scholarly journals Nox, Reactive Oxygen Species and Regulation of Vascular Cell Fate

Antioxidants ◽  
2017 ◽  
Vol 6 (4) ◽  
pp. 90 ◽  
Author(s):  
Denise Burtenshaw ◽  
Roya Hakimjavadi ◽  
Eileen Redmond ◽  
Paul Cahill
Keyword(s):  
Reactive Oxygen Species ◽  
Cell Fate ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Vascular Cell

SbMYB15 transcription factor mitigates cadmium and nickel stress in transgenic tobacco by limiting uptake and modulating antioxidative defence system

2019 ◽  
Vol 46 (8) ◽  
pp. 702 ◽  
Author(s):  
Komal K. Sapara ◽  
Jackson Khedia ◽  
Parinita Agarwal ◽  
Doddabhimappa R. Gangapur ◽  
Pradeep K. Agarwal
Keyword(s):  
Reactive Oxygen Species ◽  
Heavy Metal ◽  
Transgenic Tobacco ◽  
Cell Fate ◽  
Metal Tolerance ◽  
Heavy Metal Tolerance ◽  
Reactive Oxygen ◽  
Transcript Expression ◽  
Oxygen Species ◽  
Salicornia Brachiata

Plants require different inorganic minerals in an appropriate amount for growth; however, imbalance can limit growth and productivity. Heavy metal accumulation causes toxicity and generates signalling crosstalk with reactive oxygen species (ROS), phytohormones, genes and transcription factors (TFs). The MYB (myeloblastoma) TFs participate in plant processes such as metabolism, development, cell fate, hormone pathways and responses to stresses. This is the first report towards characterisation of R2R3-type MYB TF, SbMYB15, from succulent halophyte Salicornia brachiata Roxb. for heavy metal tolerance. The SbMYB15 showed >5-fold increased transcript expression in the presence of CdCl2 and NiCl2•6H2O. The constitutive overexpression of SbMYB15 conferred cadmium and nickel tolerance in transgenic tobacco, with improved growth and chlorophyll content. Further, the transgenics showed reduced generation of reactive oxygen species (H2O2 and O2•−) as compared with the wild-type (WT) with both Cd2+ and Ni2+ stress. Transgenics also showed low uptake of heavy metal ions, increased scavenging activity of the antioxidative enzymes (CAT and SOD) and higher transcript expression of antioxidative genes (CAT1 and MnSOD). Thus, the present study signifies that SbMYB15 can be deployed for developing heavy metal tolerance in crop plants via genetic engineering.

scholarly journals Level of reactive oxygen species induced by p21WAF(1)/CIP(1)is critical for the determination of cell fate

2009 ◽  
Vol 100 (7) ◽  
pp. 1275-1283 ◽  
Author(s):  
Takafumi Inoue ◽  
Kiyoko Kato ◽  
Hidenori Kato ◽  
Kazuo Asanoma ◽  
Ayumi Kuboyama ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Cell Fate ◽  
Reactive Oxygen ◽  
Oxygen Species

scholarly journals Emerging Roots Alter Epidermal Cell Fate through Mechanical and Reactive Oxygen Species Signaling

2012 ◽  
Vol 24 (8) ◽  
pp. 3296-3306 ◽  
Author(s):  
Bianka Steffens ◽  
Alexander Kovalev ◽  
Stanislav N. Gorb ◽  
Margret Sauter
Keyword(s):  
Reactive Oxygen Species ◽  
Cell Fate ◽  
Epidermal Cell ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Reactive Oxygen Species Signaling

The Effect of Dipyridamole on Vascular Cell-Derived Reactive Oxygen Species

2005 ◽  
Vol 315 (2) ◽  
pp. 494-500 ◽  
Author(s):  
Subrata Chakrabarti ◽  
Olga Vitseva ◽  
David Iyu ◽  
Sonia Varghese ◽  
Jane E. Freedman
Keyword(s):  
Reactive Oxygen Species ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Vascular Cell

scholarly journals Sulfur sequestration promotes multicellularity during nutrient limitation

Nature ◽  
2021 ◽  
Author(s):  
Beth Kelly ◽  
Gustavo E. Carrizo ◽  
Joy Edwards-Hicks ◽  
David E. Sanin ◽  
Michal A. Stanczak ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Nutrient Limitation ◽  
Cell Fate ◽  
Cellular Proliferation ◽  
Reactive Oxygen ◽  
Protein Translation ◽  
Oxygen Species ◽  
Iron Sulfur Cluster ◽  
Signalling Molecules ◽  
And Function

AbstractThe behaviour of Dictyostelium discoideum depends on nutrients1. When sufficient food is present these amoebae exist in a unicellular state, but upon starvation they aggregate into a multicellular organism2,3. This biology makes D. discoideum an ideal model for investigating how fundamental metabolism commands cell differentiation and function. Here we show that reactive oxygen species—generated as a consequence of nutrient limitation—lead to the sequestration of cysteine in the antioxidant glutathione. This sequestration limits the use of the sulfur atom of cysteine in processes that contribute to mitochondrial metabolism and cellular proliferation, such as protein translation and the activity of enzymes that contain an iron–sulfur cluster. The regulated sequestration of sulfur maintains D. discoideum in a nonproliferating state that paves the way for multicellular development. This mechanism of signalling through reactive oxygen species highlights oxygen and sulfur as simple signalling molecules that dictate cell fate in an early eukaryote, with implications for responses to nutrient fluctuations in multicellular eukaryotes.

scholarly journals Roles of Reactive Oxygen Species in Cardiac Differentiation, Reprogramming, and Regenerative Therapies

2020 ◽  
Vol 2020 ◽  
pp. 1-14
Author(s):  
Jialiang Liang ◽  
Min Wu ◽  
Chen Chen ◽  
Mingjie Mai ◽  
Jinsong Huang ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Cell Fate ◽  
Heart Development ◽  
Molecular Mechanisms ◽  
Reactive Oxygen ◽  
Cardiac Regeneration ◽  
Cardiac Differentiation ◽  
Ros Generation ◽  
Oxygen Species ◽  
Regenerative Therapies

Reactive oxygen species (ROS) have been implicated in mechanisms of heart development and regenerative therapies such as the use of pluripotent stem cells. The roles of ROS mediating cell fate are dependent on the intensity of stimuli, cellular context, and metabolic status. ROS mainly act through several targets (such as kinases and transcription factors) and have diverse roles in different stages of cardiac differentiation, proliferation, and maturation. Therefore, further detailed investigation and characterization of redox signaling will help the understanding of the molecular mechanisms of ROS during different cellular processes and enable the design of targeted strategies to foster cardiac regeneration and functional recovery. In this review, we focus on the roles of ROS in cardiac differentiation as well as transdifferentiation (direct reprogramming). The potential mechanisms are discussed in regard to ROS generation pathways and regulation of downstream targets. Further methodological optimization is required for translational research in order to robustly enhance the generation efficiency of cardiac myocytes through metabolic modulations. Additionally, we highlight the deleterious effect of the host’s ROS on graft (donor) cells in a paracrine manner during stem cell-based implantation. This knowledge is important for the development of antioxidant strategies to enhance cell survival and engraftment of tissue engineering-based technologies. Thus, proper timing and level of ROS generation after a myocardial injury need to be tailored to ensure the maximal efficacy of regenerative therapies and avoid undesired damage.

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