scholarly journals Analysis of Phenolic and Flavonoid Contents, and the Anti-Oxidative Potential and Lipid Peroxidation Inhibitory Activity of Methanolic Extract of Carissa opaca Roots and Its Fractions in Different Solvents

Antioxidants ◽  
2014 ◽  
Vol 3 (4) ◽  
pp. 671-683 ◽  
Author(s):  
Dildar Ahmed ◽  
Khaizran Fatima ◽  
Ramsha Saeed
Keyword(s):  
Lipid Peroxidation ◽  
Inhibitory Activity ◽  
Methanolic Extract ◽  
Oxidative Potential ◽  
Carissa Opaca ◽  
Lipid Peroxidation Inhibitory Activity ◽  
Phenolic And Flavonoid

Lipid peroxidation inhibitory activity of some constituents isolated from the stem bark ofEucalyptus globulus

2000 ◽  
Vol 23 (2) ◽  
pp. 147-150 ◽  
Author(s):  
Bong-Sik Yun ◽  
In-Kyoung Lee ◽  
Jong-Pyung Kim ◽  
Sung-Hyun Chung ◽  
Gyu-Seop Shim ◽  
...  
Keyword(s):  
Lipid Peroxidation ◽  
Inhibitory Activity ◽  
Stem Bark ◽  
Lipid Peroxidation Inhibitory Activity

Limonoids from Meliaceae with Lipid Peroxidation Inhibitory Activity

2011 ◽  
Vol 6 (6) ◽  
pp. 1934578X1100600 ◽  
Author(s):  
Robert G. Fowles ◽  
Baldwin S. Mootoo ◽  
Russel S. Ramsewak ◽  
William F. Reynolds ◽  
Muraleedharan G. G. Nair
Keyword(s):  
Lipid Peroxidation ◽  
Antioxidant Activity ◽  
Inhibitory Activity ◽  
Natural Compounds ◽  
Lipid Peroxidation Inhibitory Activity ◽  
Positive Controls

In this study the antioxidant activity of natural limonoids from Meliaceae swietenolide (1), 3,6-O,O-diacetylswietenolide (2), swietenine (3), swietemahonin G (4) and 2-hydroxyswietenine (5) were investigated along with the semisynthetic analogues (6-25) of compounds 1, 3-4. Lipid peroxidation (LPO) inhibitory assays revealed 85.6, 13.3, 77.3, 61.2 and 24.6 % inhibition for the natural compounds 1-5. Excellent antioxidant activity was seen for the semisynthetic analogues 10 (98.3 %), 16-17, 21-22 and 25 (100 %), which were more active than the positive controls BHA (91.3 %) and TBHQ (95.7 %).

QSAR Analysis of the Lipid Peroxidation Inhibitory Activity with Structure and Energetics of 36 Flavonoids Derivatives

2006 ◽  
Vol 53 (6) ◽  
pp. 1251-1261 ◽  
Author(s):  
Hsien-Ren Liao ◽  
Yeong-Sheng Chang ◽  
Ling-Ling Yang ◽  
Yu-Chun Lin ◽  
Yu-Ma Chou ◽  
...  
Keyword(s):  
Lipid Peroxidation ◽  
Inhibitory Activity ◽  
Qsar Analysis ◽  
Lipid Peroxidation Inhibitory Activity

scholarly journals Lipid Peroxidation Inhibitory Activity In vitro of Mezzetia parviflora Becc. Wood Bark Polar extract

2017 ◽  
Vol 9 (2) ◽  
pp. 171-175 ◽  
Author(s):  
Mufidah Murdifin ◽  
Ermina Pakki ◽  
Gemini Alam ◽  
Marianti A. Manggau ◽  
Lukman Muslimin ◽  
...  
Keyword(s):  
Lipid Peroxidation ◽  
Inhibitory Activity ◽  
Wood Bark ◽  
Lipid Peroxidation Inhibitory Activity

Phenolic constituents and inhibitory effects of the leaf of Rauvolfia vomitoria Afzel on free radicals, cholinergic and monoaminergic enzymes in rat’s brain in vitro

2020 ◽  
Vol 0 (0) ◽  
Author(s):  
Olubukola H. Oyeniran ◽  
Adedayo O. Ademiluyi ◽  
Ganiyu Oboh
Keyword(s):  
Lipid Peroxidation ◽  
Free Radicals ◽  
Methanolic Extract ◽  
Array Detector ◽  
Oh Radicals ◽  
Inhibitory Effects ◽  
Methanolic Extracts ◽  
Phenolic Constituents ◽  
Rauvolfia Vomitoria

AbstractObjectivesRauvolfia vomitoria is a medicinal plant used traditionally in Africa in the management of several human diseases including psychosis. However, there is inadequate scientific information on the potency of the phenolic constituents of R. vomitoria leaf in the management of neurodegeneration. Therefore, this study characterized the phenolic constituents and investigated the effects of aqueous and methanolic extracts of R. vomitoria leaf on free radicals, Fe2+-induced lipid peroxidation, and critical enzymes linked to neurodegeneration in rat’s brain in vitro.MethodsThe polyphenols were evaluated by characterizing phenolic constituents using high-performance liquid chromatography coupled with diode array detector (HPLC-DAD). The antioxidant properties were assessed through the extracts ability to reduce Fe3+ to Fe2+; inhibit ABTS, DPPH, and OH radicals and Fe2+-induced lipid peroxidation. The effects of the extracts on AChE and MAO were also evaluated.ResultsThe phenolic characterization of R. vomitoria leaf revealed that there were more flavonoids present. Both aqueous and methanolic extracts of R. vomitoria leaf had inhibitory effects with the methanolic extract having higher significant (p≤0.05) free radicals scavenging ability coupled with inhibition of monoamine oxidases. However, there was no significant (p≤0.05) difference obtained in the inhibition of lipid peroxidation and cholinesterases.ConclusionThis study suggests that the rich phenolic constituents of R. vomitoria leaf might contribute to the observed antioxidative and neuroprotective effects. The methanolic extract was more potent than the aqueous extract; therefore, extraction of R. vomitoria leaf with methanol could offer better health-promoting effects in neurodegenerative condition.

scholarly journals Mammalian Arginase Inhibitory Activity of Methanolic Extracts and Isolated Compounds from Cyperus Species

Molecules ◽  
2021 ◽  
Vol 26 (6) ◽  
pp. 1694
Author(s):  
Kamel Arraki ◽  
Perle Totoson ◽  
Alain Decendit ◽  
Andy Zedet ◽  
Justine Maroilley ◽  
...  
Keyword(s):  
Inhibitory Activity ◽  
Methanolic Extract ◽  
Significant Inhibition ◽  
Isolation And Identification ◽  
Vasorelaxant Effect ◽  
Methanolic Extracts ◽  
Phytochemical Investigation ◽  
Ic50 Values ◽  
First Time

Polyphenolic enriched extracts from two species of Cyperus, Cyperus glomeratus and Cyperus thunbergii, possess mammalian arginase inhibitory capacities, with the percentage inhibition ranging from 80% to 95% at 100 µg/mL and 40% to 64% at 10 µg/mL. Phytochemical investigation of these species led to the isolation and identification of two new natural stilbene oligomers named thunbergin A-B (1–2), together with three other stilbenes, trans-resveratrol (3), trans-scirpusin A (4), trans-cyperusphenol A (6), and two flavonoids, aureusidin (5) and luteolin (7), which were isolated for the first time from C.thunbergii and C. glomeratus. Structures were established on the basis of the spectroscopic data from MS and NMR experiments. The arginase inhibitory activity of compounds 1–7 was evaluated through an in vitro arginase inhibitory assay using purified liver bovine arginase. As a result, five compounds (1, 4–7) showed significant inhibition of arginase, with IC50 values between 17.6 and 60.6 µM, in the range of those of the natural arginase inhibitor piceatannol (12.6 µM). In addition, methanolic extract from Cyperus thunbergii exhibited an endothelium and NO-dependent vasorelaxant effect on thoracic aortic rings from rats and improved endothelial dysfunction in an adjuvant-induced arthritis rat model.

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