scholarly journals Genetic Polymorphism of β-Casein Gene in Polish Red Cattle—Preliminary Study of A1 and A2 Frequency in Genetic Conservation Herd

Animals ◽  
2019 ◽  
Vol 9 (6) ◽  
pp. 377 ◽  
Author(s):  
Anna Cieślińska ◽  
Ewa Fiedorowicz ◽  
Grzegorz Zwierzchowski ◽  
Natalia Kordulewska ◽  
Beata Jarmołowska ◽  
...  
Keyword(s):  
Bioactive Peptides ◽  
Genomic Sequence ◽  
Type I Diabetes ◽  
Significant Risk ◽  
Milk Proteins ◽  
Significant Risk Factor ◽  
Sudden Infant Death ◽  
Sudden Infant ◽  
Type I ◽  
Preliminary Study

Although there is growing interest in Red cow’s milk in Poland, to date there are few reports investigating the characteristics of milk components in the studied population. Particular emphasis on milk proteins is advised, since β-casein is a source of bioactive peptides named β-casomorphins. β-casomorphin 7, which originates mostly from β-casein variants A1, may be a significant risk factor in human ischemic heart disease, arteriosclerosis, type I diabetes, sudden infant death syndrome, and autism. The aim of the present study was to identify CSN2 polymorphism gene in exon 7 using the genomic sequence from GenBank (M55158), g.8101C>A, (codon 67). Blood samples were collected from 201 Polish Red cattle (24 males and 177 females). The genotype of β-casein was determined using PCR-ACRS. The frequency of β-casein A2 in Polish Red population was 0.47. β-casein A2 frequency in Polish Red bulls and in cows was 0.58 and 0.37, respectively.

Association of Lunate Morphology With Progression to Scaphoid Fracture Nonunion

Hand ◽  
2020 ◽  
pp. 155894472093736
Author(s):  
Rachel E. Hein ◽  
Amanda N. Fletcher ◽  
Rose T. Tillis ◽  
Eric Q. Pang ◽  
David S. Ruch ◽  
...  
Keyword(s):  
Scaphoid Fracture ◽  
Significant Risk ◽  
Significant Risk Factor ◽  
Delayed Union ◽  
Type I ◽  
Type Ii ◽  
Fracture Location ◽  
Scaphoid Fractures ◽  
Fracture Nonunion ◽  
N 93

Background: The purpose of our study was to review a series of patients with scaphoid fractures to determine whether there was an association between lunate morphology and progression to delayed union or nonunion when treated operatively or nonoperatively. Secondary aims included evaluation of the relationship between lunate morphology and scaphoid fracture location. Methods: A retrospective review of all patients with a diagnosis of scaphoid fracture was performed at our institution between 2014 and 2017. Medical records and radiographs were evaluated to determine lunate morphology, scaphoid fracture location, treatment, and time to union. Differences between groups were determined using χ2 analysis with significance set at P <.05. Multiple logistic regression analyses were used to evaluate scaphoid union in the setting of lunate morphology when controlling for confounders. Results: A total of 169 patients were included; 45.0% (n = 76) of patients had type I lunate morphology, and 55.0% (n = 93) had type II. In all, 64.5% (n = 49) of patients with type I lunate and 68.8% (n = 64) with type II lunate had a fracture at the scaphoid waist. Among all patients with a scaphoid fracture, type II lunates were more likely than type I lunates to progress to nonunion when treated both operatively and nonoperatively (18.3% vs 4.0%, P = .0042). Lunate facet size was not shown to be a significant risk factor for nonunion among patients with a type II lunate ( P = .4221). Conclusions: Patients with a scaphoid fracture and type II lunate morphology were more likely to progress to nonunion than patients with a type I lunate.

Sudden infant death syndrome (SIDS): a preliminary study of reticular dendritic spines in infants with SIDS

1980 ◽  
Vol 181 (1) ◽  
pp. 245-249 ◽  
Author(s):  
James J. Quattrochi ◽  
Nobuhisa Baba ◽  
Leopold Liss ◽  
William Adrion
Keyword(s):  
Sudden Infant Death Syndrome ◽  
Dendritic Spines ◽  
Infant Death ◽  
Sudden Infant Death ◽  
Sudden Infant ◽  
Preliminary Study

Prolonged Infantile Apnea: 1985

PEDIATRICS ◽  
1985 ◽  
Vol 76 (1) ◽  
pp. 129-131
Author(s):  
Keyword(s):  
Preterm Infants ◽  
Significant Risk ◽  
Sudden Infant Death ◽  
Positive Pressure ◽  
Sudden Infant ◽  
Risk Of Death ◽  
Increased Risk ◽  
Regulation Of Breathing ◽  
Prolonged Apnea ◽  
Undetermined Etiology

Knowledge regarding the etiology and optimal management of prolonged infantile apnea and its relationship to sudden infant death syndrome (SIDS) is tentative. Consequently, infantile apnea is a controversial subject; professional discussion and media attention are often emotional and even erroneous. Prolonged apnea is defined as cessation of breathing for at least 20 seconds or as a briefer episode of apnea associated with bradycardia, cyanosis, or pallor. Brief episodes of apnea are a normal occurrence in infants, but prolonged apneic episodes may lead to morbidity and rarely mortality. The vast majority of infants with prolonged apnea are not victims of SIDS; most SIDS victims were never observed to have had prolonged apnea prior to the terminal event. The risk of death from SIDS is somewhat greater in the group of infants with prolonged apnea than in the general population. Infants with sleep apnea who have required active intervention, such as positive pressure "resuscitation," may be at significant risk. Apnea of undetermined etiology that occurs in the premature infant between the actual date of birth and the original due date is apparently not predictive of SIDS. There is, however, indication that preterm infants as a group and perhaps siblings of infants who were victims of SIDS are at somewhat increased risk. Infants who have had an episode of prolonged apnea are perceived by parents and physicians as having experienced a life-threatening event and being at risk for another. Prolonged apnea can be a symptom of many disorders including infection, seizures, airway abnormalities, hypoglycemia or other metabolic problems, anemia (in preterm infants), gastroesophageal reflux, impaired regulation of breathing during sleeping and feeding, and abuse.

scholarly journals ORAL ABSTRACTS (1)Allied Professionals7CRYOABLATION FOR PAROXYSMAL ATRIAL FIBRILLATION - IS AN EP LAB REQUIRED?8A PATHWAY TO SAFETY - ANTICOAGULATION COMPLIANCE IN CIED PATIENTS WITH AF9UNDERSTANDING THE WAYS IN WHICH OCCUPATION IS AFFECTED BY POSTURAL TACHYCARDIA SYNDROME: A UK OCCUPATIONAL THERAPY PERSPECTIVE10DEVELOPMENT OF AN INTERGRATED SUPPORT PATHWAY FOR PATIENTS FULFILLING NICE CRITERIA FOR AN INTERNAL CARDIOVASCULAR DEBRIBRILLATOR (ICD) IN A DISTRICT GENERAL HOSPITAL11ARE CARDIOVASCULAR RISK FACTORS ALSO ASSOCIATED WITH THE INCIDENCE OF ATRIAL FIBRILLATION? A SYSTEMATIC REVIEW AND FIELD SYNOPSIS OF 23 FACTORS IN 32 INITIALLY HEALTHY COHORTS OF 20 MILLION PARTICIPANTS12BRAIN MRI FINDINGS IN PATIENTS WITH ATRIAL FIBRILLATION UNDERGOING CARDIOVERSIONBasic Science/Sudden Cardiac Death13PRELIMINARY ASSESSMENT OF THE “RE-ENTRY VULNERABILITY INDEX” AS A MARKER OF CARDIAC INSTABILITY IN THE HUMAN HEART USING WHOLE-HEART CONTACT EPICARDIAL MAPPING14OPTOGENETIC STIMULATION OF BRAINSTEM'S VAGAL PREGANGLIONIC NEURONES IS ASSOCIATED WITH NEURONAL NITRIC OXIDE SYNTHASE-DEPENDENT PROLONGATION OF VENTRICULAR EFFECTIVE REFRACTORY PERIOD15A DYNAMIC-CLAMP STUDY OF L-TYPE Ca2+ CURRENT IN RABBIT AND HUMAN ATRIAL MYOCYTES: THE CONTRIBUTION OF WINDOW ICaL TO EARLY AFTERDEPOLARISATIONS16WHOLE EXOME SEQUENCING IN SUDDEN INFANT DEATH SYNDROME17MEDIUM TERM SURVIVAL AND FAMILY SCREENING OUTCOMES IN AN IDIOPATHIC VENTRICULAR FIBRILLATION COHORT - A MULTICENTRE EXPERIENCE18CLINICAL CHARACTERISTICS OF SCD SURVIVORS WITH BRUGADA SYNDROME:- ARE SPONSANEOUS TYPE I ECG AND PREVIOUS SYNCOPE REALLY ASSOCIATED WITH HIGH RISK?

EP Europace ◽  
2016 ◽  
Vol 18 (suppl 2) ◽  
pp. ii4-ii7
Author(s):  
F. Champney ◽  
L.J. Maddock ◽  
J. Welford ◽  
J. Kemp ◽  
V. Allan ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Sudden Infant Death ◽  
Vulnerability Index ◽  
Postural Tachycardia Syndrome ◽  
Sudden Infant ◽  
Type I ◽  
Mri Findings ◽  
Term Survival ◽  
Postural Tachycardia ◽  
Whole Heart

scholarly journals Bovine Milk: A1 and A2 Beta Casein Milk Proteins and their Impact on Human Health: A Review

2021 ◽  
Author(s):  
P. Chitra
Keyword(s):  
Amino Acid ◽  
Type I Diabetes ◽  
Heart Diseases ◽  
Age Groups ◽  
Bovine Milk ◽  
Milk Proteins ◽  
Type I ◽  
Beta Casein ◽  
Casein Protein ◽  
Proline Amino Acid

Milk is the ideal food for all age groups of human being. Milk consists of 87 per cent water and the remaining 13 per cent is the milk sugar lactose, protein, fat, vitamins and minerals. Casein is the chief component of the milk proteins of which about 30 per cent is beta-casein. The major beta-casein variants are A1 and A2. Beta-casein consist a chain of 229 amino acids. Cows that produce milk contain proline amino acid are called as A2 cows. A2 milk is found basically in indigenous cows and buffaloes of India. Around 5,000 years ago, a mutation occurred in this proline amino acid, converting it to histidine amino acid at 67 th position. Cows that have this mutated beta casein protein are called A1 cows. Different mutations bovine beta casein produce 13 genetic variants and out of these A1 and A2 are the most common. A1 β-casein is enzymatically broken down in the intestine to produce beta-casmorphin-7 (β-CM-7) which is an opioid peptide similar to morphine. BCM-7 interacts with the human gastrointestinal tract, internal organs and brainstem. BCM-7 adversely affects the immune response and is also considered as a risk factor for chronic heart diseases (CHD) and juvenile insulin dependent type I diabetes mellitus (DM-I). The original beta casein protein in bovine milk was A2. A2 is more comparable to the human beta casein than A1 in terms of digestive breakdown. Indigenous dairy breeds of cow (Red Sindhi, Sahiwal, Tharparkar, Gir and Rathi) and buffalo produce A2 milk and India is endowed with rich A2 dairy animals.

scholarly journals Inferior Surface Leukoplakia of Vocal Folds: Risk of Recurrence: A Preliminary Study

2021 ◽  
pp. 014556132198943
Author(s):  
Hisashi Hasegawa ◽  
Hiroumi Matsuzaki ◽  
Kiyoshi Makiyama ◽  
Takeshi Oshima
Keyword(s):  
Risk Factor ◽  
Vocal Fold ◽  
Significant Risk ◽  
Vocal Folds ◽  
Significant Risk Factor ◽  
Clinicopathological Characteristics ◽  
Inferior Surface ◽  
Preliminary Study ◽  
Risk Factor For Recurrence ◽  
Vocal Fold Leukoplakia

Objectives: This study aimed to identify vocal fold leukoplakia (VFL) lesions on the inferior surface as a risk factor for recurrence. Methods: This was a retrospective study with data collected from 2001 to 2018. The study comprised 37 patients with VFL, divided into the nonrecurrent and recurrent groups. We examined the clinicopathological characteristics and the surgical procedures performed in each patient. Results: Among the 37 patients, 15 (40.5%) had residual (3) or recurrent (12) VFL. Of those patients with and without recurrence, 8 of 12 (66.7%) and 6 of 22 (27.3%), respectively, had inferior surface lesions of the vocal fold at the initial operation ( P = .036). Recurrences were significantly higher in patients with inferior surface lesions. Other evaluated factors did not show significance for recurrence. Conclusion: The presence of VFL lesions on the inferior surface is a significant risk factor for recurrence.

scholarly journals Family Support towards Resilience in Adolescents with Type I Diabetes: A Preliminary Study in Indonesia

2019 ◽  
Vol 4 (2) ◽  
pp. 66-71
Author(s):  
Nur Agustini ◽  
◽  
Nani Nurhaeni ◽  
Hening Pujasari ◽  
Elni Abidin ◽  
...  
Keyword(s):  
Family Support ◽  
Type I Diabetes ◽  
Type I ◽  
Preliminary Study

Sudden Infant Death Syndrome and Sleeping Position

PEDIATRICS ◽  
1992 ◽  
Vol 90 (1) ◽  
pp. 115-118
Author(s):  
CARL E. HUNT ◽  
DANIEL C. SHANNON
Keyword(s):  
Sudden Infant Death Syndrome ◽  
Infant Death ◽  
Task Force ◽  
Significant Risk ◽  
Epidemiological Data ◽  
Sudden Infant Death ◽  
Weight Of Evidence ◽  
Sudden Infant ◽  
Term Infants ◽  
Sleeping Position

Do something, anything! is a universal cry at the onset of the pain and suffering of illness; healers have responded with imagination and boundless enthusiasm. —Lewis Thomas (NY Rev Books. September 24, 1987) We have learned, to our sorrow, that strong emotional interest in the force of speedy medical action when there is substantial uncertainty has led to recurring iatrogenic disasters. —William Silverman1 The American Academy of Pediatrics Task Force on Infant Positioning and SIDS recently has reviewed the existing epidemiological data and concluded that (1) the weight of evidence implicates the prone position as a significant risk factor for sudden infant death syndrome (SIDS), and (2) for healthy and full-term infants, prone sleeping should be abandoned in favor of the supine or lateral position.2

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