Drosophila melanogaster as an in vivo model to study the potential toxicity of cerium oxide nanoparticles

2019 ◽  
Vol 490 ◽  
pp. 70-80 ◽  
Author(s):  
Vignesh Sundararajan ◽  
Pallavi Dan ◽  
Ajay Kumar ◽  
G. Devanand Venkatasubbu ◽  
Sahoko Ichihara ◽  
...  
Keyword(s):  
Drosophila Melanogaster ◽  
Cerium Oxide ◽  
Cerium Oxide Nanoparticles ◽  
In Vivo Model ◽  
Oxide Nanoparticles ◽  
Potential Toxicity

scholarly journals In Vitro and In Vivo Antioxidant Activity of the New Magnetic-Cerium Oxide Nanoconjugates

Nanomaterials ◽  
2019 ◽  
Vol 9 (11) ◽  
pp. 1565 ◽  
Author(s):  
Turin-Moleavin ◽  
Fifere ◽  
Lungoci ◽  
Rosca ◽  
Coroaba ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Antioxidant Activity ◽  
Iron Oxide ◽  
Cerium Oxide ◽  
Chemical Activation ◽  
Radical Scavenging ◽  
Cerium Oxide Nanoparticles ◽  
Oxide Nanoparticles

Background. Cerium oxide nanoparticles present the mimetic activity of superoxide dismutase, being able to inactivate the excess of reactive oxygen species (ROS) correlated with a large number of pathologies, such as stents restenosis and the occurrence of genetic mutations that can cause cancer. This study presents the synthesis and biological characterisation of nanoconjugates based on nanoparticles of iron oxide interconnected with cerium oxide conjugates. Methods. The synthesis of magnetite-nanoceria nanoconjugates has been done in several stages, where the key to the process is the coating of nanoparticles with polyethyleneimine and its chemical activation-reticulation with glutaraldehyde. The nanoconjugates are characterised by several techniques, and the antioxidant activity was evaluated in vitro and in vivo. Results. Iron oxide nanoparticles interconnected with cerium oxide nanoparticles were obtained, having an average diameter of 8 nm. Nanoconjugates prove to possess superparamagnetic properties and the saturation magnetisation varies with the addition of diamagnetic components in the system, remaining within the limits of biomedical applications. In vitro free-radical scavenging properties of nanoceria are improved after the coating of nanoparticles with polyethylenimine and conjugation with magnetite nanoparticles. In vivo studies reveal increased antioxidant activity in all organs and fluids collected from mice, which demonstrates the ability of the nanoconjugates to reduce oxidative stress. Conclusion. Nanoconjugates possess magnetic properties, being able to scavenge free radicals, reducing the oxidative stress. The combination of the two properties mentioned above makes them excellent candidates for theranostic applications.

scholarly journals Cerium Oxide Nanoparticles Reduce Free Radical‐Mediated Toxicity in Drosophila melanogaster

2008 ◽  
Vol 22 (S1) ◽  
Author(s):  
Courtney Alicia Cohen ◽  
Julie A Karfakis ◽  
Matthew D Kurnick ◽  
Beverly Rzigalinski
Keyword(s):  
Drosophila Melanogaster ◽  
Free Radical ◽  
Cerium Oxide ◽  
Cerium Oxide Nanoparticles ◽  
Oxide Nanoparticles

Cerium Oxide Nanoparticles are Nontoxic for Mouse Embryogenesis In Vitro and In Vivo

2017 ◽  
Vol 13 ◽  
pp. 248-254 ◽  
Author(s):  
Alexander S. Chernov ◽  
Dmitry A. Reshetnikov ◽  
Anton L. Popov ◽  
Nelly R. Popova ◽  
Irina V. Savintseva ◽  
...  
Keyword(s):  
Cerium Oxide ◽  
Reproductive System ◽  
Biomedical Applications ◽  
Complex Analysis ◽  
Mouse Embryos ◽  
Cerium Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
Wide Range

Cerium oxide nanoparticles (nanoceria) are considered as one of the most promising nanomaterials for biomedical applications. Complex analysis of cytotoxicity, including the assessment of effects on the reproductive system, is required for development of new biomedical materials. In this study, we investigated the effects of ultra-small citrate-stabilized cerium oxide nanoparticles on the development of mouse embryos in vitro and embryogenesis process in vivo. We have shown that nanoceria in a wide range of concentrations do not exert a toxic effect on the development of 2-cell embryos and embryogenesis.

scholarly journals In vivo-induced size transformation of cerium oxide nanoparticles in both lung and liver does not affect long-term hepatic accumulation following pulmonary exposure

PLoS ONE ◽  
2018 ◽  
Vol 13 (8) ◽  
pp. e0202477 ◽  
Author(s):  
Justyna Modrzynska ◽  
Trine Berthing ◽  
Gitte Ravn-Haren ◽  
Kirsten Kling ◽  
Alicja Mortensen ◽  
...  
Keyword(s):  
Cerium Oxide ◽  
Cerium Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
Pulmonary Exposure

Intrinsically radiolabeled multifunctional cerium oxide nanoparticles for in vivo studies

2013 ◽  
Vol 1 (10) ◽  
pp. 1421 ◽  
Author(s):  
Likun Yang ◽  
Gobalakrishnan Sundaresan ◽  
Minghao Sun ◽  
Purnima Jose ◽  
David Hoffman ◽  
...  
Keyword(s):  
Cerium Oxide ◽  
In Vivo Studies ◽  
Cerium Oxide Nanoparticles ◽  
Oxide Nanoparticles
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