scholarly journals Alpha-Lipoic Acid as a Nutritive Supplement for Humans and Animals: An Overview of Its Use in Dog Food

Animals ◽  
2021 ◽  
Vol 11 (5) ◽  
pp. 1454
Author(s):  
Reshma M. Anthony ◽  
Jennifer M. MacLeay ◽  
Kathy L. Gross
Keyword(s):  
Body Weight ◽  
Lipoic Acid ◽  
Animal Studies ◽  
Healthy Adult ◽  
Oral Intake ◽  
Maximum Tolerated Dose ◽  
Cochrane Library ◽  
Alpha Lipoic Acid ◽  
Dog Food ◽  
Upper Limit

Alpha-lipoic acid (a-LA) is used as a nutritive additive in dog food. Therefore, we performed a systematic review of studies published to date in PubMed, Google Scholar, Cochrane Library and MedlinePlus involving alpha-lipoic acid supplementation, which included human clinical trials as well as animal studies, to evaluate its utility as a supplement in foods for healthy, adult dogs. While an upper limit of alpha-lipoic acid intake in humans has not been conclusively determined, the levels for oral intake of a-LA have been better defined in animals, and distinct differences based on species have been described. The maximum tolerated oral dose of a-LA in dogs has been reported as 126 mg/kg body weight and the LD50 as 400 to 500 mg/kg body weight. The antioxidant, anti-inflammatory and neuro-protective benefits of alpha-lipoic acid in dogs were observed at concentrations much lower than the maximum tolerated dose or proposed LD50. At concentrations of 2.7–4.94 mg/kg body weight/day, alpha-lipoic acid is well tolerated and posed no health risks to dogs while providing improved antioxidant capacity. This review thereby supports the utility of alpha-lipoic acid as an effective nutritive additive in dog food.

scholarly journals Alpha-Lipoic Acid Is an Effective Nutritive Antioxidant for Healthy Adult Dogs

Animals ◽  
2021 ◽  
Vol 11 (2) ◽  
pp. 274
Author(s):  
Reshma M. Anthony ◽  
Jennifer M. MacLeay ◽  
Dennis E. Jewell ◽  
John J. Brejda ◽  
Kathy L. Gross
Keyword(s):  
Body Weight ◽  
Lipoic Acid ◽  
Healthy Adult ◽  
Serum Biochemistry ◽  
Baseline Period ◽  
Blood Parameters ◽  
Reference Ranges ◽  
Alpha Lipoic Acid ◽  
Total Glutathione ◽  
Glutathione Status

This study was designed to determine the effect of alpha-lipoic acid on the glutathione status in healthy adult dogs. Following a 15 month baseline period during which dogs were fed a food containing no alpha-lipoic acid, dogs were randomly allocated into four groups. Groups were then fed a nutritionally complete and balanced food with either 0, 75, 150 or 300 ppm of alpha-lipoic acid added for 6 months. Evaluations included physical examination, body weight, food intake, hematology, serum biochemistry profile and measurements of glutathione in plasma and erythrocyte lysates. Throughout, blood parameters remained within reference ranges, dogs were healthy and body weight did not change significantly. A significant increase of 0.05 ng/mL of total glutathione in red blood cell (RBC) lysate for each 1 mg/kg bodyweight/day increase in a-LA intake was observed. In addition, a significant increase was observed for GSH, GSSG and total glutathione in RBC lysate at Month 6. We conclude that alpha-lipoic acid, as part of a complete and balanced food, was associated with increasing glutathione activity in healthy adult dogs.

Alpha-lipoic acid

2006 ◽  
Vol 238 ◽  
pp. 1-2
Keyword(s):  
Diabetic Neuropathy ◽  
Lipoic Acid ◽  
Toxic Metals ◽  
Animal Studies ◽  
Clinical Evidence ◽  
Alpha Lipoic Acid ◽  
Clinical Indications

In a nutshellALA is a powerful antioxidant, both water and lipid soluble, that can also regenerate other antioxidants.A range of ‘antioxidant’ and other clinical indications (such as chelating toxic metals) have been tested in small, open trials and/or animal studies. The most convincing clinical evidence so far is for a possible role in diabetes, particularly in treating diabetic neuropathy.

Effects of Alpha-Lipoic Acid on Body Weight in Obese Subjects

2011 ◽  
Vol 124 (1) ◽  
pp. 85.e1-85.e8 ◽  
Author(s):  
Eun Hee Koh ◽  
Woo Je Lee ◽  
Sang Ah Lee ◽  
Eun Hee Kim ◽  
Eun Hee Cho ◽  
...  
Keyword(s):  
Body Weight ◽  
Lipoic Acid ◽  
Alpha Lipoic Acid ◽  
Obese Subjects

scholarly journals Pemberian alpha lipoic acid per oral dan latihan fisik intensitas sedang menurunkan berat badan dan lemak abodminal lebih banyak daripada latihan fisik intensitas sedang saja pada tikus Wistar jantan dengan obesitas

2017 ◽  
Vol 9 (1) ◽  
Author(s):  
Aji B. Chandra ◽  
Alex Pangkahila ◽  
Wimpie Pangkahila
Keyword(s):  
Body Weight ◽  
Physical Exercise ◽  
Lipoic Acid ◽  
Abdominal Fat ◽  
Control Group ◽  
Alpha Lipoic Acid ◽  
Control Group Design ◽  
Post Test ◽  
Visceral Abdominal Fat ◽  
Per Oral

Abstract: This study was aimed to prove that oral administration of ALA and moderate physical exercise decrease body weight and abdominal fat more than moderate physical exercise only in obese male Wistar rats. This was a true experimental study with a post-test only control group design. Subjects were 30 Wistar rats (Rattus norvegicus), male, healthy, aged 4-5 months, and obese with minimum weight of 250 g, divided into 3 groups, as follows: 1) P0, the control group with no treatment; 2) P1, given moderate physical exercise (swimming for 20 minutes/day, for 4 weeks); 3) P2, given moderate physical exercise and ALA per oral 15 mg/day for 4 weeks. The results showed that the average body weight after 4 weeks of treatment of P0 group was 279.10±5.84 g; of P1 group was 257.90±10.31 g; and of P2 group was 213.90±8.92 g (P < 0.01). The mean weight of subcutaneous abdominal fat of P0 group was 0.96±0.45 g; of P1 group was 0.63±0.31 g; and of P2 group was 0.40±0.23 g (P < 0.01 ). Moreover, the mean weight of visceral abdominal fat of P0 group was 1.23±0.37 g; of P1 group was 0.83±0.24 g; and of P2 group was 0.39±0.25 g (P < 0,01). Conclusion: Oral administration of ALA and moderate physical exercise decrease body weight, subcutaneous abdominal fat, and visceral abdominal fat more than moderate physical exercise only in obese male Wistar rats.Keywords: alpha lipoic acid, obesity, body weight, abdominal fatAbstrak: Penelitian ini bertujuan untuk membuktikan bahwa pemberian ALA per oral yang dikombinasi dengan latihan fisik intensitas sedang menurunkan berat badan, lemak subkutan abdominal, dan lemak viseral abdominal lebih banyak daripada latihan fisik intensitas sedang saja pada tikus Wistar jantan dengan obesitas. Jenis penelitian ialah eksperimental murni dengan post-test only control group design. Subjek penelitian ialah 30 ekor tikus putih (Rattus norvegicus) jantan, galur Wistar, sehat, usia 4-5 bulan, dan obes dengan berat badan minimal 250 g yang terbagi menjadi tiga kelompok masing-masing berjumlah 10 ekor tikus, yaitu: P0 (kelompok kontrol), tidak mendapat perlakuan apapun; P1, kelompok perlakuan 1 yang diberikan latihan fisik intensitas sedang (renang durasi 20 menit/hari selama 4 minggu); dan P2, kelompok perlakuan 2 yang diberikan latihan fisik intensitas sedang serta ALA per oral dengan dosis 15mg/hari selama 4 minggu. Hasil penelitian menunjukkan bahwa rerata berat badan setelah 4 minggu perlakuan pada kelompok P0 ialah 279,10±5,84 gr; pada kelompok P1 257,90±10,31 gr; dan pada kelompok P2 213,90±8,92 gr (P < 0,01). Rerata berat lemak subkutan abdominal pada kelompok P0 ialah 0,96±0,45 gr; pada kelompok P1 0,63±0,31 gr; dan pada kelompok P2 0,40±0,23 gr (P < 0,01). Selain itu, rerata berat lemak viseral abdominal pada kelompok P0 ialah 1,23±0,37 gr; pada kelompok P1 0,83±0,24 gr; dan pada kelompok P2 0,39±0,25 gr (P < 0,01). Simpulan: Pemberian ALA per oral dengan latihan fisik intensitas sedang dapat menurunkan berat badan, lemak subkutan abdominal, dan lemak viseral abdominal lebih banyak daripada latihan fisik intensitas sedang saja pada tikus Wistar jantan dengan obesitasKata kunci: alpha lipoic acid, obesitas, berat badan, lemak abdominal

The Effect of Prebiotic Products on Decreasing Adiposity Parameters in Overweight and Obese Individuals: A Systematic Review and Meta- Analysis

2020 ◽  
Vol 28 (2) ◽  
pp. 419-431
Author(s):  
Hua Qu ◽  
Lei Song ◽  
Ying Zhang ◽  
Zhu-ye Gao ◽  
Da-zhuo Shi
Keyword(s):  
Body Weight ◽  
Fat Mass ◽  
Animal Studies ◽  
Weighted Mean Difference ◽  
Meta Analysis ◽  
Small Sample ◽  
Inflammatory Biomarkers ◽  
Cochrane Library ◽  
Small Sample Sizes ◽  
Factor Α

Background: Prebiotics are substrates selectively utilized by host microorganisms to confer health benefits. The potential of prebiotics to decrease body weight in overweight/obese individuals was suggested by some clinical and animal studies. However, these studies were based on relatively small sample sizes and the precise effects of prebiotic products have not yet been evaluated. Therefore, the present meta-analysis of Randomized Controlled Trials (RCTs) was designed to comprehensively assess the effects of prebiotic products on overweight and obese individuals. Methods: PubMed, EMBASE and Cochrane Library were searched to identify RCT investigating the effects of prebiotic products on overweight and obese individuals. We calculated the pooled weighted mean difference (WMD) to assess the effects of prebiotic products on Body Mass Index (BMI), body weight, fat mass and inflammatory biomarkers. Results: Twelve RCTs with a total of 535 overweight and obese individuals were enrolled. Compared with placebo, prebiotic products decreased C reactive protein (WMD, -1.06 mg/L; 95%CI, -1.72 to - 0.40; p=0.002), tumour necrosis factor-α(WMD, -0.64 pg/mL; 95%CI, -1.11 to -0.18; p=0.006) and other inflammatory markers, such as interleukin-1β，lipopolysaccharide (p<0.05); whereas no reductions in BMI (WMD, -0.20 kg/m2; 95%CI, -0.58 to 0.19; p=0.32), body weight (WMD, -0.51 kg; 95%CI, -1.18 to 0.16; p=0.14) and fat mass (WMD, 0.11 kg; 95%CI, -0.04 to 0.25; p=0.15) were observed. Conclusion: In the present analysis, comprehensive evidence suggested that prebiotic products did not decrease adiposity parameters (BMI, body weight and body fat mass), but they could decrease the levels of systemic inflammatory biomarkers, implying adherence to prebiotic products might be a promising complementary approach to managing inflammatory states in overweight and obese individuals.

scholarly journals Protective Effect of Alpha-Lipoic Acid on Salivary Dysfunction in a Mouse Model of Radioiodine Therapy-Induced Sialoadenitis

2020 ◽  
Vol 21 (11) ◽  
pp. 4136 ◽  
Author(s):  
Jung Hwa Jung ◽  
Jin Hyun Kim ◽  
Myeong Hee Jung ◽  
Seung Won Kim ◽  
Bae Kwon Jeong ◽  
...  
Keyword(s):  
Body Weight ◽  
Mouse Model ◽  
Lipoic Acid ◽  
Single Photon ◽  
Photon Emission ◽  
Control Group ◽  
Emission Computed Tomography ◽  
Alpha Lipoic Acid ◽  
99Mtc Pertechnetate ◽  
Group I

Radioiodine (RI) therapy is known to cause salivary gland (SG) dysfunction. The effects of antioxidants on RI-induced SG damage have not been well described. This study was performed to investigate the radioprotective effects of alpha lipoic acid (ALA) administered prior to RI therapy in a mouse model of RI-induced sialadenitis. Four-week-old female C57BL/6 mice were divided into four groups (n = 10 per group): group I, normal control; group II, ALA alone (100 mg/kg); group III, RI alone (0.01 mCi/g body weight, orally); and group IV, ALA + RI (ALA at 100 mg/kg, 24 h and 30 min before RI exposure at 0.01 mCi/g body weight). The animals in these groups were divided into two subgroups and euthanized at 30 or 90 days post-RI treatment. Changes in salivary 99mTc pertechnetate uptake and excretion were tracked by single-photon emission computed tomography. Salivary histological examinations and TUNEL assays were performed. The 99mTc pertechnetate excretion level recovered in the ALA treatment group. Salivary epithelial (aquaporin 5) cells of the ALA + RI group were protected from RI damage. The ALA + RI group exhibited more mucin-containing parenchyma and less fibrotic tissues than the RI only group. Fewer apoptotic cells were observed in the ALA + RI group compared to the RI only group. Pretreatment with ALA before RI therapy is potentially beneficial in protecting against RI-induced salivary dysfunction.

Effects of alpha lipoic acid and its derivative “andrographolid‐lipoic acid‐1” on ulcerative colitis: A systematic review with meta‐analysis of animal studies

2018 ◽  
Vol 120 (4) ◽  
pp. 4766-4782 ◽  
Author(s):  
Mahsa Moeinian ◽  
Amir Hossein Abdolghaffari ◽  
Shekoufeh Nikfar ◽  
Saeideh Momtaz ◽  
Mohammad Abdollahi
Keyword(s):  
Systematic Review ◽  
Ulcerative Colitis ◽  
Lipoic Acid ◽  
Animal Studies ◽  
Meta Analysis ◽  
Alpha Lipoic Acid
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