placebo-controlled crossover trial. Participants were randomly assigned to receive ALA (600 mg/day) or placebo for 4 weeks separated by a 4-week washout period. Before and at the end of each treatment period, participants exercised following an exhaustive treadmill exercise protocol. Blood samples were obtained before (at rest), immediately after and 1h after exercise for later analysis of total antioxidant capacity (TAC), uric acid, bilirubin, thiobarbituric acid reactive substances (TBARS) and protein carbonyls (PC). ALA resulted in significantly increased resting TAC and bilirubin concentrations. Moreover, TAC increased immediately and 1h after exercise following both treatment periods, whereas bilirubin increased immediately after and 1h after exercise following only ALA. No significant change in uric acid, TBARS or PC was observed at any time point. ALA supplementation for 4 weeks may enhance antioxidant status in G6PD individuals; however, it does not affect redox responses to acute exercise until exhaustion or exercise performance.

Acute exercise markedly increases blood oxidative stress in boys and girls

2007 ◽  
Vol 32 (2) ◽  
pp. 197-205 ◽  
Author(s):  
Michalis G. Nikolaidis ◽  
Antonios Kyparos ◽  
Marina Hadziioannou ◽  
Neraida Panou ◽  
Leonidas Samaras ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Acute Exercise ◽  
Maximum Velocity ◽  
Thiobarbituric Acid ◽  
Redox Status ◽  
Protein Carbonyls ◽  
Post Exercise ◽  
Calculated Effect ◽  
Total Antioxidant ◽  
Exercise Induced

This study investigated the effect of an acute swimming protocol on selected blood redox status indices in trained children. Eleven boys and 11 girls (aged 9–11 y) swam 12 bouts of 50 m at a pace corresponding to 70%–75% of the participant’s 50 m maximum velocity, with each bout separated by 1 min rest periods. At rest, no differences in any redox status marker between boys and girls were observed. As compared with the pre-exercise values, significant increases in thiobarbituric acid-reactive substances (TBARS), protein carbonyls, catalase activity, total antioxidant capacity (TAC), and oxidized glutathione (GSSG) concentration, as well as significant decreases in reduced glutathione (GSH) concentration and GSH:GSSG, were found post-exercise in both boys and girls. The magnitude of the exercise-induced alterations in the blood redox status based on the calculated effect sizes could be considered large for all parameters in both sexes (median effect size in absolute values was equal to 1.38). The main finding of the present study is that an acute swimming bout at 70%–75% maximum velocity resulted in blood oxidative stress in a similar manner in both trained young boys and girls.

scholarly journals Age-Related Responses in Circulating Markers of Redox Status in Healthy Adolescents and Adults during the Course of a Training Macrocycle

2015 ◽  
Vol 2015 ◽  
pp. 1-17 ◽  
Author(s):  
Athanasios Zalavras ◽  
Ioannis G. Fatouros ◽  
Chariklia K. Deli ◽  
Dimitris Draganidis ◽  
Anastasios A. Theodorou ◽  
...  
Keyword(s):  
Uric Acid ◽  
Aerobic Capacity ◽  
Catalase Activity ◽  
Acute Exercise ◽  
Age Groups ◽  
Redox Status ◽  
The Body ◽  
Protein Carbonyls ◽  
Age Related ◽  
Response To Exercise

Redox status changes during an annual training cycle in young and adult track and field athletes and possible differences between the two age groups were assessed. Forty-six individuals (24 children and 22 adults) were assigned to four groups: trained adolescents, (TAD,N=13), untrained adolescents (UAD,N=11), trained adults (TA,N=12), and untrained adults (UA,N=10). Aerobic capacity and redox status related variables [total antioxidant capacity (TAC), glutathione (GSH), catalase activity, TBARS, protein carbonyls (PC), uric acid, and bilirubin] were assessed at rest and in response to a time-trial bout before training, at mid- and posttraining. TAC, catalase activity, TBARS, PC, uric acid, and bilirubin increased and GSH declined in all groups in response to acute exercise independent of training status and age. Training improved aerobic capacity, TAC, and GSH at rest and in response to exercise. Age affected basal and exercise-induced responses since adults demonstrated a greater TAC and GSH levels at rest and a greater rise of TBARS, protein carbonyls, and TAC and decline of GSH in response to exercise. Catalase activity, uric acid, and bilirubin responses were comparable among groups. These results suggest that acute exercise, age, and training modulate the antioxidant reserves of the body.

scholarly journals Buprenorphine and Methadone as Opioid Maintenance Treatments for Heroin-Addicted Patients Induce Oxidative Stress in Blood

2019 ◽  
Vol 2019 ◽  
pp. 1-9 ◽  
Author(s):  
Christonikos Leventelis ◽  
Nikolaos Goutzourelas ◽  
Aikaterini Kortsinidou ◽  
Ypatios Spanidis ◽  
Georgia Toulia ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Thiobarbituric Acid ◽  
Redox Status ◽  
Protein Carbonyls ◽  
Healthy Individuals ◽  
Thiobarbituric Acid Reactive Substances ◽  
Antioxidant Defence ◽  
Total Antioxidant ◽  
Beneficial Action ◽  
The Impact

Buprenorphine and methadone are two substances widely used in the substitution treatment of patients who are addicted to opioids. Although it is known that they partly act efficiently towards this direction, there is no evidence regarding their effects on the redox status of patients, a mechanism that could potentially improve their action. Therefore, the aim of the present investigation was to examine the impact of buprenorphine and methadone, which are administered as substitutes to heroin-dependent patients on specific redox biomarkers in the blood. From the results obtained, both the buprenorphine (n=21) and the methadone (n=21) groups exhibited oxidative stress and compromised antioxidant defence. This was evident by the decreased glutathione (GSH) concentration and catalase activity in erythrocytes and the increased concentrations of thiobarbituric acid reactive substances (TBARS) and protein carbonyls in the plasma, while there was no significant alteration of plasma total antioxidant capacity (TAC) compared to the healthy individuals (n=29). Furthermore, methadone revealed more severe oxidant action compared to buprenorphine. Based on relevant studies, the tested substitutes mitigate the detrimental effects of heroin on patient redox status; still it appears that they need to be boosted. Therefore, concomitant antioxidant administration could potentially enhance their beneficial action, and most probably, buprenorphine that did not induce oxidative stress in such a severe mode as methadone, on the regulation of blood redox status.

scholarly journals Antioxidant Effect of Alpha-Lipoic Acid in 6-Hydroxydopamine Unilateral Intrastriatal Injected Rats

Antioxidants ◽  
2020 ◽  
Vol 9 (2) ◽  
pp. 122 ◽  
Author(s):  
Pavlina Andreeva-Gateva ◽  
Lubomir Traikov ◽  
Zafer Sabit ◽  
Dimitar Bakalov ◽  
Radka Tafradjiiska-Hadjiolova
Keyword(s):  
Lipoic Acid ◽  
Thiobarbituric Acid ◽  
Tbars Level ◽  
Alpha Lipoic Acid ◽  
Simultaneous Application ◽  
Evaluation Procedures ◽  
Male Wistar Rats ◽  
Cell Processes ◽  
6 Hydroxydopamine ◽  
Gpx Activity

The toxin 6-hydroxydopamine (6-OHDA) is a highly oxidizable dopamine (DA) analog that is widely used for reproducing several cell processes identified in Parkinson’s disease (PD). Due to the close similarity of its neurotoxic mechanism to those of DA, it is suitable as a model for testing the effects of potentially neuroprotective drugs. This study aimed to evaluate the effect of alpha-lipoic acid (LA) on brain oxidative stress (OS) in unilateral intrastriatal (6-OHDA) injected rats. Forty male Wistar rats, four months old (220–260 g), were evaluated. Half of them received LA (35 mg/kg i.p.) from the start to the end of the experiment. On day 2 of the trial, ten LA-supplemented rats and ten non-LA-supplemented rats were subjected to the apomorphine test. Brain homogenates were evaluated for thiobarbituric acid-reactive substances (TBARS) and glutathione peroxidase (GPx) activity. The same evaluation procedures were repeated on day 14 with the remaining animals. An increased TBARS level and decreased GPx activity, suggestive for OS, were recorded in homogenates on day 14 vs. day 2 of the experiment in the 6-OHDA treated rats. The simultaneous application of LA mitigated these changes. Our study demonstrates that the low dose of LA could be of value for decreasing the OS of the neurotoxic 6-OHDA, supporting the need for further studies of the benefit of LA treatment in PD.

Alpha-lipoic acid does not alter stress protein response to acute exercise in diabetic brain

2010 ◽  
Vol 28 (8) ◽  
pp. 644-650 ◽  
Author(s):  
Jani Lappalainen ◽  
Zekine Lappalainen ◽  
Niku K. J. Oksala ◽  
David E. Laaksonen ◽  
Savita Khanna ◽  
...  
Keyword(s):  
Lipoic Acid ◽  
Acute Exercise ◽  
Stress Protein ◽  
Alpha Lipoic Acid ◽  
Diabetic Brain ◽  
Protein Response

Double-blind, randomized, placebo-controlled crossover trial of alpha-lipoic acid for the treatment of fibromyalgia pain

Pain ◽  
2020 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Ian Gilron ◽  
Sylvia Robb ◽  
Dongsheng Tu ◽  
Ronald Holden ◽  
Tanveer Towheed ◽  
...  
Keyword(s):  
Lipoic Acid ◽  
Crossover Trial ◽  
Alpha Lipoic Acid ◽  
Double Blind

Alpha Lipoic Acid Reduces Symptoms and Inflammation Biomarkers in Patients with Chronic Hemorrhoidal Illness

2018 ◽  
Vol 88 (5-6) ◽  
pp. 281-290
Author(s):  
Marizela Šabanović ◽  
Midhat Jašić ◽  
Amer Odobašić ◽  
Emilija Spaseska Aleksovska ◽  
Suzana Pavljašević ◽  
...  
Keyword(s):  
Lipoic Acid ◽  
Hemorrhoidal Disease ◽  
Control Group ◽  
Alpha Lipoic Acid ◽  
Open Label ◽  
Double Blind ◽  
Treatment Regimens ◽  
Reactive Protein ◽  
Number Of Patients ◽  
Serum Crp

Abstract. Background: Oral dietary supplementation is becoming increasingly popular as an addition to classical approaches for the prevention and treatment of hemorrhoidal disease. Aim: To examine the effect of orally administrated alpha lipoic acid (ALA), known for its antioxidant and anti-inflammatory properties, in the treatment of patients with permanent symptoms of hemorrhoidal disease. Methods: Patients with second- and third-degree hemorrhoids (n = 100) were enrolled into a randomized, open label, single-center trial. The study group (n = 50) was treated with 200 mg of orally administered ALA once a day during the 12-week period, the control group (n = 50) did not receive any treatment. Results: There were no significant differences in demographics, diagnosis, or exposure to major risk factors between the study and placebo group at baseline. ALA significantly improved subjective efficacy variables, such as pain and discomfort (p < 0.01) as well as objective signs of the disease, such as bleeding (p < 0.01), in comparison to the control group. Furthermore, the 3-month treatment significantly reduced the number of patients with positive C-reactive protein (CRP) value (serum CRP > 5 mg/L) from 18% before to only 2% after the treatment (χ2 = 4.65; p < 0.01). Average leukocyte count has also been significantly reduced in the treatment group (p < 0.01) from 7.29 × 109/L before to 6.18 × 109/L after treatment. Conclusions: The obtained results indicate that ALA is effective in the treatment of second- and third-degree hemorrhoids. Larger, double-blind controlled trials are needed to confirm the results and to investigate optimal treatment regimens.

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