scholarly journals Alpha-Lipoic Acid Is an Effective Nutritive Antioxidant for Healthy Adult Dogs

Animals ◽  
2021 ◽  
Vol 11 (2) ◽  
pp. 274
Author(s):  
Reshma M. Anthony ◽  
Jennifer M. MacLeay ◽  
Dennis E. Jewell ◽  
John J. Brejda ◽  
Kathy L. Gross
Keyword(s):  
Body Weight ◽  
Lipoic Acid ◽  
Healthy Adult ◽  
Serum Biochemistry ◽  
Baseline Period ◽  
Blood Parameters ◽  
Reference Ranges ◽  
Alpha Lipoic Acid ◽  
Total Glutathione ◽  
Glutathione Status

This study was designed to determine the effect of alpha-lipoic acid on the glutathione status in healthy adult dogs. Following a 15 month baseline period during which dogs were fed a food containing no alpha-lipoic acid, dogs were randomly allocated into four groups. Groups were then fed a nutritionally complete and balanced food with either 0, 75, 150 or 300 ppm of alpha-lipoic acid added for 6 months. Evaluations included physical examination, body weight, food intake, hematology, serum biochemistry profile and measurements of glutathione in plasma and erythrocyte lysates. Throughout, blood parameters remained within reference ranges, dogs were healthy and body weight did not change significantly. A significant increase of 0.05 ng/mL of total glutathione in red blood cell (RBC) lysate for each 1 mg/kg bodyweight/day increase in a-LA intake was observed. In addition, a significant increase was observed for GSH, GSSG and total glutathione in RBC lysate at Month 6. We conclude that alpha-lipoic acid, as part of a complete and balanced food, was associated with increasing glutathione activity in healthy adult dogs.

scholarly journals Alpha-Lipoic Acid as a Nutritive Supplement for Humans and Animals: An Overview of Its Use in Dog Food

Animals ◽  
2021 ◽  
Vol 11 (5) ◽  
pp. 1454
Author(s):  
Reshma M. Anthony ◽  
Jennifer M. MacLeay ◽  
Kathy L. Gross
Keyword(s):  
Body Weight ◽  
Lipoic Acid ◽  
Animal Studies ◽  
Healthy Adult ◽  
Oral Intake ◽  
Maximum Tolerated Dose ◽  
Cochrane Library ◽  
Alpha Lipoic Acid ◽  
Dog Food ◽  
Upper Limit

Alpha-lipoic acid (a-LA) is used as a nutritive additive in dog food. Therefore, we performed a systematic review of studies published to date in PubMed, Google Scholar, Cochrane Library and MedlinePlus involving alpha-lipoic acid supplementation, which included human clinical trials as well as animal studies, to evaluate its utility as a supplement in foods for healthy, adult dogs. While an upper limit of alpha-lipoic acid intake in humans has not been conclusively determined, the levels for oral intake of a-LA have been better defined in animals, and distinct differences based on species have been described. The maximum tolerated oral dose of a-LA in dogs has been reported as 126 mg/kg body weight and the LD50 as 400 to 500 mg/kg body weight. The antioxidant, anti-inflammatory and neuro-protective benefits of alpha-lipoic acid in dogs were observed at concentrations much lower than the maximum tolerated dose or proposed LD50. At concentrations of 2.7–4.94 mg/kg body weight/day, alpha-lipoic acid is well tolerated and posed no health risks to dogs while providing improved antioxidant capacity. This review thereby supports the utility of alpha-lipoic acid as an effective nutritive additive in dog food.

Effects of Alpha-Lipoic Acid on Body Weight in Obese Subjects

2011 ◽  
Vol 124 (1) ◽  
pp. 85.e1-85.e8 ◽  
Author(s):  
Eun Hee Koh ◽  
Woo Je Lee ◽  
Sang Ah Lee ◽  
Eun Hee Kim ◽  
Eun Hee Cho ◽  
...  
Keyword(s):  
Body Weight ◽  
Lipoic Acid ◽  
Alpha Lipoic Acid ◽  
Obese Subjects

scholarly journals Pemberian alpha lipoic acid per oral dan latihan fisik intensitas sedang menurunkan berat badan dan lemak abodminal lebih banyak daripada latihan fisik intensitas sedang saja pada tikus Wistar jantan dengan obesitas

2017 ◽  
Vol 9 (1) ◽  
Author(s):  
Aji B. Chandra ◽  
Alex Pangkahila ◽  
Wimpie Pangkahila
Keyword(s):  
Body Weight ◽  
Physical Exercise ◽  
Lipoic Acid ◽  
Abdominal Fat ◽  
Control Group ◽  
Alpha Lipoic Acid ◽  
Control Group Design ◽  
Post Test ◽  
Visceral Abdominal Fat ◽  
Per Oral

Abstract: This study was aimed to prove that oral administration of ALA and moderate physical exercise decrease body weight and abdominal fat more than moderate physical exercise only in obese male Wistar rats. This was a true experimental study with a post-test only control group design. Subjects were 30 Wistar rats (Rattus norvegicus), male, healthy, aged 4-5 months, and obese with minimum weight of 250 g, divided into 3 groups, as follows: 1) P0, the control group with no treatment; 2) P1, given moderate physical exercise (swimming for 20 minutes/day, for 4 weeks); 3) P2, given moderate physical exercise and ALA per oral 15 mg/day for 4 weeks. The results showed that the average body weight after 4 weeks of treatment of P0 group was 279.10±5.84 g; of P1 group was 257.90±10.31 g; and of P2 group was 213.90±8.92 g (P < 0.01). The mean weight of subcutaneous abdominal fat of P0 group was 0.96±0.45 g; of P1 group was 0.63±0.31 g; and of P2 group was 0.40±0.23 g (P < 0.01 ). Moreover, the mean weight of visceral abdominal fat of P0 group was 1.23±0.37 g; of P1 group was 0.83±0.24 g; and of P2 group was 0.39±0.25 g (P < 0,01). Conclusion: Oral administration of ALA and moderate physical exercise decrease body weight, subcutaneous abdominal fat, and visceral abdominal fat more than moderate physical exercise only in obese male Wistar rats.Keywords: alpha lipoic acid, obesity, body weight, abdominal fatAbstrak: Penelitian ini bertujuan untuk membuktikan bahwa pemberian ALA per oral yang dikombinasi dengan latihan fisik intensitas sedang menurunkan berat badan, lemak subkutan abdominal, dan lemak viseral abdominal lebih banyak daripada latihan fisik intensitas sedang saja pada tikus Wistar jantan dengan obesitas. Jenis penelitian ialah eksperimental murni dengan post-test only control group design. Subjek penelitian ialah 30 ekor tikus putih (Rattus norvegicus) jantan, galur Wistar, sehat, usia 4-5 bulan, dan obes dengan berat badan minimal 250 g yang terbagi menjadi tiga kelompok masing-masing berjumlah 10 ekor tikus, yaitu: P0 (kelompok kontrol), tidak mendapat perlakuan apapun; P1, kelompok perlakuan 1 yang diberikan latihan fisik intensitas sedang (renang durasi 20 menit/hari selama 4 minggu); dan P2, kelompok perlakuan 2 yang diberikan latihan fisik intensitas sedang serta ALA per oral dengan dosis 15mg/hari selama 4 minggu. Hasil penelitian menunjukkan bahwa rerata berat badan setelah 4 minggu perlakuan pada kelompok P0 ialah 279,10±5,84 gr; pada kelompok P1 257,90±10,31 gr; dan pada kelompok P2 213,90±8,92 gr (P < 0,01). Rerata berat lemak subkutan abdominal pada kelompok P0 ialah 0,96±0,45 gr; pada kelompok P1 0,63±0,31 gr; dan pada kelompok P2 0,40±0,23 gr (P < 0,01). Selain itu, rerata berat lemak viseral abdominal pada kelompok P0 ialah 1,23±0,37 gr; pada kelompok P1 0,83±0,24 gr; dan pada kelompok P2 0,39±0,25 gr (P < 0,01). Simpulan: Pemberian ALA per oral dengan latihan fisik intensitas sedang dapat menurunkan berat badan, lemak subkutan abdominal, dan lemak viseral abdominal lebih banyak daripada latihan fisik intensitas sedang saja pada tikus Wistar jantan dengan obesitasKata kunci: alpha lipoic acid, obesitas, berat badan, lemak abdominal

scholarly journals EXPERIENCE OF ALPHA - LIPOIC ACID IN THE TREATMENT OF PSORIASIS IN PATIENTS WITH BAD HABITS

2021 ◽  
Vol 21 (2) ◽  
pp. 4-7
Author(s):  
O. Bezeha ◽  
Ya. Yemchenko ◽  
K. Vasylyeva
Keyword(s):  
Lipoic Acid ◽  
Blood Parameters ◽  
Toxic Substances ◽  
Alpha Lipoic Acid ◽  
Public Health Burden ◽  
High Prevalence ◽  
Complex Therapy ◽  
Psoriasis Therapy ◽  
New Treatment

The prevalence of psoriasis poses a considerable public health burden and requires the elaboration of new treatment approaches. Despite the high prevalence and incidence of the disease and large amounts of reports on this problem, there has not been established an integral vision on the pathogenesis of this dermatosis. Risk factors for psoriasis can be divided into two groups, first of all, external and internal ones. Special attention is paid to smoking and alcohol consumption. The aim of our study was to determine the role of alpha - lipoic acid as a component of the complex therapy for psoriatic patients with alcohol and smoking abuse. The study has demonstrated that alpha-lipoic acid increases the reserves of intracellular glutathione, prevents the damage of mitochondria during lipid peroxidation. This enables to restore the balance of redox processes in hepatocytes and reduces the damaging effects of toxic substances. The effectiveness of the psoriasis therapy including alpha-lipoic acid was evaluated by comparing the biochemical blood parameters of the patients who took the therapy with alpha-lipoic acid (I group) and who did not (II group). The obtained results show the patients of the I group the have indicators of total cholesterol improved by 73.7%, the indicators of total and direct bilirubin improved by 25.7% and 32.4%; infiltration and erythema has considerably diminished by 92.9% of the patients that is 2.3 times higher compared with patients of the II group (control). We consider that this study has supported higher therapeutic efficacy of the proposed method of complex therapy for psoriatic patients of the I group that includes the addition of 600 mg of alpha-lipoic acid as a single dose taken in 30 minutes before the first meal for a month.

scholarly journals Potential of Gmelina leaf meal diets on the productive and physiological characteristics of growing rabbits

2020 ◽  
Vol 12 (1) ◽  
Author(s):  
P.C. Jiwuba ◽  
U.O. Ikpe ◽  
N.L. Azodo
Keyword(s):  
Body Weight ◽  
Weight Gain ◽  
Feed Intake ◽  
Body Weight Gain ◽  
Serum Biochemistry ◽  
Blood Parameters ◽  
Haematological Parameters ◽  
Feed Conversion ◽  
Leaf Meal ◽  
Enhanced Production

Abstract. Rabbit production is highly attracting attention in the world today due to its reputation in supplying one of the safest meat and other useful animal products. Hence, a 49-day study was carried out to determine the feed intake, body weight gain, serum biochemistry and haematological parameters of 80 growing rabbits fed Gmelina arborea leaf meal (GALM) in their diets. Four diets were formulated: T1, T2, T3 and T4 containing GALM at 0%, 10%, 20% and 30%, respectively. The rabbits were randomly divided into four experimental groups of twenty animals each, with five rabbits constituting a replicate. Blood samples were drawn from each animal on the last day of the trial and evaluated for serum biochemistry and haematological parameters. Results on proximate composition revealed that the nutrient requirements were met. Feed intake and body weight gain (p<0.05) were improved in T4 in comparison with other groups. Feed conversion ratio was however best for T3 and T4 (p<0.05). The haematological parameters differed significantly (p<0.05) and were improved at 30% GALM inclusion across the groups. Results showed that all the serum biochemical parameters studied except globulin differed significantly (p<0.05) among the treatment groups. Cholesterol was reduced at 30% GALM inclusion (p<0.05). All the blood parameters fell within the physiological range for clinically healthy rabbits; an indication that GALM had a beneficial effect on rabbits. Diet T4 had the best performance data among the treatment diets and is therefore recommended for rabbit enhanced production.

scholarly journals Protective Effect of Alpha-Lipoic Acid on Salivary Dysfunction in a Mouse Model of Radioiodine Therapy-Induced Sialoadenitis

2020 ◽  
Vol 21 (11) ◽  
pp. 4136 ◽  
Author(s):  
Jung Hwa Jung ◽  
Jin Hyun Kim ◽  
Myeong Hee Jung ◽  
Seung Won Kim ◽  
Bae Kwon Jeong ◽  
...  
Keyword(s):  
Body Weight ◽  
Mouse Model ◽  
Lipoic Acid ◽  
Single Photon ◽  
Photon Emission ◽  
Control Group ◽  
Emission Computed Tomography ◽  
Alpha Lipoic Acid ◽  
99Mtc Pertechnetate ◽  
Group I

Radioiodine (RI) therapy is known to cause salivary gland (SG) dysfunction. The effects of antioxidants on RI-induced SG damage have not been well described. This study was performed to investigate the radioprotective effects of alpha lipoic acid (ALA) administered prior to RI therapy in a mouse model of RI-induced sialadenitis. Four-week-old female C57BL/6 mice were divided into four groups (n = 10 per group): group I, normal control; group II, ALA alone (100 mg/kg); group III, RI alone (0.01 mCi/g body weight, orally); and group IV, ALA + RI (ALA at 100 mg/kg, 24 h and 30 min before RI exposure at 0.01 mCi/g body weight). The animals in these groups were divided into two subgroups and euthanized at 30 or 90 days post-RI treatment. Changes in salivary 99mTc pertechnetate uptake and excretion were tracked by single-photon emission computed tomography. Salivary histological examinations and TUNEL assays were performed. The 99mTc pertechnetate excretion level recovered in the ALA treatment group. Salivary epithelial (aquaporin 5) cells of the ALA + RI group were protected from RI damage. The ALA + RI group exhibited more mucin-containing parenchyma and less fibrotic tissues than the RI only group. Fewer apoptotic cells were observed in the ALA + RI group compared to the RI only group. Pretreatment with ALA before RI therapy is potentially beneficial in protecting against RI-induced salivary dysfunction.

scholarly journals Evaluation of faba beans as an ingredient in dog diets: apparent total tract digestibility of extruded diets with graded levels of dehulled faba beans (Vicia faba L.) by dogs

2020 ◽  
Vol 98 (4) ◽  
Author(s):  
Isabella Corsato Alvarenga ◽  
Dalton Holt ◽  
Charles G Aldrich
Keyword(s):  
Body Weight ◽  
Complete Blood Count ◽  
Control Diet ◽  
Latin Square ◽  
Blood Chemistry ◽  
Blood Parameters ◽  
Least Square ◽  
Reference Ranges ◽  
Significance Level ◽  
Faba Beans

Abstract The growing pet food market is continuously in search for novel ingredients. Legumes such as faba beans (FB) are increasing in popularity and are known to benefit human health, but little is known about their use in pet foods. The objective of this study was to determine the effect of dehulled FB utilization by dogs. Experimental diets were extruded with 0%, 10%, 20%, and 30% FB inclusion (FB0, FB10, FB20, and FB30, respectively). Beagle dogs (n = 12) were fed the diets for 9-d adaptation with 5-d total fecal collection in a replicated 4 × 4 Latin square design. Apparent total tract digestibility (ATTD) was determined by external marker Cr2O3. At the culmination of each period, blood samples were collected from brachial venipuncture for complete blood count and blood chemistry. Palatability was determined with a 2-bowl test (n = 20). Means of blood parameters were separated by multivariate analysis of variance (MANOVA) with the aid of statistical software (SAS v9.4). Contrasts and least square means of fecal parameters and ATTD were computed. Significance level was considered to be α = 0.05. Dogs ate all food on offer and maintained body weight. There was no difference (P &gt; 0.05) among treatments (FB10, FB20, and FB30) and the control (FB0) relative to food intake, fecal output (“as is” basis), and fecal score, but feces were softer when dogs were fed the treatments (P = 0.031) and there was a linear increase (P = 0.011) in defecation frequency (stools/day) when FB increased in the diets. Dry matter, organic matter, and crude protein digestibilities were slightly higher when dogs were fed the control diet (P &lt; 0.05) compared with the FB diets. All blood and serum chemistry parameters were similar among treatments and within the reference ranges. Dogs preferred the control diet relative to the 10% and 30% FB diets, but the 20% FB preference was similar to the control. Dogs remained healthy, maintained body weight and no adverse health events were observed during the study. Dehulled FB are a suitable ingredient for dog foods, but concentrations should not exceed 20% to avoid reduction in palatability and stool quality.

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