scholarly journals Overweight in Domestic Cats Living in Urban Areas of Italy: Risk Factors for an Emerging Welfare Issue

Animals ◽  
2021 ◽  
Vol 11 (8) ◽  
pp. 2246
Author(s):  
Laura Arena ◽  
Laura Menchetti ◽  
Silvana Diverio ◽  
Giovanna Guardini ◽  
Angelo Gazzano ◽  
...  
Keyword(s):  
Body Condition ◽  
Urban Areas ◽  
Dietary Habits ◽  
Significant Risk ◽  
Significant Risk Factor ◽  
P Value ◽  
Welfare Issue ◽  
Mixed Breed ◽  
Welfare Implications ◽  
And Behavior

Overweight is common in cats and has health and welfare implications. This study aimed to assess potential predictive/protective factors for feline overweight associated with owner management and their relationship with cat behavior and welfare. A questionnaire was administered to 197 owners to collect information about cat demographics, management, environment, dietary habits and behavior. The feline Body Mass Index was recorded for each cat. Univariate logistic regression was used to evaluate the association of parameters with overweight cats. Variables with a p-value < 0.10 at univariable analyses were selected for the multivariable model. Most cats were mixed- breed, 1–7 years old and neutered; 51.3% were overweight. Age higher than 7 years, neutering, being alone all day and being stressed were predictive for overweight (p < 0.05). Conversely, the presence of other animals had a protective effect (p < 0.05). A general disagreement between owners’ perception and clinical evaluation of cats’ body condition was a common and significant risk factor for overweight (OR = 8.532, 95% CI = 4.073–17.875; p < 0.001). According to the owners, many veterinarians did not inform them about their cat being overweight nor about the risks (p < 0.001). This study provides helpful information on the influence of management and environment on cats’ body condition and its relationship with cat welfare.

scholarly journals Risk factors for hypertensive crisis in children with acute glomerulonephritis

2016 ◽  
Vol 56 (2) ◽  
pp. 101
Author(s):  
Sherly Yuniarchan ◽  
Risky Vitria Prasetyo ◽  
Ninik Asmaningsih Soemyarso ◽  
Mohammad Sjaifullah Noer
Keyword(s):  
Risk Factors ◽  
Logistic Regression ◽  
Risk Factor ◽  
Pediatric Population ◽  
Hypertensive Crisis ◽  
Significant Risk ◽  
Significant Risk Factor ◽  
P Value ◽  
Acute Glomerulonephritis ◽  
Female Ratio

Background Hypertensive crisis occurs in 1-4% of the hypertensive pediatric population, mostly due to acute glomerulonephritis (AGN). Some factors have been suggested to affect blood pressure (BP) in children, such as age, sex, race/ethnicity, obesity, and socioeconomic status, but little is known for risk factors for hypertensive crisis in AGN.Objective To analyze the risk factors for hypertensive crisis in children with AGN.Methods Retrospectively, we studied possible risk factors for hypertensive crisis in children with AGN at Dr. Soetomo Hospital from 2007 to 2011. Hypertensive crisis was defined as systolic BP ≥180 mmHg or diastolic BP ≥120 mmHg (for children ≥ 6 years of age); and systolic and/or diastolic BP >50% above the 95th percentile (for children aged <6 years). We evaluated the demographic and clinical characteristics as potential risk factors. Statistical analysis was done with Chi-square, Fisher’s exact, and logistic regression tests. Variables with P <0.25 in the univariable analysis were further analyzed by the multivariable logistic regression model. A P value of < 0.05 was considered statistically significant.Results There were 101 children included (mean age 9.7 (SD 2.17) years), with a male-to-female ratio of 2.7:1. Hypertensive crisis occurred in 42 (41.6%) children, of whom 8 had hypertensive urgency and 34 had hypertensive emergency. Proteinuria was seen in 53 children with AGN (52.5%) and was the significant risk factor for hypertensive crisis in our subjects (OR=2.75; 95%CI 1.16 to 6.52; P=0.021). Gender, clinical profiles, ethnicity, nutritional status, blood urea nitrogen (BUN), and glomerular filtration rate (GFR) were not significant risk factors for hypertensive crisis.Conclusion Proteinuria is the significant risk factor for hypertensive crisis in children with AGN.

scholarly journals P1708EFFECT OF PREGNANCY ON KIDNEY TRANSPLANT RECIPIENTS: A PROPENSITY SCORE-MATCHED STUDY

2020 ◽  
Vol 35 (Supplement_3) ◽  
Author(s):  
Toyofumi Abe ◽  
Taniguchi Ayumu ◽  
Kawamura Masataka ◽  
Kato Taigo ◽  
Tomoko Namba-Hamano ◽  
...  
Keyword(s):  
Multivariate Analysis ◽  
Risk Factor ◽  
Kidney Transplant ◽  
Graft Survival ◽  
Significant Risk ◽  
Significant Risk Factor ◽  
P Value ◽  
Transplant Recipients ◽  
Kidney Transplant Recipients ◽  
Pregnancy And Delivery

Abstract Background and Aims This study aimed to evaluate whether the experience of pregnancy and delivery would be associated with poor maternal outcome among kidney transplant recipients. Method A total of 401 female transplant recipients from the Osaka University Transplantation Group Database were included in this study. 73 women who underwent renal transplantation between 1970 and 2017 and became pregnant and delivered at Osaka University Kidney Transplant Group Hospitals. Multivariable logistic regression analysis was used to assess the impact of pregnancy and delivery on renal transplant recipient outcome after one-to-one propensity score (PS) matching for 12 variables including serum creatinine at one year post-transplant between the parous group and the nulliparous group. The outcomes were kidney graft survival and patient survival. Results In all patients before PS matching, 75 (18.7%) of the 401 patients died and 137 (34.2%) of the 401 patients lost their kidney grafts during the follow-up period. In the multivariate analysis, pregnancy and delivery was not a significant risk factor for death (adjusted HR 0.662 [95%CI, 0.265-1.656], p-value 0.378) and for death-censored graft survival (adjusted HR 1.224 [95%CI, 0.683-2.196], p-value 0.497). In the PS matched population, 14 (17.5%) of the 80 patients died and 31 (38.8%) of the 80 patients lost their grafts. In the multivariate analysis, pregnancy and delivery was not a significant risk factor for death (adjusted HR 0.611 [95%CI, 0.180-2.072], p-value 0.430) and for death-censored graft survival (adjusted HR 1.308 [95%CI, 0.501-3.416], p-value 0.584). Conclusion Pregnancy and delivery after kidney transplantation was not associated with poor kidney transplant outcome in recipients with adequate and stable graft function.

scholarly journals Analysis of lymphocyte T(CD4+) cells expression on severe early childhood caries and free caries

2020 ◽  
Author(s):  
Muhammad Luthfi ◽  
Priyawan Rachmadi ◽  
Aqsa Sjuhada Oki ◽  
Retno Indrawati ◽  
Agung Sosiawan ◽  
...  
Keyword(s):  
T Cells ◽  
Early Childhood ◽  
Early Childhood Caries ◽  
Significant Risk ◽  
Significant Risk Factor ◽  
Cell Receptor ◽  
P Value ◽  
Cd4 Cells ◽  
Severe Early Childhood Caries ◽  
Childhood Caries

Early childhood caries (ECC) is still one of the many diseases found in children throughout the world. Cariogenic bacteria are a significant risk factor for ECC associated with early colonization and high levels of cariogenic microbes (Streptococcus mutans, S. mutans). Lymphocyte T (CD4+) cells known as helper T cells, are effector cells for mediated host immunity. Naive T cells (CD4+) must be activated to initiate effector function. This activation occurs through interaction with professional antigen- presenting cells (pro-APC), especially dendritic cells that lead to intracellular pathways that regulate T cell receptor (TCR) more specifically against antigen in T cells. Lymphocyte cells from samples were collected from severe early childhood caries (S-ECC) and Free caries aged 5 to 6 years. The subjects were instructed to gargle 10 mL of sterile NaCl 1.5% solution for 30 seconds, and expectorate it into a sterile glass then analyzing T lymphocyte cell (CD4+) expression using flow cytometry. Lymphocyte T (CD4+) cell expression at SECC (6.2525±64482) while in free caries (8.4138±1.10397) with P-value (P=0. 000). Conclusion of lymphocyte T (CD4+) cells expression at S-ECC is lower than that occurring in free caries.

scholarly journals Dietary phenotype and advanced glycation end-products predict WTC-obstructive airways disease: a longitudinal observational study

2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Rachel Lam ◽  
Sophia Kwon ◽  
Jessica Riggs ◽  
Maria Sunseri ◽  
George Crowley ◽  
...  
Keyword(s):  
Observational Study ◽  
Dietary Habits ◽  
Significant Risk ◽  
Significant Risk Factor ◽  
Airway Hyperreactivity ◽  
Dietary Quality ◽  
Short Version ◽  
Advanced Glycation ◽  
Sugary Drinks ◽  
Obstructive Airways Disease

Abstract Background Diet is a modifier of metabolic syndrome which in turn is associated with World Trade Center obstructive airways disease (WTC-OAD). We have designed this study to (1) assess the dietary phenotype (food types, physical activity, and dietary habits) of the Fire Department of New York (FDNY) WTC-Health Program (WTC-HP) cohort and (2) quantify the association of dietary quality and its advanced glycation end product (AGE) content with the development of WTC-OAD. Methods WTC-OAD, defined as developing WTC-Lung Injury (WTC-LI; FEV1 < LLN) and/or airway hyperreactivity (AHR; positive methacholine and/or positive bronchodilator response). Rapid Eating and Activity Assessment for Participants-Short Version (REAP-S) deployed on 3/1/2018 in the WTC-HP annual monitoring assessment. Clinical and REAP-S data of consented subjects was extracted (7/17/2019). Diet quality [low-(15–19), moderate-(20–29), and high-(30–39)] and AGE content per REAP-S questionnaire were assessed for association with WTC-OAD. Regression models adjusted for smoking, hyperglycemia, hypertension, age on 9/11, WTC-exposure, BMI, and job description. Results N = 9508 completed the annual questionnaire, while N = 4015 completed REAP-S and had spirometry. WTC-OAD developed in N = 921, while N = 3094 never developed WTC-OAD. Low- and moderate-dietary quality, eating more (processed meats, fried foods, sugary drinks), fewer (vegetables, whole-grains),and having a diet abundant in AGEs were significantly associated with WTC-OAD. Smoking was not a significant risk factor of WTC-OAD. Conclusions REAP-S was successfully implemented in the FDNY WTC-HP monitoring questionnaire and produced valuable dietary phenotyping. Our observational study has identified low dietary quality and AGE abundant dietary habits as risk factors for pulmonary disease in the context of WTC-exposure. Dietary phenotyping, not only focuses our metabolomic/biomarker profiling but also further informs future dietary interventions that may positively impact particulate matter associated lung disease.

scholarly journals Association between Smoking and Academic Performance among Under-Graduate Students of Pakistan, A Cross-Sectional Study

2019 ◽  
Author(s):  
Sana Ullah ◽  
Siham Sikander ◽  
Mudassar Mushtaq Jawad Abbasi ◽  
Syed Aftab Rahim ◽  
Babar Hayat ◽  
...  
Keyword(s):  
Academic Performance ◽  
Undergraduate Students ◽  
Rural Areas ◽  
Urban Areas ◽  
Dietary Habits ◽  
Smoking Initiation ◽  
Cross Sectional Study ◽  
Self Report ◽  
P Value ◽  
Cross Sectional

Abstract Background Prevalence of smoking is on the rise and its harmful effects on every organ of body are well known. Smoking is a growing concern due to adverse effects on health, its association with academic performance is not well studied. Objectives This study aims to assess the prevalence of smoking among undergraduate students of age 18-24 years in a public sector university of Islamabad, association between smoking and academic performance and also to assess the reasons of smoking initiation among undergraduate students. Methods The study included 500 undergraduate students. A self-report structured questionnaire was used to assess smoking, dietary habits, physical activity, parent’s smoking, friend’s smoking, time spent on mobile and TV and academic performance for collection of data. Logistic regression was used for association between smoking and academic performance. Results Results of study show that 112/500 (22.4%) students were smokers among them 93/112 (34.6%) were males and 19/112 (8.2%) were females. The mean age of study participants was 21.50 years (SD: 1.72. Prevalence of smoking was higher in students belonging to rural areas 23.5% to that of urban areas 21.9%. Three major reasons of smoking initiation; 25% students stated peers and friends, 21% stated easy availability while 14% said it was fun and enjoyment they started smoking. High academic performance was found to be inversely proportional to student’s smoking; at p-value 0.000 smokers had 2.5 (1.77, 3.74) odds of lower academic performance, boys having 2.17 (1.56, 3.03) odds of lower academic performance in last semester exams. Conclusion Findings highlighted extensive cigarette smoking among undergraduate students of Islamabad. Smoking is significantly and negatively associated with academic performance.

Role of the oestrogen receptor (ESR1 PvuII and ESR1 325 C→G) and progesterone receptor (PROGINS) polymorphisms in genetic susceptibility to migraine in a North Indian population

Cephalalgia ◽  
2009 ◽  
Vol 30 (3) ◽  
pp. 311-320 ◽  
Author(s):  
G Joshi ◽  
S Pradhan ◽  
B Mittal
Keyword(s):  
Progesterone Receptor ◽  
Genetic Susceptibility ◽  
Oestrogen Receptor ◽  
Indian Population ◽  
Significant Risk ◽  
Significant Risk Factor ◽  
Protective Role ◽  
Recessive Model ◽  
P Value ◽  
North Indian Population

We aimed to explore the single-locus, haplotype and epistasis patterns and the contribution of oestrogen receptor [ESR1 PvuII (rs2234693), ESR1 325 C→G (rs1801132)] and progesterone receptor [PROGINS (rs1042838)] polymorphisms in genetic susceptibility to migraine by analysing 613 subjects consisting of 217 migraine patients, 217 healthy controls (HC) and 179 patients with tension-type headache (TTH). Entire data were analysed by taking the Bonferroni corrected P-value into account. We found significant association of TT genotype [odds ratio (OR) 3.458, confidence interval (CI) 1.757, 6.806; P = 0.0003] and T allele (OR 1.729, CI 1.309, 2.284; P = 0.0001) of ESR1 PvuII single nucleotide polymorphism with migraine when compared with HC. Significant association was seen only in female migraine patients at both genotype ( P = 0.002; OR 3.834, CI 1.625, 9.043) and allele level ( P = 0.002; OR 1.721, CI 1.228, 2.413). Moreover, higher risk was limited to migraine with aura (MA) (in case of TT genotype, P = 0.002; OR 4.377, CI 1.703, 1.246; in case of T allele, P = 0.001; OR 1.888, CI 1.305, 2.735) rather than migraine without aura (MoA) ( P-value of TT genotype = 0.003; OR 3.082, CI 1.465, 6.483; P-value T allele = 0.002; OR 1.630, CI 1.188, 2.236). In case of a recessive model, risk was seen with migraine patients ( P = 0.0003; OR 2.514, CI 1.635, 3.867), MA ( P = 0.0001; OR 3.583, CI 1.858, 6.909) and MoA patients ( P = 0.002; OR 2.125, CI 1.304, 3.464) when compared with HC. No risk was observed when TTH patients were compared with HC. No significance of ESR 325 G→C polymorphism was seen in any of the models under study. Significant differences in genotypic ( P = 0.0001) and allelic frequency ( P = 0.0002) were seen in case of PROGINS polymorphism when migraine patients were compared with HC, showing a protective effect (for A1A2 genotype, OR 0.292, CI 0.155, 0.549; for A2 allele, OR 0.320, CI 0.174, 0.589). Moreover, significance was seen only in case of female migraine patients at genotype ( P = 0.002; OR 0.344, CI 0.176, 0.684) as well as allele levels ( P = 0.004; OR 0.379, CI 0.198, 0.727) in case of PROGINS polymorphism. ESR1 PvuII TT*ESR1 325 C→G CG genotype, PROGINS A1A2*ESR1 325 C→G CG genotype and ESR1 PvuII CT*PROGINS A1A2 interacted significantly, but significance was lost after Bonferroni correction. In conclusion, ESR1 PvuII polymorphism is a significant risk factor for migraine particularly in women and MA patients, but ESR 325 C→G polymorphism is not associated with migraine susceptibility. PROGINS polymorphism seems to play a protective role in genetic susceptibility to migraine in the North Indian population.

scholarly journals Salt Taste Genotype, Dietary Habits and Biomarkers of Health: No Associations in an Elderly Cohort

Nutrients ◽  
2020 ◽  
Vol 12 (4) ◽  
pp. 1056 ◽  
Author(s):  
Celeste Ferraris ◽  
Alexandria Turner ◽  
Kiranjit Kaur ◽  
Jessica Piper ◽  
Martin Veysey ◽  
...  
Keyword(s):  
Diet Quality ◽  
Dietary Habits ◽  
Sodium Intake ◽  
Significant Risk ◽  
Significant Risk Factor ◽  
Nucleotide Polymorphisms ◽  
Least Squares Regression ◽  
Cross Sectional ◽  
Salt Taste ◽  
Elderly Cohort

A small amount of emerging research has observed variations between individual sensitivity, preference and intake of salt in the presence of single nucleotide polymorphisms (SNP) on the genes encoding salt taste receptors. Sodium intake is a significant risk factor for common diseases in elderly populations such as hypertension and cardiovascular disease; however, this does not fully explain the risk. Research into the influence of salt taste genetics on diet quality is yet to be undertaken and current research on indicators of health is limited and mixed in the direction of associations. Therefore, a secondary analysis of data from a well-characterised elderly cohort (the cross-sectional Retirement Health and Lifestyle Study, n = 536) was conducted to explore relationships between the salt taste-related SNP TRPV1-rs8065080 (assessed by Taqman genotyping assay), dietary habits and biomarkers of health. Data were analysed with standard least squares regression modelling and Tukey’s HSD post hoc tests. No association was found between the TRPV1-rs8065080 genotype, sodium intake or multiple diet quality indices (assessed by food frequency questionnaire). Sodium-related markers of health including blood pressure and markers of kidney function (urinary creatinine and albumin/creatinine ratio) and general health markers, such as Body Mass Index (BMI), were also not related to TRPV1-rs8065080 genotype. To date, this study is the most comprehensive investigation conducted to determine if the TRPV1-rs8065080 genotype relates to sodium intake and health markers influenced by sodium intake. Although no significant relationships were found, these findings are an important contribution to the limited body of knowledge surround this SNP. In addition to further research across other ages and cultures, the TRPV1-rs8065080 genotype may interact with other ion channels, and so further studies are required to determine if polymorphic variations influence sodium intake, diet and health.

scholarly journals ANESTHETIC CONCERNS IN PAEDS CARDIAC CATHETERIZATION AT ARMED FORCES INSTITUTE OF CARDIOLOGY / NATIONAL INSTITUTE OF HEART DISEASES

2021 ◽  
Vol 70 (Suppl-4) ◽  
pp. S752-56
Author(s):  
Dr Amna ◽  
Naila Niaz ◽  
Zainab Farid ◽  
Umair Younas ◽  
Rehana Javaid
Keyword(s):  
Cardiac Catheterization ◽  
Heart Diseases ◽  
Significant Risk ◽  
Armed Forces ◽  
Structural Heart Disease ◽  
Significant Risk Factor ◽  
P Value ◽  
Therapeutic Procedures ◽  
Pediatric Cardiac Catheterization ◽  
Medical Advances

Objective: To examine the types of procedures and analyze the frequency of anesthesia-related complications during pediatric cardiac catheterization. Study Design: A prospective observational study. Place and Duration of Study: Pediatric Cardiac Catheterization Lab at AFIC/NIHD Rawalpindi, from July 2019 to Nov 2019. Methodology: Total 180 consecutive patients undergoing cardiac catheterization fulfilling inclusion criteria were studied. Demographic variables, diseases, type of procedure, variables and anesthesia-related complications were noted. All the data was analyzed using SPSS-23. Results: The study included180 patients where 96 (53.3%) were male and 84 (46.7%) were female. Most of the patients in our study were between ages 1 to 3 years (85). 99 (55.0%) patients had diagnostic cardiac catheterizetion (CC), while 81 (45%) patients underwent interventional procedures. The overall complication rate noted as 18.9%, including arrhythmia in 11.1% followed by hypotension 4.4%, laryngospasm 3.9% and inotropic support requirement 3.3%, Mortality was 0.6%. Most of the patients presenting to the pediatric cardiac catheterization lab were for PDA device closure (16.6%). Age of child was found to be significant risk factor for cardiac catheterizetion associated complications with a p-value of 0.022. Conclusion: Congenital and structural heart disease catheterization procedures are progressively increasing, especially due to the medical advances and complex interventional therapeutic procedures. A thorough preanesthesia assessment should be carried out to optimize before cardiac catheterization.

scholarly journals Dietary Phenotype and Advanced Glycation End-Products Predict WTC-Obstructive Airways Disease: a Longitudinal Observational Study

2020 ◽  
Author(s):  
Rachel Lam ◽  
Sophia Kwon ◽  
Jessica Riggs ◽  
Maria Sunseri ◽  
George Crowley ◽  
...  
Keyword(s):  
Observational Study ◽  
Dietary Habits ◽  
Significant Risk ◽  
Significant Risk Factor ◽  
Airway Hyperreactivity ◽  
Dietary Quality ◽  
Short Version ◽  
Advanced Glycation ◽  
Sugary Drinks ◽  
Obstructive Airways Disease

Abstract BACKGROUND. Diet is a modifier of metabolic syndrome which in turn is associated with World Trade Center Obstructive Airways Disease(WTC-OAD). We have designed this study to 1.assess the dietary phenotype(food types, physical activity, and dietary habits) of the Fire Department of New York(FDNY) WTC-Health Program(WTC-HP) cohort and 2.quantify the association of dietary quality and its advanced glycation end product(AGE) content with the development of WTC-OAD.METHODS. WTC-OAD, defined as developing WTC-Lung Injury(WTC-LI;FEV1<LLN) and/or airway hyperreactivity(AHR;positive methacholine and/or positive bronchodilator response). Rapid Eating and Activity Assessment for Participants-Short Version(REAP-S) deployed on 3/1/2018 in the WTC-HP annual monitoring assessment. Clinical and REAP-S data of consented subjects was extracted(7/17/2019). Diet quality[low-(15-19), moderate-(20-29), and high-(30-39)] and AGE content per REAP-S questionnaire were assessed for association with WTC-OAD. Regression models adjusted for smoking,hyperglycemia,hypertension,age on 9/11,WTC-exposure,BMI and job description. RESULTS. N=9,508 completed the annual questionnaire, while N=4,015 completed REAP-S and had spirometry. WTC-OAD developed in N=921, while N=3,094 never developed WTC-OAD. Low- and moderate-dietary quality, eating more (processed meats,fried foods,sugary drinks), fewer(vegetables,whole-grains),and having a diet abundant in AGEs were significantly associated with WTC-OAD. Smoking was not a significant risk factor of WTC-OAD. CONCLUSIONS. REAP-S was successfully implemented in the FDNY WTC-HP monitoring questionnaire and produced valuable dietary phenotyping. Our observational study has identified low dietary quality and AGE abundant dietary habits as risk factors for pulmonary disease in the context of WTC-exposure. Dietary phenotyping, not only focuses our metabolomic/biomarker profiling but also further informs future dietary interventions that may positively impact particulate matter associated lung disease.

scholarly journals Dietary Phenotype and Advanced Glycation End-Products Predict WTC-Obstructive Airways Disease: a Longitudinal Observational Study

2020 ◽  
Author(s):  
Rachel Lam ◽  
Sophia Kwon ◽  
Jessica Riggs ◽  
Maria Sunseri ◽  
George Crowley ◽  
...  
Keyword(s):  
Observational Study ◽  
Dietary Habits ◽  
Significant Risk ◽  
Significant Risk Factor ◽  
Airway Hyperreactivity ◽  
Dietary Quality ◽  
Short Version ◽  
Advanced Glycation ◽  
Sugary Drinks ◽  
Obstructive Airways Disease

Abstract BACKGROUND. Diet is a modifier of metabolic syndrome which in turn is associated with World Trade Center Obstructive Airways Disease(WTC-OAD). We have designed this study to 1.assess the dietary phenotype(food types, physical activity, and dietary habits) of the Fire Department of New York(FDNY) WTC-Health Program(WTC-HP) cohort and 2.quantify the association of dietary quality and its advanced glycation end product(AGE) content with the development of WTC-OAD.METHODS. WTC-OAD, defined as developing WTC-Lung Injury(WTC-LI;FEV1<LLN) and/or airway hyperreactivity(AHR;positive methacholine and/or positive bronchodilator response). Rapid Eating and Activity Assessment for Participants-Short Version(REAP-S) deployed on 3/1/2018 in the WTC-HP annual monitoring assessment. Clinical and REAP-S data of consented subjects was extracted(7/17/2019). Diet quality[low-(15-19), moderate-(20-29), and high-(30-39)] and AGE content per REAP-S questionnaire were assessed for association with WTC-OAD. Regression models adjusted for smoking,hyperglycemia,hypertension,age on 9/11,WTC-exposure,BMI and job description. RESULTS. N=9,508 completed the annual questionnaire, while N=4,015 completed REAP-S and had spirometry. WTC-OAD developed in N=921, while N=3,094 never developed WTC-OAD. Low- and moderate-dietary quality, eating more (processed meats,fried foods,sugary drinks), fewer(vegetables,whole-grains),and having a diet abundant in AGEs were significantly associated with WTC-OAD. Smoking was not a significant risk factor of WTC-OAD. CONCLUSIONS. REAP-S was successfully implemented in the FDNY WTC-HP monitoring questionnaire and produced valuable dietary phenotyping. Our observational study has identified low dietary quality and AGE abundant dietary habits as risk factors for pulmonary disease in the context of WTC-exposure. Dietary phenotyping, not only focuses our metabolomic/biomarker profiling but also further informs future dietary interventions that may positively impact particulate matter associated lung disease.

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