Reactive Oxygen Species and Mitochondrial Homeostasis as Regulators of Stem Cell Fate and Function

2018 ◽  
Vol 29 (2) ◽  
pp. 149-168 ◽  
Author(s):  
Darren Q. Tan ◽  
Toshio Suda
Keyword(s):  
Reactive Oxygen Species ◽  
Stem Cell ◽  
Cell Fate ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Stem Cell Fate ◽  
Mitochondrial Homeostasis ◽  
And Function

scholarly journals Sulfur sequestration promotes multicellularity during nutrient limitation

Nature ◽  
2021 ◽  
Author(s):  
Beth Kelly ◽  
Gustavo E. Carrizo ◽  
Joy Edwards-Hicks ◽  
David E. Sanin ◽  
Michal A. Stanczak ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Nutrient Limitation ◽  
Cell Fate ◽  
Cellular Proliferation ◽  
Reactive Oxygen ◽  
Protein Translation ◽  
Oxygen Species ◽  
Iron Sulfur Cluster ◽  
Signalling Molecules ◽  
And Function

AbstractThe behaviour of Dictyostelium discoideum depends on nutrients1. When sufficient food is present these amoebae exist in a unicellular state, but upon starvation they aggregate into a multicellular organism2,3. This biology makes D. discoideum an ideal model for investigating how fundamental metabolism commands cell differentiation and function. Here we show that reactive oxygen species—generated as a consequence of nutrient limitation—lead to the sequestration of cysteine in the antioxidant glutathione. This sequestration limits the use of the sulfur atom of cysteine in processes that contribute to mitochondrial metabolism and cellular proliferation, such as protein translation and the activity of enzymes that contain an iron–sulfur cluster. The regulated sequestration of sulfur maintains D. discoideum in a nonproliferating state that paves the way for multicellular development. This mechanism of signalling through reactive oxygen species highlights oxygen and sulfur as simple signalling molecules that dictate cell fate in an early eukaryote, with implications for responses to nutrient fluctuations in multicellular eukaryotes.

scholarly journals Antioxidant proteins and reactive oxygen species are decreased in a murine epidermal side population with stem cell-like characteristics

2011 ◽  
Vol 135 (3) ◽  
pp. 293-304 ◽  
Author(s):  
Wanakee J. Carr ◽  
Rebecca E. Oberley-Deegan ◽  
Yuping Zhang ◽  
Christopher C. Oberley ◽  
Larry W. Oberley ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Stem Cell ◽  
Side Population ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Antioxidant Proteins

scholarly journals A reactive oxygen species-generating, cyclooxygenase-2 inhibiting, cancer stem cell-potent tetranuclear copper(ii) cluster

2017 ◽  
Vol 46 (38) ◽  
pp. 12785-12789 ◽  
Author(s):  
C. Lu ◽  
K. Laws ◽  
A. Eskandari ◽  
K. Suntharalingam
Keyword(s):  
Reactive Oxygen Species ◽  
Stem Cells ◽  
Schiff Base ◽  
Stem Cell ◽  
Cancer Stem Cells ◽  
Cancer Stem Cell ◽  
Cancer Cells ◽  
Reactive Oxygen ◽  
Cyclooxygenase 2 ◽  
Oxygen Species

Tetranuclear copper(ii) complexes containing multiple diclofenac and Schiff base moieties,1–4, are shown to kill bulk cancer cells and cancer stem cells (CSCs) with low micromolar potency.

SbMYB15 transcription factor mitigates cadmium and nickel stress in transgenic tobacco by limiting uptake and modulating antioxidative defence system

2019 ◽  
Vol 46 (8) ◽  
pp. 702 ◽  
Author(s):  
Komal K. Sapara ◽  
Jackson Khedia ◽  
Parinita Agarwal ◽  
Doddabhimappa R. Gangapur ◽  
Pradeep K. Agarwal
Keyword(s):  
Reactive Oxygen Species ◽  
Heavy Metal ◽  
Transgenic Tobacco ◽  
Cell Fate ◽  
Metal Tolerance ◽  
Heavy Metal Tolerance ◽  
Reactive Oxygen ◽  
Transcript Expression ◽  
Oxygen Species ◽  
Salicornia Brachiata

Plants require different inorganic minerals in an appropriate amount for growth; however, imbalance can limit growth and productivity. Heavy metal accumulation causes toxicity and generates signalling crosstalk with reactive oxygen species (ROS), phytohormones, genes and transcription factors (TFs). The MYB (myeloblastoma) TFs participate in plant processes such as metabolism, development, cell fate, hormone pathways and responses to stresses. This is the first report towards characterisation of R2R3-type MYB TF, SbMYB15, from succulent halophyte Salicornia brachiata Roxb. for heavy metal tolerance. The SbMYB15 showed >5-fold increased transcript expression in the presence of CdCl2 and NiCl2•6H2O. The constitutive overexpression of SbMYB15 conferred cadmium and nickel tolerance in transgenic tobacco, with improved growth and chlorophyll content. Further, the transgenics showed reduced generation of reactive oxygen species (H2O2 and O2•−) as compared with the wild-type (WT) with both Cd2+ and Ni2+ stress. Transgenics also showed low uptake of heavy metal ions, increased scavenging activity of the antioxidative enzymes (CAT and SOD) and higher transcript expression of antioxidative genes (CAT1 and MnSOD). Thus, the present study signifies that SbMYB15 can be deployed for developing heavy metal tolerance in crop plants via genetic engineering.

Reactive Oxygen Species and Nitric Oxide Production, Regulation and Function During Defense Response

2019 ◽  
pp. 573-590
Author(s):  
Eliana Molina‐Moya ◽  
Laura C. Terrón‐Camero ◽  
Leyre Pescador‐Azofra ◽  
Luisa M. Sandalio ◽  
María C. Romero‐Puertas
Keyword(s):  
Nitric Oxide ◽  
Reactive Oxygen Species ◽  
Defense Response ◽  
Reactive Oxygen ◽  
Nitric Oxide Production ◽  
Oxygen Species ◽  
Oxide Production ◽  
And Function

scholarly journals A reactive oxygen species-generating, cancer stem cell-potent manganese(ii) complex and its encapsulation into polymeric nanoparticles

2019 ◽  
Vol 10 (33) ◽  
pp. 7792-7800 ◽  
Author(s):  
Arvin Eskandari ◽  
Kogularamanan Suntharalingam
Keyword(s):  
Breast Cancer ◽  
Reactive Oxygen Species ◽  
Stem Cell ◽  
Cancer Stem Cell ◽  
Polymeric Nanoparticles ◽  
Reactive Oxygen ◽  
Breast Cancer Stem Cell ◽  
Oxygen Species ◽  
Inflammatory Drug ◽  
Phenanthroline Complex

Here we report the breast cancer stem cell (CSC) potency of a reactive oxygen species (ROS)-generating manganese(ii)-phenanthroline complex bearing diclofenac, a nonsteriodial anti-inflammatory drug.

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